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P09915

- MTBR_BPRH1

UniProt

P09915 - MTBR_BPRH1

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Protein
Modification methylase Rho11sI
Gene
N/A
Organism
Bacillus phage rho11s (Bacteriophage rho-11s)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

This enzyme methylates cytosine within the sequences GGCC and GAGCTC.

Catalytic activityi

S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei78 – 781 By similarity

GO - Molecular functioni

  1. DNA (cytosine-5-)-methyltransferase activity Source: UniProtKB-EC
  2. DNA binding Source: InterPro

GO - Biological processi

  1. DNA restriction-modification system Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Restriction system

Keywords - Ligandi

S-adenosyl-L-methionine

Protein family/group databases

REBASEi2835. M.Rho11sI.

Names & Taxonomyi

Protein namesi
Recommended name:
Modification methylase Rho11sI (EC:2.1.1.37)
Short name:
M.Rho11sI
Alternative name(s):
Bsu P11s
Cytosine-specific methyltransferase Rho11sI
OrganismiBacillus phage rho11s (Bacteriophage rho-11s)
Taxonomic identifieri10735 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageCaudoviralesSiphoviridaeLambdalikevirusunclassified Lambda-like viruses
Virus hostiBacillus subtilis [TaxID: 1423]

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 503503Modification methylase Rho11sI
PRO_0000087869Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP09915.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 500497SAM-dependent MTase C5-type
Add
BLAST

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR018117. C5_DNA_meth_AS.
IPR001525. C5_MeTfrase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PANTHERiPTHR10629. PTHR10629. 1 hit.
PfamiPF00145. DNA_methylase. 1 hit.
[Graphical view]
PRINTSiPR00105. C5METTRFRASE.
SUPFAMiSSF53335. SSF53335. 4 hits.
TIGRFAMsiTIGR00675. dcm. 1 hit.
PROSITEiPS00094. C5_MTASE_1. 1 hit.
PS00095. C5_MTASE_2. 1 hit.
PS51679. SAM_MT_C5. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P09915-1 [UniParc]FASTAAdd to Basket

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MSKLRVMSLF SGIGAFEAAL RNIGVEYELV GFSEIDKYAI KSYCAIHNAD    50
EQLNFGDVSK IDKKKLPEFD LLVGGSPCQS FSVAGYRKGF EDTRGTLFFQ 100
YIDTLKEKQP RYFVFENVKG LINHDKGNTL NIMAESFSEV GYRIDLELLN 150
SKFFNVPQNR ERIYIIGVRE DLIENDEWVV EKGRNDVLSK GKKRLKELNI 200
KSFNFKWSAQ DIVGRRLREI LEEYVDEKYY LSEEKTSKLI EQIEKPKEKD 250
VVFVGGINVG KRWLNNGKTY SRNFKQGNRV YDSNGIATTL TSQSVGGLGG 300
QTSLYKVEDP IMIGHIDLKG HDAIKRVYSP DGVSPTLTTM GEGHREPKIA 350
VEYVGNINPS GKGMNDQVYN SNGLSPTLTT NKGEGVKISV PNPEIRPVLT 400
PEREEKRQNG RRFKEDDEPA FTVNTIDRHG VAIGEYPKYR IRKLTPLECW 450
RLQAFDEEDF EKALSVGISN SQLYKQAGNS ITVTVLESIF KELIHTYVNE 500
ESE 503
Length:503
Mass (Da):57,130
Last modified:November 1, 1995 - v2
Checksum:iAAAFB8FE01B8129E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X05242 Genomic DNA. Translation: CAA28869.1.
PIRiA28137. CTBPRH.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X05242 Genomic DNA. Translation: CAA28869.1 .
PIRi A28137. CTBPRH.

3D structure databases

ProteinModelPortali P09915.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

REBASEi 2835. M.Rho11sI.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
InterProi IPR018117. C5_DNA_meth_AS.
IPR001525. C5_MeTfrase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view ]
PANTHERi PTHR10629. PTHR10629. 1 hit.
Pfami PF00145. DNA_methylase. 1 hit.
[Graphical view ]
PRINTSi PR00105. C5METTRFRASE.
SUPFAMi SSF53335. SSF53335. 4 hits.
TIGRFAMsi TIGR00675. dcm. 1 hit.
PROSITEi PS00094. C5_MTASE_1. 1 hit.
PS00095. C5_MTASE_2. 1 hit.
PS51679. SAM_MT_C5. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Organization of multispecific DNA methyltransferases encoded by temperate Bacillus subtilis phages."
    Behrens B., Noyer-Weidner M., Pawlek B., Lauster R., Balganesh T.S., Trautner T.A.
    EMBO J. 6:1137-1142(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Trautner T.A.
    Submitted (SEP-1987) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION TO 476.

Entry informationi

Entry nameiMTBR_BPRH1
AccessioniPrimary (citable) accession number: P09915
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: November 1, 1995
Last modified: June 11, 2014
This is version 67 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. Restriction enzymes and methylases
    Classification of restriction enzymes and methylases and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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