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P09913 (IFIT2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 113. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Interferon-induced protein with tetratricopeptide repeats 2

Short name=IFIT-2
Alternative name(s):
ISG-54 K
Interferon-induced 54 kDa protein
Short name=IFI-54K
Gene names
Name:IFIT2
Synonyms:G10P2, IFI54
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length472 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Induction

By interferons.

Sequence similarities

Belongs to the IFIT family.

Contains 6 TPR repeats.

Ontologies

Keywords
   Coding sequence diversityPolymorphism
   DomainRepeat
TPR repeat
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processnegative regulation of protein binding

Inferred from direct assay. Source: BHF-UCL

response to virus

Inferred from direct assay. Source: BHF-UCL

type I interferon-mediated signaling pathway

Traceable author statement. Source: Reactome

   Cellular componentcytosol

Traceable author statement. Source: Reactome

   Molecular functionprotein binding

Inferred from physical interaction. Source: BHF-UCL

Complete GO annotation...

Binary interactions

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 472472Interferon-induced protein with tetratricopeptide repeats 2
PRO_0000106347

Regions

Repeat51 – 8434TPR 1
Repeat136 – 17136TPR 2
Repeat172 – 20837TPR 3
Repeat247 – 28034TPR 4
Repeat334 – 36734TPR 5
Repeat371 – 40535TPR 6

Amino acid modifications

Modified residue4241Phosphoserine Ref.5

Natural variations

Natural variant791E → A.
Corresponds to variant rs17468739 [ dbSNP | Ensembl ].
VAR_052615
Natural variant1211K → R.
Corresponds to variant rs2070845 [ dbSNP | Ensembl ].
VAR_052616
Natural variant3521D → E.
Corresponds to variant rs1727 [ dbSNP | Ensembl ].
VAR_014490

Sequences

Sequence LengthMass (Da)Tools
P09913 [UniParc].

Last modified July 1, 1989. Version 1.
Checksum: 3CF11319A5008FB9

FASTA47254,632
        10         20         30         40         50         60 
MSENNKNSLE SSLRQLKCHF TWNLMEGENS LDDFEDKVFY RTEFQNREFK ATMCNLLAYL 

        70         80         90        100        110        120 
KHLKGQNEAA LECLRKAEEL IQQEHADQAE IRSLVTWGNY AWVYYHMGRL SDVQIYVDKV 

       130        140        150        160        170        180 
KHVCEKFSSP YRIESPELDC EEGWTRLKCG GNQNERAKVC FEKALEKKPK NPEFTSGLAI 

       190        200        210        220        230        240 
ASYRLDNWPP SQNAIDPLRQ AIRLNPDNQY LKVLLALKLH KMREEGEEEG EGEKLVEEAL 

       250        260        270        280        290        300 
EKAPGVTDVL RSAAKFYRRK DEPDKAIELL KKALEYIPNN AYLHCQIGCC YRAKVFQVMN 

       310        320        330        340        350        360 
LRENGMYGKR KLLELIGHAV AHLKKADEAN DNLFRVCSIL ASLHALADQY EDAEYYFQKE 

       370        380        390        400        410        420 
FSKELTPVAK QLLHLRYGNF QLYQMKCEDK AIHHFIEGVK INQKSREKEK MKDKLQKIAK 

       430        440        450        460        470 
MRLSKNGADS EALHVLAFLQ ELNEKMQQAD EDSERGLESG SLIPSASSWN GE 

« Hide

References

« Hide 'large scale' references
[1]"Interferon-stimulated transcription: isolation of an inducible gene and identification of its regulatory region."
Levy D., Larner A., Chaudhuri A., Babiss L.E., Darnell J.E. Jr.
Proc. Natl. Acad. Sci. U.S.A. 83:8929-8933(1986) [PubMed: 3466167] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The DNA sequence and comparative analysis of human chromosome 10."
Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. expand/collapse author list , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
Nature 429:375-381(2004) [PubMed: 15164054] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"Regulation of two interferon-inducible human genes by interferon, poly(rI).poly(rC) and viruses."
Wathelet M.G., Clauss I.M., Content J., Huez G.A.
Eur. J. Biochem. 174:323-329(1988) [PubMed: 2454816] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-2.
[4]"The IFI-56K and IFI-54K interferon-inducible human genes belong to the same gene family."
Wathelet M.G., Clauss I.M., Content J., Huez G.A.
FEBS Lett. 231:164-171(1988) [PubMed: 3360121] [Abstract]
Cited for: SIMILARITY TO IFI-56K.
[5]"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
Cell 127:635-648(2006) [PubMed: 17081983] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-424, MASS SPECTROMETRY.
Tissue: Cervix carcinoma.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M14660, M14659 Genomic DNA. Translation: AAA59191.1.
AL353751 Genomic DNA. Translation: CAI12238.1.
X07557 Genomic DNA. Translation: CAA30438.1.
IPIIPI00018298.
PIRI59087.
RefSeqNP_001538.4. NM_001547.4.
UniGeneHs.437609.

3D structure databases

ProteinModelPortalP09913.
SMRP09913. Positions 52-283, 314-407, 426-465.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-48848N.
IntActP09913. 32 interactions.
MINTMINT-1479068.
STRINGP09913.

PTM databases

PhosphoSiteP09913.

Polymorphism databases

DMDM124488.

Proteomic databases

PRIDEP09913.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000371826; ENSP00000360891; ENSG00000119922.
GeneID3433.
KEGGhsa:3433.
UCSCuc009xts.1. human.

Organism-specific databases

CTD3433.
GeneCardsGC10P091051.
H-InvDBHIX0025911.
HGNCHGNC:5409. IFIT2.
HPAHPA003408.
MIM147040. gene.
neXtProtNX_P09913.
PharmGKBPA29650.
GenAtlasSearch...

Phylogenomic databases

eggNOGprNOG14891.
HOVERGENHBG066330.
InParanoidP09913.
OMAKFSSPYR.
OrthoDBEOG4NVZK4.

Enzyme and pathway databases

ReactomeREACT_6900. Immune System.

Gene expression databases

ArrayExpressP09913.
BgeeP09913.
CleanExHS_IFIT2.
GenevestigatorP09913.
GermOnlineENSG00000119922. Homo sapiens.

Family and domain databases

InterProIPR024124. Interferon-induced_IFIT2.
IPR013026. TPR-contain.
IPR011990. TPR-like_helical.
IPR019734. TPR_repeat.
[Graphical view]
Gene3DG3DSA:1.25.40.10. TPR-like_helical. 2 hits.
PANTHERPTHR10271:SF4. PTHR10271:SF4. 1 hit.
SMARTSM00028. TPR. 3 hits.
[Graphical view]
PROSITEPS50005. TPR. 1 hit.
PS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio13536.
SOURCESearch...

Entry information

Entry nameIFIT2_HUMAN
AccessionPrimary (citable) accession number: P09913
Secondary accession number(s): Q5T767
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: January 25, 2012
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 10

Human chromosome 10: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families