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Protein

Tagatose 1,6-diphosphate aldolase

Gene

lacD

Organism
Staphylococcus aureus (strain Mu50 / ATCC 700699)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

D-tagatose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

Pathwayi: D-tagatose 6-phosphate degradation

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-tagatose 6-phosphate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Tagatose-6-phosphate kinase (fruB), Tagatose-6-phosphate kinase (lacC)
  2. Tagatose 1,6-diphosphate aldolase (lacD)
This subpathway is part of the pathway D-tagatose 6-phosphate degradation, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-tagatose 6-phosphate, the pathway D-tagatose 6-phosphate degradation and in Carbohydrate metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Lactose metabolism

Enzyme and pathway databases

UniPathwayiUPA00704; UER00716.

Names & Taxonomyi

Protein namesi
Recommended name:
Tagatose 1,6-diphosphate aldolase (EC:4.1.2.40)
Alternative name(s):
D-tagatose-1,6-bisphosphate aldolase
Tagatose-bisphosphate aldolase
Gene namesi
Name:lacD
Ordered Locus Names:SAV2192
OrganismiStaphylococcus aureus (strain Mu50 / ATCC 700699)
Taxonomic identifieri158878 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000002481 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002039451 – 326Tagatose 1,6-diphosphate aldolaseAdd BLAST326

Proteomic databases

PaxDbiP0A009.
PRIDEiP0A009.

2D gel databases

World-2DPAGE0002:P0A009.

Interactioni

Protein-protein interaction databases

STRINGi158878.SAV2192.

Structurei

Secondary structure

1326
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi5 – 14Combined sources10
Beta strandi21 – 26Combined sources6
Helixi30 – 37Combined sources8
Helixi46 – 60Combined sources15
Helixi61 – 63Combined sources3
Beta strandi65 – 69Combined sources5
Turni71 – 73Combined sources3
Helixi75 – 79Combined sources5
Beta strandi86 – 90Combined sources5
Helixi113 – 118Combined sources6
Beta strandi122 – 130Combined sources9
Helixi136 – 156Combined sources21
Beta strandi160 – 166Combined sources7
Helixi177 – 194Combined sources18
Helixi197 – 199Combined sources3
Beta strandi202 – 206Combined sources5
Helixi212 – 214Combined sources3
Turni216 – 218Combined sources3
Helixi227 – 239Combined sources13
Beta strandi245 – 248Combined sources4
Helixi254 – 267Combined sources14
Beta strandi273 – 276Combined sources4
Helixi278 – 281Combined sources4
Helixi284 – 290Combined sources7
Helixi293 – 301Combined sources9
Helixi303 – 318Combined sources16

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3KAOX-ray1.90A1-326[»]
ProteinModelPortaliP0A009.
SMRiP0A009.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0A009.

Family & Domainsi

Sequence similaritiesi

Belongs to the aldolase LacD family.Curated

Phylogenomic databases

eggNOGiENOG4105D2M. Bacteria.
COG3684. LUCA.
HOGENOMiHOG000241518.
KOiK01635.
OMAiLCQIAEN.
PhylomeDBiP0A009.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00734. LacD. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR002915. DeoC/FbaB/lacD_aldolase.
IPR005927. Tag_1.6-dipho_adolase.
[Graphical view]
PfamiPF01791. DeoC. 1 hit.
[Graphical view]
SMARTiSM01133. DeoC. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01232. lacD. 1 hit.

Sequencei

Sequence statusi: Complete.

P0A009-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKSNQKIAS IEQLSNNEGI ISALAFDQRG ALKRMMAKHQ TEEPTVAQIE
60 70 80 90 100
QLKVLVAEEL TQYASSILLD PEYGLPASDA RNKDCGLLLA YEKTGYDVNA
110 120 130 140 150
KGRLPDCLVE WSAKRLKEQG ANAVKFLLYY DVDDAEEINI QKKAYIERIG
160 170 180 190 200
SECVAEDIPF FLEVLTYDDN IPDNGSVEFA KVKPRKVNEA MKLFSEPRFN
210 220 230 240 250
VDVLKVEVPV NMKYVEGFAE GEVVYTKEEA AQHFKDQDAA THLPYIYLSA
260 270 280 290 300
GVSAELFQET LKFAHEAGAK FNGVLCGRAT WSGAVQVYIE QGEDAAREWL
310 320
RTTGFKNIDD LNKVLKDTAT SWKQRK
Length:326
Mass (Da):36,595
Last modified:March 1, 2005 - v1
Checksum:i20766B1B841372C1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000017 Genomic DNA. Translation: BAB58354.1.
RefSeqiWP_000047009.1. NC_002758.2.

Genome annotation databases

EnsemblBacteriaiBAB58354; BAB58354; SAV2192.
GeneIDi28380207.
KEGGisav:SAV2192.
PATRICi19565278. VBIStaAur52173_2265.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000017 Genomic DNA. Translation: BAB58354.1.
RefSeqiWP_000047009.1. NC_002758.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3KAOX-ray1.90A1-326[»]
ProteinModelPortaliP0A009.
SMRiP0A009.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi158878.SAV2192.

2D gel databases

World-2DPAGE0002:P0A009.

Proteomic databases

PaxDbiP0A009.
PRIDEiP0A009.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB58354; BAB58354; SAV2192.
GeneIDi28380207.
KEGGisav:SAV2192.
PATRICi19565278. VBIStaAur52173_2265.

Phylogenomic databases

eggNOGiENOG4105D2M. Bacteria.
COG3684. LUCA.
HOGENOMiHOG000241518.
KOiK01635.
OMAiLCQIAEN.
PhylomeDBiP0A009.

Enzyme and pathway databases

UniPathwayiUPA00704; UER00716.

Miscellaneous databases

EvolutionaryTraceiP0A009.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00734. LacD. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR002915. DeoC/FbaB/lacD_aldolase.
IPR005927. Tag_1.6-dipho_adolase.
[Graphical view]
PfamiPF01791. DeoC. 1 hit.
[Graphical view]
SMARTiSM01133. DeoC. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01232. lacD. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiLACD_STAAM
AccessioniPrimary (citable) accession number: P0A009
Secondary accession number(s): P11100
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: March 1, 2005
Last modified: November 2, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.