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Protein

Serine-protein kinase RsbW

Gene

rsbW

Organism
Staphylococcus aureus (strain N315)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Negative regulator of sigma-B activity. Phosphorylates and inactivates its specific antagonist protein, RsbV. Upon phosphorylation of RsbV, RsbW is released and binds to sigma-B, thereby blocking its ability to form an RNA polymerase holoenzyme (E-sigma-B).UniRule annotation

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine-protein kinase RsbWUniRule annotation (EC:2.7.11.1UniRule annotation)
Alternative name(s):
Anti-sigma-B factorUniRule annotation
Sigma-B negative effector RsbWUniRule annotation
Gene namesi
Name:rsbWUniRule annotation
Ordered Locus Names:SA1870
OrganismiStaphylococcus aureus (strain N315)
Taxonomic identifieri158879 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000000751 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002035441 – 159Serine-protein kinase RsbWAdd BLAST159

Structurei

3D structure databases

ProteinModelPortaliP0A0H7
SMRiP0A0H7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the anti-sigma-factor family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000269932
KOiK04757
OMAiKMGFSYE

Family and domain databases

CDDicd00075 HATPase_c, 1 hit
Gene3Di3.30.565.10, 1 hit
HAMAPiMF_00638 Anti_sigma_B, 1 hit
InterProiView protein in InterPro
IPR003594 HATPase_C
IPR036890 HATPase_C_sf
IPR010193 RsbW
PfamiView protein in Pfam
PF13581 HATPase_c_2, 1 hit
SUPFAMiSSF55874 SSF55874, 1 hit
TIGRFAMsiTIGR01924 rsbW_low_gc, 1 hit

Sequencei

Sequence statusi: Complete.

P0A0H7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQSKEDFIEM RVPASAEYVS LIRLTLSGVF SRAGATYDDI EDAKIAVSEA
60 70 80 90 100
VTNAVKHAYK ENNNVGIINI YFEILEDKIK IVISDKGDSF DYETTKSKIG
110 120 130 140 150
PYDKDENIDF LREGGLGLFL IESLMDEVTV YKESGVTISM TKYIKKEQVR

NNGERVEIS
Length:159
Mass (Da):17,921
Last modified:March 1, 2005 - v1
Checksum:i57FA8EB8C1F9902B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000018 Genomic DNA Translation: BAB43152.1
PIRiG89998

Genome annotation databases

EnsemblBacteriaiBAB43152; BAB43152; BAB43152
KEGGisau:SA1870

Similar proteinsi

Entry informationi

Entry nameiRSBW_STAAN
AccessioniPrimary (citable) accession number: P0A0H7
Secondary accession number(s): O08077, P95843
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: March 1, 2005
Last modified: May 23, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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