P0A081 (MSRA1_STAAM) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Peptide methionine sulfoxide reductase MsrA 1
Short name=Protein-methionine-S-oxide reductase 1
EC=1.8.4.11

Alternative name(s):
Peptide-methionine (S)-S-oxide reductase 1
Short name=Peptide Met(O) reductase 1

Gene names

Name:	msrA1
Synonyms:	msrA
Ordered Locus Names:	SAV1361

Organism

Staphylococcus aureus (strain Mu50 / ATCC 700699) [Complete proteome] [HAMAP]

Taxonomic identifier

158878 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	169 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine By similarity. HAMAP MF_01401
Catalytic activity	Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin. Ref.2 L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. Ref.2
Miscellaneous	Stereospecific for the S isomer of MetO. HAMAP MF_01401
Sequence similarities	Belongs to the MsrA Met sulfoxide reductase family.

Ontologies

Keywords
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	protein metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	peptide-methionine-(S)-S-oxide reductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 169	169	Peptide methionine sulfoxide reductase MsrA 1 HAMAP MF_01401		PRO_0000138581
Sites
	Active site	12	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	P0A081 [UniParc]. Last modified March 1, 2005. Version 1. Checksum: 6C5406148DAAC9A0	FASTA	169	19,611
	10 20 30 40 50 60 MNINTAYFAG GCFWCMTKPF DTFDGIEKVT SGYMGGHIEN PTYEQVKSGT SGHLETVEIQ 70 80 90 100 110 120 YDVALFSYNK LLEIFFSVID PLDTGGQYQD RGPQYQTAIF YTNDHQKELA ETYIEQLKNT 130 140 150 160 INADKAIATK ILPASQFYKA EDYHQDFYKK NPERYAEEQK IRQEYKNKQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Whole genome sequencing of meticillin-resistant Staphylococcus aureus." Kuroda M., Ohta T., Uchiyama I., Baba T., Yuzawa H., Kobayashi I., Cui L., Oguchi A., Aoki K., Nagai Y., Lian J.-Q., Ito T., Kanamori M., Matsumaru H., Maruyama A., Murakami H., Hosoyama A., Mizutani-Ui Y. , Takahashi N.K., Sawano T., Inoue R., Kaito C., Sekimizu K., Hirakawa H., Kuhara S., Goto S., Yabuzaki J., Kanehisa M., Yamashita A., Oshima K., Furuya K., Yoshino C., Shiba T., Hattori M., Ogasawara N., Hayashi H., Hiramatsu K. Lancet 357:1225-1240(2001) [PubMed: 11418146] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Mu50 / ATCC 700699.
[2]	"Purification and characterization of methionine sulfoxide reductases from mouse and Staphylococcus aureus and their substrate stereospecificity." Moskovitz J., Singh V.K., Requena J., Wilkinson B.J., Jayaswal R.K., Stadtman E.R. Biochem. Biophys. Res. Commun. 290:62-65(2002) [PubMed: 11779133] [Abstract] Cited for: CATALYTIC ACTIVITY, STEREOSPECIFICITY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000017 Genomic DNA. Translation: BAB57523.1.
RefSeq	NP_371885.1. NC_002758.2.
3D structure databases
ProteinModelPortal	P0A081.
ModBase	Search...
Protein-protein interaction databases
STRING	P0A081.
2D gel databases
World-2DPAGE	0002:P0A081.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTAT00000007864; EBSTAP00000007682; EBSTAG00000007863.
GeneID	1121336.
GenomeReviews	Gene locus SAV1361 in contig BA000017_GR.
KEGG	sav:SAV1361.
PATRIC	19563446. VBIStaAur52173_1400.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0225.
GeneTree	EBGT00050000024265.
HOGENOM	HBG748152.
OMA	KIEYDVA.
PhylomeDB	P0A081.
ProtClustDB	PRK14054.
Enzyme and pathway databases
BioCyc	SAUR158878:SAV1361-MONOMER.
Family and domain databases
HAMAP	MF_01401. MsrA. [Tree]
InterPro	IPR002569. Peptide_Met_Sox_Rdtase_MsrA. [Graphical view]
Gene3D	G3DSA:3.30.1060.10. MsrA. 1 hit.
KO	K07304.
Pfam	PF01625. PMSR. 1 hit. [Graphical view]
SUPFAM	SSF55068. MsrA. 1 hit.
TIGRFAMs	TIGR00401. MsrA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MSRA1_STAAM

Accession

Primary (citable) accession number: P0A081
Secondary accession number(s): Q99QD5

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 1, 2005
Last sequence update:	March 1, 2005
Last modified:	January 25, 2012
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program