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Protein

Accessory gene regulator protein A

Gene

agrA

Organism
Staphylococcus aureus
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for high-level post-exponential phase expression of a series of secreted proteins.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation, Two-component regulatory system

Names & Taxonomyi

Protein namesi
Recommended name:
Accessory gene regulator protein A
Gene namesi
Name:agrA
Synonyms:agr
OrganismiStaphylococcus aureus
Taxonomic identifieri1280 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1681616

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000810001 – 238Accessory gene regulator protein AAdd BLAST238

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei594-aspartylphosphatePROSITE-ProRule annotation1

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

IntActiP0A0I7, 1 interactor
MINTiP0A0I7

Chemistry databases

BindingDBiP0A0I7

Structurei

Secondary structure

1238
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi142 – 146Combined sources5
Beta strandi148 – 155Combined sources8
Helixi156 – 158Combined sources3
Beta strandi159 – 163Combined sources5
Beta strandi169 – 177Combined sources9
Beta strandi179 – 182Combined sources4
Helixi186 – 190Combined sources5
Beta strandi196 – 200Combined sources5
Beta strandi203 – 206Combined sources4
Helixi207 – 209Combined sources3
Beta strandi210 – 214Combined sources5
Turni215 – 218Combined sources4
Beta strandi219 – 222Combined sources4
Beta strandi227 – 229Combined sources3
Turni232 – 234Combined sources3
Helixi235 – 237Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3BS1X-ray1.60A137-238[»]
4G4KX-ray1.52A/B137-238[»]
ProteinModelPortaliP0A0I7
SMRiP0A0I7
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0A0I7

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 125Response regulatoryPROSITE-ProRule annotationAdd BLAST124
Domaini143 – 238HTH LytTR-typePROSITE-ProRule annotationAdd BLAST96

Phylogenomic databases

eggNOGiENOG4108WCX Bacteria
COG3279 LUCA

Family and domain databases

CDDicd00156 REC, 1 hit
InterProiView protein in InterPro
IPR011006 CheY-like_superfamily
IPR007492 LytTR_DNA-bd_dom
IPR001789 Sig_transdc_resp-reg_receiver
PfamiView protein in Pfam
PF04397 LytTR, 1 hit
PF00072 Response_reg, 1 hit
SMARTiView protein in SMART
SM00850 LytTR, 1 hit
SM00448 REC, 1 hit
SUPFAMiSSF52172 SSF52172, 1 hit
PROSITEiView protein in PROSITE
PS50930 HTH_LYTTR, 1 hit
PS50110 RESPONSE_REGULATORY, 1 hit

Sequencei

Sequence statusi: Complete.

P0A0I7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIFICEDDP KQRENMVTII KNYIMIEEKP MEIALATDNP YEVLEQAKNM
60 70 80 90 100
NDIGCYFLDI QLSTDINGIK LGSEIRKHDP VGNIIFVTSH SELTYLTFVY
110 120 130 140 150
KVAAMDFIFK DDPAELRTRI IDCLETAHTR LQLLSKDNSV ETIELKRGSN
160 170 180 190 200
SVYVQYDDIM FFESSTKSHR LIAHLDNRQI EFYGNLKELS QLDDRFFRCH
210 220 230
NSFVVNRHNI ESIDSKERIV YFKNKEHCYA SVRNVKKI
Length:238
Mass (Da):27,906
Last modified:February 15, 2005 - v1
Checksum:i757788C90AAFB420
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M21854 Genomic DNA Translation: AAA26597.1
X52543 Genomic DNA Translation: CAA36784.1
U85097 Genomic DNA Translation: AAB80782.1
U85095 Genomic DNA Translation: AAB81231.1
U85096 Genomic DNA Translation: AAB80778.1
PIRiA32357
RefSeqiWP_000688492.1, NZ_PJLW01000159.1

Similar proteinsi

Entry informationi

Entry nameiAGRA_STAAU
AccessioniPrimary (citable) accession number: P0A0I7
Secondary accession number(s): P13131
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: February 15, 2005
Last modified: March 28, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure
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Main funding by: National Institutes of Health