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Protein

Surfeit locus protein 1

Gene

Surf1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in mitochondrial respiratory chain complex IV assembly. Probably involved in the biogenesis of the COX complex.By similarity

GO - Molecular functioni

  • cytochrome-c oxidase activity Source: MGI

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Surfeit locus protein 1
Gene namesi
Name:Surf1
Synonyms:Surf-1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:98443. Surf1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei68 – 8619HelicalSequence analysisAdd
BLAST
Transmembranei280 – 30021HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial inner membrane Source: UniProtKB-SubCell
  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 306306Surfeit locus protein 1PRO_0000215653Add
BLAST

Proteomic databases

EPDiP09925.
MaxQBiP09925.
PaxDbiP09925.
PRIDEiP09925.

PTM databases

iPTMnetiP09925.
PhosphoSiteiP09925.
SwissPalmiP09925.

Expressioni

Gene expression databases

BgeeiENSMUSG00000015790.
CleanExiMM_SURF1.
ExpressionAtlasiP09925. baseline and differential.
GenevisibleiP09925. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000128488.

Structurei

3D structure databases

ProteinModelPortaliP09925.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SURF1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1563. Eukaryota.
COG3346. LUCA.
GeneTreeiENSGT00530000064194.
HOVERGENiHBG058486.
InParanoidiP09925.
KOiK14998.
OMAiHWYYRDL.
OrthoDBiEOG091G0IWR.

Family and domain databases

CDDicd06662. SURF1. 1 hit.
InterProiIPR002994. Surf1/Shy1.
[Graphical view]
PfamiPF02104. SURF1. 1 hit.
[Graphical view]
PROSITEiPS50895. SURF1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P09925-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAVMALAVL PRRMTRWSQW AYAGRAQFCA VRRSVFGFSV RSGMVCRPRR
60 70 80 90 100
CCSSTAETAA AKAEDDSFLQ WFLLLIPATA FGLGTWQVQR RKWKLKLIAE
110 120 130 140 150
LESRVMAEPI PLPADPMELK NLEYRPVKVR GHFDHSKELY IMPRTMVDPV
160 170 180 190 200
REARDAGRLS STESGAHVVT PFHCSDLGVT ILVNRGFVPR KKVNPETRQK
210 220 230 240 250
GQVLGEVDLV GIVRLTENRK PFVPENSPER NHWYYRDLEA MAKITGADPI
260 270 280 290 300
FIDADFHSTA PGGPIGGQTR VTLRNEHMQY ILTWYGLCAA TSYLWFQKFV

RRTPIM
Length:306
Mass (Da):34,798
Last modified:June 6, 2002 - v3
Checksum:i8D9ECE9FB726AEB7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti9 – 91V → G in AAA40153 (PubMed:3025660).Curated
Sequence conflicti14 – 141M → I in BAB22123 (PubMed:16141072).Curated
Sequence conflicti284 – 2841W → CR in AAA40153 (PubMed:3025660).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14689 Genomic DNA. Translation: AAA40153.1.
AK002469 mRNA. Translation: BAB22123.1.
BC004755 mRNA. Translation: AAH04755.1.
CCDSiCCDS50543.1.
PIRiB25394.
RefSeqiNP_001258653.2. NM_001271724.1.
NP_038705.2. NM_013677.2.
UniGeneiMm.347512.

Genome annotation databases

EnsembliENSMUST00000015934; ENSMUSP00000015934; ENSMUSG00000015790.
GeneIDi20930.
KEGGimmu:20930.
UCSCiuc008iwh.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14689 Genomic DNA. Translation: AAA40153.1.
AK002469 mRNA. Translation: BAB22123.1.
BC004755 mRNA. Translation: AAH04755.1.
CCDSiCCDS50543.1.
PIRiB25394.
RefSeqiNP_001258653.2. NM_001271724.1.
NP_038705.2. NM_013677.2.
UniGeneiMm.347512.

3D structure databases

ProteinModelPortaliP09925.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000128488.

PTM databases

iPTMnetiP09925.
PhosphoSiteiP09925.
SwissPalmiP09925.

Proteomic databases

EPDiP09925.
MaxQBiP09925.
PaxDbiP09925.
PRIDEiP09925.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000015934; ENSMUSP00000015934; ENSMUSG00000015790.
GeneIDi20930.
KEGGimmu:20930.
UCSCiuc008iwh.2. mouse.

Organism-specific databases

CTDi6834.
MGIiMGI:98443. Surf1.

Phylogenomic databases

eggNOGiKOG1563. Eukaryota.
COG3346. LUCA.
GeneTreeiENSGT00530000064194.
HOVERGENiHBG058486.
InParanoidiP09925.
KOiK14998.
OMAiHWYYRDL.
OrthoDBiEOG091G0IWR.

Miscellaneous databases

PROiP09925.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000015790.
CleanExiMM_SURF1.
ExpressionAtlasiP09925. baseline and differential.
GenevisibleiP09925. MM.

Family and domain databases

CDDicd06662. SURF1. 1 hit.
InterProiIPR002994. Surf1/Shy1.
[Graphical view]
PfamiPF02104. SURF1. 1 hit.
[Graphical view]
PROSITEiPS50895. SURF1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSURF1_MOUSE
AccessioniPrimary (citable) accession number: P09925
Secondary accession number(s): Q99KB4, Q9DCU5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: June 6, 2002
Last modified: September 7, 2016
This is version 125 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.