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P09920 (CSF3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 112. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Granulocyte colony-stimulating factor

Short name=G-CSF
Gene names
Name:Csf3
Synonyms:Csfg
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length208 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes.

Subunit structure

Monomer.

Subcellular location

Secreted.

Post-translational modification

O-glycosylated By similarity.

Sequence similarities

Belongs to the IL-6 superfamily.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionCytokine
Growth factor
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processcellular response to cytokine stimulus

Inferred from electronic annotation. Source: Ensembl

cellular response to lipopolysaccharide

Inferred from electronic annotation. Source: Ensembl

granulocyte differentiation

Non-traceable author statement PubMed 15664994. Source: UniProtKB

immune response

Inferred from electronic annotation. Source: InterPro

negative regulation of neuron death

Inferred from electronic annotation. Source: Ensembl

positive regulation of actin cytoskeleton reorganization

Inferred from electronic annotation. Source: Ensembl

positive regulation of actin filament polymerization

Inferred from electronic annotation. Source: Ensembl

positive regulation of cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of peptidyl-serine phosphorylation

Inferred from electronic annotation. Source: Ensembl

positive regulation of peptidyl-tyrosine phosphorylation

Inferred from electronic annotation. Source: Ensembl

positive regulation of phosphatidylinositol 3-kinase signaling

Inferred from electronic annotation. Source: Ensembl

positive regulation of protein binding

Inferred from electronic annotation. Source: Ensembl

positive regulation of protein kinase B signaling

Inferred from electronic annotation. Source: Ensembl

positive regulation of transcription factor import into nucleus

Inferred from electronic annotation. Source: Ensembl

positive regulation of transcription from RNA polymerase II promoter

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentextracellular space

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functioncytokine activity

Non-traceable author statement PubMed 15664994. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3030
Chain31 – 208178Granulocyte colony-stimulating factor
PRO_0000015571

Amino acid modifications

Glycosylation1691O-linked (GalNAc...) By similarity
Disulfide bond72 ↔ 78 By similarity
Disulfide bond100 ↔ 110 By similarity

Sequences

Sequence LengthMass (Da)Tools
P09920 [UniParc].

Last modified July 1, 1989. Version 1.
Checksum: 0BF3622135C906DB

FASTA20822,421
        10         20         30         40         50         60 
MAQLSAQRRM KLMALQLLLW QSALWSGREA VPLVTVSALP PSLPLPRSFL LKSLEQVRKI 

        70         80         90        100        110        120 
QASGSVLLEQ LCATYKLCHP EELVLLGHSL GIPKASLSGC SSQALQQTQC LSQLHSGLCL 

       130        140        150        160        170        180 
YQGLLQALSG ISPALAPTLD LLQLDVANFA TTIWQQMENL GVAPTVQPTQ SAMPAFTSAF 

       190        200 
QRRAGGVLAI SYLQGFLETA RLALHHLA 

« Hide

References

[1]"Isolation and characterization of the cDNA for murine granulocyte colony-stimulating factor."
Tsuchiya M., Asano S., Kaziro Y., Nagata S.
Proc. Natl. Acad. Sci. U.S.A. 83:7633-7637(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The chromosomal gene structure for murine granulocyte colony-stimulating factor."
Tsuchiya M., Kaziro Y., Nagata S.
Eur. J. Biochem. 165:7-12(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Structural studies on the murine granulocyte colony-stimulating factor."
Simpson R.J., Nice E.C., Nicola N.A.
Biol. Chem. Hoppe-Seyler 368:1327-1331(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: PARTIAL PROTEIN SEQUENCE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M13926 mRNA. Translation: AAA37672.1.
X05402 Genomic DNA. Translation: CAA28986.1.
PIRA26496. A29536.
RefSeqNP_034101.1. NM_009971.1.
UniGeneMm.1238.

3D structure databases

ProteinModelPortalP09920.
SMRP09920. Positions 45-208.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-6118N.

PTM databases

PhosphoSiteP09920.

Proteomic databases

PRIDEP09920.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000038886; ENSMUSP00000037762; ENSMUSG00000038067.
GeneID12985.
KEGGmmu:12985.
UCSCuc007lgy.1. mouse.

Organism-specific databases

CTD1440.
MGIMGI:1339751. Csf3.

Phylogenomic databases

eggNOGNOG47652.
HOGENOMHOG000015371.
HOVERGENHBG005411.
InParanoidP09920.
KOK05423.
OMAKLCHPEE.
OrthoDBEOG73JKX9.
PhylomeDBP09920.
TreeFamTF337698.

Gene expression databases

BgeeP09920.
CleanExMM_CSF3.
GenevestigatorP09920.

Family and domain databases

Gene3D1.20.1250.10. 1 hit.
InterProIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR003573. IL-6/IL-23/GCSF/MGF.
[Graphical view]
PfamPF00489. IL6. 1 hit.
[Graphical view]
PIRSFPIRSF001935. IL6_MGF_GCSF. 1 hit.
PRINTSPR00433. IL6GCSFMGF.
SMARTSM00126. IL6. 1 hit.
[Graphical view]
SUPFAMSSF47266. SSF47266. 1 hit.
PROSITEPS00254. INTERLEUKIN_6. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio282772.
PROP09920.
SOURCESearch...

Entry information

Entry nameCSF3_MOUSE
AccessionPrimary (citable) accession number: P09920
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: April 16, 2014
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot