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Protein

Granulocyte colony-stimulating factor

Gene

Csf3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine, Growth factor

Enzyme and pathway databases

ReactomeiR-MMU-449836 Other interleukin signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Granulocyte colony-stimulating factor
Short name:
G-CSF
Gene namesi
Name:Csf3
Synonyms:Csfg
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1339751 Csf3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Add BLAST30
ChainiPRO_000001557131 – 208Granulocyte colony-stimulating factorAdd BLAST178

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi72 ↔ 78By similarity
Disulfide bondi100 ↔ 110By similarity
Glycosylationi169O-linked (GalNAc...) threonineBy similarity1

Post-translational modificationi

O-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP09920
PRIDEiP09920

PTM databases

PhosphoSitePlusiP09920

Expressioni

Gene expression databases

BgeeiENSMUSG00000038067
CleanExiMM_CSF3
ExpressionAtlasiP09920 baseline and differential
GenevisibleiP09920 MM

Interactioni

Subunit structurei

Monomer.

GO - Molecular functioni

Protein-protein interaction databases

DIPiDIP-6118N
STRINGi10090.ENSMUSP00000037762

Structurei

3D structure databases

ProteinModelPortaliP09920
SMRiP09920
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-6 superfamily.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IIM2 Eukaryota
ENOG4111DA4 LUCA
GeneTreeiENSGT00390000017328
HOGENOMiHOG000015371
HOVERGENiHBG005411
InParanoidiP09920
KOiK05423
OMAiKLCHPEE
OrthoDBiEOG091G0NDU
PhylomeDBiP09920
TreeFamiTF337698

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR030474 IL-6/GCSF/MGF
IPR030473 IL6/GCSF/MGF_CS
PfamiView protein in Pfam
PF16647 GCSF, 1 hit
PIRSFiPIRSF001935 IL6_MGF_GCSF, 1 hit
PRINTSiPR00433 IL6GCSFMGF
SMARTiView protein in SMART
SM00126 IL6, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit
PROSITEiView protein in PROSITE
PS00254 INTERLEUKIN_6, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P09920-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQLSAQRRM KLMALQLLLW QSALWSGREA VPLVTVSALP PSLPLPRSFL
60 70 80 90 100
LKSLEQVRKI QASGSVLLEQ LCATYKLCHP EELVLLGHSL GIPKASLSGC
110 120 130 140 150
SSQALQQTQC LSQLHSGLCL YQGLLQALSG ISPALAPTLD LLQLDVANFA
160 170 180 190 200
TTIWQQMENL GVAPTVQPTQ SAMPAFTSAF QRRAGGVLAI SYLQGFLETA

RLALHHLA
Length:208
Mass (Da):22,421
Last modified:July 1, 1989 - v1
Checksum:i0BF3622135C906DB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13926 mRNA Translation: AAA37672.1
X05402 Genomic DNA Translation: CAA28986.1
CCDSiCCDS25360.1
PIRiA29536 A26496
RefSeqiNP_034101.1, NM_009971.1
UniGeneiMm.1238

Genome annotation databases

EnsembliENSMUST00000038886; ENSMUSP00000037762; ENSMUSG00000038067
GeneIDi12985
KEGGimmu:12985
UCSCiuc007lgy.1 mouse

Similar proteinsi

Entry informationi

Entry nameiCSF3_MOUSE
AccessioniPrimary (citable) accession number: P09920
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: May 23, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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