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Protein

Acyl carrier protein

Gene

acpP

Organism
Staphylococcus aureus (strain MW2)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Carrier of the growing fatty acid chain in fatty acid biosynthesis. Is able to confer high methicillin resistance to S.aureus when overproduced (By similarity).UniRule annotation

Pathwayi: fatty acid biosynthesis

This protein is involved in the pathway fatty acid biosynthesis, which is part of Lipid metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway fatty acid biosynthesis and in Lipid metabolism.

GO - Biological processi

Keywordsi

Biological processAntibiotic resistance, Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

UniPathwayiUPA00094.

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl carrier proteinUniRule annotation
Short name:
ACPUniRule annotation
Gene namesi
Name:acpPUniRule annotation
Synonyms:hmrB
Ordered Locus Names:MW1115
OrganismiStaphylococcus aureus (strain MW2)
Taxonomic identifieri196620 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000000418 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001801931 – 77Acyl carrier proteinAdd BLAST77

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei36O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1

Post-translational modificationi

4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.UniRule annotation

Keywords - PTMi

Phosphopantetheine, Phosphoprotein

Structurei

3D structure databases

ProteinModelPortaliP0A003.
SMRiP0A003.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 76CarrierPROSITE-ProRule annotationAdd BLAST76

Sequence similaritiesi

Belongs to the acyl carrier protein (ACP) family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000178184.
KOiK02078.
OMAiSKMGVNK.

Family and domain databases

HAMAPiMF_01217. Acyl_carrier. 1 hit.
InterProiView protein in InterPro
IPR003231. Acyl_carrier.
IPR009081. PP-bd_ACP.
IPR006162. Ppantetheine_attach_site.
PfamiView protein in Pfam
PF00550. PP-binding. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD000887. PD000887. 1 hit.
SUPFAMiSSF47336. SSF47336. 1 hit.
TIGRFAMsiTIGR00517. acyl_carrier. 1 hit.
PROSITEiView protein in PROSITE
PS50075. CARRIER. 1 hit.
PS00012. PHOSPHOPANTETHEINE. 1 hit.

Sequencei

Sequence statusi: Complete.

P0A003-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENFDKVKDI IVDRLGVDAD KVTEDASFKD DLGADSLDIA ELVMELEDEF
60 70
GTEIPDEEAE KINTVGDAVK FINSLEK
Length:77
Mass (Da):8,549
Last modified:March 1, 2005 - v1
Checksum:i11B458391E5BB83E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000033 Genomic DNA. Translation: BAB94980.1.
RefSeqiWP_000426914.1. NC_003923.1.

Genome annotation databases

EnsemblBacteriaiBAB94980; BAB94980; BAB94980.
GeneIDi31213993.
KEGGisam:MW1115.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000033 Genomic DNA. Translation: BAB94980.1.
RefSeqiWP_000426914.1. NC_003923.1.

3D structure databases

ProteinModelPortaliP0A003.
SMRiP0A003.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB94980; BAB94980; BAB94980.
GeneIDi31213993.
KEGGisam:MW1115.

Phylogenomic databases

HOGENOMiHOG000178184.
KOiK02078.
OMAiSKMGVNK.

Enzyme and pathway databases

UniPathwayiUPA00094.

Family and domain databases

HAMAPiMF_01217. Acyl_carrier. 1 hit.
InterProiView protein in InterPro
IPR003231. Acyl_carrier.
IPR009081. PP-bd_ACP.
IPR006162. Ppantetheine_attach_site.
PfamiView protein in Pfam
PF00550. PP-binding. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD000887. PD000887. 1 hit.
SUPFAMiSSF47336. SSF47336. 1 hit.
TIGRFAMsiTIGR00517. acyl_carrier. 1 hit.
PROSITEiView protein in PROSITE
PS50075. CARRIER. 1 hit.
PS00012. PHOSPHOPANTETHEINE. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiACP_STAAW
AccessioniPrimary (citable) accession number: P0A003
Secondary accession number(s): Q99QN7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: March 1, 2005
Last modified: June 7, 2017
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.