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P09920

- CSF3_MOUSE

UniProt

P09920 - CSF3_MOUSE

Protein

Granulocyte colony-stimulating factor

Gene

Csf3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 1 (01 Jul 1989)
      Previous versions | rss
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    Functioni

    Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes.

    GO - Molecular functioni

    1. cytokine activity Source: UniProtKB

    GO - Biological processi

    1. cellular response to cytokine stimulus Source: Ensembl
    2. cellular response to lipopolysaccharide Source: Ensembl
    3. granulocyte differentiation Source: UniProtKB
    4. immune response Source: InterPro
    5. negative regulation of neuron death Source: Ensembl
    6. positive regulation of actin cytoskeleton reorganization Source: Ensembl
    7. positive regulation of actin filament polymerization Source: Ensembl
    8. positive regulation of cell proliferation Source: Ensembl
    9. positive regulation of peptidyl-serine phosphorylation Source: Ensembl
    10. positive regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
    11. positive regulation of phosphatidylinositol 3-kinase signaling Source: Ensembl
    12. positive regulation of protein binding Source: Ensembl
    13. positive regulation of protein kinase B signaling Source: Ensembl
    14. positive regulation of transcription factor import into nucleus Source: Ensembl
    15. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl

    Keywords - Molecular functioni

    Cytokine, Growth factor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Granulocyte colony-stimulating factor
    Short name:
    G-CSF
    Gene namesi
    Name:Csf3
    Synonyms:Csfg
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:1339751. Csf3.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-KW

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3030Add
    BLAST
    Chaini31 – 208178Granulocyte colony-stimulating factorPRO_0000015571Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi72 ↔ 78By similarity
    Disulfide bondi100 ↔ 110By similarity
    Glycosylationi169 – 1691O-linked (GalNAc...)By similarity

    Post-translational modificationi

    O-glycosylated.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiP09920.

    PTM databases

    PhosphoSiteiP09920.

    Expressioni

    Gene expression databases

    BgeeiP09920.
    CleanExiMM_CSF3.
    GenevestigatoriP09920.

    Interactioni

    Subunit structurei

    Monomer.

    Protein-protein interaction databases

    DIPiDIP-6118N.

    Structurei

    3D structure databases

    ProteinModelPortaliP09920.
    SMRiP09920. Positions 45-208.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the IL-6 superfamily.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG47652.
    HOGENOMiHOG000015371.
    HOVERGENiHBG005411.
    InParanoidiP09920.
    KOiK05423.
    OMAiKLCHPEE.
    OrthoDBiEOG73JKX9.
    PhylomeDBiP09920.
    TreeFamiTF337698.

    Family and domain databases

    Gene3Di1.20.1250.10. 1 hit.
    InterProiIPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR003573. IL-6/IL-23/GCSF/MGF.
    [Graphical view]
    PfamiPF00489. IL6. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001935. IL6_MGF_GCSF. 1 hit.
    PRINTSiPR00433. IL6GCSFMGF.
    SMARTiSM00126. IL6. 1 hit.
    [Graphical view]
    SUPFAMiSSF47266. SSF47266. 1 hit.
    PROSITEiPS00254. INTERLEUKIN_6. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P09920-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAQLSAQRRM KLMALQLLLW QSALWSGREA VPLVTVSALP PSLPLPRSFL    50
    LKSLEQVRKI QASGSVLLEQ LCATYKLCHP EELVLLGHSL GIPKASLSGC 100
    SSQALQQTQC LSQLHSGLCL YQGLLQALSG ISPALAPTLD LLQLDVANFA 150
    TTIWQQMENL GVAPTVQPTQ SAMPAFTSAF QRRAGGVLAI SYLQGFLETA 200
    RLALHHLA 208
    Length:208
    Mass (Da):22,421
    Last modified:July 1, 1989 - v1
    Checksum:i0BF3622135C906DB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M13926 mRNA. Translation: AAA37672.1.
    X05402 Genomic DNA. Translation: CAA28986.1.
    CCDSiCCDS25360.1.
    PIRiA29536. A26496.
    RefSeqiNP_034101.1. NM_009971.1.
    UniGeneiMm.1238.

    Genome annotation databases

    EnsembliENSMUST00000038886; ENSMUSP00000037762; ENSMUSG00000038067.
    GeneIDi12985.
    KEGGimmu:12985.
    UCSCiuc007lgy.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M13926 mRNA. Translation: AAA37672.1 .
    X05402 Genomic DNA. Translation: CAA28986.1 .
    CCDSi CCDS25360.1.
    PIRi A29536. A26496.
    RefSeqi NP_034101.1. NM_009971.1.
    UniGenei Mm.1238.

    3D structure databases

    ProteinModelPortali P09920.
    SMRi P09920. Positions 45-208.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-6118N.

    PTM databases

    PhosphoSitei P09920.

    Proteomic databases

    PRIDEi P09920.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000038886 ; ENSMUSP00000037762 ; ENSMUSG00000038067 .
    GeneIDi 12985.
    KEGGi mmu:12985.
    UCSCi uc007lgy.1. mouse.

    Organism-specific databases

    CTDi 1440.
    MGIi MGI:1339751. Csf3.

    Phylogenomic databases

    eggNOGi NOG47652.
    HOGENOMi HOG000015371.
    HOVERGENi HBG005411.
    InParanoidi P09920.
    KOi K05423.
    OMAi KLCHPEE.
    OrthoDBi EOG73JKX9.
    PhylomeDBi P09920.
    TreeFami TF337698.

    Miscellaneous databases

    NextBioi 282772.
    PROi P09920.
    SOURCEi Search...

    Gene expression databases

    Bgeei P09920.
    CleanExi MM_CSF3.
    Genevestigatori P09920.

    Family and domain databases

    Gene3Di 1.20.1250.10. 1 hit.
    InterProi IPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR003573. IL-6/IL-23/GCSF/MGF.
    [Graphical view ]
    Pfami PF00489. IL6. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001935. IL6_MGF_GCSF. 1 hit.
    PRINTSi PR00433. IL6GCSFMGF.
    SMARTi SM00126. IL6. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47266. SSF47266. 1 hit.
    PROSITEi PS00254. INTERLEUKIN_6. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and characterization of the cDNA for murine granulocyte colony-stimulating factor."
      Tsuchiya M., Asano S., Kaziro Y., Nagata S.
      Proc. Natl. Acad. Sci. U.S.A. 83:7633-7637(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The chromosomal gene structure for murine granulocyte colony-stimulating factor."
      Tsuchiya M., Kaziro Y., Nagata S.
      Eur. J. Biochem. 165:7-12(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Structural studies on the murine granulocyte colony-stimulating factor."
      Simpson R.J., Nice E.C., Nicola N.A.
      Biol. Chem. Hoppe-Seyler 368:1327-1331(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: PARTIAL PROTEIN SEQUENCE.

    Entry informationi

    Entry nameiCSF3_MOUSE
    AccessioniPrimary (citable) accession number: P09920
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: July 1, 1989
    Last modified: October 1, 2014
    This is version 114 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3