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Protein

Quinolone resistance protein NorA

Gene

norA

Organism
Staphylococcus aureus
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Involved in quinolone resistance. May constitute a membrane-associated active efflux pump of hydrophilic quinolones.

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Transport

Protein family/group databases

TCDBi2.A.1.2.10. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Quinolone resistance protein NorA
Gene namesi
Name:norA
OrganismiStaphylococcus aureus
Taxonomic identifieri1280 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei5 – 2521HelicalSequence analysisAdd
BLAST
Transmembranei42 – 6221HelicalSequence analysisAdd
BLAST
Transmembranei69 – 8921HelicalSequence analysisAdd
BLAST
Transmembranei99 – 11921HelicalSequence analysisAdd
BLAST
Transmembranei129 – 14921HelicalSequence analysisAdd
BLAST
Transmembranei157 – 17721HelicalSequence analysisAdd
BLAST
Transmembranei201 – 22121HelicalSequence analysisAdd
BLAST
Transmembranei239 – 25921HelicalSequence analysisAdd
BLAST
Transmembranei269 – 28921HelicalSequence analysisAdd
BLAST
Transmembranei293 – 31321HelicalSequence analysisAdd
BLAST
Transmembranei331 – 35121HelicalSequence analysisAdd
BLAST
Transmembranei355 – 37521HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL5114.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 388388Quinolone resistance protein NorAPRO_0000173374Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi93062.SACOL0754.

Chemistry

BindingDBiP0A0J7.

Structurei

3D structure databases

ProteinModelPortaliP0A0J7.
SMRiP0A0J7. Positions 19-186.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105DP8. Bacteria.
ENOG410XQPT. LUCA.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR004734. Multidrug-R.
IPR001958. Tet-R_TetA/multi-R_MdtG.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
PRINTSiPR01035. TCRTETA.
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00880. 2_A_01_02. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0A0J7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKQIFVLYF NIFLIFLGIG LVIPVLPVYL KDLGLTGSDL GLLVAAFALS
60 70 80 90 100
QMIISPFGGT LADKLGKKLI ICIGLILFSV SEFMFAVGHN FSVLMLSRVI
110 120 130 140 150
GGMSAGMVMP GVTGLIADIS PSHQKAKNFG YMSAIINSGF ILGPGIGGFM
160 170 180 190 200
AEVSHRMPFY FAGALGILAF IMSIVLIHDP KKSTTSGFQK LEPQLLTKIN
210 220 230 240 250
WKVFITPVIL TLVLSFGLSA FETLYSLYTA DKVNYSPKDI SIAITGGGIF
260 270 280 290 300
GALFQIYFFD KFMKYFSELT FIAWSLLYSV VVLILLVFAN GYWSIMLISF
310 320 330 340 350
VVFIGFDMIR PAITNYFSNI AGERQGFAGG LNSTFTSMGN FIGPLIAGAL
360 370 380
FDVHIEAPIY MAIGVSLAGV VIVLIEKQHR AKLKEQNM
Length:388
Mass (Da):42,265
Last modified:March 1, 2005 - v1
Checksum:iC36177EAEAADAC57
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti263 – 2631M → V in AAB59089 (PubMed:2173911).Curated
Sequence conflicti362 – 3621A → D in AAB59089 (PubMed:2173911).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti352 – 3521D → A No quinolone resistance.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D90119 Genomic DNA. Translation: BAA14147.1.
M62960 Genomic DNA. Translation: AAB59089.1.
PIRiA36242.
A37838.
RefSeqiWP_001041274.1. NZ_LT009690.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D90119 Genomic DNA. Translation: BAA14147.1.
M62960 Genomic DNA. Translation: AAB59089.1.
PIRiA36242.
A37838.
RefSeqiWP_001041274.1. NZ_LT009690.1.

3D structure databases

ProteinModelPortaliP0A0J7.
SMRiP0A0J7. Positions 19-186.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi93062.SACOL0754.

Chemistry

BindingDBiP0A0J7.
ChEMBLiCHEMBL5114.

Protein family/group databases

TCDBi2.A.1.2.10. the major facilitator superfamily (mfs).

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG4105DP8. Bacteria.
ENOG410XQPT. LUCA.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR004734. Multidrug-R.
IPR001958. Tet-R_TetA/multi-R_MdtG.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
PRINTSiPR01035. TCRTETA.
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00880. 2_A_01_02. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNORA_STAAU
AccessioniPrimary (citable) accession number: P0A0J7
Secondary accession number(s): P21191
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: March 1, 2005
Last modified: September 7, 2016
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.