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Protein

rRNA adenine N-6-methyltransferase

Gene

ermA

Organism
Staphylococcus aureus
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

This protein produces a dimethylation of the adenine residue at position 2085 in 23S rRNA, resulting in reduced affinity between ribosomes and macrolide-lincosamide-streptogramin B antibiotics.

Catalytic activityi

2 S-adenosyl-L-methionine + adenine(2085) in 23S rRNA = 2 S-adenosyl-L-homocysteine + N6-dimethyladenine(2085) in 23S rRNA.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei11S-adenosyl-L-methionine; via carbonyl oxygenPROSITE-ProRule annotation1
Binding sitei13S-adenosyl-L-methionine; via amide nitrogenPROSITE-ProRule annotation1
Binding sitei38S-adenosyl-L-methionine; via carbonyl oxygenPROSITE-ProRule annotation1
Binding sitei59S-adenosyl-L-methioninePROSITE-ProRule annotation1
Binding sitei84S-adenosyl-L-methioninePROSITE-ProRule annotation1
Binding sitei101S-adenosyl-L-methioninePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, RNA-binding, Transferase
Biological processAntibiotic resistance
LigandS-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
rRNA adenine N-6-methyltransferase (EC:2.1.1.184)
Alternative name(s):
Erythromycin resistance protein
Macrolide-lincosamide-streptogramin B resistance protein
Gene namesi
Name:ermA
OrganismiStaphylococcus aureus
Taxonomic identifieri1280 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001016811 – 243rRNA adenine N-6-methyltransferaseAdd BLAST243

Structurei

3D structure databases

ProteinModelPortaliP0A0H3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG41071EZ Bacteria
COG0030 LUCA
KOiK00561

Family and domain databases

Gene3Di1.10.8.100, 2 hits
InterProiView protein in InterPro
IPR001737 KsgA/Erm
IPR023165 rRNA_Ade_diMease-like
IPR020596 rRNA_Ade_Mease_Trfase_CS
IPR020598 rRNA_Ade_methylase_Trfase_N
IPR029063 SAM-dependent_MTases
PANTHERiPTHR11727 PTHR11727, 1 hit
PfamiView protein in Pfam
PF00398 RrnaAD, 1 hit
SMARTiView protein in SMART
SM00650 rADc, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
PROSITEiView protein in PROSITE
PS01131 RRNA_A_DIMETH, 1 hit
PS51689 SAM_RNA_A_N6_MT, 1 hit

Sequencei

Sequence statusi: Complete.

P0A0H3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNQKNPKDTQ NFITSKKHVK EILNHTNISK QDNVIEIGSG KGHFTKELVK
60 70 80 90 100
MSRSVTAIEI DGGLCQVTKE AVNPSENIKV IQTDILKFSF PKHINYKIYG
110 120 130 140 150
NIPYNISTDI VKRITFESQA KYSYLIVEKG FAKRLQNLQR ALGLLLMVEM
160 170 180 190 200
DIKMLKKVPP LYFHPKPSVD SVLIVLERHQ PLISKKDYKK YRSFVYKWVN
210 220 230 240
REYRVLFTKN QFRQALKHAN VTNINKLSKE QFLSIFNSYK LFH
Length:243
Mass (Da):28,408
Last modified:January 1, 1988 - v1
Checksum:i03DDAFABE867525A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03216 Genomic DNA Translation: CAA26964.1
PIRiE24584 A25101
RefSeqiWP_001072201.1, NZ_PNPE01000031.1
YP_006958113.1, NC_019144.1

Genome annotation databases

GeneIDi13913675
31596596
KEGGiag:CAA26964

Similar proteinsi

Entry informationi

Entry nameiERMA_STAAU
AccessioniPrimary (citable) accession number: P0A0H3
Secondary accession number(s): P06699
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: May 23, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Transposable element

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