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Protein

Somatoliberin

Gene

Ghrh

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GRF is released by the hypothalamus and acts on the adenohypophyse to stimulate the secretion of growth hormone.

GO - Molecular functioni

  • growth hormone-releasing hormone activity Source: RGD
  • growth hormone-releasing hormone receptor binding Source: RGD

GO - Biological processi

  • adenohypophysis development Source: RGD
  • adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: RGD
  • adenylate cyclase-modulating G-protein coupled receptor signaling pathway Source: RGD
  • cellular response to interleukin-6 Source: RGD
  • circadian sleep/wake cycle, non-REM sleep Source: RGD
  • growth hormone secretion Source: RGD
  • negative regulation of cardiac muscle cell apoptotic process Source: RGD
  • positive regulation of cAMP metabolic process Source: RGD
  • positive regulation of circadian sleep/wake cycle, non-REM sleep Source: RGD
  • positive regulation of cytosolic calcium ion concentration Source: RGD
  • positive regulation of growth hormone secretion Source: RGD
  • positive regulation of transcription, DNA-templated Source: RGD
  • response to dexamethasone Source: RGD
  • response to hypoxia Source: RGD
  • response to leptin Source: RGD
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-RNO-418555. G alpha (s) signalling events.
R-RNO-420092. Glucagon-type ligand receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Somatoliberin
Alternative name(s):
Growth hormone-releasing factor
Short name:
GRF
Growth hormone-releasing hormone
Short name:
GHRH
Gene namesi
Name:Ghrh
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi61883. Ghrh.

Subcellular locationi

GO - Cellular componenti

  • axon terminus Source: RGD
  • extracellular space Source: RGD
  • neuron projection Source: RGD
  • perikaryon Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence analysisAdd
BLAST
Propeptidei20 – 30111 PublicationPRO_0000011447Add
BLAST
Peptidei31 – 7343SomatoliberinPRO_0000011448Add
BLAST
Propeptidei75 – 10430PRO_0000011449Add
BLAST

Keywords - PTMi

Cleavage on pair of basic residues

Proteomic databases

PaxDbiP09916.
PRIDEiP09916.

Expressioni

Gene expression databases

ExpressionAtlasiP09916. baseline.
GenevisibleiP09916. RN.

Interactioni

GO - Molecular functioni

  • growth hormone-releasing hormone activity Source: RGD
  • growth hormone-releasing hormone receptor binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010298.

Family & Domainsi

Sequence similaritiesi

Belongs to the glucagon family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J1XI. Eukaryota.
ENOG410ZCJQ. LUCA.
GeneTreeiENSGT00390000008103.
HOGENOMiHOG000115417.
HOVERGENiHBG004478.
InParanoidiP09916.
KOiK05260.
OMAiIMSRQQG.

Family and domain databases

InterProiIPR000532. Glucagon_GIP_secretin_VIP.
[Graphical view]
PfamiPF00123. Hormone_2. 1 hit.
[Graphical view]
SMARTiSM00070. GLUCA. 1 hit.
[Graphical view]
PROSITEiPS00260. GLUCAGON. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P09916-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLWVFFVLL TLTSGSHCSL PPSPPFRVRR HADAIFTSSY RRILGQLYAR
60 70 80 90 100
KLLHEIMNRQ QGERNQEQRS RFNRHLDRVW AEDKQMALES ILQGFPRMKL

SAEA
Length:104
Mass (Da):12,266
Last modified:February 1, 1991 - v2
Checksum:iF9C17485742B2887
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02319 Genomic DNA. No translation available.
X02335
, X02320, X02321, X02322 Genomic DNA. Translation: CAA26194.1.
M73486 mRNA. Translation: AAA41220.1.
U10156 mRNA. Translation: AAC52184.1.
PIRiA32731.
RefSeqiNP_113765.1. NM_031577.1.
XP_008760526.1. XM_008762304.1.
UniGeneiRn.10693.

Genome annotation databases

EnsembliENSRNOT00000010443; ENSRNOP00000010444; ENSRNOG00000007782.
ENSRNOT00000082145; ENSRNOP00000072891; ENSRNOG00000007782.
GeneIDi29446.
KEGGirno:29446.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02319 Genomic DNA. No translation available.
X02335
, X02320, X02321, X02322 Genomic DNA. Translation: CAA26194.1.
M73486 mRNA. Translation: AAA41220.1.
U10156 mRNA. Translation: AAC52184.1.
PIRiA32731.
RefSeqiNP_113765.1. NM_031577.1.
XP_008760526.1. XM_008762304.1.
UniGeneiRn.10693.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010298.

Proteomic databases

PaxDbiP09916.
PRIDEiP09916.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000010443; ENSRNOP00000010444; ENSRNOG00000007782.
ENSRNOT00000082145; ENSRNOP00000072891; ENSRNOG00000007782.
GeneIDi29446.
KEGGirno:29446.

Organism-specific databases

CTDi2691.
RGDi61883. Ghrh.

Phylogenomic databases

eggNOGiENOG410J1XI. Eukaryota.
ENOG410ZCJQ. LUCA.
GeneTreeiENSGT00390000008103.
HOGENOMiHOG000115417.
HOVERGENiHBG004478.
InParanoidiP09916.
KOiK05260.
OMAiIMSRQQG.

Enzyme and pathway databases

ReactomeiR-RNO-418555. G alpha (s) signalling events.
R-RNO-420092. Glucagon-type ligand receptors.

Miscellaneous databases

PROiP09916.

Gene expression databases

ExpressionAtlasiP09916. baseline.
GenevisibleiP09916. RN.

Family and domain databases

InterProiIPR000532. Glucagon_GIP_secretin_VIP.
[Graphical view]
PfamiPF00123. Hormone_2. 1 hit.
[Graphical view]
SMARTiSM00070. GLUCA. 1 hit.
[Graphical view]
PROSITEiPS00260. GLUCAGON. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSLIB_RAT
AccessioniPrimary (citable) accession number: P09916
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: February 1, 1991
Last modified: September 7, 2016
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.