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P0A005

- ARSC_STAAN

UniProt

P0A005 - ARSC_STAAN

Protein

Protein ArsC

Gene

arsC

Organism
Staphylococcus aureus (strain N315)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Reduces arsenate [As(V)] to arsenite [As(III)] and dephosphorylates tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. Could switch between different functions in different circumstances.UniRule annotation

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.UniRule annotation
    Arsenate + thioredoxin = arsenite + thioredoxin disulfide + H2O.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei10 – 101Nucleophile; for reductase activity and phosphatase activityUniRule annotation
    Active sitei82 – 821Nucleophile; for reductase activityUniRule annotation
    Active sitei89 – 891Nucleophile; for reductase activityUniRule annotation

    GO - Molecular functioni

    1. arsenate reductase (thioredoxin) activity Source: UniProtKB-HAMAP
    2. protein tyrosine phosphatase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. response to arsenic-containing substance Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Oxidoreductase

    Keywords - Biological processi

    Arsenical resistance

    Enzyme and pathway databases

    BioCyciSAUR158879:GJCB-2687-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein ArsCUniRule annotation
    Alternative name(s):
    Arsenate reductaseUniRule annotation (EC:1.20.4.-UniRule annotation)
    Arsenical pump modifierUniRule annotation
    Low molecular weight protein-tyrosine-phosphataseUniRule annotation (EC:3.1.3.48UniRule annotation)
    Gene namesi
    Name:arsCUniRule annotation
    Ordered Locus Names:SAP018
    Encoded oniPlasmid pN3150 Publication
    OrganismiStaphylococcus aureus (strain N315)
    Taxonomic identifieri158879 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
    ProteomesiUP000000751: Plasmid pN315

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 131131Protein ArsCPRO_0000162526Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi10 ↔ 82Redox-active; alternateUniRule annotation
    Disulfide bondi82 ↔ 89Redox-active; alternateUniRule annotation

    Keywords - PTMi

    Disulfide bond

    Interactioni

    Subunit structurei

    Monomer.UniRule annotation

    Protein-protein interaction databases

    STRINGi158879.SAP018.

    Structurei

    3D structure databases

    ProteinModelPortaliP0A005.
    SMRiP0A005. Positions 2-131.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the low molecular weight phosphotyrosine protein phosphatase superfamily. ArsC family.UniRule annotation

    Keywords - Domaini

    Redox-active center

    Phylogenomic databases

    eggNOGiCOG0394.
    HOGENOMiHOG000273093.
    KOiK03741.
    OMAiGHANETC.
    OrthoDBiEOG6JDWJC.

    Family and domain databases

    HAMAPiMF_01624. Arsenate_reduct.
    InterProiIPR014064. Arsenate_reductase_ArsC.
    IPR023485. Ptyr_pPase_SF.
    IPR017867. Tyr_phospatase_low_mol_wt.
    [Graphical view]
    PANTHERiPTHR11717. PTHR11717. 1 hit.
    PfamiPF01451. LMWPc. 1 hit.
    [Graphical view]
    SMARTiSM00226. LMWPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52788. SSF52788. 1 hit.
    TIGRFAMsiTIGR02691. arsC_pI258_fam. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P0A005-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDKKTIYFIC TGNSCRSQMA EGWGKEILGE GWNVYSAGIE THGVNPKAIE    50
    AMKEVDIDIS NHTSDLIDND ILKQSDLVVT LCSDADNNCP ILPPNVKKEH 100
    WGFDDPAGKE WSEFQRVRDE IKLAIEKFKL R 131
    Length:131
    Mass (Da):14,813
    Last modified:February 15, 2005 - v1
    Checksum:i03871148DC433A18
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP003139 Genomic DNA. Translation: BAB43887.1.
    RefSeqiNP_395554.1. NC_003140.1.

    Genome annotation databases

    EnsemblBacteriaiBAB43887; BAB43887; BAB43887.
    GeneIDi1122760.
    KEGGisau:SAP018.
    PATRICi19577621. VBIStaAur116463_2728.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP003139 Genomic DNA. Translation: BAB43887.1 .
    RefSeqi NP_395554.1. NC_003140.1.

    3D structure databases

    ProteinModelPortali P0A005.
    SMRi P0A005. Positions 2-131.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 158879.SAP018.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB43887 ; BAB43887 ; BAB43887 .
    GeneIDi 1122760.
    KEGGi sau:SAP018.
    PATRICi 19577621. VBIStaAur116463_2728.

    Phylogenomic databases

    eggNOGi COG0394.
    HOGENOMi HOG000273093.
    KOi K03741.
    OMAi GHANETC.
    OrthoDBi EOG6JDWJC.

    Enzyme and pathway databases

    BioCyci SAUR158879:GJCB-2687-MONOMER.

    Family and domain databases

    HAMAPi MF_01624. Arsenate_reduct.
    InterProi IPR014064. Arsenate_reductase_ArsC.
    IPR023485. Ptyr_pPase_SF.
    IPR017867. Tyr_phospatase_low_mol_wt.
    [Graphical view ]
    PANTHERi PTHR11717. PTHR11717. 1 hit.
    Pfami PF01451. LMWPc. 1 hit.
    [Graphical view ]
    SMARTi SM00226. LMWPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52788. SSF52788. 1 hit.
    TIGRFAMsi TIGR02691. arsC_pI258_fam. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: N315.
    2. "Shotgun proteomic analysis of total and membrane protein extracts of S. aureus strain N315."
      Vaezzadeh A.R., Deshusses J., Lescuyer P., Hochstrasser D.F.
      Submitted (OCT-2007) to UniProtKB
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Strain: N315.

    Entry informationi

    Entry nameiARSC_STAAN
    AccessioniPrimary (citable) accession number: P0A005
    Secondary accession number(s): P30330
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 15, 2005
    Last sequence update: February 15, 2005
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Plasmid

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3