P09913 (IFIT2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Interferon-induced protein with tetratricopeptide repeats 2
Short name=IFIT-2

Alternative name(s):
ISG-54 K
Interferon-induced 54 kDa protein
Short name=IFI-54K

Gene names

Name:	IFIT2
Synonyms:	G10P2, IFI54

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	472 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Induction	By interferons.
Sequence similarities	Belongs to the IFIT family. Contains 6 TPR repeats.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Domain	Repeat TPR repeat
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	negative regulation of protein binding Inferred from direct assay. Source: BHF-UCL response to virus Inferred from direct assay. Source: BHF-UCL type I interferon-mediated signaling pathway Traceable author statement. Source: Reactome
Cellular component	cytosol Traceable author statement. Source: Reactome
Molecular function	protein binding Inferred from physical interaction. Source: BHF-UCL
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
IFIT1	P09914	5	EBI-3507167,EBI-745117
IFIT3	O14879	4	EBI-3507167,EBI-745127

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 472	472	Interferon-induced protein with tetratricopeptide repeats 2		PRO_0000106347
Regions
	Repeat	51 – 84	34	TPR 1
	Repeat	136 – 171	36	TPR 2
	Repeat	172 – 208	37	TPR 3
	Repeat	247 – 280	34	TPR 4
	Repeat	334 – 367	34	TPR 5
	Repeat	371 – 405	35	TPR 6
Amino acid modifications
	Modified residue	424	1	Phosphoserine Ref.5
Natural variations
	Natural variant	79	1	E → A. Corresponds to variant rs17468739 [ dbSNP | Ensembl ].		VAR_052615
	Natural variant	121	1	K → R. Corresponds to variant rs2070845 [ dbSNP | Ensembl ].		VAR_052616
	Natural variant	352	1	D → E. Corresponds to variant rs1727 [ dbSNP | Ensembl ].		VAR_014490

Sequences

	Sequence		Length	Mass (Da)
	P09913 [UniParc]. Last modified July 1, 1989. Version 1. Checksum: 3CF11319A5008FB9	FASTA	472	54,632
	10 20 30 40 50 60 MSENNKNSLE SSLRQLKCHF TWNLMEGENS LDDFEDKVFY RTEFQNREFK ATMCNLLAYL 70 80 90 100 110 120 KHLKGQNEAA LECLRKAEEL IQQEHADQAE IRSLVTWGNY AWVYYHMGRL SDVQIYVDKV 130 140 150 160 170 180 KHVCEKFSSP YRIESPELDC EEGWTRLKCG GNQNERAKVC FEKALEKKPK NPEFTSGLAI 190 200 210 220 230 240 ASYRLDNWPP SQNAIDPLRQ AIRLNPDNQY LKVLLALKLH KMREEGEEEG EGEKLVEEAL 250 260 270 280 290 300 EKAPGVTDVL RSAAKFYRRK DEPDKAIELL KKALEYIPNN AYLHCQIGCC YRAKVFQVMN 310 320 330 340 350 360 LRENGMYGKR KLLELIGHAV AHLKKADEAN DNLFRVCSIL ASLHALADQY EDAEYYFQKE 370 380 390 400 410 420 FSKELTPVAK QLLHLRYGNF QLYQMKCEDK AIHHFIEGVK INQKSREKEK MKDKLQKIAK 430 440 450 460 470 MRLSKNGADS EALHVLAFLQ ELNEKMQQAD EDSERGLESG SLIPSASSWN GE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Interferon-stimulated transcription: isolation of an inducible gene and identification of its regulatory region." Levy D., Larner A., Chaudhuri A., Babiss L.E., Darnell J.E. Jr. Proc. Natl. Acad. Sci. U.S.A. 83:8929-8933(1986) [PubMed: 3466167] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J. Nature 429:375-381(2004) [PubMed: 15164054] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"Regulation of two interferon-inducible human genes by interferon, poly(rI).poly(rC) and viruses." Wathelet M.G., Clauss I.M., Content J., Huez G.A. Eur. J. Biochem. 174:323-329(1988) [PubMed: 2454816] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-2.
[4]	"The IFI-56K and IFI-54K interferon-inducible human genes belong to the same gene family." Wathelet M.G., Clauss I.M., Content J., Huez G.A. FEBS Lett. 231:164-171(1988) [PubMed: 3360121] [Abstract] Cited for: SIMILARITY TO IFI-56K.
[5]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-424, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M14660, M14659 Genomic DNA. Translation: AAA59191.1. AL353751 Genomic DNA. Translation: CAI12238.1. X07557 Genomic DNA. Translation: CAA30438.1.
IPI	IPI00018298.
PIR	I59087.
RefSeq	NP_001538.4. NM_001547.4.
UniGene	Hs.437609.
3D structure databases
ProteinModelPortal	P09913.
SMR	P09913. Positions 52-283, 314-407, 426-465.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-48848N.
IntAct	P09913. 32 interactions.
MINT	MINT-1479068.
STRING	P09913.
PTM databases
PhosphoSite	P09913.
Polymorphism databases
DMDM	124488.
Proteomic databases
PRIDE	P09913.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000371826; ENSP00000360891; ENSG00000119922.
GeneID	3433.
KEGG	hsa:3433.
UCSC	uc009xts.1. human.
Organism-specific databases
CTD	3433.
GeneCards	GC10P091051.
H-InvDB	HIX0025911.
HGNC	HGNC:5409. IFIT2.
HPA	HPA003408.
MIM	147040. gene.
neXtProt	NX_P09913.
PharmGKB	PA29650.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG14891.
HOVERGEN	HBG066330.
InParanoid	P09913.
OMA	KFSSPYR.
OrthoDB	EOG4NVZK4.
Enzyme and pathway databases
Reactome	REACT_6900. Immune System.
Gene expression databases
ArrayExpress	P09913.
Bgee	P09913.
CleanEx	HS_IFIT2.
Genevestigator	P09913.
GermOnline	ENSG00000119922. Homo sapiens.
Family and domain databases
InterPro	IPR024124. Interferon-induced_IFIT2. IPR013026. TPR-contain. IPR011990. TPR-like_helical. IPR019734. TPR_repeat. [Graphical view]
Gene3D	G3DSA:1.25.40.10. TPR-like_helical. 2 hits.
PANTHER	PTHR10271:SF4. PTHR10271:SF4. 1 hit.
SMART	SM00028. TPR. 3 hits. [Graphical view]
PROSITE	PS50005. TPR. 1 hit. PS50293. TPR_REGION. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	13536.
SOURCE	Search...

Entry information

Entry name

IFIT2_HUMAN

Accession

Primary (citable) accession number: P09913
Secondary accession number(s): Q5T767

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
Last sequence update:	July 1, 1989
Last modified:	January 25, 2012
This is version 113 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.