P09895 (RL5_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
60S ribosomal protein L5

Gene names

Name:

Rpl5

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	297 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Required for rRNA maturation and formation of the 60S ribosomal subunits By similarity. This protein binds 5S RNA.
Subcellular location	Cytoplasm By similarity. Nucleus › nucleolus By similarity.
Sequence similarities	Belongs to the ribosomal protein L18P family.

Ontologies

Keywords
Cellular component	Cytoplasm Nucleus
Ligand	RNA-binding rRNA-binding
Molecular function	Ribonucleoprotein Ribosomal protein
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	cellular response to inorganic substance Inferred from expression pattern PubMed 12930674. Source: RGD positive regulation of phosphatase activity Inferred from direct assay PubMed 7649987. Source: RGD translation Inferred from electronic annotation. Source: InterPro
Cellular_component	aminoacyl-tRNA synthetase multienzyme complex Inferred from direct assay PubMed 8982850. Source: RGD nucleolus Inferred from electronic annotation. Source: UniProtKB-SubCell ribosome Traceable author statement Ref.1. Source: RGD
Molecular_function	5S rRNA binding Traceable author statement Ref.1. Source: RGD structural constituent of ribosome Traceable author statement Ref.1. Source: RGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 297	296	60S ribosomal protein L5		PRO_0000131436
Amino acid modifications
	Modified residue	5	1	N6-acetyllysine By similarity
	Modified residue	48	1	N6-acetyllysine By similarity
	Modified residue	272	1	Phosphoserine By similarity
Experimental info
	Sequence conflict	236	1	Missing in AAA42074. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P09895 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: ABBB47AF1EBE4366	FASTA	297	34,459
	10 20 30 40 50 60 MGFVKVVKNK AYFKRYQVRF RRRREGKTDY YARKRLVIQD KNKYNTPKYR MIVRVTNRDI 70 80 90 100 110 120 ICQIAYARIE GDMIVCAAYA HELPKYGVKV GLTNYAAAYC TGLLLARRLL NRFGMDKIYE 130 140 150 160 170 180 GQVEVNGDEY NVESIDGQPG AFTCYLDAGL ARTTTGNKVF GALKGAVDGG LSIPHSTKRF 190 200 210 220 230 240 PGYDSESKEF NAEVHRKHIM GQNVADYMRY LMEEDEDAYK KQFSQYIKNN VTPDMMEEMY 250 260 270 280 290 KKAHAAIREN PVYEKKPKRE VKKKRWNRPK MSLAQKKDRV AQKKASFLRA QERAAES

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The primary structure of rat ribosomal protein L5. A comparison of the sequence of amino acids in the proteins that interact with 5 S rRNA." Chan Y.-L., Lin A., McNally J., Wool I.G. J. Biol. Chem. 262:12879-12886(1987) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Sprague-Dawley. Tissue: Liver.
[2]	"Molecular cloning and nucleotide sequence of cDNA specific for rat ribosomal protein L5." Tamura S., Kuwano Y., Nakayama T., Tanaka S., Tanaka T., Ogata K. Eur. J. Biochem. 168:83-87(1987) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE. Tissue: Liver.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Pituitary.
[4]	"Distinct domains in ribosomal protein L5 mediate 5 S rRNA binding and nucleolar localization." Michael W.M., Dreyfuss G. J. Biol. Chem. 271:11571-11574(1996) [PubMed] [Europe PMC] [Abstract] Cited for: RNA-BINDING.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M17419 mRNA. Translation: AAA42074.1. X06148 mRNA. Translation: CAA29506.1. BC060561 mRNA. Translation: AAH60561.1.
IPI	IPI00230914.
PIR	R5RTL5. S00111.
RefSeq	NP_112361.1. NM_031099.1.
UniGene	Rn.155004. Rn.92980.
3D structure databases
ProteinModelPortal	P09895.
SMR	P09895. Positions 11-247.
ModBase	Search...
Protein-protein interaction databases
IntAct	P09895. 1 interaction.
STRING	10116.ENSRNOP00000036514.
Proteomic databases
PaxDb	P09895.
PRIDE	P09895.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000030428; ENSRNOP00000036514; ENSRNOG00000023529.
GeneID	81763.
KEGG	rno:81763.
UCSC	RGD:619825. rat.
Organism-specific databases
CTD	6125.
RGD	619825. Rpl5.
Phylogenomic databases
eggNOG	COG0256.
GeneTree	ENSGT00390000008456.
HOGENOM	HOG000105947.
HOVERGEN	HBG009347.
InParanoid	P09895.
KO	K02932.
OrthoDB	EOG4Z8XX0.
Gene expression databases
Genevestigator	P09895.
GermOnline	ENSRNOG00000023529. Rattus norvegicus.
Family and domain databases
InterPro	IPR005485. Rbsml_L5_euk/L18_arc. IPR025607. Rbsml_L5e/L18P_C. IPR005484. Ribosomal_L18/L5. [Graphical view]
PANTHER	PTHR23410. PTHR23410. 1 hit.
Pfam	PF14204. Ribosomal_L18_c. 1 hit. PF00861. Ribosomal_L18p. 1 hit. [Graphical view]
PRINTS	PR00058. RIBOSOMALL5.
ProtoNet	Search...
Other
NextBio	615554.

Entry information

Entry name

RL5_RAT

Accession

Primary (citable) accession number: P09895

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
Last sequence update:	January 23, 2007
Last modified:	April 3, 2013
This is version 101 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program