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Protein

Interferon alpha-inducible protein 6

Gene

IFI6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  • immune response Source: ProtInc
  • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: HGNC
  • negative regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: BHF-UCL
  • negative regulation of mitochondrial depolarization Source: HGNC
  • release of cytochrome c from mitochondria Source: HGNC
  • type I interferon signaling pathway Source: Reactome

Enzyme and pathway databases

ReactomeiR-HSA-909733 Interferon alpha/beta signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon alpha-inducible protein 6
Alternative name(s):
Interferon-induced protein 6-16
Short name:
Ifi-6-16
Gene namesi
Name:IFI6
Synonyms:G1P3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000126709.14
HGNCiHGNC:4054 IFI6
MIMi147572 gene
neXtProtiNX_P09912

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei41 – 61HelicalSequence analysisAdd BLAST21
Transmembranei75 – 95HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi2537
OpenTargetsiENSG00000126709
PharmGKBiPA28466

Polymorphism and mutation databases

BioMutaiIFI6
DMDMi20178294

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000000874124 – 130Interferon alpha-inducible protein 6Add BLAST107

Proteomic databases

PeptideAtlasiP09912
PRIDEiP09912

PTM databases

iPTMnetiP09912
PhosphoSitePlusiP09912

Expressioni

Inductioni

By alpha and beta interferons.1 Publication

Gene expression databases

BgeeiENSG00000126709
CleanExiHS_IFI6
GenevisibleiP09912 HS

Organism-specific databases

HPAiHPA005543

Interactioni

Protein-protein interaction databases

BioGridi108812, 2 interactors

Structurei

3D structure databases

ProteinModelPortaliP09912
SMRiP09912
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IFI6/IFI27 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000002592
HOGENOMiHOG000112988
HOVERGENiHBG006160
InParanoidiP09912
OMAiLMSWSAI
OrthoDBiEOG091G0VGD
PhylomeDBiP09912
TreeFamiTF340510

Family and domain databases

Gene3Di1.10.246.160, 1 hit
InterProiView protein in InterPro
IPR009311 IFI6/IFI27-like
IPR038213 IFI6/IFI27-like_sf
PANTHERiPTHR16932 PTHR16932, 1 hit
PfamiView protein in Pfam
PF06140 Ifi-6-16, 1 hit

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform A (identifier: P09912-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRQKAVSLFL CYLLLFTCSG VEAGKKKCSE SSDSGSGFWK ALTFMAVGGG
60 70 80 90 100
LAVAGLPALG FTGAGIAANS VAASLMSWSA ILNGGGVPAG GLVATLQSLG
110 120 130
AGGSSVVIGN IGALMGYATH KYLDSEEDEE
Length:130
Mass (Da):12,927
Last modified:April 16, 2002 - v2
Checksum:iB1C2992A59203B38
GO
Isoform B (identifier: P09912-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     24-24: G → GENAG

Show »
Length:134
Mass (Da):13,298
Checksum:iAEEE9641CDAF5CA1
GO
Isoform C (identifier: P09912-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     24-24: G → GENAGKDAG

Show »
Length:138
Mass (Da):13,670
Checksum:iD6498E4F200EB939
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti8L → V (PubMed:3017706).Curated1
Sequence conflicti8L → V (PubMed:7596809).Curated1
Sequence conflicti116G → R (PubMed:3017706).Curated1
Sequence conflicti116G → R (PubMed:7596809).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00150224G → GENAG in isoform B. 1 Publication1
Alternative sequenceiVSP_00150324G → GENAGKDAG in isoform C. Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02492 mRNA Translation: CAA26322.1
U22970 Genomic DNA Translation: AAC50159.1
U22970 Genomic DNA Translation: AAC50160.1
U22970 Genomic DNA Translation: AAC50161.1
BT006850 mRNA Translation: AAP35496.1
AK314488 mRNA Translation: BAG37089.1
AL445490 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07744.1
CH471059 Genomic DNA Translation: EAX07745.1
CH471059 Genomic DNA Translation: EAX07746.1
BC011601 mRNA Translation: AAH11601.1
BC015603 mRNA Translation: AAH15603.1
BN000257 mRNA Translation: CAE12275.1
CCDSiCCDS306.1 [P09912-1]
CCDS307.1 [P09912-2]
CCDS308.1 [P09912-3]
PIRiA26316
RefSeqiNP_002029.3, NM_002038.3 [P09912-1]
NP_075010.1, NM_022872.2 [P09912-2]
NP_075011.1, NM_022873.2 [P09912-3]
UniGeneiHs.523847
Hs.730125

Genome annotation databases

EnsembliENST00000339145; ENSP00000342513; ENSG00000126709 [P09912-3]
ENST00000361157; ENSP00000354736; ENSG00000126709 [P09912-1]
ENST00000362020; ENSP00000355152; ENSG00000126709 [P09912-2]
GeneIDi2537
KEGGihsa:2537
UCSCiuc001bon.2 human [P09912-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiIFI6_HUMAN
AccessioniPrimary (citable) accession number: P09912
Secondary accession number(s): Q13141
, Q13142, Q5VVR2, Q5VVR3, Q6IE95, Q969M8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: April 16, 2002
Last modified: March 28, 2018
This is version 147 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health