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Protein

Fructose-bisphosphate aldolase C

Gene

ALDOC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.1 Publication

Kineticsi

  1. KM=10.7 µM for fructose 1,6-bisphosphate1 Publication
  2. KM=16 mM for fructose 1-phosphate1 Publication

    Pathwayi: glycolysis

    This protein is involved in step 4 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.
    Proteins known to be involved in the 4 steps of the subpathway in this organism are:
    1. no protein annotated in this organism
    2. Glucose-6-phosphate isomerase, Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase, Glucose-6-phosphate isomerase (GPI)
    3. ATP-dependent 6-phosphofructokinase (PFKM), ATP-dependent 6-phosphofructokinase, liver type (PFKL), ATP-dependent 6-phosphofructokinase, muscle type (PFKM), ATP-dependent 6-phosphofructokinase, platelet type (PFKP)
    4. Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase (ALDOB), Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase (ALDOA), Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase C (ALDOC), Fructose-bisphosphate aldolase (HEL-S-87p), Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase (ALDOA), Fructose-bisphosphate aldolase (ALDOC), Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase (ALDOB), Fructose-bisphosphate aldolase (ALDOA), Fructose-bisphosphate aldolase (ALDOA), Fructose-bisphosphate aldolase B (ALDOB), Fructose-bisphosphate aldolase A (ALDOA), Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase (ALDOC)
    This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
    View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Binding sitei56Substrate1
    Binding sitei147Substrate1
    Active sitei188Proton acceptorBy similarity1
    Active sitei230Schiff-base intermediate with dihydroxyacetone-P1
    Sitei364Necessary for preference for fructose 1,6-bisphosphate over fructose 1-phosphate1

    GO - Molecular functioni

    • cytoskeletal protein binding Source: BHF-UCL
    • fructose-bisphosphate aldolase activity Source: UniProtKB

    GO - Biological processi

    • canonical glycolysis Source: Reactome
    • epithelial cell differentiation Source: UniProtKB
    • fructose 1,6-bisphosphate metabolic process Source: UniProtKB
    • fructose metabolic process Source: ProtInc
    • gluconeogenesis Source: Reactome
    Complete GO annotation...

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    Schiff base

    Enzyme and pathway databases

    BioCyciMetaCyc:HS03200-MONOMER.
    ZFISH:HS03200-MONOMER.
    ReactomeiR-HSA-6798695. Neutrophil degranulation.
    R-HSA-70171. Glycolysis.
    R-HSA-70263. Gluconeogenesis.
    SABIO-RKP09972.
    UniPathwayiUPA00109; UER00183.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Fructose-bisphosphate aldolase C (EC:4.1.2.13)
    Alternative name(s):
    Brain-type aldolase
    Gene namesi
    Name:ALDOC
    Synonyms:ALDC
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    Proteomesi
    • UP000005640 Componenti: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:418. ALDOC.

    Subcellular locationi

    GO - Cellular componenti

    • cytoskeleton Source: BHF-UCL
    • cytosol Source: Reactome
    • extracellular exosome Source: UniProtKB
    • mitochondrion Source: Ensembl
    Complete GO annotation...

    Pathology & Biotechi

    Organism-specific databases

    DisGeNETi230.
    OpenTargetsiENSG00000109107.
    PharmGKBiPA24711.

    Polymorphism and mutation databases

    BioMutaiALDOC.
    DMDMi113613.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Initiator methionineiRemovedBy similarity
    ChainiPRO_00002169472 – 364Fructose-bisphosphate aldolase CAdd BLAST363

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Modified residuei36PhosphoserineCombined sources1
    Modified residuei39PhosphoserineCombined sources1
    Modified residuei45PhosphoserineCombined sources1
    Modified residuei111N6-acetyllysineCombined sources1

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    EPDiP09972.
    MaxQBiP09972.
    PaxDbiP09972.
    PeptideAtlasiP09972.
    PRIDEiP09972.

    2D gel databases

    UCD-2DPAGEP09972.

    PTM databases

    iPTMnetiP09972.
    PhosphoSitePlusiP09972.
    SwissPalmiP09972.

    Expressioni

    Gene expression databases

    BgeeiENSG00000109107.
    CleanExiHS_ALDOC.
    ExpressionAtlasiP09972. baseline and differential.
    GenevisibleiP09972. HS.

    Organism-specific databases

    HPAiCAB020828.
    HPA003282.

    Interactioni

    Subunit structurei

    Homotetramer. Interacts with ATP6V1E1. May interact with PLD2.2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ALDOAP04075-23EBI-2952751,EBI-10194102
    LNX1Q8TBB15EBI-2952751,EBI-739832

    GO - Molecular functioni

    • cytoskeletal protein binding Source: BHF-UCL

    Protein-protein interaction databases

    BioGridi106731. 68 interactors.
    IntActiP09972. 8 interactors.
    STRINGi9606.ENSP00000226253.

    Structurei

    Secondary structure

    1364
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details
    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Helixi10 – 23Combined sources14
    Beta strandi29 – 33Combined sources5
    Helixi37 – 45Combined sources9
    Helixi53 – 64Combined sources12
    Helixi68 – 70Combined sources3
    Turni71 – 73Combined sources3
    Beta strandi74 – 79Combined sources6
    Helixi82 – 85Combined sources4
    Helixi94 – 100Combined sources7
    Beta strandi104 – 108Combined sources5
    Beta strandi113 – 115Combined sources3
    Beta strandi119 – 121Combined sources3
    Beta strandi123 – 125Combined sources3
    Helixi131 – 140Combined sources10
    Beta strandi145 – 152Combined sources8
    Helixi161 – 179Combined sources19
    Turni180 – 182Combined sources3
    Beta strandi184 – 191Combined sources8
    Helixi199 – 219Combined sources21
    Helixi224 – 226Combined sources3
    Helixi246 – 257Combined sources12
    Turni258 – 260Combined sources3
    Beta strandi267 – 271Combined sources5
    Helixi277 – 288Combined sources12
    Beta strandi295 – 303Combined sources9
    Helixi304 – 314Combined sources11
    Helixi321 – 338Combined sources18
    Turni339 – 341Combined sources3

    3D structure databases

    Select the link destinations:
    PDBei
    RCSB PDBi
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    1XFBX-ray3.00A/B/C/D/E/F/G/H/I/J/K/L1-364[»]
    ProteinModelPortaliP09972.
    SMRiP09972.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP09972.

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiKOG1557. Eukaryota.
    COG3588. LUCA.
    GeneTreeiENSGT00390000010235.
    HOVERGENiHBG002386.
    InParanoidiP09972.
    KOiK01623.
    OMAiWRGQQDN.
    OrthoDBiEOG091G0A9T.
    PhylomeDBiP09972.
    TreeFamiTF314203.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    InterProiIPR029768. Aldolase_I_AS.
    IPR013785. Aldolase_TIM.
    IPR000741. FBA_I.
    [Graphical view]
    PfamiPF00274. Glycolytic. 1 hit.
    [Graphical view]
    PROSITEiPS00158. ALDOLASE_CLASS_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P09972-1 [UniParc]FASTAAdd to basket

    « Hide

            10         20         30         40         50
    MPHSYPALSA EQKKELSDIA LRIVAPGKGI LAADESVGSM AKRLSQIGVE
    60 70 80 90 100
    NTEENRRLYR QVLFSADDRV KKCIGGVIFF HETLYQKDDN GVPFVRTIQD
    110 120 130 140 150
    KGIVVGIKVD KGVVPLAGTD GETTTQGLDG LSERCAQYKK DGADFAKWRC
    160 170 180 190 200
    VLKISERTPS ALAILENANV LARYASICQQ NGIVPIVEPE ILPDGDHDLK
    210 220 230 240 250
    RCQYVTEKVL AAVYKALSDH HVYLEGTLLK PNMVTPGHAC PIKYTPEEIA
    260 270 280 290 300
    MATVTALRRT VPPAVPGVTF LSGGQSEEEA SFNLNAINRC PLPRPWALTF
    310 320 330 340 350
    SYGRALQASA LNAWRGQRDN AGAATEEFIK RAEVNGLAAQ GKYEGSGEDG
    360
    GAAAQSLYIA NHAY
    Length:364
    Mass (Da):39,456
    Last modified:January 23, 2007 - v2
    Checksum:i506A570B3E507971
    GO

    Sequence cautioni

    The sequence AAI03761 differs from that shown. Reason: Erroneous initiation.Curated

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Sequence conflicti311L → V in CAA30270 (PubMed:3267224).Curated1

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    X05196 Genomic DNA. Translation: CAA28825.1.
    X07292 Genomic DNA. Translation: CAA30270.1.
    AF054987 mRNA. Translation: AAC09348.1.
    BT007006 mRNA. Translation: AAP35652.1.
    CR541862 mRNA. Translation: CAG46660.1.
    CR541881 mRNA. Translation: CAG46679.1.
    AK312281 mRNA. Translation: BAG35210.1.
    CH471159 Genomic DNA. Translation: EAW51104.1.
    BC003613 mRNA. Translation: AAH03613.3.
    BC103760 mRNA. Translation: AAI03761.1. Different initiation.
    BC065565 mRNA. Translation: AAH65565.2.
    BC106925 mRNA. Translation: AAI06926.1.
    BC106926 mRNA. Translation: AAI06927.1.
    CCDSiCCDS11236.1.
    PIRiA25861. ADHUC.
    RefSeqiNP_005156.1. NM_005165.2.
    XP_005258006.1. XM_005257949.2.
    XP_011522858.1. XM_011524556.1.
    UniGeneiHs.155247.

    Genome annotation databases

    EnsembliENST00000226253; ENSP00000226253; ENSG00000109107.
    ENST00000395321; ENSP00000378731; ENSG00000109107.
    GeneIDi230.
    KEGGihsa:230.
    UCSCiuc002hbp.4. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    X05196 Genomic DNA. Translation: CAA28825.1.
    X07292 Genomic DNA. Translation: CAA30270.1.
    AF054987 mRNA. Translation: AAC09348.1.
    BT007006 mRNA. Translation: AAP35652.1.
    CR541862 mRNA. Translation: CAG46660.1.
    CR541881 mRNA. Translation: CAG46679.1.
    AK312281 mRNA. Translation: BAG35210.1.
    CH471159 Genomic DNA. Translation: EAW51104.1.
    BC003613 mRNA. Translation: AAH03613.3.
    BC103760 mRNA. Translation: AAI03761.1. Different initiation.
    BC065565 mRNA. Translation: AAH65565.2.
    BC106925 mRNA. Translation: AAI06926.1.
    BC106926 mRNA. Translation: AAI06927.1.
    CCDSiCCDS11236.1.
    PIRiA25861. ADHUC.
    RefSeqiNP_005156.1. NM_005165.2.
    XP_005258006.1. XM_005257949.2.
    XP_011522858.1. XM_011524556.1.
    UniGeneiHs.155247.

    3D structure databases

    Select the link destinations:
    PDBei
    RCSB PDBi
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    1XFBX-ray3.00A/B/C/D/E/F/G/H/I/J/K/L1-364[»]
    ProteinModelPortaliP09972.
    SMRiP09972.
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    BioGridi106731. 68 interactors.
    IntActiP09972. 8 interactors.
    STRINGi9606.ENSP00000226253.

    PTM databases

    iPTMnetiP09972.
    PhosphoSitePlusiP09972.
    SwissPalmiP09972.

    Polymorphism and mutation databases

    BioMutaiALDOC.
    DMDMi113613.

    2D gel databases

    UCD-2DPAGEP09972.

    Proteomic databases

    EPDiP09972.
    MaxQBiP09972.
    PaxDbiP09972.
    PeptideAtlasiP09972.
    PRIDEiP09972.

    Protocols and materials databases

    DNASUi230.
    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000226253; ENSP00000226253; ENSG00000109107.
    ENST00000395321; ENSP00000378731; ENSG00000109107.
    GeneIDi230.
    KEGGihsa:230.
    UCSCiuc002hbp.4. human.

    Organism-specific databases

    CTDi230.
    DisGeNETi230.
    GeneCardsiALDOC.
    HGNCiHGNC:418. ALDOC.
    HPAiCAB020828.
    HPA003282.
    MIMi103870. gene.
    neXtProtiNX_P09972.
    OpenTargetsiENSG00000109107.
    PharmGKBiPA24711.
    GenAtlasiSearch...

    Phylogenomic databases

    eggNOGiKOG1557. Eukaryota.
    COG3588. LUCA.
    GeneTreeiENSGT00390000010235.
    HOVERGENiHBG002386.
    InParanoidiP09972.
    KOiK01623.
    OMAiWRGQQDN.
    OrthoDBiEOG091G0A9T.
    PhylomeDBiP09972.
    TreeFamiTF314203.

    Enzyme and pathway databases

    UniPathwayiUPA00109; UER00183.
    BioCyciMetaCyc:HS03200-MONOMER.
    ZFISH:HS03200-MONOMER.
    ReactomeiR-HSA-6798695. Neutrophil degranulation.
    R-HSA-70171. Glycolysis.
    R-HSA-70263. Gluconeogenesis.
    SABIO-RKP09972.

    Miscellaneous databases

    ChiTaRSiALDOC. human.
    EvolutionaryTraceiP09972.
    GeneWikiiAldolase_C.
    GenomeRNAii230.
    PROiP09972.
    SOURCEiSearch...

    Gene expression databases

    BgeeiENSG00000109107.
    CleanExiHS_ALDOC.
    ExpressionAtlasiP09972. baseline and differential.
    GenevisibleiP09972. HS.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    InterProiIPR029768. Aldolase_I_AS.
    IPR013785. Aldolase_TIM.
    IPR000741. FBA_I.
    [Graphical view]
    PfamiPF00274. Glycolytic. 1 hit.
    [Graphical view]
    PROSITEiPS00158. ALDOLASE_CLASS_I. 1 hit.
    [Graphical view]
    ProtoNetiSearch...

    Entry informationi

    Entry nameiALDOC_HUMAN
    AccessioniPrimary (citable) accession number: P09972
    Secondary accession number(s): B2R5R3
    , Q3SYL3, Q6FH94, Q6P0L5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: January 23, 2007
    Last modified: November 30, 2016
    This is version 176 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    In vertebrates, three forms of this ubiquitous glycolytic enzyme are found, aldolase A in muscle, aldolase B in liver and aldolase C in brain.

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    4. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    5. SIMILARITY comments
      Index of protein domains and families

    Similar proteinsi

    Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
    100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
    90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
    50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.