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Protein

Fructose-bisphosphate aldolase C

Gene

ALDOC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

In vertebrates, three forms of this ubiquitous glycolytic enzyme are found, aldolase A in muscle, aldolase B in liver and aldolase C in brain.

Catalytic activityi

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.1 Publication

Kineticsi

  1. KM=10.7 µM for fructose 1,6-bisphosphate1 Publication
  2. KM=16 mM for fructose 1-phosphate1 Publication

    Pathwayi: glycolysis

    This protein is involved in step 4 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.
    Proteins known to be involved in the 4 steps of the subpathway in this organism are:
    1. no protein annotated in this organism
    2. Glucose-6-phosphate isomerase, Glucose-6-phosphate isomerase, Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase, Glucose-6-phosphate isomerase (GPI)
    3. ATP-dependent 6-phosphofructokinase (PFKM), ATP-dependent 6-phosphofructokinase, liver type (PFKL), ATP-dependent 6-phosphofructokinase, platelet type (PFKP), ATP-dependent 6-phosphofructokinase, muscle type (PFKM)
    4. Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase (ALDOB), Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase (ALDOA), Fructose-bisphosphate aldolase C (ALDOC), Fructose-bisphosphate aldolase (HEL-S-87p), Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase (ALDOA), Fructose-bisphosphate aldolase (ALDOC), Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase (ALDOB), Fructose-bisphosphate aldolase (ALDOA), Fructose-bisphosphate aldolase (ALDOA), Fructose-bisphosphate aldolase B (ALDOB), Fructose-bisphosphate aldolase A (ALDOA), Fructose-bisphosphate aldolase (ALDOC), Fructose-bisphosphate aldolase
    This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
    View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Binding sitei56Substrate1
    Binding sitei147Substrate1
    Active sitei188Proton acceptorBy similarity1
    Active sitei230Schiff-base intermediate with dihydroxyacetone-P1
    Sitei364Necessary for preference for fructose 1,6-bisphosphate over fructose 1-phosphate1

    GO - Molecular functioni

    • cytoskeletal protein binding Source: BHF-UCL
    • fructose-bisphosphate aldolase activity Source: UniProtKB

    GO - Biological processi

    • canonical glycolysis Source: Reactome
    • epithelial cell differentiation Source: UniProtKB
    • fructose 1,6-bisphosphate metabolic process Source: UniProtKB
    • fructose metabolic process Source: ProtInc
    • gluconeogenesis Source: Reactome
    • neutrophil degranulation Source: Reactome

    Keywordsi

    Molecular functionLyase
    Biological processGlycolysis
    LigandSchiff base

    Enzyme and pathway databases

    BioCyciMetaCyc:HS03200-MONOMER
    ReactomeiR-HSA-6798695 Neutrophil degranulation
    R-HSA-70171 Glycolysis
    R-HSA-70263 Gluconeogenesis
    SABIO-RKiP09972
    UniPathwayiUPA00109; UER00183

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Fructose-bisphosphate aldolase C (EC:4.1.2.13)
    Alternative name(s):
    Brain-type aldolase
    Gene namesi
    Name:ALDOC
    Synonyms:ALDC
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    Proteomesi
    • UP000005640 Componenti: Chromosome 17

    Organism-specific databases

    EuPathDBiHostDB:ENSG00000109107.13
    HGNCiHGNC:418 ALDOC
    MIMi103870 gene
    neXtProtiNX_P09972

    Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

    Pathology & Biotechi

    Organism-specific databases

    DisGeNETi230
    OpenTargetsiENSG00000109107
    PharmGKBiPA24711

    Polymorphism and mutation databases

    BioMutaiALDOC
    DMDMi113613

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    ChainiPRO_00002169471 – 364Fructose-bisphosphate aldolase CAdd BLAST364

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Modified residuei36PhosphoserineCombined sources1
    Modified residuei39PhosphoserineCombined sources1
    Modified residuei45PhosphoserineCombined sources1
    Modified residuei111N6-acetyllysineCombined sources1

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    EPDiP09972
    MaxQBiP09972
    PaxDbiP09972
    PeptideAtlasiP09972
    PRIDEiP09972

    2D gel databases

    UCD-2DPAGEiP09972

    PTM databases

    iPTMnetiP09972
    PhosphoSitePlusiP09972
    SwissPalmiP09972

    Expressioni

    Gene expression databases

    BgeeiENSG00000109107
    CleanExiHS_ALDOC
    ExpressionAtlasiP09972 baseline and differential
    GenevisibleiP09972 HS

    Organism-specific databases

    HPAiCAB020828
    HPA003282
    HPA067442

    Interactioni

    Subunit structurei

    Homotetramer. Interacts with ATP6V1E1. May interact with PLD2.2 Publications

    Binary interactionsi

    Show more details

    GO - Molecular functioni

    • cytoskeletal protein binding Source: BHF-UCL

    Protein-protein interaction databases

    BioGridi106731, 69 interactors
    IntActiP09972, 8 interactors
    STRINGi9606.ENSP00000226253

    Structurei

    Secondary structure

    1364
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details
    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Helixi10 – 23Combined sources14
    Beta strandi29 – 33Combined sources5
    Helixi37 – 45Combined sources9
    Helixi53 – 64Combined sources12
    Helixi68 – 70Combined sources3
    Turni71 – 73Combined sources3
    Beta strandi74 – 79Combined sources6
    Helixi82 – 85Combined sources4
    Helixi94 – 100Combined sources7
    Beta strandi104 – 108Combined sources5
    Beta strandi113 – 115Combined sources3
    Beta strandi119 – 121Combined sources3
    Beta strandi123 – 125Combined sources3
    Helixi131 – 140Combined sources10
    Beta strandi145 – 152Combined sources8
    Helixi161 – 179Combined sources19
    Turni180 – 182Combined sources3
    Beta strandi184 – 191Combined sources8
    Helixi199 – 219Combined sources21
    Helixi224 – 226Combined sources3
    Helixi246 – 257Combined sources12
    Turni258 – 260Combined sources3
    Beta strandi267 – 271Combined sources5
    Helixi277 – 288Combined sources12
    Beta strandi295 – 303Combined sources9
    Helixi304 – 314Combined sources11
    Helixi321 – 338Combined sources18
    Turni339 – 341Combined sources3

    3D structure databases

    Select the link destinations:
    PDBei
    RCSB PDBi
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    1XFBX-ray3.00A/B/C/D/E/F/G/H/I/J/K/L1-364[»]
    ProteinModelPortaliP09972
    SMRiP09972
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP09972

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiKOG1557 Eukaryota
    COG3588 LUCA
    GeneTreeiENSGT00390000010235
    HOVERGENiHBG002386
    InParanoidiP09972
    KOiK01623
    OMAiMTHQYPA
    OrthoDBiEOG091G0A9T
    PhylomeDBiP09972
    TreeFamiTF314203

    Family and domain databases

    Gene3Di3.20.20.70, 1 hit
    InterProiView protein in InterPro
    IPR029768 Aldolase_I_AS
    IPR013785 Aldolase_TIM
    IPR000741 FBA_I
    PfamiView protein in Pfam
    PF00274 Glycolytic, 1 hit
    PROSITEiView protein in PROSITE
    PS00158 ALDOLASE_CLASS_I, 1 hit

    Sequencei

    Sequence statusi: Complete.

    P09972-1 [UniParc]FASTAAdd to basket

    « Hide

            10         20         30         40         50
    MPHSYPALSA EQKKELSDIA LRIVAPGKGI LAADESVGSM AKRLSQIGVE
    60 70 80 90 100
    NTEENRRLYR QVLFSADDRV KKCIGGVIFF HETLYQKDDN GVPFVRTIQD
    110 120 130 140 150
    KGIVVGIKVD KGVVPLAGTD GETTTQGLDG LSERCAQYKK DGADFAKWRC
    160 170 180 190 200
    VLKISERTPS ALAILENANV LARYASICQQ NGIVPIVEPE ILPDGDHDLK
    210 220 230 240 250
    RCQYVTEKVL AAVYKALSDH HVYLEGTLLK PNMVTPGHAC PIKYTPEEIA
    260 270 280 290 300
    MATVTALRRT VPPAVPGVTF LSGGQSEEEA SFNLNAINRC PLPRPWALTF
    310 320 330 340 350
    SYGRALQASA LNAWRGQRDN AGAATEEFIK RAEVNGLAAQ GKYEGSGEDG
    360
    GAAAQSLYIA NHAY
    Length:364
    Mass (Da):39,456
    Last modified:January 23, 2007 - v2
    Checksum:i506A570B3E507971
    GO

    Sequence cautioni

    The sequence AAI03761 differs from that shown. Reason: Erroneous initiation.Curated

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Sequence conflicti311L → V in CAA30270 (PubMed:3267224).Curated1

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    X05196 Genomic DNA Translation: CAA28825.1
    X07292 Genomic DNA Translation: CAA30270.1
    AF054987 mRNA Translation: AAC09348.1
    BT007006 mRNA Translation: AAP35652.1
    CR541862 mRNA Translation: CAG46660.1
    CR541881 mRNA Translation: CAG46679.1
    AK312281 mRNA Translation: BAG35210.1
    CH471159 Genomic DNA Translation: EAW51104.1
    BC003613 mRNA Translation: AAH03613.3
    BC103760 mRNA Translation: AAI03761.1 Different initiation.
    BC065565 mRNA Translation: AAH65565.2
    BC106925 mRNA Translation: AAI06926.1
    BC106926 mRNA Translation: AAI06927.1
    CCDSiCCDS11236.1
    PIRiA25861 ADHUC
    RefSeqiNP_005156.1, NM_005165.2
    XP_005258006.1, XM_005257949.2
    XP_011522858.1, XM_011524556.1
    UniGeneiHs.155247

    Genome annotation databases

    EnsembliENST00000226253; ENSP00000226253; ENSG00000109107
    ENST00000395321; ENSP00000378731; ENSG00000109107
    GeneIDi230
    KEGGihsa:230
    UCSCiuc002hbp.4 human

    Similar proteinsi

    Entry informationi

    Entry nameiALDOC_HUMAN
    AccessioniPrimary (citable) accession number: P09972
    Secondary accession number(s): B2R5R3
    , Q3SYL3, Q6FH94, Q6P0L5
    Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: January 23, 2007
    Last modified: May 23, 2018
    This is version 184 of the entry and version 2 of the sequence. See complete history.
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    4. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    5. SIMILARITY comments
      Index of protein domains and families

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