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P09915

- MTBR_BPRH1

UniProt

P09915 - MTBR_BPRH1

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Protein

Modification methylase Rho11sI

Gene
N/A
Organism
Bacillus phage rho11s (Bacteriophage rho-11s)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

This enzyme methylates cytosine within the sequences GGCC and GAGCTC.

Catalytic activityi

S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei78 – 781PROSITE-ProRule annotation

GO - Molecular functioni

  1. DNA (cytosine-5-)-methyltransferase activity Source: UniProtKB-EC
  2. DNA binding Source: InterPro

GO - Biological processi

  1. DNA restriction-modification system Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Restriction system

Keywords - Ligandi

S-adenosyl-L-methionine

Protein family/group databases

REBASEi2835. M.Rho11sI.

Names & Taxonomyi

Protein namesi
Recommended name:
Modification methylase Rho11sI (EC:2.1.1.37)
Short name:
M.Rho11sI
Alternative name(s):
Bsu P11s
Cytosine-specific methyltransferase Rho11sI
OrganismiBacillus phage rho11s (Bacteriophage rho-11s)
Taxonomic identifieri10735 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageCaudoviralesSiphoviridaeLambdalikevirusunclassified Lambda-like viruses
Virus hostiBacillus subtilis [TaxID: 1423]

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 503503Modification methylase Rho11sIPRO_0000087869Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP09915.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 500497SAM-dependent MTase C5-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.PROSITE-ProRule annotation
Contains 1 SAM-dependent MTase C5-type domain.PROSITE-ProRule annotation

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR018117. C5_DNA_meth_AS.
IPR001525. C5_MeTfrase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PANTHERiPTHR10629. PTHR10629. 1 hit.
PfamiPF00145. DNA_methylase. 1 hit.
[Graphical view]
PRINTSiPR00105. C5METTRFRASE.
SUPFAMiSSF53335. SSF53335. 4 hits.
TIGRFAMsiTIGR00675. dcm. 1 hit.
PROSITEiPS00094. C5_MTASE_1. 1 hit.
PS00095. C5_MTASE_2. 1 hit.
PS51679. SAM_MT_C5. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P09915-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSKLRVMSLF SGIGAFEAAL RNIGVEYELV GFSEIDKYAI KSYCAIHNAD
60 70 80 90 100
EQLNFGDVSK IDKKKLPEFD LLVGGSPCQS FSVAGYRKGF EDTRGTLFFQ
110 120 130 140 150
YIDTLKEKQP RYFVFENVKG LINHDKGNTL NIMAESFSEV GYRIDLELLN
160 170 180 190 200
SKFFNVPQNR ERIYIIGVRE DLIENDEWVV EKGRNDVLSK GKKRLKELNI
210 220 230 240 250
KSFNFKWSAQ DIVGRRLREI LEEYVDEKYY LSEEKTSKLI EQIEKPKEKD
260 270 280 290 300
VVFVGGINVG KRWLNNGKTY SRNFKQGNRV YDSNGIATTL TSQSVGGLGG
310 320 330 340 350
QTSLYKVEDP IMIGHIDLKG HDAIKRVYSP DGVSPTLTTM GEGHREPKIA
360 370 380 390 400
VEYVGNINPS GKGMNDQVYN SNGLSPTLTT NKGEGVKISV PNPEIRPVLT
410 420 430 440 450
PEREEKRQNG RRFKEDDEPA FTVNTIDRHG VAIGEYPKYR IRKLTPLECW
460 470 480 490 500
RLQAFDEEDF EKALSVGISN SQLYKQAGNS ITVTVLESIF KELIHTYVNE

ESE
Length:503
Mass (Da):57,130
Last modified:November 1, 1995 - v2
Checksum:iAAAFB8FE01B8129E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X05242 Genomic DNA. Translation: CAA28869.1.
PIRiA28137. CTBPRH.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X05242 Genomic DNA. Translation: CAA28869.1 .
PIRi A28137. CTBPRH.

3D structure databases

ProteinModelPortali P09915.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

REBASEi 2835. M.Rho11sI.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
InterProi IPR018117. C5_DNA_meth_AS.
IPR001525. C5_MeTfrase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view ]
PANTHERi PTHR10629. PTHR10629. 1 hit.
Pfami PF00145. DNA_methylase. 1 hit.
[Graphical view ]
PRINTSi PR00105. C5METTRFRASE.
SUPFAMi SSF53335. SSF53335. 4 hits.
TIGRFAMsi TIGR00675. dcm. 1 hit.
PROSITEi PS00094. C5_MTASE_1. 1 hit.
PS00095. C5_MTASE_2. 1 hit.
PS51679. SAM_MT_C5. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Organization of multispecific DNA methyltransferases encoded by temperate Bacillus subtilis phages."
    Behrens B., Noyer-Weidner M., Pawlek B., Lauster R., Balganesh T.S., Trautner T.A.
    EMBO J. 6:1137-1142(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Trautner T.A.
    Submitted (SEP-1987) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION TO 476.

Entry informationi

Entry nameiMTBR_BPRH1
AccessioniPrimary (citable) accession number: P09915
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: November 1, 1995
Last modified: October 1, 2014
This is version 68 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. Restriction enzymes and methylases
    Classification of restriction enzymes and methylases and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3