ID   COND1_LUPAN             Reviewed;         152 AA.
AC   F5B8W8; P09930; P09931;
DT   16-JAN-2019, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   27-MAR-2024, entry version 42.
DE   RecName: Full=Conglutin delta 1 {ECO:0000303|PubMed:21457583};
DE   AltName: Allergen=Lup an delta-conglutin {ECO:0000305};
DE   Contains:
DE     RecName: Full=Conglutin delta-2 large chain {ECO:0000303|Ref.1};
DE   Contains:
DE     RecName: Full=Conglutin delta-2 small chain {ECO:0000303|Ref.1};
DE   Flags: Precursor;
GN   ORFNames=TanjilG_06295 {ECO:0000312|EMBL:OIW12090.1};
OS   Lupinus angustifolius (Narrow-leaved blue lupine).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC   genistoids sensu lato; core genistoids; Genisteae; Lupinus.
OX   NCBI_TaxID=3871;
RN   [1]
RP   PROTEIN SEQUENCE, DISULFIDE BOND, AND SUBUNIT.
RC   STRAIN=cv. White;
RX   DOI=10.1016/0014-5793(86)80167-3;
RA   Lilley G.G., Inglis A.S.;
RT   "Amino acid sequence of conglutin delta, a sulfur-rich seed protein of
RT   Lupinus angustifolius L. Sequence homology with the C-III alpha-amylase
RT   inhibitor from wheat.";
RL   FEBS Lett. 195:235-241(1986).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE, AND ALLERGEN.
RC   STRAIN=cv. Tanjil; TISSUE=Seed;
RX   PubMed=21457583; DOI=10.1186/1471-2229-11-59;
RA   Foley R.C., Gao L.-L., Spriggs A., Soo L.Y.C., Goggin D.E., Smith P.M.C.,
RA   Atkins C.A., Singh K.B.;
RT   "Identification and characterisation of seed storage protein transcripts
RT   from Lupinus angustifolius.";
RL   BMC Plant Biol. 11:59-59(2011).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Tanjil; TISSUE=Seedling;
RX   PubMed=27557478; DOI=10.1111/pbi.12615;
RA   Hane J.K., Ming Y., Kamphuis L.G., Nelson M.N., Garg G., Atkins C.A.,
RA   Bayer P.E., Bravo A., Bringans S., Cannon S., Edwards D., Foley R.,
RA   Gao L.L., Harrison M.J., Huang W., Hurgobin B., Li S., Liu C.W.,
RA   McGrath A., Morahan G., Murray J., Weller J., Jian J., Singh K.B.;
RT   "A comprehensive draft genome sequence for lupin (Lupinus angustifolius),
RT   an emerging health food: insights into plant-microbe interactions and
RT   legume evolution.";
RL   Plant Biotechnol. J. 15:318-330(2017).
RN   [4]
RP   TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RC   STRAIN=cv. Unicrop;
RX   PubMed=9247543; DOI=10.1023/a:1005868105651;
RA   Ilgoutz S.C., Knittel N., Lin J.M., Sterle S., Gayler K.R.;
RT   "Transcription of genes for conglutin gamma and a leginsulin-like protein
RT   in narrow-leafed lupin.";
RL   Plant Mol. Biol. 34:613-627(1997).
CC   -!- SUBUNIT: Heterodimer of a small chain and a large chain; disulfide-
CC       linked. {ECO:0000269|Ref.1}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum
CC       {ECO:0000250|UniProtKB:Q99235}.
CC   -!- TISSUE SPECIFICITY: Expressed in developing cotyledons and in the
CC       embryonic axis of germinating seeds. {ECO:0000269|PubMed:9247543}.
CC   -!- DEVELOPMENTAL STAGE: Accumulates during seed development.
CC       {ECO:0000269|PubMed:21457583, ECO:0000269|PubMed:9247543}.
CC   -!- ALLERGEN: Causes an allergic reaction in human.
CC       {ECO:0000305|PubMed:21457583}.
CC   -!- SIMILARITY: Belongs to the 2S seed storage albumins family.
CC       {ECO:0000305}.
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DR   EMBL; HQ670418; AEB33721.1; -; mRNA.
DR   EMBL; KV861577; OIW12090.1; -; Genomic_DNA.
DR   EMBL; CM007365; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   PIR; A23617; A23617.
DR   PIR; B23617; B23617.
DR   RefSeq; XP_019443091.1; XM_019587546.1.
DR   AlphaFoldDB; F5B8W8; -.
DR   SMR; F5B8W8; -.
DR   STRING; 3871.F5B8W8; -.
DR   Allergome; 7698; Lup an delta_Conglutin.
DR   EnsemblPlants; OIV93891; OIV93891; TanjilG_05594.
DR   EnsemblPlants; OIW12090; OIW12090; TanjilG_06295.
DR   GeneID; 109347615; -.
DR   Gramene; OIV93891; OIV93891; TanjilG_05594.
DR   Gramene; OIW12090; OIW12090; TanjilG_06295.
DR   KEGG; lang:109347615; -.
DR   OMA; PCEKHIM; -.
DR   OrthoDB; 945792at2759; -.
DR   Proteomes; UP000188354; Chromosome LG05.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR   GO; GO:0045735; F:nutrient reservoir activity; IEA:InterPro.
DR   Gene3D; 1.10.110.10; Plant lipid-transfer and hydrophobic proteins; 1.
DR   InterPro; IPR036312; Bifun_inhib/LTP/seed_sf.
DR   InterPro; IPR016140; Bifunc_inhib/LTP/seed_store.
DR   InterPro; IPR000617; Napin/2SS/CON.
DR   PANTHER; PTHR35496; 2S SEED STORAGE PROTEIN 1-RELATED; 1.
DR   PANTHER; PTHR35496:SF20; 2S SEED STORAGE PROTEIN 1-RELATED; 1.
DR   SMART; SM00499; AAI; 1.
DR   SUPFAM; SSF47699; Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin; 1.
PE   1: Evidence at protein level;
KW   Allergen; Direct protein sequencing; Disulfide bond; Endoplasmic reticulum;
KW   Reference proteome; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..152
FT                   /note="Conglutin delta 1"
FT                   /id="PRO_5010962431"
FT   CHAIN           23..59
FT                   /note="Conglutin delta-2 small chain"
FT                   /id="PRO_0000221439"
FT   CHAIN           73..152
FT                   /note="Conglutin delta-2 large chain"
FT                   /id="PRO_0000221438"
FT   DISULFID        30..101
FT                   /evidence="ECO:0000250|UniProtKB:Q6PSU2"
FT   DISULFID        30
FT                   /note="Interchain (between small and large chains, with C-
FT                   101 in large chain)"
FT                   /evidence="ECO:0000250|UniProtKB:P09930"
FT   DISULFID        42..89
FT                   /note="Or C-45 with C-104"
FT                   /evidence="ECO:0000250|UniProtKB:Q6PSU2"
FT   DISULFID        42
FT                   /note="Interchain (between small and large chains, with C-
FT                   89 or C-90 in large chain)"
FT                   /evidence="ECO:0000250|UniProtKB:P09930"
FT   DISULFID        89
FT                   /note="Interchain (between small and large chains, with C-
FT                   42 in small chain) (or C-90)"
FT                   /evidence="ECO:0000269|Ref.1"
FT   DISULFID        90..137
FT                   /note="Or C-103 with C-152"
FT                   /evidence="ECO:0000250|UniProtKB:Q6PSU2"
FT   DISULFID        90..137
FT                   /note="Or C-89 with C-137"
FT                   /evidence="ECO:0000269|Ref.1"
FT   DISULFID        101
FT                   /note="Interchain (between small and large chains, with C-
FT                   30 in small chain)"
FT                   /evidence="ECO:0000269|Ref.1"
FT   DISULFID        103..145
FT                   /evidence="ECO:0000269|Ref.1"
SQ   SEQUENCE   152 AA;  17752 MW;  BBBBBA7600ED5839 CRC64;
     MAKLTILIAL VAALVLVVHT SAFRSSEQSC KRQLQQVNLR HCENHIDQRI QQQQEEEEDR
     ARKLRGIKHV ILRHKSSQES EESEELDQCC EQLNELNSQR CQCRALQQIY ESQSEQCEGR
     QQEQQLEGEL EKLPRICGFG PLRRCNINPD EE
//