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P0A0I0

- FABG_STAAW

UniProt

P0A0I0 - FABG_STAAW

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Protein
3-oxoacyl-[acyl-carrier-protein] reductase FabG
Gene
fabG, MW1114
Organism
Staphylococcus aureus (strain MW2)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis By similarity.

Catalytic activityi

(3R)-3-hydroxyacyl-[acyl-carrier-protein] + NADP+ = 3-oxoacyl-[acyl-carrier-protein] + NADPH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei89 – 891NADP; via carbonyl oxygen By similarity
Binding sitei141 – 1411Substrate By similarity
Active sitei154 – 1541Proton acceptor By similarity
Binding sitei187 – 1871NADP; via amide nitrogen and carbonyl oxygen By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi11 – 144NADP By similarity
Nucleotide bindingi62 – 632NADP By similarity
Nucleotide bindingi154 – 1585NADP By similarity

GO - Molecular functioni

  1. 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity Source: UniProtKB
  2. NAD binding Source: InterPro
  3. NADP binding Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. fatty acid elongation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciRETL1328306-WGS:GSTH-3774-MONOMER.
SAUR196620:GJ9Z-1139-MONOMER.
UniPathwayiUPA00094.

Names & Taxonomyi

Protein namesi
Recommended name:
3-oxoacyl-[acyl-carrier-protein] reductase FabG (EC:1.1.1.100)
Alternative name(s):
3-ketoacyl-acyl carrier protein reductase
Beta-Ketoacyl-acyl carrier protein reductase
Beta-ketoacyl-ACP reductase
Gene namesi
Name:fabG
Ordered Locus Names:MW1114
OrganismiStaphylococcus aureus (strain MW2)
Taxonomic identifieri196620 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000000418: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2462463-oxoacyl-[acyl-carrier-protein] reductase FabG
PRO_0000054688Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.

Protein-protein interaction databases

STRINGi196620.MW1114.

Structurei

3D structure databases

ProteinModelPortaliP0A0I0.
SMRiP0A0I0. Positions 1-246.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1028.
KOiK00059.
OMAiIKAEWLT.
OrthoDBiEOG6N3CR8.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR011284. 3oxo_ACP_reduc.
IPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view]
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PIRSFiPIRSF000126. 11-beta-HSD1. 1 hit.
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
TIGRFAMsiTIGR01830. 3oxo_ACP_reduc. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0A0I0-1 [UniParc]FASTAAdd to Basket

« Hide

MKMTKSALVT GASRGIGRSI ALQLAEEGYN VAVNYAGSKE KAEAVVEEIK    50
AKGVDSFAIQ ANVADADEVK AMIKEVVSQF GSLDVLVNNA GITRDNLLMR 100
MKEQEWDDVI DTNLKGVFNC IQKATPQMLR QRSGAIINLS SVVGAVGNPG 150
QANYVATKAG VIGLTKSAAR ELASRGITVN AVAPGFIVSD MTDALSDELK 200
EQMLTQIPLA RFGQDTDIAN TVAFLASDKA KYITGQTIHV NGGMYM 246
Length:246
Mass (Da):26,146
Last modified:March 1, 2005 - v1
Checksum:i2BD7CA319D3A37C5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000033 Genomic DNA. Translation: BAB94979.1.
RefSeqiNP_645931.1. NC_003923.1.

Genome annotation databases

EnsemblBacteriaiBAB94979; BAB94979; BAB94979.
GeneIDi1003226.
KEGGisam:MW1114.
PATRICi19568818. VBIStaAur44266_1169.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000033 Genomic DNA. Translation: BAB94979.1 .
RefSeqi NP_645931.1. NC_003923.1.

3D structure databases

ProteinModelPortali P0A0I0.
SMRi P0A0I0. Positions 1-246.
ModBasei Search...

Protein-protein interaction databases

STRINGi 196620.MW1114.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB94979 ; BAB94979 ; BAB94979 .
GeneIDi 1003226.
KEGGi sam:MW1114.
PATRICi 19568818. VBIStaAur44266_1169.

Phylogenomic databases

eggNOGi COG1028.
KOi K00059.
OMAi IKAEWLT.
OrthoDBi EOG6N3CR8.

Enzyme and pathway databases

UniPathwayi UPA00094 .
BioCyci RETL1328306-WGS:GSTH-3774-MONOMER.
SAUR196620:GJ9Z-1139-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR011284. 3oxo_ACP_reduc.
IPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view ]
Pfami PF00106. adh_short. 1 hit.
[Graphical view ]
PIRSFi PIRSF000126. 11-beta-HSD1. 1 hit.
PRINTSi PR00081. GDHRDH.
PR00080. SDRFAMILY.
TIGRFAMsi TIGR01830. 3oxo_ACP_reduc. 1 hit.
PROSITEi PS00061. ADH_SHORT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MW2.

Entry informationi

Entry nameiFABG_STAAW
AccessioniPrimary (citable) accession number: P0A0I0
Secondary accession number(s): Q99QK7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: March 1, 2005
Last modified: July 9, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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