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Protein

Gamma-hemolysin component A

Gene

hlgA

Organism
Staphylococcus aureus (strain Mu50 / ATCC 700699)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Toxin that seems to act by forming pores in the membrane of the cell. Has a hemolytic and a leucotoxic activity (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Toxin

Keywords - Biological processi

Cytolysis, Hemolysis

Enzyme and pathway databases

BioCyciSAUR158878:GJJ5-2487-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-hemolysin component A
Alternative name(s):
H-gamma-2
H-gamma-II
Gene namesi
Name:hlgA
Synonyms:hlg2
Ordered Locus Names:SAV2419
OrganismiStaphylococcus aureus (strain Mu50 / ATCC 700699)
Taxonomic identifieri158878 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000002481 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929By similarityAdd
BLAST
Chaini30 – 309280Gamma-hemolysin component APRO_0000018419Add
BLAST

Proteomic databases

PaxDbiP0A071.

Interactioni

Subunit structurei

Toxicity requires sequential binding and synergistic association of a class S and a class F component which form heterooligomeric complexes. HlgA (class S) associates with HlgB (class F) thus forming an AB toxin in strains producing both gamma-hemolysins and leukocidins. HlgA and LukF-PV can also form a complex (By similarity).By similarity

Protein-protein interaction databases

DIPiDIP-59713N.

Structurei

Secondary structure

1
309
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi42 – 5110Combined sources
Turni52 – 554Combined sources
Beta strandi56 – 6510Combined sources
Beta strandi70 – 8415Combined sources
Beta strandi88 – 914Combined sources
Beta strandi98 – 11316Combined sources
Beta strandi118 – 1258Combined sources
Beta strandi131 – 14717Combined sources
Turni148 – 1503Combined sources
Beta strandi151 – 17929Combined sources
Beta strandi182 – 1898Combined sources
Beta strandi191 – 1944Combined sources
Beta strandi197 – 2004Combined sources
Turni204 – 2074Combined sources
Beta strandi212 – 2154Combined sources
Helixi216 – 2194Combined sources
Helixi223 – 2253Combined sources
Helixi228 – 2314Combined sources
Beta strandi237 – 2448Combined sources
Beta strandi246 – 2483Combined sources
Beta strandi250 – 27021Combined sources
Beta strandi273 – 29523Combined sources
Turni296 – 2994Combined sources
Beta strandi300 – 3078Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3B07X-ray2.50B/D/F/H30-309[»]
4P1YX-ray2.99B/D/F/H42-309[»]
ProteinModelPortaliP0A071.
SMRiP0A071. Positions 40-309.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aerolysin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000280105.
KOiK11038.
OMAiMAPLANP.
PhylomeDBiP0A071.

Family and domain databases

Gene3Di2.70.240.10. 1 hit.
InterProiIPR003963. Bi-component_toxin_staph.
IPR016183. Leukocidin/porin.
[Graphical view]
PfamiPF07968. Leukocidin. 1 hit.
[Graphical view]
PRINTSiPR01468. BICOMPNTOXIN.
SUPFAMiSSF56959. SSF56959. 1 hit.
TIGRFAMsiTIGR01002. hlyII. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0A071-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIKNKILTAT LAVGLIAPLA NPFIEISKAE NKIEDIGQGA EIIKRTQDIT
60 70 80 90 100
SKRLAITQNI QFDFVKDKKY NKDALVVKMQ GFISSRTTYS DLKKYPYIKR
110 120 130 140 150
MIWPFQYNIS LKTKDSNVDL INYLPKNKID SADVSQKLGY NIGGNFQSAP
160 170 180 190 200
SIGGSGSFNY SKTISYNQKN YVTEVESQNS KGVKWGVKAN SFVTPNGQVS
210 220 230 240 250
AYDQYLFAQD PTGPAARDYF VPDNQLPPLI QSGFNPSFIT TLSHERGKGD
260 270 280 290 300
KSEFEITYGR NMDATYAYVT RHRLAVDRKH DAFKNRNVTV KYEVNWKTHE

VKIKSITPK
Length:309
Mass (Da):34,956
Last modified:March 1, 2005 - v1
Checksum:i15CAE12E1025B616
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000017 Genomic DNA. Translation: BAB58581.1.
RefSeqiWP_000594519.1. NC_002758.2.

Genome annotation databases

EnsemblBacteriaiBAB58581; BAB58581; SAV2419.
KEGGisav:SAV2419.
PATRICi19565756. VBIStaAur52173_2504.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000017 Genomic DNA. Translation: BAB58581.1.
RefSeqiWP_000594519.1. NC_002758.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3B07X-ray2.50B/D/F/H30-309[»]
4P1YX-ray2.99B/D/F/H42-309[»]
ProteinModelPortaliP0A071.
SMRiP0A071. Positions 40-309.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-59713N.

Proteomic databases

PaxDbiP0A071.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB58581; BAB58581; SAV2419.
KEGGisav:SAV2419.
PATRICi19565756. VBIStaAur52173_2504.

Phylogenomic databases

HOGENOMiHOG000280105.
KOiK11038.
OMAiMAPLANP.
PhylomeDBiP0A071.

Enzyme and pathway databases

BioCyciSAUR158878:GJJ5-2487-MONOMER.

Family and domain databases

Gene3Di2.70.240.10. 1 hit.
InterProiIPR003963. Bi-component_toxin_staph.
IPR016183. Leukocidin/porin.
[Graphical view]
PfamiPF07968. Leukocidin. 1 hit.
[Graphical view]
PRINTSiPR01468. BICOMPNTOXIN.
SUPFAMiSSF56959. SSF56959. 1 hit.
TIGRFAMsiTIGR01002. hlyII. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiHLGA_STAAM
AccessioniPrimary (citable) accession number: P0A071
Secondary accession number(s): P31714
, Q07225, Q53689, Q53690
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: March 1, 2005
Last modified: September 7, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.