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Protein

Regulatory protein SWI6

Gene

SWI6

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Part of a complex involved in cell-cycle-dependent transcription. SWI4 and SWI6 are required for formation of the cell-cycle box factor-DNA complex. The repeated element in the upstream region of HO (5'-CACGAAAA-3') is called the cell cycle box (CCB).

GO - Molecular functioni

GO - Biological processi

  • positive regulation of reciprocal meiotic recombination Source: SGD
  • positive regulation of transcription from RNA polymerase II promoter Source: SGD
  • positive regulation of transcription from RNA polymerase II promoter in response to heat stress Source: SGD
  • positive regulation of transcription involved in G1/S transition of mitotic cell cycle Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-32306-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Regulatory protein SWI6
Alternative name(s):
Cell-cycle box factor subunit SWI6
MBF subunit P90
Trans-acting activator of HO endonuclease gene
Gene namesi
Name:SWI6
Ordered Locus Names:YLR182W
ORF Names:L9470.8
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

EuPathDBiFungiDB:YLR182W.
SGDiS000004172. SWI6.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: SGD
  • MBF transcription complex Source: SGD
  • nuclear chromatin Source: GO_Central
  • nucleus Source: SGD
  • SBF transcription complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000670711 – 803Regulatory protein SWI6Add BLAST803

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei149PhosphoserineCombined sources1
Modified residuei160Phosphoserine; by CDC28Combined sources1 Publication1
Modified residuei176PhosphoserineCombined sources1
Modified residuei179PhosphothreonineCombined sources1
Modified residuei182PhosphothreonineCombined sources1
Modified residuei547PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated by CDC28 and dephosphorylated by CDC14.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP09959.
PRIDEiP09959.

PTM databases

iPTMnetiP09959.

Interactioni

Subunit structurei

Component of the transcription complex MCB-binding factor (MBF) composed of SWI6 and MBP1. Component of the transcription complex SCB-binding factor (SBF) composed of SWI6 and SWI4. Interacts with MSA1 and STB1.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
MBP1P396785EBI-18641,EBI-10485
SWI4P253028EBI-18641,EBI-18626

Protein-protein interaction databases

BioGridi31453. 395 interactors.
DIPiDIP-598N.
IntActiP09959. 56 interactors.
MINTiMINT-528932.

Structurei

Secondary structure

1803
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 11Combined sources9
Beta strandi16 – 23Combined sources8
Turni24 – 26Combined sources3
Beta strandi29 – 31Combined sources3
Helixi32 – 34Combined sources3
Helixi35 – 44Combined sources10
Helixi47 – 49Combined sources3
Helixi58 – 68Combined sources11
Beta strandi80 – 82Combined sources3
Helixi84 – 93Combined sources10
Turni97 – 100Combined sources4
Helixi101 – 103Combined sources3
Beta strandi104 – 106Combined sources3
Beta strandi214 – 216Combined sources3
Turni225 – 227Combined sources3
Helixi244 – 258Combined sources15
Helixi292 – 302Combined sources11
Helixi321 – 327Combined sources7
Helixi331 – 339Combined sources9
Helixi354 – 360Combined sources7
Helixi363 – 366Combined sources4
Helixi370 – 377Combined sources8
Helixi378 – 382Combined sources5
Helixi391 – 399Combined sources9
Helixi405 – 421Combined sources17
Helixi422 – 424Combined sources3
Beta strandi427 – 429Combined sources3
Helixi448 – 452Combined sources5
Helixi455 – 461Combined sources7
Turni462 – 464Combined sources3
Helixi473 – 480Combined sources8
Helixi483 – 491Combined sources9
Helixi506 – 509Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1SW6X-ray2.10A/B188-512[»]
2XFVX-ray1.90A/B2-126[»]
ProteinModelPortaliP09959.
SMRiP09959.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP09959.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati318 – 346ANK 1Add BLAST29
Repeati347 – 383ANK 2Add BLAST37
Repeati384 – 469ANK 3Add BLAST86
Repeati470 – 498ANK 4Add BLAST29
Repeati499 – 514ANK 5Add BLAST16

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi631 – 640Glu-rich (acidic)10

Sequence similaritiesi

Contains 5 ANK repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

GeneTreeiENSGT00530000067565.
HOGENOMiHOG000057104.
InParanoidiP09959.
KOiK06648.
OMAiYYLDILM.
OrthoDBiEOG092C0OUJ.

Family and domain databases

Gene3Di1.25.40.20. 2 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR032468. Swi6.
[Graphical view]
PANTHERiPTHR11707:SF37. PTHR11707:SF37. 2 hits.
PfamiPF00023. Ank. 1 hit.
PF13606. Ank_3. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 2 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 2 hits.
PS50088. ANK_REPEAT. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P09959-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALEEVVRYL GPHNEIPLTL TRDSETGHFL LKHFLPILQQ YHDTGNINET
60 70 80 90 100
NPDSFPTDEE RNKLLAHYGI AVNTDDRGEL WIELEKCLQL LNMLNLFGLF
110 120 130 140 150
QDAFEFEEPE TDQDEEDPSH SKLPENKTKS ENSKDNISSK RINNLQDMSL
160 170 180 190 200
DSDAHRELGS PLKKLKIDTS VIDAESDSTP NTARGKPNDD INKGPSGDNE
210 220 230 240 250
NNGTDDNDRT AGPIITFTHD LTSDFLSSPL KIMKALPSPV VNDNEQKMKL
260 270 280 290 300
EAFLQRLLFP EIQEMPTSLN NDSSNRNSEG GSSNQQQQHV SFDSLLQEVN
310 320 330 340 350
DAFPNTQLNL NIPVDEHGNT PLHWLTSIAN LELVKHLVKH GSNRLYGDNM
360 370 380 390 400
GESCLVKAVK SVNNYDSGTF EALLDYLYPC LILEDSMNRT ILHHIIITSG
410 420 430 440 450
MTGCSAAAKY YLDILMGWIV KKQNRPIQSG TNEKESKPND KNGERKDSIL
460 470 480 490 500
ENLDLKWIIA NMLNAQDSNG DTCLNIAARL GNISIVDALL DYGADPFIAN
510 520 530 540 550
KSGLRPVDFG AGTSKLQNTN GGDENSKMVS KGDYDGQKNG KAKKIRSQLL
560 570 580 590 600
KNPPETTSLI NDVQNLLNSI SKDYENETVQ YNEKLEKLHK ELNEQREELA
610 620 630 640 650
NSREQLANVK QLKDEYSLMQ EQLTNLKAGI EEEEESFREE SKKLGIIADE
660 670 680 690 700
SSGIDWDSSE YDADEPFKVE FLSDFLEDKL QKNYEGDISK LLEAESKEQI
710 720 730 740 750
MEQIRNQLPA EKIQSMLPPT VLLKARINAY KRNDKHLTNV LDTISTKQSE
760 770 780 790 800
LENKFRRVLS LCLKIDENKV DNMLDGLLQA ISSEDPQDID TDEMQDFLKK

HAS
Length:803
Mass (Da):90,560
Last modified:July 1, 1989 - v1
Checksum:i9B317FCACEEC493C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X06238 Genomic DNA. Translation: CAA29581.1.
U17246 Genomic DNA. Translation: AAB67460.1.
BK006945 Genomic DNA. Translation: DAA09502.1.
PIRiS03161. RGBYW6.
RefSeqiNP_013283.1. NM_001182069.1.

Genome annotation databases

EnsemblFungiiYLR182W; YLR182W; YLR182W.
GeneIDi850879.
KEGGisce:YLR182W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X06238 Genomic DNA. Translation: CAA29581.1.
U17246 Genomic DNA. Translation: AAB67460.1.
BK006945 Genomic DNA. Translation: DAA09502.1.
PIRiS03161. RGBYW6.
RefSeqiNP_013283.1. NM_001182069.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1SW6X-ray2.10A/B188-512[»]
2XFVX-ray1.90A/B2-126[»]
ProteinModelPortaliP09959.
SMRiP09959.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31453. 395 interactors.
DIPiDIP-598N.
IntActiP09959. 56 interactors.
MINTiMINT-528932.

PTM databases

iPTMnetiP09959.

Proteomic databases

MaxQBiP09959.
PRIDEiP09959.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYLR182W; YLR182W; YLR182W.
GeneIDi850879.
KEGGisce:YLR182W.

Organism-specific databases

EuPathDBiFungiDB:YLR182W.
SGDiS000004172. SWI6.

Phylogenomic databases

GeneTreeiENSGT00530000067565.
HOGENOMiHOG000057104.
InParanoidiP09959.
KOiK06648.
OMAiYYLDILM.
OrthoDBiEOG092C0OUJ.

Enzyme and pathway databases

BioCyciYEAST:G3O-32306-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP09959.
PROiP09959.

Family and domain databases

Gene3Di1.25.40.20. 2 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR032468. Swi6.
[Graphical view]
PANTHERiPTHR11707:SF37. PTHR11707:SF37. 2 hits.
PfamiPF00023. Ank. 1 hit.
PF13606. Ank_3. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 2 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 2 hits.
PS50088. ANK_REPEAT. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSWI6_YEAST
AccessioniPrimary (citable) accession number: P09959
Secondary accession number(s): D6VYI6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: November 30, 2016
This is version 180 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 3340 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.