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P0A0J3

- SODM1_STAA8

UniProt

P0A0J3 - SODM1_STAA8

Protein

Superoxide dismutase [Mn] 1

Gene

sodA

Organism
Staphylococcus aureus (strain NCTC 8325)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (01 Mar 2005)
      Previous versions | rss
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    Functioni

    Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. May play a role in maintaining cell viability throughout all stages of growth, but may be the major SOD activity in the exponential growth-phase. Has a role in resisting external superoxide stress. Involved in acid tolerance and the acid-adaptive response. Mediates the derepression of perR regulon in the response to HOCl stress when the level of SOD activity is low.3 Publications

    Catalytic activityi

    2 superoxide + 2 H+ = O2 + H2O2.3 Publications

    Cofactori

    Binds 1 manganese ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi27 – 271ManganeseBy similarity
    Metal bindingi81 – 811ManganeseBy similarity
    Metal bindingi161 – 1611ManganeseBy similarity
    Metal bindingi165 – 1651ManganeseBy similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. superoxide dismutase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Stress response

    Keywords - Ligandi

    Manganese, Metal-binding

    Enzyme and pathway databases

    BioCyciSAUR93061:GIWJ-1579-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Superoxide dismutase [Mn] 1 (EC:1.15.1.1)
    Gene namesi
    Name:sodA
    Ordered Locus Names:SAOUHSC_01653
    OrganismiStaphylococcus aureus (strain NCTC 8325)
    Taxonomic identifieri93061 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
    ProteomesiUP000008816: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 199199Superoxide dismutase [Mn] 1PRO_0000160075Add
    BLAST

    Expressioni

    Inductioni

    Transcriptionally induced by internally generated superoxide stress in a manganese-dependent way. The presence of manganese increases SodA homodimer activity and simultaneously decreases SodM homodimer activity. This occurs primarily due to post-transcriptional effects, since the expression of the gene is independent of manganese availability in the absence of superoxide generating compounds.

    Interactioni

    Subunit structurei

    Homodimer. Can also form a heterodimer with SodM.1 Publication

    Protein-protein interaction databases

    STRINGi93061.SAOUHSC_01653.

    Structurei

    3D structure databases

    ProteinModelPortaliP0A0J3.
    SMRiP0A0J3. Positions 2-196.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0605.
    HOGENOMiHOG000013583.
    KOiK04564.
    OMAiPLPYDYN.
    OrthoDBiEOG63NMNT.

    Family and domain databases

    InterProiIPR001189. Mn/Fe_SOD.
    IPR019833. Mn/Fe_SOD_BS.
    IPR019832. Mn/Fe_SOD_C.
    IPR019831. Mn/Fe_SOD_N.
    [Graphical view]
    PANTHERiPTHR11404. PTHR11404. 1 hit.
    PfamiPF02777. Sod_Fe_C. 1 hit.
    PF00081. Sod_Fe_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000349. SODismutase. 1 hit.
    PRINTSiPR01703. MNSODISMTASE.
    SUPFAMiSSF46609. SSF46609. 1 hit.
    SSF54719. SSF54719. 1 hit.
    PROSITEiPS00088. SOD_MN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P0A0J3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAFELPKLPY AFDALEPHFD KETMEIHHDR HHNTYVTKLN AAVEGTDLES    50
    KSIEEIVANL DSVPANIQTA VRNNGGGHLN HSLFWELLSP NSEEKGTVVE 100
    KIKEQWGSLE EFKKEFADKA AARFGSGWAW LVVNNGQLEI VTTPNQDNPL 150
    TEGKTPILGL DVWEHAYYLK YQNKRPDYIG AFWNVVNWEK VDELYNATK 199
    Length:199
    Mass (Da):22,711
    Last modified:March 1, 2005 - v1
    Checksum:iF2CEC7B4701AC559
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF121672 Genomic DNA. Translation: AAD17309.1.
    CP000253 Genomic DNA. Translation: ABD30729.1.
    RefSeqiWP_000863556.1. NC_007795.1.
    YP_500165.1. NC_007795.1.

    Genome annotation databases

    EnsemblBacteriaiABD30729; ABD30729; SAOUHSC_01653.
    GeneIDi3920105.
    KEGGisao:SAOUHSC_01653.
    PATRICi19580689. VBIStaAur99865_1504.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF121672 Genomic DNA. Translation: AAD17309.1 .
    CP000253 Genomic DNA. Translation: ABD30729.1 .
    RefSeqi WP_000863556.1. NC_007795.1.
    YP_500165.1. NC_007795.1.

    3D structure databases

    ProteinModelPortali P0A0J3.
    SMRi P0A0J3. Positions 2-196.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 93061.SAOUHSC_01653.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABD30729 ; ABD30729 ; SAOUHSC_01653 .
    GeneIDi 3920105.
    KEGGi sao:SAOUHSC_01653.
    PATRICi 19580689. VBIStaAur99865_1504.

    Phylogenomic databases

    eggNOGi COG0605.
    HOGENOMi HOG000013583.
    KOi K04564.
    OMAi PLPYDYN.
    OrthoDBi EOG63NMNT.

    Enzyme and pathway databases

    BioCyci SAUR93061:GIWJ-1579-MONOMER.

    Family and domain databases

    InterProi IPR001189. Mn/Fe_SOD.
    IPR019833. Mn/Fe_SOD_BS.
    IPR019832. Mn/Fe_SOD_C.
    IPR019831. Mn/Fe_SOD_N.
    [Graphical view ]
    PANTHERi PTHR11404. PTHR11404. 1 hit.
    Pfami PF02777. Sod_Fe_C. 1 hit.
    PF00081. Sod_Fe_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000349. SODismutase. 1 hit.
    PRINTSi PR01703. MNSODISMTASE.
    SUPFAMi SSF46609. SSF46609. 1 hit.
    SSF54719. SSF54719. 1 hit.
    PROSITEi PS00088. SOD_MN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of the major superoxide dismutase of Staphylococcus aureus and its role in starvation survival, stress resistance, and pathogenicity."
      Clements M.O., Watson S.P., Foster S.J.
      J. Bacteriol. 181:3898-3903(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], EXPRESSION, ENZYMATIC ACTIVITY, COFACTOR, FUNCTION.
    2. "The Staphylococcus aureus NCTC 8325 genome."
      Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J.
      (In) Fischetti V., Novick R., Ferretti J., Portnoy D., Rood J. (eds.); Gram positive pathogens, 2nd edition, pp.381-412, ASM Press, Washington D.C. (2006)
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NCTC 8325.
    3. "Identification and characterization of a second superoxide dismutase gene (sodM) from Staphylococcus aureus."
      Wright Valderas M., Hart M.E.
      J. Bacteriol. 183:3399-3407(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: ENZYMATIC ACTIVITY.
    4. "The superoxide dismutase gene sodM is unique to Staphylococcus aureus: absence of sodM in coagulase-negative staphylococci."
      Wright Valderas M., Gatson J.W., Wreyford N., Hart M.E.
      J. Bacteriol. 184:2465-2472(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: ENZYMATIC ACTIVITY, SUBUNIT.
    5. "Role and regulation of the superoxide dismutases of Staphylococcus aureus."
      Karavolos M.H., Horsburgh M.J., Ingham E., Foster S.J.
      Microbiology 149:2749-2758(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN OXIDATIVE STRESS RESISTANCE, EXPRESSION, REGULATION.
    6. "The impairment of superoxide dismutase coordinates the derepression of the perR regulon in the response of Staphylococcus aureus to HOCl stress."
      Maalej S., Dammak I., Dukan S.
      Microbiology 152:855-861(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN REGULATION OF PERR REGULON.

    Entry informationi

    Entry nameiSODM1_STAA8
    AccessioniPrimary (citable) accession number: P0A0J3
    Secondary accession number(s): Q2FY20, Q9Z5W5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 2005
    Last sequence update: March 1, 2005
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    According to PubMed:10383955 the levels of SodA activity and sodA expression are growth-phase dependent, occurring most during post-exponential phase. This response was also dependent on the level of aeration, with highest activity and expression occurring under high aeration.
    Transcribed from two sigma-A-type promoters (PA1 and PA2). Transcriptional data show an indirect repression of PA1 promoter by sigma-B.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3