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Protein

Regulatory protein cro

Gene

cro

Organism
Salmonella phage P22 (Bacteriophage P22)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Cro represses genes normally expressed in early phage development and is necessary for the late stage of lytic growth. It does this by binding to the OL and OR operators regions normally used by the repressor protein for lysogenic maintenance.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi13 – 32H-T-H motifSequence analysisAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Regulatory protein cro
Alternative name(s):
Antirepressor
Gene namesi
Name:cro
OrganismiSalmonella phage P22 (Bacteriophage P22)
Taxonomic identifieri10754 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageCaudoviralesPodoviridaeP22virus
Virus hostiSalmonella typhimurium [TaxID: 90371]
Proteomesi
  • UP000001795 Componenti: Genome
  • UP000007960 Componenti: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000775781 – 61Regulatory protein croAdd BLAST61

Expressioni

Keywords - Developmental stagei

Early protein

Structurei

Secondary structure

161
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi3 – 10Combined sources8
Helixi13 – 20Combined sources8
Helixi24 – 29Combined sources6
Helixi36 – 45Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1RZSNMR-A1-61[»]
ProteinModelPortaliP09964.
SMRiP09964.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP09964.

Family & Domainsi

Phylogenomic databases

OrthoDBiVOG090001XN.

Family and domain databases

InterProiView protein in InterPro
IPR010982. Lambda_DNA-bd_dom.
SUPFAMiSSF47413. SSF47413. 1 hit.

Sequencei

Sequence statusi: Complete.

P09964-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYKKDVIDHF GTQRAVAKAL GISDAAVSQW KEVIPEKDAY RLEIVTAGAL
60
KYQENAYRQA A
Length:61
Mass (Da):6,828
Last modified:July 1, 1989 - v1
Checksum:iCD37A130D8CF14AF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M12584 Genomic DNA. Translation: AAA32268.1.
AF217253 Genomic DNA. Translation: AAF75025.1.
BK000583 Genomic DNA. Translation: DAA01022.1.
M10074 Genomic DNA. Translation: AAA32273.1.
PIRiA25867. RGBP22.
RefSeqiNP_059607.1. NC_002371.2.

Genome annotation databases

GeneIDi1262827.
KEGGivg:1262827.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiRCRO_BPP22
AccessioniPrimary (citable) accession number: P09964
Secondary accession number(s): Q38659, Q7PCF1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: May 10, 2017
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references