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P09948

- CISY_RICPR

UniProt

P09948 - CISY_RICPR

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Protein

Citrate synthase

Gene
gltA, RP844
Organism
Rickettsia prowazekii (strain Madrid E)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.

Enzyme regulationi

Allosterically inhibited by NADH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei311 – 3111 By similarity
Active sitei370 – 3701 By similarity

GO - Molecular functioni

  1. citrate (Si)-synthase activity Source: InterPro

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Tricarboxylic acid cycle

Enzyme and pathway databases

UniPathwayiUPA00223; UER00717.

Names & Taxonomyi

Protein namesi
Recommended name:
Citrate synthase (EC:2.3.3.16)
Gene namesi
Name:gltA
Ordered Locus Names:RP844
OrganismiRickettsia prowazekii (strain Madrid E)
Taxonomic identifieri272947 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
ProteomesiUP000002480: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 436436Citrate synthasePRO_0000169967Add
BLAST

Proteomic databases

PRIDEiP09948.

Interactioni

Subunit structurei

Homohexamer.

Protein-protein interaction databases

STRINGi272947.RP844.

Structurei

3D structure databases

ProteinModelPortaliP09948.
SMRiP09948. Positions 12-435.

Family & Domainsi

Sequence similaritiesi

Belongs to the citrate synthase family.

Phylogenomic databases

eggNOGiCOG0372.
HOGENOMiHOG000021224.
KOiK01647.
OMAiKETCDEV.
OrthoDBiEOG6P8TP4.

Family and domain databases

Gene3Di1.10.230.10. 1 hit.
1.10.580.10. 1 hit.
InterProiIPR016142. Citrate_synth-like_lrg_a-sub.
IPR016143. Citrate_synth-like_sm_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR024176. Citrate_synthase_bac-typ.
IPR010953. Citrate_synthase_typ-I.
[Graphical view]
PANTHERiPTHR11739. PTHR11739. 1 hit.
PfamiPF00285. Citrate_synt. 1 hit.
[Graphical view]
PIRSFiPIRSF001369. Citrate_synth. 1 hit.
PRINTSiPR00143. CITRTSNTHASE.
SUPFAMiSSF48256. SSF48256. 1 hit.
TIGRFAMsiTIGR01798. cit_synth_I. 1 hit.
PROSITEiPS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P09948-1 [UniParc]FASTAAdd to Basket

« Hide

MTNGNNNNLE FAELKIRGKL FKLPILKASI GKDVIDISRV SAEADYFTYD    50
PGFMSTASCQ STITYIDGDK GILWYRGYDI KDLAEKSDFL EVAYLMIYGE 100
LPSSDQYCNF TKKVAHHSLV NERLHYLFQT FCSSSHPMAI MLAAVGSLSA 150
FYPDLLNFNE TDYELTAIRM IAKIPTIAAM SYKYSIGQPF IYPDNSLDFT 200
ENFLHMMFAT PCTKYKVNPI IKNALNKIFI LHADHEQNAS TSTVRIAGSS 250
GANPFACIST GIASLWGPAH GGANEAVINM LKEIGSSENI PKYVAKAKDK 300
NDPFRLMGFG HRVYKSYDPR AAVLKETCKE VLNELGQLDN NPLLQIAIEL 350
EALALKDEYF IERKLYPNVD FYSGIIYKAM GIPSQMFTVL FAIARTVGWM 400
AQWKEMHEDP EQKISRPRQL YTGYVHREYK CIVERK 436
Length:436
Mass (Da):49,324
Last modified:July 1, 1989 - v1
Checksum:i57F947C151A494B8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M17149 Genomic DNA. Translation: AAA26383.1.
AJ235273 Genomic DNA. Translation: CAA15268.1.
U14334 Genomic DNA. Translation: AAA85524.1.
U20244 Genomic DNA. Translation: AAA85708.1.
PIRiA26971. YKRECP.
RefSeqiNP_221192.1. NC_000963.1.
WP_004596795.1. NC_000963.1.

Genome annotation databases

EnsemblBacteriaiCAA15268; CAA15268; CAA15268.
GeneIDi883416.
KEGGirpr:RP844.
PATRICi17902564. VBIRicPro72556_0882.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M17149 Genomic DNA. Translation: AAA26383.1 .
AJ235273 Genomic DNA. Translation: CAA15268.1 .
U14334 Genomic DNA. Translation: AAA85524.1 .
U20244 Genomic DNA. Translation: AAA85708.1 .
PIRi A26971. YKRECP.
RefSeqi NP_221192.1. NC_000963.1.
WP_004596795.1. NC_000963.1.

3D structure databases

ProteinModelPortali P09948.
SMRi P09948. Positions 12-435.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272947.RP844.

Proteomic databases

PRIDEi P09948.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAA15268 ; CAA15268 ; CAA15268 .
GeneIDi 883416.
KEGGi rpr:RP844.
PATRICi 17902564. VBIRicPro72556_0882.

Phylogenomic databases

eggNOGi COG0372.
HOGENOMi HOG000021224.
KOi K01647.
OMAi KETCDEV.
OrthoDBi EOG6P8TP4.

Enzyme and pathway databases

UniPathwayi UPA00223 ; UER00717 .

Family and domain databases

Gene3Di 1.10.230.10. 1 hit.
1.10.580.10. 1 hit.
InterProi IPR016142. Citrate_synth-like_lrg_a-sub.
IPR016143. Citrate_synth-like_sm_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR024176. Citrate_synthase_bac-typ.
IPR010953. Citrate_synthase_typ-I.
[Graphical view ]
PANTHERi PTHR11739. PTHR11739. 1 hit.
Pfami PF00285. Citrate_synt. 1 hit.
[Graphical view ]
PIRSFi PIRSF001369. Citrate_synth. 1 hit.
PRINTSi PR00143. CITRTSNTHASE.
SUPFAMi SSF48256. SSF48256. 1 hit.
TIGRFAMsi TIGR01798. cit_synth_I. 1 hit.
PROSITEi PS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence of the Rickettsia prowazekii citrate synthase gene."
    Wood D.O., Williamson L.R., Winkler H.H., Krause D.C.
    J. Bacteriol. 169:3564-3572(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Madrid E.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Madrid E.
  3. "The citrate synthase-encoding gene of Rickettsia prowazekii is controlled by two promoters."
    Cai J., Pang H., Wood D.O., Winkler H.H.
    Gene 163:115-119(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-35.
    Strain: Madrid E.
  4. Balayeva N., Eremeeva M., Tissot-Dupont H., Zakharov I., Raoult D.
    Submitted (JAN-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 267-392.
    Strain: ATCC VR-142 / Breinl.

Entry informationi

Entry nameiCISY_RICPR
AccessioniPrimary (citable) accession number: P09948
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: September 3, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Citrate synthase is found in nearly all cells capable of oxidative metabolism.

Keywords - Technical termi

Allosteric enzyme, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Rickettsia prowazekii
    Rickettsia prowazekii (strain Madrid E): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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