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Protein

Gamma-hemolysin component B

Gene

hlgB

Organism
Staphylococcus aureus (strain N315)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Toxin that seems to act by forming pores in the membrane of the cell. Has a hemolytic and a leucotoxic activity (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Toxin

Keywords - Biological processi

Cytolysis, Hemolysis

Enzyme and pathway databases

BioCyciSAUR158879:GJCB-2369-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-hemolysin component B
Alternative name(s):
H-gamma-1
H-gamma-I
Gene namesi
Name:hlgB
Ordered Locus Names:SA2209
OrganismiStaphylococcus aureus (strain N315)
Taxonomic identifieri158879 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000000751 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence analysisAdd
BLAST
Chaini26 – 325300Gamma-hemolysin component BPRO_0000018423Add
BLAST

Interactioni

Subunit structurei

Toxicity requires sequential binding and synergistic association of a class S and a class F component which form heterooligomeric complexes. HlgB (class F) associates with either HlgA thus forming an AB toxin or with HlgC thus forming a CB toxin (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliP0A075.
SMRiP0A075. Positions 42-325.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aerolysin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000111768.
OMAiNAKTHTS.

Family and domain databases

Gene3Di2.70.240.10. 1 hit.
InterProiIPR003963. Bi-component_toxin_staph.
IPR016183. Leukocidin/porin.
[Graphical view]
PfamiPF07968. Leukocidin. 1 hit.
[Graphical view]
PRINTSiPR01468. BICOMPNTOXIN.
SUPFAMiSSF56959. SSF56959. 1 hit.
TIGRFAMsiTIGR01002. hlyII. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0A075-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKMNKLVKSS VATSMALLLL SGTANAEGKI TPVSVKKVDD KVTLYKTTAT
60 70 80 90 100
ADSDKFKISQ ILTFNFIKDK SYDKDTLVLK ATGNINSGFV KPNPNDYDFS
110 120 130 140 150
KLYWGAKYNV SISSQSNDSV NVVDYAPKNQ NEEFQVQNTL GYTFGGDISI
160 170 180 190 200
SNGLSGGLNG NTAFSETINY KQESYRTTLS RNTNYKNVGW GVEAHKIMNN
210 220 230 240 250
GWGPYGRDSF HPTYGNELFL AGRQSSAYAG QNFIAQHQMP LLSRSNFNPE
260 270 280 290 300
FLSVLSHRQD GAKKSKITVT YQREMDLYQI RWNGFYWAGA NYKNFKTRTF
310 320
KSTYEIDWEN HKVKLLDTKE TENNK
Length:325
Mass (Da):36,711
Last modified:February 15, 2005 - v1
Checksum:i082999EB9339B6A0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000018 Genomic DNA. Translation: BAB43511.1.
PIRiF90043.
RefSeqiWP_000783428.1. NC_002745.2.

Genome annotation databases

EnsemblBacteriaiBAB43511; BAB43511; BAB43511.
PATRICi19576954. VBIStaAur116463_2395.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000018 Genomic DNA. Translation: BAB43511.1.
PIRiF90043.
RefSeqiWP_000783428.1. NC_002745.2.

3D structure databases

ProteinModelPortaliP0A075.
SMRiP0A075. Positions 42-325.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB43511; BAB43511; BAB43511.
PATRICi19576954. VBIStaAur116463_2395.

Phylogenomic databases

HOGENOMiHOG000111768.
OMAiNAKTHTS.

Enzyme and pathway databases

BioCyciSAUR158879:GJCB-2369-MONOMER.

Family and domain databases

Gene3Di2.70.240.10. 1 hit.
InterProiIPR003963. Bi-component_toxin_staph.
IPR016183. Leukocidin/porin.
[Graphical view]
PfamiPF07968. Leukocidin. 1 hit.
[Graphical view]
PRINTSiPR01468. BICOMPNTOXIN.
SUPFAMiSSF56959. SSF56959. 1 hit.
TIGRFAMsiTIGR01002. hlyII. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiHLGB_STAAN
AccessioniPrimary (citable) accession number: P0A075
Secondary accession number(s): Q07226
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: February 15, 2005
Last modified: September 7, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.