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P0A0H9

- FABG_STAAM

UniProt

P0A0H9 - FABG_STAAM

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Protein

3-oxoacyl-[acyl-carrier-protein] reductase FabG

Gene

fabG

Organism
Staphylococcus aureus (strain Mu50 / ATCC 700699)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.By similarity

Catalytic activityi

(3R)-3-hydroxyacyl-[acyl-carrier-protein] + NADP+ = 3-oxoacyl-[acyl-carrier-protein] + NADPH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei89 – 891NADP; via carbonyl oxygenBy similarity
Binding sitei141 – 1411SubstrateBy similarity
Active sitei154 – 1541Proton acceptorPROSITE-ProRule annotation
Binding sitei187 – 1871NADP; via amide nitrogen and carbonyl oxygenBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi11 – 144NADPBy similarity
Nucleotide bindingi62 – 632NADPBy similarity
Nucleotide bindingi154 – 1585NADPBy similarity

GO - Molecular functioni

  1. 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity Source: UniProtKB-EC
  2. NAD binding Source: InterPro

GO - Biological processi

  1. fatty acid biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciSAUR158878:GJJ5-1249-MONOMER.
UniPathwayiUPA00094.

Names & Taxonomyi

Protein namesi
Recommended name:
3-oxoacyl-[acyl-carrier-protein] reductase FabG (EC:1.1.1.100)
Alternative name(s):
3-ketoacyl-acyl carrier protein reductase
Beta-Ketoacyl-acyl carrier protein reductase
Beta-ketoacyl-ACP reductase
Gene namesi
Name:fabG
Ordered Locus Names:SAV1231
OrganismiStaphylococcus aureus (strain Mu50 / ATCC 700699)
Taxonomic identifieri158878 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000002481: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2462463-oxoacyl-[acyl-carrier-protein] reductase FabGPRO_0000054684Add
BLAST

2D gel databases

World-2DPAGE0002:P0A0H9.

Interactioni

Subunit structurei

Homotetramer.1 Publication

Protein-protein interaction databases

STRINGi158878.SAV1231.

Structurei

Secondary structure

1
246
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi6 – 94
Helixi15 – 2612
Beta strandi30 – 378
Helixi39 – 5113
Beta strandi56 – 605
Helixi66 – 8015
Beta strandi85 – 884
Turni98 – 1003
Helixi103 – 11311
Helixi115 – 13117
Beta strandi134 – 1396
Helixi142 – 1465
Helixi152 – 17221
Helixi173 – 1753
Beta strandi177 – 1848
Helixi188 – 1903
Helixi197 – 2048
Helixi215 – 22511
Helixi228 – 2303
Beta strandi237 – 2415

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3OSUX-ray1.90A/B1-246[»]
ProteinModelPortaliP0A0H9.
SMRiP0A0H9. Positions 1-246.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1028.
KOiK00059.
OMAiDEFGAID.
OrthoDBiEOG6N3CR8.
PhylomeDBiP0A0H9.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR011284. 3oxo_ACP_reduc.
IPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view]
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PIRSFiPIRSF000126. 11-beta-HSD1. 1 hit.
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
TIGRFAMsiTIGR01830. 3oxo_ACP_reduc. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0A0H9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKMTKSALVT GASRGIGRSI ALQLAEEGYN VAVNYAGSKE KAEAVVEEIK
60 70 80 90 100
AKGVDSFAIQ ANVADADEVK AMIKEVVSQF GSLDVLVNNA GITRDNLLMR
110 120 130 140 150
MKEQEWDDVI DTNLKGVFNC IQKATPQMLR QRSGAIINLS SVVGAVGNPG
160 170 180 190 200
QANYVATKAG VIGLTKSAAR ELASRGITVN AVAPGFIVSD MTDALSDELK
210 220 230 240
EQMLTQIPLA RFGQDTDIAN TVAFLASDKA KYITGQTIHV NGGMYM
Length:246
Mass (Da):26,146
Last modified:March 1, 2005 - v1
Checksum:i2BD7CA319D3A37C5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000017 Genomic DNA. Translation: BAB57393.1.
RefSeqiNP_371755.1. NC_002758.2.

Genome annotation databases

EnsemblBacteriaiBAB57393; BAB57393; SAV1231.
GeneIDi1121208.
KEGGisav:SAV1231.
PATRICi19563175. VBIStaAur52173_1265.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000017 Genomic DNA. Translation: BAB57393.1 .
RefSeqi NP_371755.1. NC_002758.2.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3OSU X-ray 1.90 A/B 1-246 [» ]
ProteinModelPortali P0A0H9.
SMRi P0A0H9. Positions 1-246.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 158878.SAV1231.

2D gel databases

World-2DPAGE 0002:P0A0H9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB57393 ; BAB57393 ; SAV1231 .
GeneIDi 1121208.
KEGGi sav:SAV1231.
PATRICi 19563175. VBIStaAur52173_1265.

Phylogenomic databases

eggNOGi COG1028.
KOi K00059.
OMAi DEFGAID.
OrthoDBi EOG6N3CR8.
PhylomeDBi P0A0H9.

Enzyme and pathway databases

UniPathwayi UPA00094 .
BioCyci SAUR158878:GJJ5-1249-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR011284. 3oxo_ACP_reduc.
IPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view ]
Pfami PF00106. adh_short. 1 hit.
[Graphical view ]
PIRSFi PIRSF000126. 11-beta-HSD1. 1 hit.
PRINTSi PR00081. GDHRDH.
PR00080. SDRFAMILY.
TIGRFAMsi TIGR01830. 3oxo_ACP_reduc. 1 hit.
PROSITEi PS00061. ADH_SHORT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Mu50 / ATCC 700699.
  2. "Crystal structure of the 3-oxoacyl-acyl carrier protein reductase, FabG, from Staphylococcus aureus."
    Anderson S.M., Wawrzak Z., Onopriyenko O., Edwards A., Anderson W.F., Savchenko A.
    Submitted (SEP-2010) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS), SUBUNIT.

Entry informationi

Entry nameiFABG_STAAM
AccessioniPrimary (citable) accession number: P0A0H9
Secondary accession number(s): Q99QK7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: March 1, 2005
Last modified: October 1, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3