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Protein

Mercuric reductase

Gene

merA

Organism
Staphylococcus aureus
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Resistance to Hg2+ in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg0 (By similarity).By similarity

Miscellaneous

The active site is a redox-active disulfide bond.By similarity

Catalytic activityi

Hg + NADP+ + H+ = Hg2+ + NADPH.

Cofactori

FADBy similarityNote: Binds 1 FAD per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi544MercuryPROSITE-ProRule annotation1
Metal bindingi545MercuryPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi115 – 123FADBy similarity9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processMercuric resistance
LigandFAD, Flavoprotein, Mercury, Metal-binding, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Mercuric reductase (EC:1.16.1.1)
Alternative name(s):
Hg(II) reductase
Gene namesi
Name:merA
Encoded oniPlasmid pI2580 Publication
OrganismiStaphylococcus aureus
Taxonomic identifieri1280 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000680021 – 547Mercuric reductaseAdd BLAST547

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi123 ↔ 128Redox-activeBy similarity

Keywords - PTMi

Disulfide bond

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP0A0E5
SMRiP0A0E5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 68HMAPROSITE-ProRule annotationAdd BLAST64

Sequence similaritiesi

Keywords - Domaini

Redox-active center

Family and domain databases

CDDicd00371 HMA, 1 hit
Gene3Di3.30.390.30, 1 hit
3.50.50.60, 3 hits
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR023753 FAD/NAD-binding_dom
IPR016156 FAD/NAD-linked_Rdtase_dimer_sf
IPR017969 Heavy-metal-associated_CS
IPR006121 HMA_dom
IPR036163 HMA_dom_sf
IPR021179 Mercury_reductase_MerA
IPR001100 Pyr_nuc-diS_OxRdtase
IPR004099 Pyr_nucl-diS_OxRdtase_dimer
IPR012999 Pyr_OxRdtase_I_AS
PfamiView protein in Pfam
PF00403 HMA, 1 hit
PF07992 Pyr_redox_2, 1 hit
PF02852 Pyr_redox_dim, 1 hit
PIRSFiPIRSF000350 Mercury_reductase_MerA, 1 hit
SUPFAMiSSF51905 SSF51905, 1 hit
SSF55008 SSF55008, 1 hit
SSF55424 SSF55424, 1 hit
TIGRFAMsiTIGR02053 MerA, 1 hit
PROSITEiView protein in PROSITE
PS01047 HMA_1, 1 hit
PS50846 HMA_2, 1 hit
PS00076 PYRIDINE_REDOX_1, 1 hit

Sequencei

Sequence statusi: Complete.

P0A0E5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQNSYKIPI QGMTCTGCEE HVTEALEQAG AKDVSADFRR GEAIFELSDD
60 70 80 90 100
QIEKAKQNIS AAGYQPGEEE SQPSENSVDF NRDGDYDLLI IGSGGAAFSA
110 120 130 140 150
AIKANENGAK VAMVERGTVG GTCVNIGCVP SKTMLRAGEI NGLAQNNPFT
160 170 180 190 200
GLQTSTGAAD LAQLTEQKDG LVSQMRQEKY IDLIEEYGFD LIRGEASFID
210 220 230 240 250
DKTIQVNGQN ITSKSFLIAT GASPAVPEIP GMNEVDYLTS TSALELKEVP
260 270 280 290 300
QRLAVIGSGY IAAELGQMFH NLGTEVTLMQ RSERLFKTYD PEISEAIDES
310 320 330 340 350
LTEQGLNLIT GVTYQKVEQN GKSTSIYIEV NGQEQVIEAD QVLVATGRKP
360 370 380 390 400
NTETLNLESA GVKTGKKGEV LTNEYLQTSN NRIYAAGDVT LGPQFVYVAA
410 420 430 440 450
YEGGIVANNA LGLAKRKIDL RFVPGVTFTN PSIATVGLTE QQAKEKGYDV
460 470 480 490 500
KTSVLPLDAV PRALVNHETT GVYKLVVNAQ TQKLIGAHIV SENAGDVIYA
510 520 530 540
ATLAVQFGLT IEDLTDSFAP YLTMAEGLKL AALTFDKDVS KLSCCAG
Length:547
Mass (Da):58,566
Last modified:January 1, 1988 - v1
Checksum:iB0BEA5FCFA99C049
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L29436 Genomic DNA Translation: AAA98245.1
PIRiE29504
RefSeqiWP_000193219.1, NZ_PKSE01000054.1
YP_006937593.1, NC_013319.1
YP_006938295.1, NC_013337.1
YP_006938628.1, NC_013347.1
YP_006938790.1, NC_013352.1
YP_006958467.1, NC_018968.1

Genome annotation databases

GeneIDi13874741
13875462
13875805
13875971
13913500

Similar proteinsi

Entry informationi

Entry nameiMERA_STAAU
AccessioniPrimary (citable) accession number: P0A0E5
Secondary accession number(s): P08663
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: May 23, 2018
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Plasmid

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