Reviewed, UniProtKB/Swiss-Prot P0A082 (MSRA1_STAAN)

Names and origin

Protein names

Recommended name:
    Peptide methionine sulfoxide reductase msrA 1
      Short name=Protein-methionine-S-oxide reductase 1
    EC=1.8.4.11
Alternative name(s):
    Peptide-methionine (S)-S-oxide reductase 1
      Short name=Peptide Met(O) reductase 1

Gene names

Name:	msrA1
Synonyms:	msrA
Ordered Locus Names:	SA1194

Organism

Staphylococcus aureus (strain N315) [Complete proteome] [HAMAP]

Taxonomic identifier

158879 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	169 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine By similarity.
Catalytic activity	Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin. Ref.2 L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. Ref.2
Miscellaneous	Stereospecific for the S isomer of MetO. HAMAP MF_01401
Sequence similarities	Belongs to the msrA Met sulfoxide reductase family.

Ontologies

Keywords
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW protein modification process Inferred from electronic annotation. Source: HAMAP
Molecular function	peptide-methionine-(S)-S-oxide reductase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 169	169	Peptide methionine sulfoxide reductase msrA 1 HAMAP MF_01401		PRO_0000138583
Sites
	Active site	12	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	P0A082-1 [UniParc]. Last modified March 1, 2005. Version 1. Checksum: 6C5406148DAAC9A0	FASTA	169	19,611
	10 20 30 40 50 60 MNINTAYFAG GCFWCMTKPF DTFDGIEKVT SGYMGGHIEN PTYEQVKSGT SGHLETVEIQ 70 80 90 100 110 120 YDVALFSYNK LLEIFFSVID PLDTGGQYQD RGPQYQTAIF YTNDHQKELA ETYIEQLKNT 130 140 150 160 INADKAIATK ILPASQFYKA EDYHQDFYKK NPERYAEEQK IRQEYKNKQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Whole genome sequencing of meticillin-resistant Staphylococcus aureus." Kuroda M., Ohta T., Uchiyama I., Baba T., Yuzawa H., Kobayashi I., Cui L., Oguchi A., Aoki K., Nagai Y., Lian J.-Q., Ito T., Kanamori M., Matsumaru H., Maruyama A., Murakami H., Hosoyama A., Mizutani-Ui Y. , Takahashi N.K., Sawano T., Inoue R., Kaito C., Sekimizu K., Hirakawa H., Kuhara S., Goto S., Yabuzaki J., Kanehisa M., Yamashita A., Oshima K., Furuya K., Yoshino C., Shiba T., Hattori M., Ogasawara N., Hayashi H., Hiramatsu K. Lancet 357:1225-1240(2001) [PubMed: 11418146] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"Purification and characterization of methionine sulfoxide reductases from mouse and Staphylococcus aureus and their substrate stereospecificity." Moskovitz J., Singh V.K., Requena J., Wilkinson B.J., Jayaswal R.K., Stadtman E.R. Biochem. Biophys. Res. Commun. 290:62-65(2002) [PubMed: 11779133] [Abstract] Cited for: CATALYTIC ACTIVITY, STEREOSPECIFICITY.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BA000018 Genomic DNA. Translation: BAB42453.1.
PIR	A89912.
RefSeq	NP_374474.1.
3D structure databases
HSSP	HSSP built from PDB template 1FF3 based on UniProtKB P27110.
ModBase	Search...
Protein-protein interaction databases
STRING	P0A082.
Genome annotation databases
GeneID	1124032.
GenomeReviews	Gene locus SA1194 in contig BA000018_GR.
KEGG	sau:SA1194.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	P0A082.
OMA	DDGGQFQ.
Enzyme and pathway databases
BioCyc	SAUR158879:SA1194-MON.
Family and domain databases
HAMAP	MF_01401. [Tree]
InterPro	IPR002569. Peptide_Met_Sox_Rdtase_MsrA. [Graphical view]
Gene3D	G3DSA:3.30.1060.10. MsrA. 1 hit.
Pfam	PF01625. PMSR. 1 hit. [Graphical view]
ProDom	PD003489. PMSR. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00401. msrA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MSRA1_STAAN

Accession

Primary (citable) accession number: P0A082
Secondary accession number(s): Q99QD5

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 1, 2005
Last sequence update:	March 1, 2005
Last modified:	November 3, 2009
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)