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Protein

Methicillin resistance mecR1 protein

Gene

mecR1

Organism
Staphylococcus aureus (strain N315)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Penicillin-interactive protein and potential antirepressor.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Antibiotic resistance

Enzyme and pathway databases

BioCyciSAUR158879:GJCB-43-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Methicillin resistance mecR1 protein
Gene namesi
Name:mecR1
Synonyms:mecR
Ordered Locus Names:SA0039
OrganismiStaphylococcus aureus (strain N315)
Taxonomic identifieri158879 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000000751 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 585585Methicillin resistance mecR1 proteinPRO_0000096350Add
BLAST

Structurei

Secondary structure

1
585
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi334 – 3385Combined sources
Beta strandi348 – 3503Combined sources
Helixi352 – 3587Combined sources
Beta strandi361 – 3699Combined sources
Turni370 – 3734Combined sources
Beta strandi374 – 3796Combined sources
Helixi380 – 3834Combined sources
Beta strandi385 – 3873Combined sources
Helixi390 – 3934Combined sources
Helixi394 – 40310Combined sources
Beta strandi406 – 4083Combined sources
Helixi424 – 4263Combined sources
Helixi432 – 4376Combined sources
Helixi441 – 4488Combined sources
Helixi453 – 46311Combined sources
Beta strandi478 – 4814Combined sources
Helixi486 – 49712Combined sources
Beta strandi501 – 5033Combined sources
Helixi505 – 51410Combined sources
Beta strandi516 – 5194Combined sources
Beta strandi521 – 53414Combined sources
Beta strandi537 – 55115Combined sources
Beta strandi553 – 5619Combined sources
Helixi568 – 58114Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2IWBX-ray1.80A340-585[»]
2IWCX-ray2.10A334-585[»]
2IWDX-ray2.40A340-585[»]
ProteinModelPortaliP0A0B0.
SMRiP0A0B0. Positions 142-216, 340-585.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0A0B0.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni351 – 585235Beta-lactamase-likeAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase M56 family.Curated

Phylogenomic databases

HOGENOMiHOG000279682.
OMAiVNGWFIG.
OrthoDBiEOG6CVV8V.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR001460. PCN-bd_Tpept.
IPR008756. Peptidase_M56.
[Graphical view]
PfamiPF05569. Peptidase_M56. 1 hit.
PF00905. Transpeptidase. 1 hit.
[Graphical view]
SUPFAMiSSF56601. SSF56601. 1 hit.

Sequencei

Sequence statusi: Complete.

P0A0B0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSSFLMLSI ISSLLTICVI FLVRMLYIKY TQNIMSHKIW LLVLVSTLIP
60 70 80 90 100
LIPFYKISNF TFSKDMMNRN VSDTTSSVSH MLDGQQSSVT KDLAINVNQF
110 120 130 140 150
ETSNITYMIL LIWVFGSLLC LFYMIKAFRQ IDVIKSSSLE SSYLNERLKV
160 170 180 190 200
CQSKMQFYKK HITISYSSNI DNPMVFGLVK SQIVLPTVVV ETMNDKEIEY
210 220 230 240 250
IILHELSHVK SHDLIFNQLY VVFKMIFWFN PALYISKTMM DNDCEKVCDR
260 270 280 290 300
NVLKILNRHE HIRYGESILK CSILKSQHIN NVAAQYLLGF NSNIKERVKY
310 320 330 340 350
IALYDSMPKP NRNKRIVAYI VCSISLLIQA PLLSAHVQQD KYETNVSYKK
360 370 380 390 400
LNQLAPYFKG FDGSFVLYNE REQAYSIYNE PESKQRYSPN STYKIYLALM
410 420 430 440 450
AFDQNLLSLN HTEQQWDKHQ YPFKEWNQDQ NLNSSMKYSV NWYYENLNKH
460 470 480 490 500
LRQDEVKSYL DLIEYGNEEI SGNENYWNES SLKISAIEQV NLLKNMKQHN
510 520 530 540 550
MHFDNKAIEK VENSMTLKQK DTYKYVGKTG TGIVNHKEAN GWFVGYVETK
560 570 580
DNTYYFATHL KGEDNANGEK AQQISERILK EMELI
Length:585
Mass (Da):68,503
Last modified:March 1, 2005 - v1
Checksum:iD3E1075FC9AD57C0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63598 Genomic DNA. Translation: CAA45142.1.
BA000018 Genomic DNA. Translation: BAB41257.1.
RefSeqiWP_000952923.1. NC_002745.2.

Genome annotation databases

EnsemblBacteriaiBAB41257; BAB41257; BAB41257.
PATRICi19572099. VBIStaAur116463_0039.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63598 Genomic DNA. Translation: CAA45142.1.
BA000018 Genomic DNA. Translation: BAB41257.1.
RefSeqiWP_000952923.1. NC_002745.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2IWBX-ray1.80A340-585[»]
2IWCX-ray2.10A334-585[»]
2IWDX-ray2.40A340-585[»]
ProteinModelPortaliP0A0B0.
SMRiP0A0B0. Positions 142-216, 340-585.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB41257; BAB41257; BAB41257.
PATRICi19572099. VBIStaAur116463_0039.

Phylogenomic databases

HOGENOMiHOG000279682.
OMAiVNGWFIG.
OrthoDBiEOG6CVV8V.

Enzyme and pathway databases

BioCyciSAUR158879:GJCB-43-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP0A0B0.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR001460. PCN-bd_Tpept.
IPR008756. Peptidase_M56.
[Graphical view]
PfamiPF05569. Peptidase_M56. 1 hit.
PF00905. Transpeptidase. 1 hit.
[Graphical view]
SUPFAMiSSF56601. SSF56601. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and nucleotide sequence determination of the regulator region of mecA gene in methicillin-resistant Staphylococcus aureus (MRSA)."
    Hiramatsu K., Asada K., Suzuki E., Okonogi K., Yokota T.
    FEBS Lett. 298:133-136(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: N315.

Entry informationi

Entry nameiMECR_STAAN
AccessioniPrimary (citable) accession number: P0A0B0
Secondary accession number(s): P26597, P72353
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: March 1, 2005
Last modified: March 16, 2016
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.