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Protein

Peptide methionine sulfoxide reductase MsrA 1

Gene

msrA1

Organism
Staphylococcus aureus (strain NCTC 8325)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity).By similarity

Catalytic activityi

Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin.
L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei12By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide methionine sulfoxide reductase MsrA 1 (EC:1.8.4.11)
Short name:
Protein-methionine-S-oxide reductase 1
Alternative name(s):
Peptide-methionine (S)-S-oxide reductase 1
Short name:
Peptide Met(O) reductase 1
Gene namesi
Name:msrA1
Synonyms:msrA
Ordered Locus Names:SAOUHSC_01360
OrganismiStaphylococcus aureus (strain NCTC 8325)
Taxonomic identifieri93061 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000008816 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001385891 – 169Peptide methionine sulfoxide reductase MsrA 1Add BLAST169

Interactioni

Protein-protein interaction databases

STRINGi93061.SAOUHSC_01360.

Structurei

3D structure databases

ProteinModelPortaliP0A084.
SMRiP0A084.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4108HW8. Bacteria.
COG0225. LUCA.
HOGENOMiHOG000263863.
KOiK07304.
OMAiVEHIFNK.

Family and domain databases

Gene3Di3.30.1060.10. 1 hit.
HAMAPiMF_01401. MsrA. 1 hit.
InterProiIPR028427. Met_Sox_Rdtase.
IPR002569. Met_Sox_Rdtase_MsrA.
[Graphical view]
PANTHERiPTHR10173. PTHR10173. 1 hit.
PfamiPF01625. PMSR. 1 hit.
[Graphical view]
SUPFAMiSSF55068. SSF55068. 1 hit.
TIGRFAMsiTIGR00401. msrA. 1 hit.

Sequencei

Sequence statusi: Complete.

P0A084-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNINTAYFAG GCFWCMTKPF DTFDGIEKVT SGYMGGHIEN PTYEQVKSGT
60 70 80 90 100
SGHLETVEIQ YDVALFSYNK LLEIFFSVID PLDTGGQYQD RGPQYQTAIF
110 120 130 140 150
YTNDHQKELA ETYIEQLKNT INADKAIATK ILPASQFYKA EDYHQDFYKK
160
NPERYAEEQK IRQEYKNKQ
Length:169
Mass (Da):19,611
Last modified:March 1, 2005 - v1
Checksum:i6C5406148DAAC9A0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF311784 Genomic DNA. Translation: AAK00894.1.
CP000253 Genomic DNA. Translation: ABD30455.1.
RefSeqiWP_001024830.1. NC_007795.1.
YP_499887.1. NC_007795.1.

Genome annotation databases

EnsemblBacteriaiABD30455; ABD30455; SAOUHSC_01360.
GeneIDi28381063.
3920065.
KEGGisao:SAOUHSC_01360.
PATRICi19580169. VBIStaAur99865_1244.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF311784 Genomic DNA. Translation: AAK00894.1.
CP000253 Genomic DNA. Translation: ABD30455.1.
RefSeqiWP_001024830.1. NC_007795.1.
YP_499887.1. NC_007795.1.

3D structure databases

ProteinModelPortaliP0A084.
SMRiP0A084.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi93061.SAOUHSC_01360.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABD30455; ABD30455; SAOUHSC_01360.
GeneIDi28381063.
3920065.
KEGGisao:SAOUHSC_01360.
PATRICi19580169. VBIStaAur99865_1244.

Phylogenomic databases

eggNOGiENOG4108HW8. Bacteria.
COG0225. LUCA.
HOGENOMiHOG000263863.
KOiK07304.
OMAiVEHIFNK.

Family and domain databases

Gene3Di3.30.1060.10. 1 hit.
HAMAPiMF_01401. MsrA. 1 hit.
InterProiIPR028427. Met_Sox_Rdtase.
IPR002569. Met_Sox_Rdtase_MsrA.
[Graphical view]
PANTHERiPTHR10173. PTHR10173. 1 hit.
PfamiPF01625. PMSR. 1 hit.
[Graphical view]
SUPFAMiSSF55068. SSF55068. 1 hit.
TIGRFAMsiTIGR00401. msrA. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMSRA1_STAA8
AccessioniPrimary (citable) accession number: P0A084
Secondary accession number(s): Q2G2M1, Q99QD5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: March 1, 2005
Last modified: November 2, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.