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P09948 (CISY_RICPR) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Citrate synthase

EC=2.3.3.1
Gene names
Name:gltA
Ordered Locus Names:RP844
OrganismRickettsia prowazekii (strain Madrid E) [Reference proteome] [HAMAP]
Taxonomic identifier272947 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group

Protein attributes

Sequence length436 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.

Enzyme regulation

Allosterically inhibited by NADH.

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 1/2.

Subunit structure

Homohexamer.

Miscellaneous

Citrate synthase is found in nearly all cells capable of oxidative metabolism.

Sequence similarities

Belongs to the citrate synthase family.

Ontologies

Keywords
   Biological processTricarboxylic acid cycle
   Molecular functionTransferase
   Technical termAllosteric enzyme
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcellular carbohydrate metabolic process

Inferred from electronic annotation. Source: InterPro

tricarboxylic acid cycle

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: InterPro

   Molecular_functioncitrate (Si)-synthase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 436436Citrate synthase
PRO_0000169967

Sites

Active site3111 By similarity
Active site3701 By similarity

Sequences

Sequence LengthMass (Da)Tools
P09948 [UniParc].

Last modified July 1, 1989. Version 1.
Checksum: 57F947C151A494B8

FASTA43649,324
        10         20         30         40         50         60 
MTNGNNNNLE FAELKIRGKL FKLPILKASI GKDVIDISRV SAEADYFTYD PGFMSTASCQ 

        70         80         90        100        110        120 
STITYIDGDK GILWYRGYDI KDLAEKSDFL EVAYLMIYGE LPSSDQYCNF TKKVAHHSLV 

       130        140        150        160        170        180 
NERLHYLFQT FCSSSHPMAI MLAAVGSLSA FYPDLLNFNE TDYELTAIRM IAKIPTIAAM 

       190        200        210        220        230        240 
SYKYSIGQPF IYPDNSLDFT ENFLHMMFAT PCTKYKVNPI IKNALNKIFI LHADHEQNAS 

       250        260        270        280        290        300 
TSTVRIAGSS GANPFACIST GIASLWGPAH GGANEAVINM LKEIGSSENI PKYVAKAKDK 

       310        320        330        340        350        360 
NDPFRLMGFG HRVYKSYDPR AAVLKETCKE VLNELGQLDN NPLLQIAIEL EALALKDEYF 

       370        380        390        400        410        420 
IERKLYPNVD FYSGIIYKAM GIPSQMFTVL FAIARTVGWM AQWKEMHEDP EQKISRPRQL 

       430 
YTGYVHREYK CIVERK 

« Hide

References

« Hide 'large scale' references
[1]"Nucleotide sequence of the Rickettsia prowazekii citrate synthase gene."
Wood D.O., Williamson L.R., Winkler H.H., Krause D.C.
J. Bacteriol. 169:3564-3572(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Madrid E.
[2]"The genome sequence of Rickettsia prowazekii and the origin of mitochondria."
Andersson S.G.E., Zomorodipour A., Andersson J.O., Sicheritz-Ponten T., Alsmark U.C.M., Podowski R.M., Naeslund A.K., Eriksson A.-S., Winkler H.H., Kurland C.G.
Nature 396:133-140(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Madrid E.
[3]"The citrate synthase-encoding gene of Rickettsia prowazekii is controlled by two promoters."
Cai J., Pang H., Wood D.O., Winkler H.H.
Gene 163:115-119(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-35.
Strain: Madrid E.
[4]Balayeva N., Eremeeva M., Tissot-Dupont H., Zakharov I., Raoult D.
Submitted (JAN-1995) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 267-392.
Strain: ATCC VR-142 / Breinl.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M17149 Genomic DNA. Translation: AAA26383.1.
AJ235273 Genomic DNA. Translation: CAA15268.1.
U14334 Genomic DNA. Translation: AAA85524.1.
U20244 Genomic DNA. Translation: AAA85708.1.
PIRYKRECP. A26971.
RefSeqNP_221192.1. NC_000963.1.

3D structure databases

ProteinModelPortalP09948.
SMRP09948. Positions 12-435.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272947.RP844.

Proteomic databases

PRIDEP09948.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAA15268; CAA15268; CAA15268.
GeneID883416.
KEGGrpr:RP844.
PATRIC17902564. VBIRicPro72556_0882.

Phylogenomic databases

eggNOGCOG0372.
HOGENOMHOG000021224.
KOK01647.
OMANKEDGVR.
OrthoDBEOG6P8TP4.
ProtClustDBPRK05614.

Enzyme and pathway databases

UniPathwayUPA00223; UER00717.

Family and domain databases

Gene3D1.10.230.10. 1 hit.
1.10.580.10. 1 hit.
InterProIPR016142. Citrate_synth-like_lrg_a-sub.
IPR016143. Citrate_synth-like_sm_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR024176. Citrate_synthase_bac-typ.
IPR010953. Citrate_synthase_typ-II.
[Graphical view]
PANTHERPTHR11739. PTHR11739. 1 hit.
PfamPF00285. Citrate_synt. 1 hit.
[Graphical view]
PIRSFPIRSF001369. Citrate_synth. 1 hit.
PRINTSPR00143. CITRTSNTHASE.
SUPFAMSSF48256. SSF48256. 1 hit.
TIGRFAMsTIGR01798. cit_synth_I. 1 hit.
PROSITEPS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCISY_RICPR
AccessionPrimary (citable) accession number: P09948
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: November 13, 2013
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia prowazekii

Rickettsia prowazekii (strain Madrid E): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways