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P09948

- CISY_RICPR

UniProt

P09948 - CISY_RICPR

Protein

Citrate synthase

Gene

gltA

Organism
Rickettsia prowazekii (strain Madrid E)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (01 Jul 1989)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.PROSITE-ProRule annotation

    Enzyme regulationi

    Allosterically inhibited by NADH.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei311 – 3111PROSITE-ProRule annotation
    Active sitei370 – 3701PROSITE-ProRule annotation

    GO - Molecular functioni

    1. citrate (Si)-synthase activity Source: InterPro

    GO - Biological processi

    1. cellular carbohydrate metabolic process Source: InterPro
    2. tricarboxylic acid cycle Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Tricarboxylic acid cycle

    Enzyme and pathway databases

    UniPathwayiUPA00223; UER00717.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Citrate synthase (EC:2.3.3.16)
    Gene namesi
    Name:gltA
    Ordered Locus Names:RP844
    OrganismiRickettsia prowazekii (strain Madrid E)
    Taxonomic identifieri272947 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
    ProteomesiUP000002480: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 436436Citrate synthasePRO_0000169967Add
    BLAST

    Proteomic databases

    PRIDEiP09948.

    Interactioni

    Subunit structurei

    Homohexamer.

    Protein-protein interaction databases

    STRINGi272947.RP844.

    Structurei

    3D structure databases

    ProteinModelPortaliP09948.
    SMRiP09948. Positions 12-435.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the citrate synthase family.Curated

    Phylogenomic databases

    eggNOGiCOG0372.
    HOGENOMiHOG000021224.
    KOiK01647.
    OMAiKETCDEV.
    OrthoDBiEOG6P8TP4.

    Family and domain databases

    Gene3Di1.10.230.10. 1 hit.
    1.10.580.10. 1 hit.
    InterProiIPR016142. Citrate_synth-like_lrg_a-sub.
    IPR016143. Citrate_synth-like_sm_a-sub.
    IPR002020. Citrate_synthase-like.
    IPR016141. Citrate_synthase-like_core.
    IPR019810. Citrate_synthase_AS.
    IPR024176. Citrate_synthase_bac-typ.
    IPR010953. Citrate_synthase_typ-I.
    [Graphical view]
    PANTHERiPTHR11739. PTHR11739. 1 hit.
    PfamiPF00285. Citrate_synt. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001369. Citrate_synth. 1 hit.
    PRINTSiPR00143. CITRTSNTHASE.
    SUPFAMiSSF48256. SSF48256. 1 hit.
    TIGRFAMsiTIGR01798. cit_synth_I. 1 hit.
    PROSITEiPS00480. CITRATE_SYNTHASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P09948-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTNGNNNNLE FAELKIRGKL FKLPILKASI GKDVIDISRV SAEADYFTYD    50
    PGFMSTASCQ STITYIDGDK GILWYRGYDI KDLAEKSDFL EVAYLMIYGE 100
    LPSSDQYCNF TKKVAHHSLV NERLHYLFQT FCSSSHPMAI MLAAVGSLSA 150
    FYPDLLNFNE TDYELTAIRM IAKIPTIAAM SYKYSIGQPF IYPDNSLDFT 200
    ENFLHMMFAT PCTKYKVNPI IKNALNKIFI LHADHEQNAS TSTVRIAGSS 250
    GANPFACIST GIASLWGPAH GGANEAVINM LKEIGSSENI PKYVAKAKDK 300
    NDPFRLMGFG HRVYKSYDPR AAVLKETCKE VLNELGQLDN NPLLQIAIEL 350
    EALALKDEYF IERKLYPNVD FYSGIIYKAM GIPSQMFTVL FAIARTVGWM 400
    AQWKEMHEDP EQKISRPRQL YTGYVHREYK CIVERK 436
    Length:436
    Mass (Da):49,324
    Last modified:July 1, 1989 - v1
    Checksum:i57F947C151A494B8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M17149 Genomic DNA. Translation: AAA26383.1.
    AJ235273 Genomic DNA. Translation: CAA15268.1.
    U14334 Genomic DNA. Translation: AAA85524.1.
    U20244 Genomic DNA. Translation: AAA85708.1.
    PIRiA26971. YKRECP.
    RefSeqiNP_221192.1. NC_000963.1.
    WP_004596795.1. NC_000963.1.

    Genome annotation databases

    EnsemblBacteriaiCAA15268; CAA15268; CAA15268.
    GeneIDi883416.
    KEGGirpr:RP844.
    PATRICi17902564. VBIRicPro72556_0882.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M17149 Genomic DNA. Translation: AAA26383.1 .
    AJ235273 Genomic DNA. Translation: CAA15268.1 .
    U14334 Genomic DNA. Translation: AAA85524.1 .
    U20244 Genomic DNA. Translation: AAA85708.1 .
    PIRi A26971. YKRECP.
    RefSeqi NP_221192.1. NC_000963.1.
    WP_004596795.1. NC_000963.1.

    3D structure databases

    ProteinModelPortali P09948.
    SMRi P09948. Positions 12-435.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272947.RP844.

    Proteomic databases

    PRIDEi P09948.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAA15268 ; CAA15268 ; CAA15268 .
    GeneIDi 883416.
    KEGGi rpr:RP844.
    PATRICi 17902564. VBIRicPro72556_0882.

    Phylogenomic databases

    eggNOGi COG0372.
    HOGENOMi HOG000021224.
    KOi K01647.
    OMAi KETCDEV.
    OrthoDBi EOG6P8TP4.

    Enzyme and pathway databases

    UniPathwayi UPA00223 ; UER00717 .

    Family and domain databases

    Gene3Di 1.10.230.10. 1 hit.
    1.10.580.10. 1 hit.
    InterProi IPR016142. Citrate_synth-like_lrg_a-sub.
    IPR016143. Citrate_synth-like_sm_a-sub.
    IPR002020. Citrate_synthase-like.
    IPR016141. Citrate_synthase-like_core.
    IPR019810. Citrate_synthase_AS.
    IPR024176. Citrate_synthase_bac-typ.
    IPR010953. Citrate_synthase_typ-I.
    [Graphical view ]
    PANTHERi PTHR11739. PTHR11739. 1 hit.
    Pfami PF00285. Citrate_synt. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001369. Citrate_synth. 1 hit.
    PRINTSi PR00143. CITRTSNTHASE.
    SUPFAMi SSF48256. SSF48256. 1 hit.
    TIGRFAMsi TIGR01798. cit_synth_I. 1 hit.
    PROSITEi PS00480. CITRATE_SYNTHASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence of the Rickettsia prowazekii citrate synthase gene."
      Wood D.O., Williamson L.R., Winkler H.H., Krause D.C.
      J. Bacteriol. 169:3564-3572(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Madrid E.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Madrid E.
    3. "The citrate synthase-encoding gene of Rickettsia prowazekii is controlled by two promoters."
      Cai J., Pang H., Wood D.O., Winkler H.H.
      Gene 163:115-119(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-35.
      Strain: Madrid E.
    4. Balayeva N., Eremeeva M., Tissot-Dupont H., Zakharov I., Raoult D.
      Submitted (JAN-1995) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 267-392.
      Strain: ATCC VR-142 / Breinl.

    Entry informationi

    Entry nameiCISY_RICPR
    AccessioniPrimary (citable) accession number: P09948
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: July 1, 1989
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Citrate synthase is found in nearly all cells capable of oxidative metabolism.

    Keywords - Technical termi

    Allosteric enzyme, Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. Rickettsia prowazekii
      Rickettsia prowazekii (strain Madrid E): entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3