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Protein

Interferon alpha-inducible protein 6

Gene

IFI6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  • immune response Source: ProtInc
  • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: HGNC
  • negative regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: BHF-UCL
  • negative regulation of mitochondrial depolarization Source: HGNC
  • release of cytochrome c from mitochondria Source: HGNC
  • type I interferon signaling pathway Source: Reactome
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000126709-MONOMER.
ReactomeiR-HSA-909733. Interferon alpha/beta signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon alpha-inducible protein 6
Alternative name(s):
Interferon-induced protein 6-16
Short name:
Ifi-6-16
Gene namesi
Name:IFI6
Synonyms:G1P3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:4054. IFI6.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei41 – 61HelicalSequence analysisAdd BLAST21
Transmembranei75 – 95HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrion Source: HGNC
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi2537.
OpenTargetsiENSG00000126709.
PharmGKBiPA28466.

Polymorphism and mutation databases

BioMutaiIFI6.
DMDMi20178294.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000000874124 – 130Interferon alpha-inducible protein 6Add BLAST107

Proteomic databases

PeptideAtlasiP09912.
PRIDEiP09912.

Expressioni

Inductioni

By alpha and beta interferons.1 Publication

Gene expression databases

BgeeiENSG00000126709.
CleanExiHS_IFI6.
GenevisibleiP09912. HS.

Organism-specific databases

HPAiHPA005543.

Interactioni

Protein-protein interaction databases

BioGridi108812. 2 interactors.

Structurei

3D structure databases

ProteinModelPortaliP09912.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IFI6/IFI27 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000002592.
HOGENOMiHOG000112988.
HOVERGENiHBG006160.
InParanoidiP09912.
OMAiLMSWSAI.
OrthoDBiEOG091G0VGD.
PhylomeDBiP09912.
TreeFamiTF340510.

Family and domain databases

InterProiIPR009311. IFI6/IFI27.
[Graphical view]
PANTHERiPTHR16932. PTHR16932. 1 hit.
PfamiPF06140. Ifi-6-16. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform A (identifier: P09912-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRQKAVSLFL CYLLLFTCSG VEAGKKKCSE SSDSGSGFWK ALTFMAVGGG
60 70 80 90 100
LAVAGLPALG FTGAGIAANS VAASLMSWSA ILNGGGVPAG GLVATLQSLG
110 120 130
AGGSSVVIGN IGALMGYATH KYLDSEEDEE
Length:130
Mass (Da):12,927
Last modified:April 16, 2002 - v2
Checksum:iB1C2992A59203B38
GO
Isoform B (identifier: P09912-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     24-24: G → GENAG

Show »
Length:134
Mass (Da):13,298
Checksum:iAEEE9641CDAF5CA1
GO
Isoform C (identifier: P09912-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     24-24: G → GENAGKDAG

Show »
Length:138
Mass (Da):13,670
Checksum:iD6498E4F200EB939
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti8L → V (PubMed:3017706).Curated1
Sequence conflicti8L → V (PubMed:7596809).Curated1
Sequence conflicti116G → R (PubMed:3017706).Curated1
Sequence conflicti116G → R (PubMed:7596809).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00150224G → GENAG in isoform B. 1 Publication1
Alternative sequenceiVSP_00150324G → GENAGKDAG in isoform C. Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02492 mRNA. Translation: CAA26322.1.
U22970 Genomic DNA. Translation: AAC50159.1.
U22970 Genomic DNA. Translation: AAC50160.1.
U22970 Genomic DNA. Translation: AAC50161.1.
BT006850 mRNA. Translation: AAP35496.1.
AK314488 mRNA. Translation: BAG37089.1.
AL445490 Genomic DNA. Translation: CAH72020.1.
AL445490 Genomic DNA. Translation: CAH72021.1.
AL445490 Genomic DNA. Translation: CAH72022.1.
CH471059 Genomic DNA. Translation: EAX07744.1.
CH471059 Genomic DNA. Translation: EAX07745.1.
CH471059 Genomic DNA. Translation: EAX07746.1.
BC011601 mRNA. Translation: AAH11601.1.
BC015603 mRNA. Translation: AAH15603.1.
BN000257 mRNA. Translation: CAE12275.1.
CCDSiCCDS306.1. [P09912-1]
CCDS307.1. [P09912-2]
CCDS308.1. [P09912-3]
PIRiA26316.
RefSeqiNP_002029.3. NM_002038.3. [P09912-1]
NP_075010.1. NM_022872.2. [P09912-2]
NP_075011.1. NM_022873.2. [P09912-3]
UniGeneiHs.523847.
Hs.730125.

Genome annotation databases

EnsembliENST00000339145; ENSP00000342513; ENSG00000126709. [P09912-3]
ENST00000361157; ENSP00000354736; ENSG00000126709. [P09912-1]
ENST00000362020; ENSP00000355152; ENSG00000126709. [P09912-2]
GeneIDi2537.
KEGGihsa:2537.
UCSCiuc001bon.2. human. [P09912-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02492 mRNA. Translation: CAA26322.1.
U22970 Genomic DNA. Translation: AAC50159.1.
U22970 Genomic DNA. Translation: AAC50160.1.
U22970 Genomic DNA. Translation: AAC50161.1.
BT006850 mRNA. Translation: AAP35496.1.
AK314488 mRNA. Translation: BAG37089.1.
AL445490 Genomic DNA. Translation: CAH72020.1.
AL445490 Genomic DNA. Translation: CAH72021.1.
AL445490 Genomic DNA. Translation: CAH72022.1.
CH471059 Genomic DNA. Translation: EAX07744.1.
CH471059 Genomic DNA. Translation: EAX07745.1.
CH471059 Genomic DNA. Translation: EAX07746.1.
BC011601 mRNA. Translation: AAH11601.1.
BC015603 mRNA. Translation: AAH15603.1.
BN000257 mRNA. Translation: CAE12275.1.
CCDSiCCDS306.1. [P09912-1]
CCDS307.1. [P09912-2]
CCDS308.1. [P09912-3]
PIRiA26316.
RefSeqiNP_002029.3. NM_002038.3. [P09912-1]
NP_075010.1. NM_022872.2. [P09912-2]
NP_075011.1. NM_022873.2. [P09912-3]
UniGeneiHs.523847.
Hs.730125.

3D structure databases

ProteinModelPortaliP09912.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108812. 2 interactors.

Polymorphism and mutation databases

BioMutaiIFI6.
DMDMi20178294.

Proteomic databases

PeptideAtlasiP09912.
PRIDEiP09912.

Protocols and materials databases

DNASUi2537.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000339145; ENSP00000342513; ENSG00000126709. [P09912-3]
ENST00000361157; ENSP00000354736; ENSG00000126709. [P09912-1]
ENST00000362020; ENSP00000355152; ENSG00000126709. [P09912-2]
GeneIDi2537.
KEGGihsa:2537.
UCSCiuc001bon.2. human. [P09912-1]

Organism-specific databases

CTDi2537.
DisGeNETi2537.
GeneCardsiIFI6.
HGNCiHGNC:4054. IFI6.
HPAiHPA005543.
MIMi147572. gene.
neXtProtiNX_P09912.
OpenTargetsiENSG00000126709.
PharmGKBiPA28466.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00390000002592.
HOGENOMiHOG000112988.
HOVERGENiHBG006160.
InParanoidiP09912.
OMAiLMSWSAI.
OrthoDBiEOG091G0VGD.
PhylomeDBiP09912.
TreeFamiTF340510.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000126709-MONOMER.
ReactomeiR-HSA-909733. Interferon alpha/beta signaling.

Miscellaneous databases

ChiTaRSiIFI6. human.
GeneWikiiIFI6.
GenomeRNAii2537.
PROiP09912.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000126709.
CleanExiHS_IFI6.
GenevisibleiP09912. HS.

Family and domain databases

InterProiIPR009311. IFI6/IFI27.
[Graphical view]
PANTHERiPTHR16932. PTHR16932. 1 hit.
PfamiPF06140. Ifi-6-16. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIFI6_HUMAN
AccessioniPrimary (citable) accession number: P09912
Secondary accession number(s): Q13141
, Q13142, Q5VVR2, Q5VVR3, Q6IE95, Q969M8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: April 16, 2002
Last modified: November 30, 2016
This is version 140 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.