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P09922

- MX1_MOUSE

UniProt

P09922 - MX1_MOUSE

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Protein
Interferon-induced GTP-binding protein Mx1
Gene
Mx1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Interferon-induced dynamin-like GTPase with antiviral activity against influenza A virus, (IAV), influenza B virus (IBV) and Thogoto virus (THOV). Inhibits FLUAV by interfering with the process of primary transcription, probably by affecting the viral polymerase function.2 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi43 – 508GTP Reviewed prediction
Nucleotide bindingi144 – 1485GTP Reviewed prediction
Nucleotide bindingi213 – 2164GTP Reviewed prediction

GO - Molecular functioni

  1. GTP binding Source: MGI
  2. GTPase activity Source: MGI
  3. protein binding Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. GTP catabolic process Source: GOC
  2. defense response to virus Source: UniProtKB-KW
  3. innate immune response Source: UniProtKB
  4. response to virus Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Antiviral defense, Immunity, Innate immunity

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon-induced GTP-binding protein Mx1
Alternative name(s):
Influenza resistance protein
Myxoma resistance protein 1
Myxovirus resistance protein 1
Gene namesi
Name:Mx1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:97243. Mx1.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi47 – 471S → C: No effect on viral infection. 1 Publication
Mutagenesisi49 – 491K → A or M: Loss of protection against viral infection. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 631631Interferon-induced GTP-binding protein Mx1
PRO_0000206593Add
BLAST

Post-translational modificationi

ISGylated By similarity.

Keywords - PTMi

Ubl conjugation

Proteomic databases

PRIDEiP09922.

PTM databases

PhosphoSiteiP09922.

Expressioni

Inductioni

By type I and type III interferons.1 Publication

Gene expression databases

CleanExiMM_MX1.
GenevestigatoriP09922.

Interactioni

Subunit structurei

Homooligomer. Oligomerizes into multimeric filamentous or ring-like structures by virtue of its stalk domain. Oligomerization is critical for GTPase activity, protein stability, and recognition of viral target structures By similarity. Interacts with TRPC1, TRPC3, TRPC4, TRPC5, TRPC6 and TRPC7 By similarity. Interacts with HSPA5 By similarity. Interacts with TUBB/TUBB5 By similarity. Interacts with DDX39A and DDX39B.1 Publication

Structurei

3D structure databases

ProteinModelPortaliP09922.
SMRiP09922. Positions 11-629.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini33 – 306274Dynamin-type G
Add
BLAST
Domaini543 – 63189GED
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni35 – 306272GTPase domain By similarity
Add
BLAST
Regioni307 – 33226Bundle signaling element (BSE) By similarity
Add
BLAST
Regioni332 – 499168Middle domain By similarity
Add
BLAST
Regioni333 – 601269Stalk By similarity
Add
BLAST
Regioni520 – 5223Critical for lipid-binding By similarity

Domaini

The C-terminal GTPase effector domain (GED) is involved in oligomerization and viral target recognition By similarity.
The middle domain mediates self-assembly and oligomerization By similarity.

Sequence similaritiesi

Contains 1 GED domain.

Phylogenomic databases

HOVERGENiHBG008788.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR000375. Dynamin_central.
IPR001401. Dynamin_GTPase.
IPR019762. Dynamin_GTPase_CS.
IPR022812. Dynamin_SF.
IPR003130. GED.
IPR020850. GTPase_effector_domain_GED.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR11566. PTHR11566. 1 hit.
PfamiPF01031. Dynamin_M. 1 hit.
PF00350. Dynamin_N. 1 hit.
PF02212. GED. 1 hit.
[Graphical view]
PRINTSiPR00195. DYNAMIN.
SMARTiSM00053. DYNc. 1 hit.
SM00302. GED. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00410. G_DYNAMIN_1. 1 hit.
PS51718. G_DYNAMIN_2. 1 hit.
PS51388. GED. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P09922-1 [UniParc]FASTAAdd to Basket

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MDSVNNLCRH YEEKVRPCID LIDTLRALGV EQDLALPAIA VIGDQSSGKS    50
SVLEALSGVA LPRGSGIVTR CPLVLKLRKL KEGEEWRGKV SYDDIEVELS 100
DPSEVEEAIN KGQNFIAGVG LGISDKLISL DVSSPNVPDL TLIDLPGITR 150
VAVGNQPADI GRQIKRLIKT YIQKQETINL VVVPSNVDIA TTEALSMAQE 200
VDPEGDRTIG VLTKPDLVDR GAEGKVLDVM RNLVYPLKKG YMIVKCRGQQ 250
DIQEQLSLTE AFQKEQVFFK DHSYFSILLE DGKATVPCLA ERLTEELTSH 300
ICKSLPLLED QINSSHQSAS EELQKYGADI PEDDRTRMSF LVNKISAFNR 350
NIMNLIQAQE TVSEGDSRLF TKLRNEFLAW DDHIEEYFKK DSPEVQSKMK 400
EFENQYRGRE LPGFVDYKAF ESIIKKRVKA LEESAVNMLR RVTKMVQTAF 450
VKILSNDFGD FLNLCCTAKS KIKEIRLNQE KEAENLIRLH FQMEQIVYCQ 500
DQVYKETLKT IREKEAEKEK TKALINPATF QNNSQFPQKG LTTTEMTQHL 550
KAYYQECRRN IGRQIPLIIQ YFILKTFGEE IEKMMLQLLQ DTSKCSWFLE 600
EQSDTREKKK FLKRRLLRLD EARQKLAKFS D 631
Length:631
Mass (Da):72,038
Last modified:July 1, 1989 - v1
Checksum:i7F0827668D190D68
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M12279 mRNA. Translation: AAA39776.1.
M21117
, M21105, M21106, M21107, M21108, M21109, M21110, M21111, M21112, M21113, M21114, M21115, M21116 Genomic DNA. Translation: AAA39777.1.
BC011113 mRNA. Translation: AAH11113.1.
PIRi