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Protein

Quinolone resistance protein NorA

Gene

norA

Organism
Staphylococcus aureus
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in quinolone resistance. May constitute a membrane-associated active efflux pump of hydrophilic quinolones.

GO - Molecular functioni

Keywordsi

Biological processTransport

Protein family/group databases

TCDBi2.A.1.2.10 the major facilitator superfamily (mfs)

Names & Taxonomyi

Protein namesi
Recommended name:
Quinolone resistance protein NorA
Gene namesi
Name:norA
OrganismiStaphylococcus aureus
Taxonomic identifieri1280 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei5 – 25HelicalSequence analysisAdd BLAST21
Transmembranei42 – 62HelicalSequence analysisAdd BLAST21
Transmembranei69 – 89HelicalSequence analysisAdd BLAST21
Transmembranei99 – 119HelicalSequence analysisAdd BLAST21
Transmembranei129 – 149HelicalSequence analysisAdd BLAST21
Transmembranei157 – 177HelicalSequence analysisAdd BLAST21
Transmembranei201 – 221HelicalSequence analysisAdd BLAST21
Transmembranei239 – 259HelicalSequence analysisAdd BLAST21
Transmembranei269 – 289HelicalSequence analysisAdd BLAST21
Transmembranei293 – 313HelicalSequence analysisAdd BLAST21
Transmembranei331 – 351HelicalSequence analysisAdd BLAST21
Transmembranei355 – 375HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL5114

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001733741 – 388Quinolone resistance protein NorAAdd BLAST388

Interactioni

Chemistry databases

BindingDBiP0A0J7

Structurei

3D structure databases

ProteinModelPortaliP0A0J7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105DP8 Bacteria
ENOG410XQPT LUCA

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR011701 MFS
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
IPR004734 Multidrug-R
IPR001958 Tet-R_TetA/multi-R_MdtG
PfamiView protein in Pfam
PF07690 MFS_1, 1 hit
PRINTSiPR01035 TCRTETA
SUPFAMiSSF103473 SSF103473, 1 hit
TIGRFAMsiTIGR00880 2_A_01_02, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit

Sequencei

Sequence statusi: Complete.

P0A0J7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKQIFVLYF NIFLIFLGIG LVIPVLPVYL KDLGLTGSDL GLLVAAFALS
60 70 80 90 100
QMIISPFGGT LADKLGKKLI ICIGLILFSV SEFMFAVGHN FSVLMLSRVI
110 120 130 140 150
GGMSAGMVMP GVTGLIADIS PSHQKAKNFG YMSAIINSGF ILGPGIGGFM
160 170 180 190 200
AEVSHRMPFY FAGALGILAF IMSIVLIHDP KKSTTSGFQK LEPQLLTKIN
210 220 230 240 250
WKVFITPVIL TLVLSFGLSA FETLYSLYTA DKVNYSPKDI SIAITGGGIF
260 270 280 290 300
GALFQIYFFD KFMKYFSELT FIAWSLLYSV VVLILLVFAN GYWSIMLISF
310 320 330 340 350
VVFIGFDMIR PAITNYFSNI AGERQGFAGG LNSTFTSMGN FIGPLIAGAL
360 370 380
FDVHIEAPIY MAIGVSLAGV VIVLIEKQHR AKLKEQNM
Length:388
Mass (Da):42,265
Last modified:March 1, 2005 - v1
Checksum:iC36177EAEAADAC57
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti263M → V in AAB59089 (PubMed:2173911).Curated1
Sequence conflicti362A → D in AAB59089 (PubMed:2173911).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti352D → A No quinolone resistance. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D90119 Genomic DNA Translation: BAA14147.1
M62960 Genomic DNA Translation: AAB59089.1
PIRiA36242
A37838
RefSeqiWP_001041274.1, NZ_PQWV01000003.1

Similar proteinsi

Entry informationi

Entry nameiNORA_STAAU
AccessioniPrimary (citable) accession number: P0A0J7
Secondary accession number(s): P21191
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: March 1, 2005
Last modified: May 23, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health