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Protein

Gamma-hemolysin component B

Gene

hlgB

Organism
Staphylococcus aureus
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Toxin that seems to act by forming pores in the membrane of the cell. Has a hemolytic and a leucotoxic activity.

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Toxin

Keywords - Biological processi

Cytolysis, Hemolysis

Protein family/group databases

TCDBi1.C.3.4.2. the -hemolysin channel-forming toxin (hl) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-hemolysin component B
Alternative name(s):
H-gamma-1
H-gamma-I
Gene namesi
Name:hlgB
OrganismiStaphylococcus aureus
Taxonomic identifieri1280 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence analysisAdd
BLAST
Chaini26 – 325300Gamma-hemolysin component BPRO_0000018424Add
BLAST

Interactioni

Subunit structurei

Toxicity requires sequential binding and synergistic association of a class S and a class F component which form heterooligomeric complexes. HlgB (class F) associates with either HlgA thus forming an AB toxin or with HlgC thus forming a CB toxin.

Protein-protein interaction databases

STRINGi93062.SACOL2422.

Structurei

Secondary structure

1
325
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi28 – 303Combined sources
Beta strandi34 – 374Combined sources
Beta strandi39 – 5315Combined sources
Turni54 – 574Combined sources
Beta strandi58 – 6912Combined sources
Beta strandi72 – 8615Combined sources
Beta strandi98 – 11417Combined sources
Beta strandi120 – 1278Combined sources
Beta strandi134 – 1429Combined sources
Turni144 – 1463Combined sources
Beta strandi148 – 1525Combined sources
Beta strandi164 – 1718Combined sources
Beta strandi175 – 1795Combined sources
Beta strandi187 – 1948Combined sources
Beta strandi199 – 2024Combined sources
Turni212 – 2143Combined sources
Helixi229 – 2313Combined sources
Helixi236 – 2383Combined sources
Helixi241 – 2444Combined sources
Beta strandi251 – 2577Combined sources
Beta strandi259 – 2613Combined sources
Beta strandi263 – 28220Combined sources
Beta strandi287 – 30721Combined sources
Turni308 – 3114Combined sources
Beta strandi312 – 32413Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1LKFX-ray1.90A27-325[»]
2LKFX-ray2.50A27-325[»]
2QK7X-ray2.40B27-325[»]
3LKFX-ray1.90A27-325[»]
ProteinModelPortaliP0A077.
SMRiP0A077. Positions 42-325.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0A077.

Family & Domainsi

Sequence similaritiesi

Belongs to the aerolysin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4106XHW. Bacteria.
ENOG410YTX5. LUCA.

Family and domain databases

Gene3Di2.70.240.10. 1 hit.
InterProiIPR003963. Bi-component_toxin_staph.
IPR016183. Leukocidin/porin.
[Graphical view]
PfamiPF07968. Leukocidin. 1 hit.
[Graphical view]
PRINTSiPR01468. BICOMPNTOXIN.
SUPFAMiSSF56959. SSF56959. 1 hit.
TIGRFAMsiTIGR01002. hlyII. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0A077-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKMNKLVKSS VATSMALLLL SGTANAEGKI TPVSVKKVDD KVTLYKTTAT
60 70 80 90 100
ADSDKFKISQ ILTFNFIKDK SYDKDTLVLK ATGNINSGFV KPNPNDYDFS
110 120 130 140 150
KLYWGAKYNV SISSQSNDSV NVVDYAPKNQ NEEFQVQNTL GYTFGGDISI
160 170 180 190 200
SNGLSGGLNG NTAFSETINY KQESYRTTLS RNTNYKNVGW GVEAHKIMNN
210 220 230 240 250
GWGPYGRDSF HPTYGNELFL AGRQSSAYAG QNFIAQHQMP LLSRSNFNPE
260 270 280 290 300
FLSVLSHRQD GAKKSKITVT YQREMDLYQI RWNGFYWAGA NYKNFKTRTF
310 320
KSTYEIDWEN HKVKLLDTKE TENNK
Length:325
Mass (Da):36,711
Last modified:February 15, 2005 - v1
Checksum:i082999EB9339B6A0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L01055 Genomic DNA. Translation: AAA26639.1.
PIRiB49238.
RefSeqiWP_000783428.1. NZ_LT009690.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L01055 Genomic DNA. Translation: AAA26639.1.
PIRiB49238.
RefSeqiWP_000783428.1. NZ_LT009690.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1LKFX-ray1.90A27-325[»]
2LKFX-ray2.50A27-325[»]
2QK7X-ray2.40B27-325[»]
3LKFX-ray1.90A27-325[»]
ProteinModelPortaliP0A077.
SMRiP0A077. Positions 42-325.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi93062.SACOL2422.

Protein family/group databases

TCDBi1.C.3.4.2. the -hemolysin channel-forming toxin (hl) family.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG4106XHW. Bacteria.
ENOG410YTX5. LUCA.

Miscellaneous databases

EvolutionaryTraceiP0A077.

Family and domain databases

Gene3Di2.70.240.10. 1 hit.
InterProiIPR003963. Bi-component_toxin_staph.
IPR016183. Leukocidin/porin.
[Graphical view]
PfamiPF07968. Leukocidin. 1 hit.
[Graphical view]
PRINTSiPR01468. BICOMPNTOXIN.
SUPFAMiSSF56959. SSF56959. 1 hit.
TIGRFAMsiTIGR01002. hlyII. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiHLGB_STAAU
AccessioniPrimary (citable) accession number: P0A077
Secondary accession number(s): Q07226
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: February 15, 2005
Last modified: September 7, 2016
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.