P09912 (IFI6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Interferon alpha-inducible protein 6

Alternative name(s):
Interferon-induced protein 6-16
Short name=Ifi-6-16

Gene names

Name:	IFI6
Synonyms:	G1P3

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	130 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein Potential.
Induction	By alpha and beta interferons. Ref.8
Sequence similarities	Belongs to the IFI6/IFI27 family.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing
Domain	Signal Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	negative regulation of apoptotic process Inferred from mutant phenotype PubMed 15685448. Source: HGNC negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Inferred from mutant phenotype PubMed 15685448. Source: HGNC negative regulation of mitochondrial depolarization Inferred from mutant phenotype PubMed 15685448. Source: HGNC release of cytochrome c from mitochondria Inferred from mutant phenotype PubMed 15685448. Source: HGNC type I interferon-mediated signaling pathway Traceable author statement. Source: Reactome
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrion Inferred from direct assay PubMed 15685448. Source: HGNC plasma membrane Traceable author statement. Source: Reactome
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform A (identifier: P09912-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform B (identifier: P09912-2)

The sequence of this isoform differs from the canonical sequence as follows:
     24-24: G → GENAG

Isoform C (identifier: P09912-3)

The sequence of this isoform differs from the canonical sequence as follows:
     24-24: G → GENAGKDAG

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 23	23	Potential
	Chain	24 – 130	107	Interferon alpha-inducible protein 6		PRO_0000008741
Regions
	Transmembrane	41 – 61	21	Helical; Potential
	Transmembrane	75 – 95	21	Helical; Potential
Natural variations
	Alternative sequence	24	1	G → GENAG in isoform B.		VSP_001502
	Alternative sequence	24	1	G → GENAGKDAG in isoform C.		VSP_001503
Experimental info
	Sequence conflict	8	1	L → V Ref.1
	Sequence conflict	8	1	L → V Ref.2
	Sequence conflict	116	1	G → R Ref.1
	Sequence conflict	116	1	G → R Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform A [UniParc]. Last modified April 16, 2002. Version 2. Checksum: B1C2992A59203B38	FASTA	130	12,927
	10 20 30 40 50 60 MRQKAVSLFL CYLLLFTCSG VEAGKKKCSE SSDSGSGFWK ALTFMAVGGG LAVAGLPALG 70 80 90 100 110 120 FTGAGIAANS VAASLMSWSA ILNGGGVPAG GLVATLQSLG AGGSSVVIGN IGALMGYATH 130 KYLDSEEDEE
	Isoform B [UniParc]. Checksum: AEEE9641CDAF5CA1	FASTA	134	13,298
	10 20 30 40 50 60 MRQKAVSLFL CYLLLFTCSG VEAGENAGKK KCSESSDSGS GFWKALTFMA VGGGLAVAGL 70 80 90 100 110 120 PALGFTGAGI AANSVAASLM SWSAILNGGG VPAGGLVATL QSLGAGGSSV VIGNIGALMG 130 YATHKYLDSE EDEE
	Isoform C [UniParc]. Checksum: D6498E4F200EB939	FASTA	138	13,670
	10 20 30 40 50 60 MRQKAVSLFL CYLLLFTCSG VEAGENAGKD AGKKKCSESS DSGSGFWKAL TFMAVGGGLA 70 80 90 100 110 120 VAGLPALGFT GAGIAANSVA ASLMSWSAIL NGGGVPAGGL VATLQSLGAG GSSVVIGNIG 130 ALMGYATHKY LDSEEDEE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of a human gene inducible by alpha- and beta-interferons and its expression in mouse cells." Kelly J.M., Porter A.C.G., Chernajovsky Y., Gilbert C.S., Stark G.R., Kerr I.M. EMBO J. 5:1601-1606(1986) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A).
[2]	"Characterisation of a novel minisatellite that provides multiple splice donor sites in an interferon-induced transcript." Turri M.G., Cuin K.A., Porter A.C.G. Nucleic Acids Res. 23:1854-1861(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS A; B AND C). Tissue: Placenta.
[3]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A).
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B). Tissue: Cerebellum.
[5]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A). Tissue: Placenta and Skin.
[8]	"Identification of a novel gene family that includes the interferon-inducible human genes 6-16 and ISG12." Parker N., Porter A.C.G. BMC Genomics 5:8-8(2004) [PubMed] [Europe PMC] [Abstract] Cited for: INDUCTION BY INTERFERONS.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X02492 mRNA. Translation: CAA26322.1. U22970 Genomic DNA. Translation: AAC50159.1. U22970 Genomic DNA. Translation: AAC50160.1. U22970 Genomic DNA. Translation: AAC50161.1. BT006850 mRNA. Translation: AAP35496.1. AK314488 mRNA. Translation: BAG37089.1. AL445490 Genomic DNA. Translation: CAH72020.1. AL445490 Genomic DNA. Translation: CAH72021.1. AL445490 Genomic DNA. Translation: CAH72022.1. CH471059 Genomic DNA. Translation: EAX07744.1. CH471059 Genomic DNA. Translation: EAX07745.1. CH471059 Genomic DNA. Translation: EAX07746.1. BC011601 mRNA. Translation: AAH11601.1. BC015603 mRNA. Translation: AAH15603.1. BN000257 mRNA. Translation: CAE12275.1.
IPI	IPI00018296. IPI00220650. IPI00220651.
PIR	A26316.
RefSeq	NP_002029.3. NM_002038.3. NP_075010.1. NM_022872.2. NP_075011.1. NM_022873.2.
UniGene	Hs.523847. Hs.730125.
3D structure databases
ProteinModelPortal	P09912.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000342513.
Polymorphism databases
DMDM	20178294.
Proteomic databases
PaxDb	P09912.
PRIDE	P09912.
Protocols and materials databases
DNASU	2537.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000339145; ENSP00000342513; ENSG00000126709. ENST00000361157; ENSP00000354736; ENSG00000126709. ENST00000362020; ENSP00000355152; ENSG00000126709.
GeneID	2537.
KEGG	hsa:2537.
UCSC	uc001bon.1. human. uc001boo.1. human.
Organism-specific databases
CTD	2537.
GeneCards	GC01M027992.
HGNC	HGNC:4054. IFI6.
HPA	HPA005543.
MIM	147572. gene.
neXtProt	NX_P09912.
PharmGKB	PA28466.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG68244.
HOGENOM	HOG000112988.
HOVERGEN	HBG006160.
OMA	AVSLFLC.
OrthoDB	EOG4TF0N1.
Enzyme and pathway databases
Reactome	REACT_6900. Immune System.
Gene expression databases
ArrayExpress	P09912.
Bgee	P09912.
CleanEx	HS_IFI6.
Genevestigator	P09912.
GermOnline	ENSG00000126709. Homo sapiens.
Family and domain databases
InterPro	IPR009311. Interferon-induced_6-16. [Graphical view]
PANTHER	PTHR16932. PTHR16932. 1 hit.
Pfam	PF06140. Ifi-6-16. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	IFI6. human.
GenomeRNAi	2537.
NextBio	10009.
SOURCE	Search...

Entry information

Entry name

IFI6_HUMAN

Accession

Primary (citable) accession number: P09912
Secondary accession number(s): Q13141 , Q13142, Q5VVR2, Q5VVR3, Q6IE95, Q969M8

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
Last sequence update:	April 16, 2002
Last modified:	April 3, 2013
This is version 111 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.