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Protein

Peptide methionine sulfoxide reductase MsrB

Gene

msrB

Organism
Staphylococcus aureus (strain NCTC 8325)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (R)-S-oxide + thioredoxin.2 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei114 – 1141NucleophilePROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Enzyme and pathway databases

BioCyciSAUR93061:GIWJ-1370-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide methionine sulfoxide reductase MsrB (EC:1.8.4.12)
Alternative name(s):
Peptide-methionine (R)-S-oxide reductase
Gene namesi
Name:msrB
Synonyms:pilB
Ordered Locus Names:SAOUHSC_01431
OrganismiStaphylococcus aureus (strain NCTC 8325)
Taxonomic identifieri93061 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000008816 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 142142Peptide methionine sulfoxide reductase MsrBPRO_0000140299Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi93061.SAOUHSC_01431.

Structurei

3D structure databases

ProteinModelPortaliP0A088.
SMRiP0A088. Positions 9-142.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 125124MsrBPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 MsrB (methionine-R-sulfoxide reductase) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4105E0X. Bacteria.
COG0229. LUCA.
HOGENOMiHOG000243425.
KOiK07305.
OMAiRMQYEVT.

Family and domain databases

Gene3Di2.170.150.20. 1 hit.
HAMAPiMF_01400. MsrB. 1 hit.
InterProiIPR028427. Met_Sox_Rdtase.
IPR002579. Met_Sox_Rdtase_MsrB.
IPR011057. Mss4-like.
[Graphical view]
PANTHERiPTHR10173. PTHR10173. 1 hit.
PfamiPF01641. SelR. 1 hit.
[Graphical view]
SUPFAMiSSF51316. SSF51316. 1 hit.
TIGRFAMsiTIGR00357. TIGR00357. 1 hit.
PROSITEiPS51790. MSRB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0A088-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKKDKSELT DIEYIVTQEN GTEPPFMNEY WNHFAKGIYV DKISGKPLFT
60 70 80 90 100
SEEKFHSECG WPSFSKALDD DEIIELVDKS FGMLRTEVRS EESNSHLGHV
110 120 130 140
FNDGPKESGG LRYCINSAAI QFIPYEKLEE LGYGDLISHF DK
Length:142
Mass (Da):16,277
Last modified:February 15, 2005 - v1
Checksum:i8B8DD1390D9F80AD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF349112 Genomic DNA. Translation: AAK83252.1.
CP000253 Genomic DNA. Translation: ABD30523.1.
RefSeqiYP_499956.1. NC_007795.1.

Genome annotation databases

EnsemblBacteriaiABD30523; ABD30523; SAOUHSC_01431.
GeneIDi3920212.
KEGGisao:SAOUHSC_01431.
PATRICi19580295. VBIStaAur99865_1307.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF349112 Genomic DNA. Translation: AAK83252.1.
CP000253 Genomic DNA. Translation: ABD30523.1.
RefSeqiYP_499956.1. NC_007795.1.

3D structure databases

ProteinModelPortaliP0A088.
SMRiP0A088. Positions 9-142.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi93061.SAOUHSC_01431.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABD30523; ABD30523; SAOUHSC_01431.
GeneIDi3920212.
KEGGisao:SAOUHSC_01431.
PATRICi19580295. VBIStaAur99865_1307.

Phylogenomic databases

eggNOGiENOG4105E0X. Bacteria.
COG0229. LUCA.
HOGENOMiHOG000243425.
KOiK07305.
OMAiRMQYEVT.

Enzyme and pathway databases

BioCyciSAUR93061:GIWJ-1370-MONOMER.

Family and domain databases

Gene3Di2.170.150.20. 1 hit.
HAMAPiMF_01400. MsrB. 1 hit.
InterProiIPR028427. Met_Sox_Rdtase.
IPR002579. Met_Sox_Rdtase_MsrB.
IPR011057. Mss4-like.
[Graphical view]
PANTHERiPTHR10173. PTHR10173. 1 hit.
PfamiPF01641. SelR. 1 hit.
[Graphical view]
SUPFAMiSSF51316. SSF51316. 1 hit.
TIGRFAMsiTIGR00357. TIGR00357. 1 hit.
PROSITEiPS51790. MSRB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMSRB_STAA8
AccessioniPrimary (citable) accession number: P0A088
Secondary accession number(s): Q2FYK9, Q93P62
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: February 15, 2005
Last modified: September 7, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Stereospecific for the R isomer of MetO.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.