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Protein

Somatoliberin

Gene

Ghrh

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GRF is released by the hypothalamus and acts on the adenohypophyse to stimulate the secretion of growth hormone.

GO - Molecular functioni

  • growth hormone-releasing hormone activity Source: RGD
  • growth hormone-releasing hormone receptor binding Source: RGD

GO - Biological processi

  • adenohypophysis development Source: RGD
  • adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: RGD
  • adenylate cyclase-modulating G-protein coupled receptor signaling pathway Source: RGD
  • cellular response to interleukin-6 Source: RGD
  • circadian sleep/wake cycle, non-REM sleep Source: RGD
  • growth hormone secretion Source: RGD
  • negative regulation of cardiac muscle cell apoptotic process Source: RGD
  • positive regulation of cAMP metabolic process Source: RGD
  • positive regulation of circadian sleep/wake cycle, non-REM sleep Source: RGD
  • positive regulation of cytosolic calcium ion concentration Source: RGD
  • positive regulation of growth hormone secretion Source: RGD
  • positive regulation of transcription, DNA-templated Source: RGD
  • response to dexamethasone Source: RGD
  • response to hypoxia Source: RGD
  • response to leptin Source: RGD

Enzyme and pathway databases

ReactomeiR-RNO-418555. G alpha (s) signalling events.
R-RNO-420092. Glucagon-type ligand receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Somatoliberin
Alternative name(s):
Growth hormone-releasing factor
Short name:
GRF
Growth hormone-releasing hormone
Short name:
GHRH
Gene namesi
Name:Ghrh
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi61883. Ghrh.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
PropeptideiPRO_000001144720 – 301 PublicationAdd BLAST11
PeptideiPRO_000001144831 – 73SomatoliberinAdd BLAST43
PropeptideiPRO_000001144975 – 104Add BLAST30

Keywords - PTMi

Cleavage on pair of basic residues

Proteomic databases

PaxDbiP09916.
PRIDEiP09916.

Expressioni

Gene expression databases

BgeeiENSRNOG00000007782.
ExpressionAtlasiP09916. baseline.
GenevisibleiP09916. RN.

Interactioni

GO - Molecular functioni

  • growth hormone-releasing hormone activity Source: RGD
  • growth hormone-releasing hormone receptor binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010298.

Structurei

3D structure databases

SMRiP09916.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glucagon family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J1XI. Eukaryota.
ENOG410ZCJQ. LUCA.
GeneTreeiENSGT00390000008103.
HOGENOMiHOG000115417.
HOVERGENiHBG004478.
InParanoidiP09916.
KOiK05260.
OMAiPLWVFFF.

Family and domain databases

InterProiView protein in InterPro
IPR000532. Glucagon_GIP_secretin_VIP.
PfamiView protein in Pfam
PF00123. Hormone_2. 1 hit.
SMARTiView protein in SMART
SM00070. GLUCA. 1 hit.
PROSITEiView protein in PROSITE
PS00260. GLUCAGON. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P09916-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLWVFFVLL TLTSGSHCSL PPSPPFRVRR HADAIFTSSY RRILGQLYAR
60 70 80 90 100
KLLHEIMNRQ QGERNQEQRS RFNRHLDRVW AEDKQMALES ILQGFPRMKL

SAEA
Length:104
Mass (Da):12,266
Last modified:February 1, 1991 - v2
Checksum:iF9C17485742B2887
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02319 Genomic DNA. No translation available.
X02335
, X02320, X02321, X02322 Genomic DNA. Translation: CAA26194.1.
M73486 mRNA. Translation: AAA41220.1.
U10156 mRNA. Translation: AAC52184.1.
PIRiA32731.
RefSeqiNP_113765.1. NM_031577.1.
XP_008760526.1. XM_008762304.1.
UniGeneiRn.10693.
Rn.214224.

Genome annotation databases

EnsembliENSRNOT00000010443; ENSRNOP00000010444; ENSRNOG00000007782.
ENSRNOT00000082145; ENSRNOP00000072891; ENSRNOG00000007782.
GeneIDi29446.
KEGGirno:29446.

Similar proteinsi

Entry informationi

Entry nameiSLIB_RAT
AccessioniPrimary (citable) accession number: P09916
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: February 1, 1991
Last modified: October 25, 2017
This is version 125 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families