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P09889

- PPA5_PIG

UniProt

P09889 - PPA5_PIG

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Protein

Tartrate-resistant acid phosphatase type 5

Gene
ACP5
Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Uteroferrin is a phosphoprotein phosphatase, synthesized in response to progesterone. It appears to function in transplacental transport of iron in pig.

Catalytic activityi

A phosphate monoester + H2O = an alcohol + phosphate.

Cofactori

Binds 2 iron ions per subunit.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi41 – 411Iron 1
Metal bindingi79 – 791Iron 1
Metal bindingi79 – 791Iron 2
Metal bindingi82 – 821Iron 1
Metal bindingi118 – 1181Iron 2
Metal bindingi213 – 2131Iron 2
Metal bindingi248 – 2481Iron 2
Metal bindingi250 – 2501Iron 1

GO - Molecular functioni

  1. acid phosphatase activity Source: UniProtKB-EC
  2. ferric iron binding Source: UniProtKB
  3. ferrous iron binding Source: UniProtKB

GO - Biological processi

  1. ion transport Source: UniProtKB-KW
  2. iron ion homeostasis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Ion transport, Iron transport, Transport

Keywords - Ligandi

Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tartrate-resistant acid phosphatase type 5 (EC:3.1.3.2)
Short name:
TR-AP
Alternative name(s):
Tartrate-resistant acid ATPase
Short name:
TrATPase
Type 5 acid phosphatase
Uteroferrin
Short name:
UF
Gene namesi
Name:ACP5
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
ProteomesiUP000008227: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Add
BLAST
Chaini21 – 340320Tartrate-resistant acid phosphatase type 5PRO_0000023984Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi124 – 1241N-linked (GlcNAc...)
Glycosylationi155 – 1551N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi169 ↔ 227

Keywords - PTMi

Disulfide bond, Glycoprotein

Miscellaneous databases

PMAP-CutDBP09889.

Interactioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000014466.

Structurei

Secondary structure

1
340
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi34 – 396
Helixi53 – 6917
Beta strandi72 – 765
Turni82 – 843
Helixi93 – 975
Turni98 – 1014
Helixi105 – 1073
Beta strandi112 – 1143
Helixi118 – 1225
Helixi125 – 1306
Helixi131 – 1333
Beta strandi142 – 1509
Beta strandi157 – 1626
Helixi165 – 1695
Helixi172 – 1743
Helixi186 – 20217
Beta strandi206 – 2116
Beta strandi220 – 2223
Helixi226 – 2316
Helixi233 – 2386
Beta strandi242 – 2465
Beta strandi248 – 2569
Beta strandi262 – 2665
Beta strandi268 – 2703
Helixi279 – 2813
Beta strandi287 – 2915
Beta strandi299 – 3057
Beta strandi310 – 3167
Beta strandi321 – 3277

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1UTEX-ray1.55A28-340[»]
ProteinModelPortaliP09889.
SMRiP09889. Positions 30-331.

Miscellaneous databases

EvolutionaryTraceiP09889.

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG1409.
HOVERGENiHBG000433.
KOiK14379.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR024927. Acid_Pase_5.
IPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PIRSFiPIRSF000898. Acid_Ptase_5. 1 hit.
SUPFAMiSSF56300. SSF56300. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P09889-1 [UniParc]FASTAAdd to Basket

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MDTWTVLLIL QASLVLPGAV GTRTNTRTAP TPILRFVAVG DWGGVPNAPF    50
HTAREMANAK AIATTVKTLG ADFILSLGDN FYFTGVHDAK DKRFQETFED 100
VFSDPSLRNV PWHVLAGNHD HLGNVSAQIA YSKISKRWNF PSPYYRLRFK 150
IPRSNVSVAI FMLDTVTLCG NSDDFVSQQP ERPRNLALAR TQLAWIKKQL 200
AAAKEDYVLV AGHYPVWSIA EHGPTHCLVK QLLPLLTTHK VTAYLCGHDH 250
NLQYLQDENG LGFVLSGAGN FMDPSKKHLR KVPNGYLRFH FGAENSLGGF 300
AYVEITPKEM SVTYIEASGK SLFKTKLPRR ARSEHQHRRA 340
Length:340
Mass (Da):38,012
Last modified:October 1, 1993 - v4
Checksum:iCEE15351288179F7
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti183 – 1842Missing1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M98553 mRNA. Translation: AAA31129.1.
M30284 mRNA. Translation: AAA31139.1.
M30283 Genomic DNA. Translation: AAA31138.1.
AF292105 Genomic DNA. Translation: AAG10065.1.
M31214 mRNA. Translation: AAA31134.1.
M31215 mRNA. Translation: AAA31135.1.
S80099 mRNA. Translation: AAD14321.1.
PIRiA46096.
RefSeqiNP_999374.1. NM_214209.1.
UniGeneiSsc.575.

Genome annotation databases

GeneIDi397414.
KEGGissc:397414.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M98553 mRNA. Translation: AAA31129.1 .
M30284 mRNA. Translation: AAA31139.1 .
M30283 Genomic DNA. Translation: AAA31138.1 .
AF292105 Genomic DNA. Translation: AAG10065.1 .
M31214 mRNA. Translation: AAA31134.1 .
M31215 mRNA. Translation: AAA31135.1 .
S80099 mRNA. Translation: AAD14321.1 .
PIRi A46096.
RefSeqi NP_999374.1. NM_214209.1.
UniGenei Ssc.575.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1UTE X-ray 1.55 A 28-340 [» ]
ProteinModelPortali P09889.
SMRi P09889. Positions 30-331.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9823.ENSSSCP00000014466.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 397414.
KEGGi ssc:397414.

Organism-specific databases

CTDi 54.

Phylogenomic databases

eggNOGi COG1409.
HOVERGENi HBG000433.
KOi K14379.

Miscellaneous databases

EvolutionaryTracei P09889.
PMAP-CutDB P09889.

Family and domain databases

Gene3Di 3.60.21.10. 1 hit.
InterProi IPR024927. Acid_Pase_5.
IPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
[Graphical view ]
Pfami PF00149. Metallophos. 1 hit.
[Graphical view ]
PIRSFi PIRSF000898. Acid_Ptase_5. 1 hit.
SUPFAMi SSF56300. SSF56300. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Uteroferrin and intracellular tartrate-resistant acid phosphatases are the products of the same gene."
    Ling P., Roberts R.M.
    J. Biol. Chem. 268:6896-6902(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
    Tissue: Spleen.
  2. "cDNA sequence, gene organization, and progesterone induction of mRNA for uteroferrin, a porcine uterine iron transport protein."
    Simmen R.C.M., Srinivas V., Roberts R.M.
    DNA 8:543-554(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "Molecular cloning and temporal expression during pregnancy of the messenger ribonucleic acid encoding uteroferrin, a progesterone-induced uterine secretory protein."
    Simmen R.C.M., Baumbach G.A., Roberts R.M.
    Mol. Endocrinol. 2:253-262(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 186-215 AND 247-301.
  5. "Assignment of the uteroferrin gene (ACP5) to swine chromosome 2q12-q21 by fluorescence in situ hybridization."
    Yasue H., Kusumoto H., Mikami H.
    Cytogenet. Cell Genet. 71:249-252(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 108-195.
  6. "Sequence homology in the metalloproteins; purple acid phosphatase from beef spleen and uteroferrin from porcine uterus."
    Hunt D.F., Yates J.R. III, Shabanowitz J., Zhu N.-Z., Zirino T., Averill B.A., Daurat-Larroque S.T., Shewale J.G., Roberts R.M., Brew K.
    Biochem. Biophys. Res. Commun. 144:1154-1160(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL PROTEIN SEQUENCE.
  7. "Crystal structure of mammalian purple acid phosphatase."
    Guddat L.W., McAlpine A.S., Hume D., Hamilton S., de Jersey J., Martin J.L.
    Structure 7:757-767(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.55 ANGSTROMS) OF 28-340.

Entry informationi

Entry nameiPPA5_PIG
AccessioniPrimary (citable) accession number: P09889
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: October 1, 1993
Last modified: July 9, 2014
This is version 113 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

External Data

Dasty 3

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