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Protein

Gamma-hemolysin component A

Gene

hlgA

Organism
Staphylococcus aureus (strain Mu50 / ATCC 700699)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Toxin that seems to act by forming pores in the membrane of the cell. Has a hemolytic and a leucotoxic activity (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionToxin
Biological processCytolysis, Hemolysis

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-hemolysin component A
Alternative name(s):
H-gamma-2
H-gamma-II
Gene namesi
Name:hlgA
Synonyms:hlg2
Ordered Locus Names:SAV2419
OrganismiStaphylococcus aureus (strain Mu50 / ATCC 700699)
Taxonomic identifieri158878 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000002481 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29By similarityAdd BLAST29
ChainiPRO_000001841930 – 309Gamma-hemolysin component AAdd BLAST280

Proteomic databases

PaxDbiP0A071

Interactioni

Subunit structurei

Toxicity requires sequential binding and synergistic association of a class S and a class F component which form heterooligomeric complexes. HlgA (class S) associates with HlgB (class F) thus forming an AB toxin in strains producing both gamma-hemolysins and leukocidins. HlgA and LukF-PV can also form a complex (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
hlgBA0A0H3JX612EBI-16223478,EBI-16223472

Protein-protein interaction databases

DIPiDIP-59713N
IntActiP0A071, 1 interactor
STRINGi158878.SAV2419

Structurei

Secondary structure

1309
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi42 – 51Combined sources10
Turni52 – 55Combined sources4
Beta strandi56 – 65Combined sources10
Beta strandi70 – 84Combined sources15
Beta strandi88 – 91Combined sources4
Beta strandi98 – 113Combined sources16
Beta strandi118 – 125Combined sources8
Beta strandi131 – 147Combined sources17
Turni148 – 150Combined sources3
Beta strandi151 – 179Combined sources29
Beta strandi182 – 189Combined sources8
Beta strandi191 – 194Combined sources4
Beta strandi197 – 200Combined sources4
Turni204 – 207Combined sources4
Beta strandi212 – 215Combined sources4
Helixi216 – 219Combined sources4
Helixi223 – 225Combined sources3
Helixi228 – 231Combined sources4
Beta strandi237 – 244Combined sources8
Beta strandi246 – 248Combined sources3
Beta strandi250 – 270Combined sources21
Beta strandi273 – 295Combined sources23
Turni296 – 299Combined sources4
Beta strandi300 – 307Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3B07X-ray2.50B/D/F/H30-309[»]
4P1YX-ray2.99B/D/F/H42-309[»]
ProteinModelPortaliP0A071
SMRiP0A071
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aerolysin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000280105
KOiK11038
OMAiMAPLANP
PhylomeDBiP0A071

Family and domain databases

InterProiView protein in InterPro
IPR003963 Bi-component_toxin_staph
IPR016183 Leukocidin/Hemolysin_toxin
IPR036435 Leukocidin/porin_MspA_sf
PfamiView protein in Pfam
PF07968 Leukocidin, 1 hit
PRINTSiPR01468 BICOMPNTOXIN
SUPFAMiSSF56959 SSF56959, 1 hit
TIGRFAMsiTIGR01002 hlyII, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0A071-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIKNKILTAT LAVGLIAPLA NPFIEISKAE NKIEDIGQGA EIIKRTQDIT
60 70 80 90 100
SKRLAITQNI QFDFVKDKKY NKDALVVKMQ GFISSRTTYS DLKKYPYIKR
110 120 130 140 150
MIWPFQYNIS LKTKDSNVDL INYLPKNKID SADVSQKLGY NIGGNFQSAP
160 170 180 190 200
SIGGSGSFNY SKTISYNQKN YVTEVESQNS KGVKWGVKAN SFVTPNGQVS
210 220 230 240 250
AYDQYLFAQD PTGPAARDYF VPDNQLPPLI QSGFNPSFIT TLSHERGKGD
260 270 280 290 300
KSEFEITYGR NMDATYAYVT RHRLAVDRKH DAFKNRNVTV KYEVNWKTHE

VKIKSITPK
Length:309
Mass (Da):34,956
Last modified:March 1, 2005 - v1
Checksum:i15CAE12E1025B616
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000017 Genomic DNA Translation: BAB58581.1
RefSeqiWP_000594519.1, NC_002758.2

Genome annotation databases

EnsemblBacteriaiBAB58581; BAB58581; SAV2419
KEGGisav:SAV2419

Similar proteinsi

Entry informationi

Entry nameiHLGA_STAAM
AccessioniPrimary (citable) accession number: P0A071
Secondary accession number(s): P31714
, Q07225, Q53689, Q53690
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: March 1, 2005
Last modified: March 28, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome
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Main funding by: National Institutes of Health