P09914 (IFIT1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Interferon-induced protein with tetratricopeptide repeats 1
Short name=IFIT-1

Alternative name(s):
Interferon-induced 56 kDa protein
Short name=IFI-56K

Gene names

Name:	IFIT1
Synonyms:	G10P1, IFI56, IFNAI1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	478 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Induction	By interferons.
Sequence similarities	Belongs to the IFIT family. Contains 10 TPR repeats.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Domain	Repeat TPR repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cellular response to exogenous dsRNA Inferred from direct assay. Source: BHF-UCL intracellular transport of viral proteins in host cell Inferred from direct assay. Source: BHF-UCL negative regulation of defense response to virus by host Inferred from direct assay. Source: BHF-UCL negative regulation of helicase activity Inferred from direct assay. Source: BHF-UCL negative regulation of protein binding Inferred from direct assay. Source: BHF-UCL negative regulation of viral genome replication Inferred from mutant phenotype. Source: BHF-UCL positive regulation of viral genome replication Inferred from direct assay. Source: BHF-UCL response to virus Inferred from direct assay. Source: BHF-UCL type I interferon-mediated signaling pathway Traceable author statement. Source: Reactome
Cellular component	cytosol Traceable author statement. Source: Reactome
Molecular function	protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
IFIT2	P09913	5	EBI-745117,EBI-3507167
IFIT3	O14879	5	EBI-745117,EBI-745127

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 478	478	Interferon-induced protein with tetratricopeptide repeats 1		PRO_0000106344
Regions
	Repeat	52 – 85	34	TPR 1
	Repeat	95 – 128	34	TPR 2
	Repeat	139 – 174	36	TPR 3
	Repeat	183 – 216	34	TPR 4
	Repeat	218 – 249	32	TPR 5
	Repeat	251 – 284	34	TPR 6
	Repeat	305 – 339	35	TPR 7
	Repeat	340 – 373	34	TPR 8
	Repeat	378 – 412	35	TPR 9
	Repeat	437 – 470	34	TPR 10
Natural variations
	Natural variant	131	1	P → H. Corresponds to variant rs11553019 [ dbSNP | Ensembl ].		VAR_052614
Experimental info
	Sequence conflict	383	1	H → Y in CAA27244. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P09914 [UniParc]. Last modified October 17, 2006. Version 2. Checksum: EF46E652A366E721	FASTA	478	55,360
	10 20 30 40 50 60 MSTNGDDHQV KDSLEQLRCH FTWELSIDDD EMPDLENRVL DQIEFLDTKY SVGIHNLLAY 70 80 90 100 110 120 VKHLKGQNEE ALKSLKEAEN LMQEEHDNQA NVRSLVTWGN FAWMYYHMGR LAEAQTYLDK 130 140 150 160 170 180 VENICKKLSN PFRYRMECPE IDCEEGWALL KCGGKNYERA KACFEKVLEV DPENPESSAG 190 200 210 220 230 240 YAISAYRLDG FKLATKNHKP FSLLPLRQAV RLNPDNGYIK VLLALKLQDE GQEAEGEKYI 250 260 270 280 290 300 EEALANMSSQ TYVFRYAAKF YRRKGSVDKA LELLKKALQE TPTSVLLHHQ IGLCYKAQMI 310 320 330 340 350 360 QIKEATKGQP RGQNREKLDK MIRSAIFHFE SAVEKKPTFE VAHLDLARMY IEAGNHRKAE 370 380 390 400 410 420 ENFQKLLCMK PVVEETMQDI HFHYGRFQEF QKKSDVNAII HYLKAIKIEQ ASLTRDKSIN 430 440 450 460 470 SLKKLVLRKL RRKALDLESL SLLGFVYKLE GNMNEALEYY ERALRLAADF ENSVRQGP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning, full-length sequence and preliminary characterization of a 56-kDa protein induced by human interferons." Wathelet M., Moutschen S., Defilippi P., Cravador A., Collet M., Huez G., Content J. Eur. J. Biochem. 155:11-17(1986) [PubMed: 3753936] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Prostate.
[3]	"Interferon-induced 56,000 Mr protein and its mRNA in human cells: molecular cloning and partial sequence of the cDNA." Chebath J., Merlin G., Metz R., Benech P., Revel M. Nucleic Acids Res. 11:1213-1226(1983) [PubMed: 6186990] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 413-478.
[4]	"New inducers revealed by the promoter sequence analysis of two interferon-activated human genes." Wathelet M.G., Clauss I.M., Nols C.B., Content J., Huez G.A. Eur. J. Biochem. 169:313-321(1987) [PubMed: 3121313] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-2.
[5]	"The IFI-56K and IFI-54K interferon-inducible human genes belong to the same gene family." Wathelet M.G., Clauss I.M., Content J., Huez G.A. FEBS Lett. 231:164-171(1988) [PubMed: 3360121] [Abstract] Cited for: SIMILARITY TO IFI-54K.
[6]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X03557 mRNA. Translation: CAA27244.1. BC007091 mRNA. Translation: AAH07091.1. X06559 Genomic DNA. Translation: CAA29802.1.
IPI	IPI00018300.
PIR	A25407.
RefSeq	NP_001539.3. NM_001548.3.
UniGene	Hs.20315.
3D structure databases
ProteinModelPortal	P09914.
SMR	P09914. Positions 24-284, 317-474.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-37898N.
IntAct	P09914. 35 interactions.
STRING	P09914.
Polymorphism databases
DMDM	116242522.
Proteomic databases
PRIDE	P09914.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000371804; ENSP00000360869; ENSG00000185745.
GeneID	3434.
KEGG	hsa:3434.
UCSC	uc001kgi.1. human.
Organism-specific databases
CTD	3434.
GeneCards	GC10P091142.
H-InvDB	HIX0009022.
HGNC	HGNC:5407. IFIT1.
MIM	147690. gene.
neXtProt	NX_P09914.
PharmGKB	PA29648.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG17844.
HOGENOM	HBG447196.
HOVERGEN	HBG066330.
InParanoid	P09914.
OMA	PESSAGY.
OrthoDB	EOG4D26PQ.
PhylomeDB	P09914.
Enzyme and pathway databases
Reactome	REACT_6900. Immune System.
Gene expression databases
ArrayExpress	P09914.
Bgee	P09914.
CleanEx	HS_IFIT1.
Genevestigator	P09914.
GermOnline	ENSG00000185745. Homo sapiens.
Family and domain databases
InterPro	IPR024121. Interferon-induced_IFIT1. IPR001440. TPR-1. IPR013026. TPR-contain. IPR011990. TPR-like_helical. IPR019734. TPR_repeat. [Graphical view]
Gene3D	G3DSA:1.25.40.10. TPR-like_helical. 2 hits.
KO	K14217.
PANTHER	PTHR10271:SF2. PTHR10271:SF2. 1 hit.
Pfam	PF00515. TPR_1. 1 hit. [Graphical view]
SMART	SM00028. TPR. 6 hits. [Graphical view]
PROSITE	PS50005. TPR. 6 hits. PS50293. TPR_REGION. 3 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	13540.
SOURCE	Search...

Entry information

Entry name

IFIT1_HUMAN

Accession

Primary (citable) accession number: P09914
Secondary accession number(s): Q96QM5

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
Last sequence update:	October 17, 2006
Last modified:	January 25, 2012
This is version 116 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.