Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Superoxide dismutase [Mn] 1

Gene

sodA

Organism
Staphylococcus aureus (strain NCTC 8325)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. May play a role in maintaining cell viability throughout all stages of growth, but may be the major SOD activity in the exponential growth-phase. Has a role in resisting external superoxide stress. Involved in acid tolerance and the acid-adaptive response. Mediates the derepression of perR regulon in the response to HOCl stress when the level of SOD activity is low.3 Publications

Miscellaneous

According to PubMed:10383955 the levels of SodA activity and sodA expression are growth-phase dependent, occurring most during post-exponential phase. This response was also dependent on the level of aeration, with highest activity and expression occurring under high aeration.
Transcribed from two sigma-A-type promoters (PA1 and PA2). Transcriptional data show an indirect repression of PA1 promoter by sigma-B.

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.3 Publications

Cofactori

Mn2+By similarityNote: Binds 1 Mn2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi27ManganeseBy similarity1
Metal bindingi81ManganeseBy similarity1
Metal bindingi161ManganeseBy similarity1
Metal bindingi165ManganeseBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
Biological processStress response
LigandManganese, Metal-binding

Enzyme and pathway databases

BioCyciSAUR93061:G1G5Y-1537-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutase [Mn] 1 (EC:1.15.1.1)
Gene namesi
Name:sodA
Ordered Locus Names:SAOUHSC_01653
OrganismiStaphylococcus aureus (strain NCTC 8325)
Taxonomic identifieri93061 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001600751 – 199Superoxide dismutase [Mn] 1Add BLAST199

Expressioni

Inductioni

Transcriptionally induced by internally generated superoxide stress in a manganese-dependent way. The presence of manganese increases SodA homodimer activity and simultaneously decreases SodM homodimer activity. This occurs primarily due to post-transcriptional effects, since the expression of the gene is independent of manganese availability in the absence of superoxide generating compounds.

Interactioni

Subunit structurei

Homodimer. Can also form a heterodimer with SodM.1 Publication

Protein-protein interaction databases

STRINGi93061.SAOUHSC_01653

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5N56X-ray2.07A/B1-199[»]
ProteinModelPortaliP0A0J3
SMRiP0A0J3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105CK4 Bacteria
COG0605 LUCA
HOGENOMiHOG000013583
KOiK04564
OMAiKWGSFDK

Family and domain databases

Gene3Di1.10.287.990, 1 hit
2.40.500.20, 1 hit
InterProiView protein in InterPro
IPR001189 Mn/Fe_SOD
IPR019833 Mn/Fe_SOD_BS
IPR019832 Mn/Fe_SOD_C
IPR019831 Mn/Fe_SOD_N
IPR036324 Mn/Fe_SOD_N_sf
IPR036314 SOD_C_sf
PfamiView protein in Pfam
PF02777 Sod_Fe_C, 1 hit
PF00081 Sod_Fe_N, 1 hit
PIRSFiPIRSF000349 SODismutase, 1 hit
PRINTSiPR01703 MNSODISMTASE
SUPFAMiSSF46609 SSF46609, 1 hit
SSF54719 SSF54719, 1 hit
PROSITEiView protein in PROSITE
PS00088 SOD_MN, 1 hit

Sequencei

Sequence statusi: Complete.

P0A0J3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFELPKLPY AFDALEPHFD KETMEIHHDR HHNTYVTKLN AAVEGTDLES
60 70 80 90 100
KSIEEIVANL DSVPANIQTA VRNNGGGHLN HSLFWELLSP NSEEKGTVVE
110 120 130 140 150
KIKEQWGSLE EFKKEFADKA AARFGSGWAW LVVNNGQLEI VTTPNQDNPL
160 170 180 190
TEGKTPILGL DVWEHAYYLK YQNKRPDYIG AFWNVVNWEK VDELYNATK
Length:199
Mass (Da):22,711
Last modified:March 1, 2005 - v1
Checksum:iF2CEC7B4701AC559
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF121672 Genomic DNA Translation: AAD17309.1
CP000253 Genomic DNA Translation: ABD30729.1
RefSeqiWP_000863556.1, NC_007795.1
YP_500165.1, NC_007795.1

Genome annotation databases

EnsemblBacteriaiABD30729; ABD30729; SAOUHSC_01653
GeneIDi3920105
KEGGisao:SAOUHSC_01653
PATRICifig|93061.5.peg.1504

Similar proteinsi

Entry informationi

Entry nameiSODM1_STAA8
AccessioniPrimary (citable) accession number: P0A0J3
Secondary accession number(s): Q2FY20, Q9Z5W5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: March 1, 2005
Last modified: April 25, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health