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Protein

Protein yellow

Gene

y

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Controls the pigmentation pattern of the adult cuticle and larval mouth parts.2 Publications

GO - Biological processi

  • cuticle pigmentation Source: FlyBase
  • developmental pigmentation Source: FlyBase
  • male courtship behavior, veined wing extension Source: FlyBase
  • male mating behavior Source: FlyBase
  • melanin biosynthetic process Source: FlyBase
  • melanin biosynthetic process from tyrosine Source: FlyBase
  • regulation of adult chitin-containing cuticle pigmentation Source: FlyBase

Keywordsi

Molecular functionDevelopmental protein

Names & Taxonomyi

Protein namesi
Recommended name:
Protein yellow
Gene namesi
Name:y
ORF Names:CG3757
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0004034. y.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Disruption phenotypei

Flies fail to pigment the adult cuticle and larval mouth parts and show reduced level of locomotor activity and male competitive mating ability.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000003105222 – 541Protein yellowAdd BLAST520

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi144N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi215N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP09957.
PRIDEiP09957.

Expressioni

Developmental stagei

Required during the later half of pupal development for the normal pigmentation of the adult cuticle.

Gene expression databases

BgeeiFBgn0004034.
GenevisibleiP09957. DM.

Interactioni

Protein-protein interaction databases

BioGridi57553. 17 interactors.
DIPiDIP-23590N.
IntActiP09957. 1 interactor.
MINTiMINT-960708.
STRINGi7227.FBpp0070070.

Structurei

3D structure databases

ProteinModelPortaliP09957.
SMRiP09957.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the major royal jelly protein family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IIRV. Eukaryota.
COG3386. LUCA.
GeneTreeiENSGT00530000064224.
InParanoidiP09957.
OMAiDQNAVGC.
OrthoDBiEOG091G140M.
PhylomeDBiP09957.

Family and domain databases

Gene3Di2.120.10.30. 1 hit.
InterProiView protein in InterPro
IPR011042. 6-blade_b-propeller_TolB-like.
IPR017996. Royal_jelly/protein_yellow.
IPR029846. Yellow.
PANTHERiPTHR10009. PTHR10009. 1 hit.
PTHR10009:SF14. PTHR10009:SF14. 1 hit.
PfamiView protein in Pfam
PF03022. MRJP. 1 hit.
PRINTSiPR01366. ROYALJELLY.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P09957-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFQDKGWILV TLITLVTPSW AAYKLQERYS WSQLDFAFPN TRLKDQALAS
60 70 80 90 100
GDYIPQNALP VGVEHFGNRL FVTVPRWRDG IPATLTYINM DRSLTGSPEL
110 120 130 140 150
IPYPDWRSNT AGDCANSITT AYRIKVDECG RLWVLDTGTV GIGNTTTNPC
160 170 180 190 200
PYAVNVFDLT TDTRIRRYEL PGVDTNPNTF IANIAVDIGK NCDDAYAYFA
210 220 230 240 250
DELGYGLIAY SWELNKSWRF SAHSYFFPDP LRGDFNVAGI NFQWGEEGIF
260 270 280 290 300
GMSLSPIRSD GYRTLYFSPL ASHRQFAVST RILRDETRTE DSYHDFVALD
310 320 330 340 350
ERGPNSHTTS RVMSDDGIEL FNLIDQNAVG CWHSSMPYSP QFHGIVDRDD
360 370 380 390 400
VGLVFPADVK IDENKNVWVL SDRMPVFLLS DLDYSDTNFR IYTAPLATLI
410 420 430 440 450
ENTVCDLRNN AYGPPNTVSI PKQAVLPMGP PLYTKQYRPV LPQKPQTSWA
460 470 480 490 500
SSPPPPSRTY LPANSGNVVS SISVSTNSVG PAGVEVPKAY IFNQHNGINY
510 520 530 540
ETSGPHLFPT HQPAQPGGQD GGLKTYVNAR QSGWWHHQHQ G
Length:541
Mass (Da):60,520
Last modified:July 1, 1989 - v1
Checksum:i7728D1FA9A4ECB7A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04427 Genomic DNA. Translation: CAA28024.1.
AE014298 Genomic DNA. Translation: AAF45497.1.
AL023873 Genomic DNA. Translation: CAA19640.1.
PIRiA25696.
RefSeqiNP_476792.1. NM_057444.3.
UniGeneiDm.23761.

Genome annotation databases

EnsemblMetazoaiFBtr0070071; FBpp0070070; FBgn0004034.
GeneIDi30980.
KEGGidme:Dmel_CG3757.
UCSCiCG3757-RA. d. melanogaster.

Similar proteinsi

Entry informationi

Entry nameiYELL_DROME
AccessioniPrimary (citable) accession number: P09957
Secondary accession number(s): Q9W5G5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: October 25, 2017
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families