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Protein

Immunoglobulin G-binding protein A

Gene

spa

Organism
Staphylococcus aureus (strain Mu50 / ATCC 700699)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

IgG-binding protein

Enzyme and pathway databases

BioCyciSAUR158878:GJJ5-111-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Immunoglobulin G-binding protein A
Short name:
IgG-binding protein A
Alternative name(s):
Staphylococcal protein A
Gene namesi
Name:spa
Ordered Locus Names:SAV0111
OrganismiStaphylococcus aureus (strain Mu50 / ATCC 700699)
Taxonomic identifieri158878 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000002481 Componenti: Chromosome

Subcellular locationi

  • Secretedcell wall PROSITE-ProRule annotation; Peptidoglycan-anchor PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell wall, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3636Sequence analysisAdd
BLAST
Chaini37 – 419383Immunoglobulin G-binding protein APRO_0000005649Add
BLAST
Propeptidei420 – 45031Removed by sortasePROSITE-ProRule annotationPRO_0000005650Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei419 – 4191Pentaglycyl murein peptidoglycan amidated threoninePROSITE-ProRule annotation

Keywords - PTMi

Peptidoglycan-anchor

Proteomic databases

PaxDbiP0A015.

Interactioni

Protein-protein interaction databases

STRINGi158878.SAV0111.

Structurei

Secondary structure

1
450
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi102 – 11312Combined sources
Helixi119 – 13113Combined sources
Helixi133 – 1353Combined sources
Helixi136 – 14914Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4HJGX-ray2.00H101-151[»]
4HKZX-ray2.08H101-151[»]
4IOIX-ray1.95H101-151[»]
ProteinModelPortaliP0A015.
SMRiP0A015. Positions 37-92, 100-153, 155-269, 351-403.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati35 – 8854B 1Add
BLAST
Repeati96 – 14954B 2Add
BLAST
Repeati154 – 20754B 3Add
BLAST
Repeati212 – 26554B 4Add
BLAST
Repeati268 – 27582-1
Repeati276 – 28382-2
Repeati284 – 29182-3
Repeati292 – 29982-4
Repeati300 – 30782-5
Repeati308 – 31582-6
Repeati316 – 32382-7
Repeati324 – 33182-8
Repeati332 – 33982-9
Repeati340 – 34782-10
Repeati348 – 35582-11
Domaini355 – 39945LysMPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni268 – 3558812 X 8 AA approximate tandem repeatsAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi416 – 4205LPXTG sorting signalPROSITE-ProRule annotation

Sequence similaritiesi

Contains 1 LysM domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG4106I9N. Bacteria.
ENOG410XXBQ. LUCA.
HOGENOMiHOG000279707.
KOiK14196.
OMAiDAQQNKF.
OrthoDBiEOG69PPZZ.

Family and domain databases

Gene3Di3.10.350.10. 1 hit.
InterProiIPR019948. Gram-positive_anchor.
IPR009063. Ig/albumin-bd.
IPR019931. LPXTG_anchor.
IPR018392. LysM_dom.
IPR005038. Octapeptide.
IPR003132. Protein_A_Ig-bd.
IPR005877. YSIRK_signal_dom.
[Graphical view]
PfamiPF02216. B. 4 hits.
PF00746. Gram_pos_anchor. 1 hit.
PF01476. LysM. 1 hit.
PF03373. Octapeptide. 10 hits.
PF04650. YSIRK_signal. 1 hit.
[Graphical view]
SMARTiSM00257. LysM. 1 hit.
[Graphical view]
SUPFAMiSSF46997. SSF46997. 4 hits.
SSF54106. SSF54106. 1 hit.
TIGRFAMsiTIGR01167. LPXTG_anchor. 1 hit.
TIGR01168. YSIRK_signal. 1 hit.
PROSITEiPS50847. GRAM_POS_ANCHORING. 1 hit.
PS51782. LYSM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0A015-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKKNIYSIR KLGVGIASVT LGTLLISGGV TPAANAAQHD EAQQNAFYQV
60 70 80 90 100
LNMPNLNADQ RNGFIQSLKD DPSQSANVLG EAQKLNDSQA PKADAQQNNF
110 120 130 140 150
NKDQQSAFYE ILNMPNLNEA QRNGFIQSLK DDPSQSTNVL GEAKKLNESQ
160 170 180 190 200
APKADNNFNK EQQNAFYEIL NMPNLNEEQR NGFIQSLKDD PSQSANLLSE
210 220 230 240 250
AKKLNESQAP KADNKFNKEQ QNAFYEILHL PNLNEEQRNG FIQSLKDDPS
260 270 280 290 300
VSKEILAEAK KLNDAQAPKE EDNKKPGKED GNKPGKEDGN KPGKEDNKKP
310 320 330 340 350
GKEDGNKPGK EDNNKPGKED GNKPGKEDNN KPGKEDGNKP GKEDGNKPGK
360 370 380 390 400
EDGNGVHVVK PGDTVNDIAK ANGTTADKIA ADNKLADKNM IKPGQELVVD
410 420 430 440 450
KKQPANHADA NKAQALPETG EENPFIGTTV FGGLSLALGA ALLAGRRREL
Length:450
Mass (Da):48,873
Last modified:March 1, 2005 - v1
Checksum:i7BBA8C8578FB1549
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000017 Genomic DNA. Translation: BAB56273.1.
RefSeqiWP_000728765.1. NC_002758.2.

Genome annotation databases

EnsemblBacteriaiBAB56273; BAB56273; SAV0111.
KEGGisav:SAV0111.
PATRICi19560823. VBIStaAur52173_0109.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000017 Genomic DNA. Translation: BAB56273.1.
RefSeqiWP_000728765.1. NC_002758.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4HJGX-ray2.00H101-151[»]
4HKZX-ray2.08H101-151[»]
4IOIX-ray1.95H101-151[»]
ProteinModelPortaliP0A015.
SMRiP0A015. Positions 37-92, 100-153, 155-269, 351-403.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi158878.SAV0111.

Proteomic databases

PaxDbiP0A015.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB56273; BAB56273; SAV0111.
KEGGisav:SAV0111.
PATRICi19560823. VBIStaAur52173_0109.

Phylogenomic databases

eggNOGiENOG4106I9N. Bacteria.
ENOG410XXBQ. LUCA.
HOGENOMiHOG000279707.
KOiK14196.
OMAiDAQQNKF.
OrthoDBiEOG69PPZZ.

Enzyme and pathway databases

BioCyciSAUR158878:GJJ5-111-MONOMER.

Miscellaneous databases

PROiP0A015.

Family and domain databases

Gene3Di3.10.350.10. 1 hit.
InterProiIPR019948. Gram-positive_anchor.
IPR009063. Ig/albumin-bd.
IPR019931. LPXTG_anchor.
IPR018392. LysM_dom.
IPR005038. Octapeptide.
IPR003132. Protein_A_Ig-bd.
IPR005877. YSIRK_signal_dom.
[Graphical view]
PfamiPF02216. B. 4 hits.
PF00746. Gram_pos_anchor. 1 hit.
PF01476. LysM. 1 hit.
PF03373. Octapeptide. 10 hits.
PF04650. YSIRK_signal. 1 hit.
[Graphical view]
SMARTiSM00257. LysM. 1 hit.
[Graphical view]
SUPFAMiSSF46997. SSF46997. 4 hits.
SSF54106. SSF54106. 1 hit.
TIGRFAMsiTIGR01167. LPXTG_anchor. 1 hit.
TIGR01168. YSIRK_signal. 1 hit.
PROSITEiPS50847. GRAM_POS_ANCHORING. 1 hit.
PS51782. LYSM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Mu50 / ATCC 700699.

Entry informationi

Entry nameiSPA_STAAM
AccessioniPrimary (citable) accession number: P0A015
Secondary accession number(s): Q99XA2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: March 1, 2005
Last modified: March 16, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.