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Protein

Tagatose 1,6-diphosphate aldolase

Gene

lacD

Organism
Staphylococcus aureus (strain Mu50 / ATCC 700699)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

D-tagatose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

Pathwayi: D-tagatose 6-phosphate degradation

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-tagatose 6-phosphate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Tagatose-6-phosphate kinase (fruB), Tagatose-6-phosphate kinase (lacC)
  2. Tagatose 1,6-diphosphate aldolase (lacD)
This subpathway is part of the pathway D-tagatose 6-phosphate degradation, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-tagatose 6-phosphate, the pathway D-tagatose 6-phosphate degradation and in Carbohydrate metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Lactose metabolism

Enzyme and pathway databases

BioCyciSAUR158878:GJJ5-2260-MONOMER.
UniPathwayiUPA00704; UER00716.

Names & Taxonomyi

Protein namesi
Recommended name:
Tagatose 1,6-diphosphate aldolase (EC:4.1.2.40)
Alternative name(s):
D-tagatose-1,6-bisphosphate aldolase
Tagatose-bisphosphate aldolase
Gene namesi
Name:lacD
Ordered Locus Names:SAV2192
OrganismiStaphylococcus aureus (strain Mu50 / ATCC 700699)
Taxonomic identifieri158878 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000002481 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 326326Tagatose 1,6-diphosphate aldolasePRO_0000203945Add
BLAST

Proteomic databases

PaxDbiP0A009.

2D gel databases

World-2DPAGE0002:P0A009.

Interactioni

Protein-protein interaction databases

STRINGi158878.SAV2192.

Structurei

Secondary structure

1
326
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi5 – 1410Combined sources
Beta strandi21 – 266Combined sources
Helixi30 – 378Combined sources
Helixi46 – 6015Combined sources
Helixi61 – 633Combined sources
Beta strandi65 – 695Combined sources
Turni71 – 733Combined sources
Helixi75 – 795Combined sources
Beta strandi86 – 905Combined sources
Helixi113 – 1186Combined sources
Beta strandi122 – 1309Combined sources
Helixi136 – 15621Combined sources
Beta strandi160 – 1667Combined sources
Helixi177 – 19418Combined sources
Helixi197 – 1993Combined sources
Beta strandi202 – 2065Combined sources
Helixi212 – 2143Combined sources
Turni216 – 2183Combined sources
Helixi227 – 23913Combined sources
Beta strandi245 – 2484Combined sources
Helixi254 – 26714Combined sources
Beta strandi273 – 2764Combined sources
Helixi278 – 2814Combined sources
Helixi284 – 2907Combined sources
Helixi293 – 3019Combined sources
Helixi303 – 31816Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3KAOX-ray1.90A1-326[»]
ProteinModelPortaliP0A009.
SMRiP0A009. Positions 2-326.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0A009.

Family & Domainsi

Sequence similaritiesi

Belongs to the aldolase LacD family.Curated

Phylogenomic databases

eggNOGiENOG4105D2M. Bacteria.
COG3684. LUCA.
HOGENOMiHOG000241518.
KOiK01635.
OMAiGRAVWQE.
OrthoDBiEOG6SR92W.
PhylomeDBiP0A009.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00734. LacD.
InterProiIPR013785. Aldolase_TIM.
IPR002915. DeoC/FbaB/lacD_aldolase.
IPR005927. Tag_1.6-dipho_adolase.
[Graphical view]
PfamiPF01791. DeoC. 1 hit.
[Graphical view]
SMARTiSM01133. DeoC. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01232. lacD. 1 hit.

Sequencei

Sequence statusi: Complete.

P0A009-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKSNQKIAS IEQLSNNEGI ISALAFDQRG ALKRMMAKHQ TEEPTVAQIE
60 70 80 90 100
QLKVLVAEEL TQYASSILLD PEYGLPASDA RNKDCGLLLA YEKTGYDVNA
110 120 130 140 150
KGRLPDCLVE WSAKRLKEQG ANAVKFLLYY DVDDAEEINI QKKAYIERIG
160 170 180 190 200
SECVAEDIPF FLEVLTYDDN IPDNGSVEFA KVKPRKVNEA MKLFSEPRFN
210 220 230 240 250
VDVLKVEVPV NMKYVEGFAE GEVVYTKEEA AQHFKDQDAA THLPYIYLSA
260 270 280 290 300
GVSAELFQET LKFAHEAGAK FNGVLCGRAT WSGAVQVYIE QGEDAAREWL
310 320
RTTGFKNIDD LNKVLKDTAT SWKQRK
Length:326
Mass (Da):36,595
Last modified:March 1, 2005 - v1
Checksum:i20766B1B841372C1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000017 Genomic DNA. Translation: BAB58354.1.
RefSeqiWP_000047009.1. NC_002758.2.

Genome annotation databases

EnsemblBacteriaiBAB58354; BAB58354; SAV2192.
KEGGisav:SAV2192.
PATRICi19565278. VBIStaAur52173_2265.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000017 Genomic DNA. Translation: BAB58354.1.
RefSeqiWP_000047009.1. NC_002758.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3KAOX-ray1.90A1-326[»]
ProteinModelPortaliP0A009.
SMRiP0A009. Positions 2-326.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi158878.SAV2192.

2D gel databases

World-2DPAGE0002:P0A009.

Proteomic databases

PaxDbiP0A009.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB58354; BAB58354; SAV2192.
KEGGisav:SAV2192.
PATRICi19565278. VBIStaAur52173_2265.

Phylogenomic databases

eggNOGiENOG4105D2M. Bacteria.
COG3684. LUCA.
HOGENOMiHOG000241518.
KOiK01635.
OMAiGRAVWQE.
OrthoDBiEOG6SR92W.
PhylomeDBiP0A009.

Enzyme and pathway databases

UniPathwayiUPA00704; UER00716.
BioCyciSAUR158878:GJJ5-2260-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP0A009.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00734. LacD.
InterProiIPR013785. Aldolase_TIM.
IPR002915. DeoC/FbaB/lacD_aldolase.
IPR005927. Tag_1.6-dipho_adolase.
[Graphical view]
PfamiPF01791. DeoC. 1 hit.
[Graphical view]
SMARTiSM01133. DeoC. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01232. lacD. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Mu50 / ATCC 700699.

Entry informationi

Entry nameiLACD_STAAM
AccessioniPrimary (citable) accession number: P0A009
Secondary accession number(s): P11100
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: March 1, 2005
Last modified: May 11, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.