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Protein

Tagatose 1,6-diphosphate aldolase

Gene

lacD

Organism
Staphylococcus aureus (strain N315)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

D-tagatose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

Pathwayi: D-tagatose 6-phosphate degradation

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-tagatose 6-phosphate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Tagatose-6-phosphate kinase (lacC), Tagatose-6-phosphate kinase (fruB)
  2. Tagatose 1,6-diphosphate aldolase (lacD)
This subpathway is part of the pathway D-tagatose 6-phosphate degradation, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-tagatose 6-phosphate, the pathway D-tagatose 6-phosphate degradation and in Carbohydrate metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Lactose metabolism

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-2744.
SAUR158879:GJCB-2142-MONOMER.
UniPathwayiUPA00704; UER00716.

Names & Taxonomyi

Protein namesi
Recommended name:
Tagatose 1,6-diphosphate aldolase (EC:4.1.2.40)
Alternative name(s):
D-tagatose-1,6-bisphosphate aldolase
Tagatose-bisphosphate aldolase
Gene namesi
Name:lacD
Ordered Locus Names:SA1994
OrganismiStaphylococcus aureus (strain N315)
Taxonomic identifieri158879 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000000751 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 326326Tagatose 1,6-diphosphate aldolasePRO_0000203946Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP0A010.
SMRiP0A010. Positions 2-326.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldolase LacD family.Curated

Phylogenomic databases

HOGENOMiHOG000241518.
OMAiGRAVWQE.
OrthoDBiEOG6SR92W.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00734. LacD.
InterProiIPR013785. Aldolase_TIM.
IPR002915. DeoC/FbaB/lacD_aldolase.
IPR005927. Tag_1.6-dipho_adolase.
[Graphical view]
PfamiPF01791. DeoC. 1 hit.
[Graphical view]
SMARTiSM01133. DeoC. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01232. lacD. 1 hit.

Sequencei

Sequence statusi: Complete.

P0A010-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKSNQKIAS IEQLSNNEGI ISALAFDQRG ALKRMMAKHQ TEEPTVAQIE
60 70 80 90 100
QLKVLVAEEL TQYASSILLD PEYGLPASDA RNKDCGLLLA YEKTGYDVNA
110 120 130 140 150
KGRLPDCLVE WSAKRLKEQG ANAVKFLLYY DVDDAEEINI QKKAYIERIG
160 170 180 190 200
SECVAEDIPF FLEVLTYDDN IPDNGSVEFA KVKPRKVNEA MKLFSEPRFN
210 220 230 240 250
VDVLKVEVPV NMKYVEGFAE GEVVYTKEEA AQHFKDQDAA THLPYIYLSA
260 270 280 290 300
GVSAELFQET LKFAHEAGAK FNGVLCGRAT WSGAVQVYIE QGEDAAREWL
310 320
RTTGFKNIDD LNKVLKDTAT SWKQRK
Length:326
Mass (Da):36,595
Last modified:March 1, 2005 - v1
Checksum:i20766B1B841372C1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000018 Genomic DNA. Translation: BAB43284.1.
RefSeqiWP_000047009.1. NC_002745.2.

Genome annotation databases

EnsemblBacteriaiBAB43284; BAB43284; BAB43284.
PATRICi19576474. VBIStaAur116463_2155.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000018 Genomic DNA. Translation: BAB43284.1.
RefSeqiWP_000047009.1. NC_002745.2.

3D structure databases

ProteinModelPortaliP0A010.
SMRiP0A010. Positions 2-326.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB43284; BAB43284; BAB43284.
PATRICi19576474. VBIStaAur116463_2155.

Phylogenomic databases

HOGENOMiHOG000241518.
OMAiGRAVWQE.
OrthoDBiEOG6SR92W.

Enzyme and pathway databases

UniPathwayiUPA00704; UER00716.
BioCyciMetaCyc:MONOMER-2744.
SAUR158879:GJCB-2142-MONOMER.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00734. LacD.
InterProiIPR013785. Aldolase_TIM.
IPR002915. DeoC/FbaB/lacD_aldolase.
IPR005927. Tag_1.6-dipho_adolase.
[Graphical view]
PfamiPF01791. DeoC. 1 hit.
[Graphical view]
SMARTiSM01133. DeoC. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01232. lacD. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: N315.
  2. "Shotgun proteomic analysis of total and membrane protein extracts of S. aureus strain N315."
    Vaezzadeh A.R., Deshusses J., Lescuyer P., Hochstrasser D.F.
    Submitted (OCT-2007) to UniProtKB
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: N315.

Entry informationi

Entry nameiLACD_STAAN
AccessioniPrimary (citable) accession number: P0A010
Secondary accession number(s): P11100
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: March 1, 2005
Last modified: May 11, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.