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Protein

Regulatory protein cro

Gene

cro

Organism
Enterobacteria phage P22 (Bacteriophage P22)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Cro represses genes normally expressed in early phage development and is necessary for the late stage of lytic growth. It does this by binding to the OL and OR operators regions normally used by the repressor protein for lysogenic maintenance.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi13 – 3220H-T-H motifSequence analysisAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Regulatory protein cro
Alternative name(s):
Antirepressor
Gene namesi
Name:cro
OrganismiEnterobacteria phage P22 (Bacteriophage P22)
Taxonomic identifieri10754 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageCaudoviralesPodoviridaeP22likevirus
Virus hostiSalmonella typhimurium [TaxID: 90371]
Proteomesi
  • UP000001795 Componenti: Genome
  • UP000007960 Componenti: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 6161Regulatory protein croPRO_0000077578Add
BLAST

Expressioni

Keywords - Developmental stagei

Early protein

Structurei

Secondary structure

1
61
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi3 – 108Combined sources
Helixi13 – 208Combined sources
Helixi24 – 296Combined sources
Helixi36 – 4510Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1RZSNMR-A1-61[»]
ProteinModelPortaliP09964.
SMRiP09964. Positions 1-61.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP09964.

Family & Domainsi

Family and domain databases

Gene3Di1.10.260.40. 1 hit.
InterProiIPR010982. Lambda_DNA-bd_dom.
[Graphical view]
SUPFAMiSSF47413. SSF47413. 1 hit.

Sequencei

Sequence statusi: Complete.

P09964-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYKKDVIDHF GTQRAVAKAL GISDAAVSQW KEVIPEKDAY RLEIVTAGAL
60
KYQENAYRQA A
Length:61
Mass (Da):6,828
Last modified:July 1, 1989 - v1
Checksum:iCD37A130D8CF14AF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M12584 Genomic DNA. Translation: AAA32268.1.
AF217253 Genomic DNA. Translation: AAF75025.1.
BK000583 Genomic DNA. Translation: DAA01022.1.
M10074 Genomic DNA. Translation: AAA32273.1.
PIRiA25867. RGBP22.
RefSeqiNP_059607.1. NC_002371.2.

Genome annotation databases

GeneIDi1262827.
KEGGivg:1262827.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M12584 Genomic DNA. Translation: AAA32268.1.
AF217253 Genomic DNA. Translation: AAF75025.1.
BK000583 Genomic DNA. Translation: DAA01022.1.
M10074 Genomic DNA. Translation: AAA32273.1.
PIRiA25867. RGBP22.
RefSeqiNP_059607.1. NC_002371.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1RZSNMR-A1-61[»]
ProteinModelPortaliP09964.
SMRiP09964. Positions 1-61.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi1262827.
KEGGivg:1262827.

Miscellaneous databases

EvolutionaryTraceiP09964.

Family and domain databases

Gene3Di1.10.260.40. 1 hit.
InterProiIPR010982. Lambda_DNA-bd_dom.
[Graphical view]
SUPFAMiSSF47413. SSF47413. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Bacteriophage P22 Cro protein: sequence, purification, and properties."
    Poteete A.R., Hehir K., Sauer R.T.
    Biochemistry 25:251-256(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Sequence of the genome of Salmonella bacteriophage P22."
    Vander Byl C.S., Kropinski A.M.B.
    J. Bacteriol. 182:6472-6481(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Sequence analysis of a region from the early right operon in phage P22 including the replication genes 18 and 12."
    Backhaus H., Petri J.B.
    Gene 32:289-303(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 47-61.
  5. "Secondary structure switching in Cro protein evolution."
    Newlove T., Konieczka J.H., Cordes M.H.
    Structure 12:569-581(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR.

Entry informationi

Entry nameiRCRO_BPP22
AccessioniPrimary (citable) accession number: P09964
Secondary accession number(s): Q38659, Q7PCF1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: December 9, 2015
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.