ID   MSRA1_STAAN             Reviewed;         169 AA.
AC   P0A082; Q99QD5;
DT   01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2005, sequence version 1.
DT   16-JUN-2009, entry version 24.
DE   RecName: Full=Peptide methionine sulfoxide reductase msrA 1;
DE            Short=Protein-methionine-S-oxide reductase 1;
DE            EC=1.8.4.11;
DE   AltName: Full=Peptide-methionine (S)-S-oxide reductase 1;
DE            Short=Peptide Met(O) reductase 1;
GN   Name=msrA1; Synonyms=msrA; OrderedLocusNames=SA1194;
OS   Staphylococcus aureus (strain N315).
OC   Bacteria; Firmicutes; Bacillales; Staphylococcus.
OX   NCBI_TaxID=158879;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   MEDLINE=21311952; PubMed=11418146; DOI=10.1016/S0140-6736(00)04403-2;
RA   Kuroda M., Ohta T., Uchiyama I., Baba T., Yuzawa H., Kobayashi I.,
RA   Cui L., Oguchi A., Aoki K., Nagai Y., Lian J.-Q., Ito T., Kanamori M.,
RA   Matsumaru H., Maruyama A., Murakami H., Hosoyama A., Mizutani-Ui Y.,
RA   Takahashi N.K., Sawano T., Inoue R., Kaito C., Sekimizu K.,
RA   Hirakawa H., Kuhara S., Goto S., Yabuzaki J., Kanehisa M.,
RA   Yamashita A., Oshima K., Furuya K., Yoshino C., Shiba T., Hattori M.,
RA   Ogasawara N., Hayashi H., Hiramatsu K.;
RT   "Whole genome sequencing of meticillin-resistant Staphylococcus
RT   aureus.";
RL   Lancet 357:1225-1240(2001).
RN   [2]
RP   CATALYTIC ACTIVITY, AND STEREOSPECIFICITY.
RX   MEDLINE=21637955; PubMed=11779133; DOI=10.1006/bbrc.2001.6171;
RA   Moskovitz J., Singh V.K., Requena J., Wilkinson B.J., Jayaswal R.K.,
RA   Stadtman E.R.;
RT   "Purification and characterization of methionine sulfoxide reductases
RT   from mouse and Staphylococcus aureus and their substrate
RT   stereospecificity.";
RL   Biochem. Biophys. Res. Commun. 290:62-65(2002).
CC   -!- FUNCTION: Has an important function as a repair enzyme for
CC       proteins that have been inactivated by oxidation. Catalyzes the
CC       reversible oxidation-reduction of methionine sulfoxide in proteins
CC       to methionine (By similarity).
CC   -!- CATALYTIC ACTIVITY: Peptide-L-methionine + thioredoxin disulfide +
CC       H(2)O = peptide-L-methionine (S)-S-oxide + thioredoxin.
CC   -!- CATALYTIC ACTIVITY: L-methionine + thioredoxin disulfide + H(2)O =
CC       L-methionine (S)-S-oxide + thioredoxin.
CC   -!- MISCELLANEOUS: Stereospecific for the S isomer of MetO.
CC   -!- SIMILARITY: Belongs to the msrA Met sulfoxide reductase family.
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DR   EMBL; BA000018; BAB42453.1; -; Genomic_DNA.
DR   PIR; A89912; A89912.
DR   RefSeq; NP_374474.1; -.
DR   HSSP; P27110; 1FF3.
DR   GeneID; 1124032; -.
DR   GenomeReviews; BA000018_GR; SA1194.
DR   KEGG; sau:SA1194; -.
DR   HOGENOM; P0A082; -.
DR   OMA; P0A082; DDGGQFQ.
DR   BioCyc; SAUR158879:SA1194-MON; -.
DR   GO; GO:0008113; F:peptide-methionine-(S)-S-oxide reductase ac...; IEA:HAMAP.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0006464; P:protein modification process; IEA:HAMAP.
DR   HAMAP; MF_01401; -; 1.
DR   InterPro; IPR002569; MsrA.
DR   Gene3D; G3DSA:3.30.1060.10; MsrA; 1.
DR   Pfam; PF01625; PMSR; 1.
DR   ProDom; PD003489; PMSR; 1.
DR   TIGRFAMs; TIGR00401; msrA; 1.
PE   1: Evidence at protein level;
KW   Complete proteome; Oxidoreductase.
FT   CHAIN         1    169       Peptide methionine sulfoxide reductase
FT                                msrA 1.
FT                                /FTId=PRO_0000138583.
FT   ACT_SITE     12     12       By similarity.
SQ   SEQUENCE   169 AA;  19611 MW;  6C5406148DAAC9A0 CRC64;
     MNINTAYFAG GCFWCMTKPF DTFDGIEKVT SGYMGGHIEN PTYEQVKSGT SGHLETVEIQ
     YDVALFSYNK LLEIFFSVID PLDTGGQYQD RGPQYQTAIF YTNDHQKELA ETYIEQLKNT
     INADKAIATK ILPASQFYKA EDYHQDFYKK NPERYAEEQK IRQEYKNKQ
//