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Protein

Peptide methionine sulfoxide reductase MsrA 1

Gene

msrA1

Organism
Staphylococcus aureus (strain NCTC 8325)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity).By similarity

Catalytic activityi

Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin.
L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei12By similarity1

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase

Enzyme and pathway databases

BioCyciSAUR93061:G1G5Y-1270-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide methionine sulfoxide reductase MsrA 1 (EC:1.8.4.11)
Short name:
Protein-methionine-S-oxide reductase 1
Alternative name(s):
Peptide-methionine (S)-S-oxide reductase 1
Short name:
Peptide Met(O) reductase 1
Gene namesi
Name:msrA1
Synonyms:msrA
Ordered Locus Names:SAOUHSC_01360
OrganismiStaphylococcus aureus (strain NCTC 8325)
Taxonomic identifieri93061 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000008816 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001385891 – 169Peptide methionine sulfoxide reductase MsrA 1Add BLAST169

Interactioni

Protein-protein interaction databases

STRINGi93061.SAOUHSC_01360

Structurei

3D structure databases

ProteinModelPortaliP0A084
SMRiP0A084
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4108HW8 Bacteria
COG0225 LUCA
HOGENOMiHOG000263863
KOiK07304
OMAiGYCAFVV

Family and domain databases

Gene3Di3.30.1060.10, 1 hit
HAMAPiMF_01401 MsrA, 1 hit
InterProiView protein in InterPro
IPR002569 Met_Sox_Rdtase_MsrA
IPR036509 Met_Sox_Rdtase_MsrA_sf
PfamiView protein in Pfam
PF01625 PMSR, 1 hit
SUPFAMiSSF55068 SSF55068, 1 hit
TIGRFAMsiTIGR00401 msrA, 1 hit

Sequencei

Sequence statusi: Complete.

P0A084-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNINTAYFAG GCFWCMTKPF DTFDGIEKVT SGYMGGHIEN PTYEQVKSGT
60 70 80 90 100
SGHLETVEIQ YDVALFSYNK LLEIFFSVID PLDTGGQYQD RGPQYQTAIF
110 120 130 140 150
YTNDHQKELA ETYIEQLKNT INADKAIATK ILPASQFYKA EDYHQDFYKK
160
NPERYAEEQK IRQEYKNKQ
Length:169
Mass (Da):19,611
Last modified:March 1, 2005 - v1
Checksum:i6C5406148DAAC9A0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF311784 Genomic DNA Translation: AAK00894.1
CP000253 Genomic DNA Translation: ABD30455.1
RefSeqiWP_001024830.1, NC_007795.1
YP_499887.1, NC_007795.1

Genome annotation databases

EnsemblBacteriaiABD30455; ABD30455; SAOUHSC_01360
GeneIDi3920065
KEGGisao:SAOUHSC_01360
PATRICifig|93061.5.peg.1244

Similar proteinsi

Entry informationi

Entry nameiMSRA1_STAA8
AccessioniPrimary (citable) accession number: P0A084
Secondary accession number(s): Q2G2M1, Q99QD5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: March 1, 2005
Last modified: March 28, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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