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Protein

UDP-N-acetylmuramoylalanine--D-glutamate ligase

Gene

murD

Organism
Staphylococcus aureus (strain Mu50 / ATCC 700699)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).By similarity

Catalytic activityi

ATP + UDP-N-acetyl-alpha-D-muramoyl-L-alanine + D-glutamate = ADP + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate.

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi118 – 124ATPSequence analysis7

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00219

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-N-acetylmuramoylalanine--D-glutamate ligase (EC:6.3.2.9)
Alternative name(s):
D-glutamic acid-adding enzyme
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase
Gene namesi
Name:murD
Ordered Locus Names:SAV1183
OrganismiStaphylococcus aureus (strain Mu50 / ATCC 700699)
Taxonomic identifieri158878 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000002481 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001090871 – 449UDP-N-acetylmuramoylalanine--D-glutamate ligaseAdd BLAST449

Proteomic databases

PaxDbiP0A089
PRIDEiP0A089

2D gel databases

World-2DPAGEi0002:P0A089

Interactioni

Protein-protein interaction databases

STRINGi158878.SAV1183

Structurei

3D structure databases

ProteinModelPortaliP0A089
SMRiP0A089
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MurCDEF family.Curated

Phylogenomic databases

eggNOGiENOG4105DMZ Bacteria
COG0771 LUCA
HOGENOMiHOG000049428
KOiK01925
OMAiVDKGNDY
PhylomeDBiP0A089

Family and domain databases

Gene3Di3.40.1190.10, 1 hit
3.90.190.20, 1 hit
HAMAPiMF_00639 MurD, 1 hit
InterProiView protein in InterPro
IPR036565 Mur-like_cat_sf
IPR004101 Mur_ligase_C
IPR036615 Mur_ligase_C_dom_sf
IPR013221 Mur_ligase_cen
IPR005762 UDP-N-AcMur-Glu_ligase
PfamiView protein in Pfam
PF02875 Mur_ligase_C, 1 hit
PF08245 Mur_ligase_M, 1 hit
SUPFAMiSSF53244 SSF53244, 1 hit
SSF53623 SSF53623, 1 hit
TIGRFAMsiTIGR01087 murD, 1 hit

Sequencei

Sequence statusi: Complete.

P0A089-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLNYTGLENK NVLVVGLAKS GYEAAKLLSK LGANVTVNDG KDLSQDAHAK
60 70 80 90 100
DLESMGISVV SGSHPLTLLD NNPIIVKNPG IPYTVSIIDE AVKRGLKILT
110 120 130 140 150
EVELSYLISE APIIAVTGTN GKTTVTSLIG DMFKKSRLTG RLSGNIGYVA
160 170 180 190 200
SKVAQEVKPT DYLVTELSSF QLLGIEKYKP HIAIITNIYS AHLDYHENLE
210 220 230 240 250
NYQNAKKQIY KNQTEEDYLI CNYHQRQVIE SEELKAKTLY FSTQQEVDGI
260 270 280 290 300
YIKDGFIVYK GVRIINTEDL VLPGEHNLEN ILAAVLACIL AGVPIKAIID
310 320 330 340 350
SLTTFSGIEH RLQYVGTNRT NKYYNDSKAT NTLATQFALN SFNQPIIWLC
360 370 380 390 400
GGLDRGNEFD ELIPYMENVR AMVVFGQTKA KFAKLGNSQG KSVIEANNVE
410 420 430 440
DAVDKVQDII EPNDVVLLSP ACASWDQYST FEERGEKFIE RFRAHLPSY
Length:449
Mass (Da):49,844
Last modified:March 1, 2005 - v1
Checksum:i071BEEE9CF74F985
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000017 Genomic DNA Translation: BAB57345.1
RefSeqiWP_000935991.1, NC_002758.2

Genome annotation databases

EnsemblBacteriaiBAB57345; BAB57345; SAV1183
KEGGisav:SAV1183

Similar proteinsi

Entry informationi

Entry nameiMURD_STAAM
AccessioniPrimary (citable) accession number: P0A089
Secondary accession number(s): O07323, O33595
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: March 1, 2005
Last modified: March 28, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health