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Protein

Pyruvate dehydrogenase E1 component subunit beta

Gene

pdhB

Organism
Staphylococcus aureus (strain MW2)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).By similarity

Catalytic activityi

Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2.

Cofactori

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei60Thiamine pyrophosphateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processGlycolysis
LigandPyruvate, Thiamine pyrophosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate dehydrogenase E1 component subunit beta (EC:1.2.4.1)
Gene namesi
Name:pdhB
Ordered Locus Names:MW0977
OrganismiStaphylococcus aureus (strain MW2)
Taxonomic identifieri196620 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000000418 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001622331 – 325Pyruvate dehydrogenase E1 component subunit betaAdd BLAST325

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta chain.

Structurei

3D structure databases

ProteinModelPortaliP0A0A2
SMRiP0A0A2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

HOGENOMiHOG000281451
KOiK00162
OMAiSRMRHHC

Family and domain databases

Gene3Di3.40.50.920, 1 hit
InterProiView protein in InterPro
IPR029061 THDP-binding
IPR009014 Transketo_C/PFOR_II
IPR005475 Transketolase-like_Pyr-bd
IPR033248 Transketolase_C
PfamiView protein in Pfam
PF02779 Transket_pyr, 1 hit
PF02780 Transketolase_C, 1 hit
SMARTiView protein in SMART
SM00861 Transket_pyr, 1 hit
SUPFAMiSSF52518 SSF52518, 1 hit
SSF52922 SSF52922, 1 hit

Sequencei

Sequence statusi: Complete.

P0A0A2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQMTMVQAI NDALKTELKN DQDVLIFGED VGVNGGVFRV TEGLQKEFGE
60 70 80 90 100
DRVFDTPLAE SGIGGLAMGL AVEGFRPVME VQFLGFVFEV FDAIAGQIAR
110 120 130 140 150
TRFRSGGTKT APVTIRSPFG GGVHTPELHA DNLEGILAQS PGLKVVIPSG
160 170 180 190 200
PYDAKGLLIS SIRSNDPVVY LEHMKLYRSF REEVPEEEYT IDIGKANVKK
210 220 230 240 250
EGNDISIITY GAMVQESMKA AEELEKDGYS VEVIDLRTVQ PIDVDTIVAS
260 270 280 290 300
VEKTGRAVVV QEAQRQAGVG AAVVAELSER AILSLEAPIG RVAAADTIYP
310 320
FTQAENVWLP NKNDIIEKAK ETLEF
Length:325
Mass (Da):35,246
Last modified:March 1, 2005 - v1
Checksum:i432ABDF6E4A720D5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000033 Genomic DNA Translation: BAB94842.1
RefSeqiWP_000068176.1, NC_003923.1

Genome annotation databases

EnsemblBacteriaiBAB94842; BAB94842; BAB94842
KEGGisam:MW0977

Entry informationi

Entry nameiODPB_STAAW
AccessioniPrimary (citable) accession number: P0A0A2
Secondary accession number(s): Q9L6H5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: March 1, 2005
Last modified: May 23, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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