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P09889

- PPA5_PIG

UniProt

P09889 - PPA5_PIG

Protein

Tartrate-resistant acid phosphatase type 5

Gene

ACP5

Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 4 (01 Oct 1993)
      Previous versions | rss
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    Functioni

    Uteroferrin is a phosphoprotein phosphatase, synthesized in response to progesterone. It appears to function in transplacental transport of iron in pig.

    Catalytic activityi

    A phosphate monoester + H2O = an alcohol + phosphate.

    Cofactori

    Binds 2 iron ions per subunit.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi41 – 411Iron 1
    Metal bindingi79 – 791Iron 1
    Metal bindingi79 – 791Iron 2
    Metal bindingi82 – 821Iron 1
    Metal bindingi118 – 1181Iron 2
    Metal bindingi213 – 2131Iron 2
    Metal bindingi248 – 2481Iron 2
    Metal bindingi250 – 2501Iron 1

    GO - Molecular functioni

    1. acid phosphatase activity Source: UniProtKB-EC
    2. ferric iron binding Source: UniProtKB
    3. ferrous iron binding Source: UniProtKB

    GO - Biological processi

    1. ion transport Source: UniProtKB-KW
    2. iron ion homeostasis Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Ion transport, Iron transport, Transport

    Keywords - Ligandi

    Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tartrate-resistant acid phosphatase type 5 (EC:3.1.3.2)
    Short name:
    TR-AP
    Alternative name(s):
    Tartrate-resistant acid ATPase
    Short name:
    TrATPase
    Type 5 acid phosphatase
    Uteroferrin
    Short name:
    UF
    Gene namesi
    Name:ACP5
    OrganismiSus scrofa (Pig)
    Taxonomic identifieri9823 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
    ProteomesiUP000008227: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Add
    BLAST
    Chaini21 – 340320Tartrate-resistant acid phosphatase type 5PRO_0000023984Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi124 – 1241N-linked (GlcNAc...)
    Glycosylationi155 – 1551N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi169 ↔ 227

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Miscellaneous databases

    PMAP-CutDBP09889.

    Interactioni

    Protein-protein interaction databases

    STRINGi9823.ENSSSCP00000014466.

    Structurei

    Secondary structure

    1
    340
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi34 – 396
    Helixi53 – 6917
    Beta strandi72 – 765
    Turni82 – 843
    Helixi93 – 975
    Turni98 – 1014
    Helixi105 – 1073
    Beta strandi112 – 1143
    Helixi118 – 1225
    Helixi125 – 1306
    Helixi131 – 1333
    Beta strandi142 – 1509
    Beta strandi157 – 1626
    Helixi165 – 1695
    Helixi172 – 1743
    Helixi186 – 20217
    Beta strandi206 – 2116
    Beta strandi220 – 2223
    Helixi226 – 2316
    Helixi233 – 2386
    Beta strandi242 – 2465
    Beta strandi248 – 2569
    Beta strandi262 – 2665
    Beta strandi268 – 2703
    Helixi279 – 2813
    Beta strandi287 – 2915
    Beta strandi299 – 3057
    Beta strandi310 – 3167
    Beta strandi321 – 3277

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1UTEX-ray1.55A28-340[»]
    ProteinModelPortaliP09889.
    SMRiP09889. Positions 30-331.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP09889.

    Family & Domainsi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG1409.
    HOVERGENiHBG000433.
    KOiK14379.

    Family and domain databases

    Gene3Di3.60.21.10. 1 hit.
    InterProiIPR024927. Acid_Pase_5.
    IPR004843. Calcineurin-like_PHP_apaH.
    IPR029052. Metallo-depent_PP-like.
    [Graphical view]
    PfamiPF00149. Metallophos. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000898. Acid_Ptase_5. 1 hit.
    SUPFAMiSSF56300. SSF56300. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P09889-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDTWTVLLIL QASLVLPGAV GTRTNTRTAP TPILRFVAVG DWGGVPNAPF    50
    HTAREMANAK AIATTVKTLG ADFILSLGDN FYFTGVHDAK DKRFQETFED 100
    VFSDPSLRNV PWHVLAGNHD HLGNVSAQIA YSKISKRWNF PSPYYRLRFK 150
    IPRSNVSVAI FMLDTVTLCG NSDDFVSQQP ERPRNLALAR TQLAWIKKQL 200
    AAAKEDYVLV AGHYPVWSIA EHGPTHCLVK QLLPLLTTHK VTAYLCGHDH 250
    NLQYLQDENG LGFVLSGAGN FMDPSKKHLR KVPNGYLRFH FGAENSLGGF 300
    AYVEITPKEM SVTYIEASGK SLFKTKLPRR ARSEHQHRRA 340
    Length:340
    Mass (Da):38,012
    Last modified:October 1, 1993 - v4
    Checksum:iCEE15351288179F7
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti183 – 1842Missing(PubMed:2598770)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M98553 mRNA. Translation: AAA31129.1.
    M30284 mRNA. Translation: AAA31139.1.
    M30283 Genomic DNA. Translation: AAA31138.1.
    AF292105 Genomic DNA. Translation: AAG10065.1.
    M31214 mRNA. Translation: AAA31134.1.
    M31215 mRNA. Translation: AAA31135.1.
    S80099 mRNA. Translation: AAD14321.1.
    PIRiA46096.
    RefSeqiNP_999374.1. NM_214209.1.
    UniGeneiSsc.575.

    Genome annotation databases

    GeneIDi397414.
    KEGGissc:397414.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M98553 mRNA. Translation: AAA31129.1 .
    M30284 mRNA. Translation: AAA31139.1 .
    M30283 Genomic DNA. Translation: AAA31138.1 .
    AF292105 Genomic DNA. Translation: AAG10065.1 .
    M31214 mRNA. Translation: AAA31134.1 .
    M31215 mRNA. Translation: AAA31135.1 .
    S80099 mRNA. Translation: AAD14321.1 .
    PIRi A46096.
    RefSeqi NP_999374.1. NM_214209.1.
    UniGenei Ssc.575.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1UTE X-ray 1.55 A 28-340 [» ]
    ProteinModelPortali P09889.
    SMRi P09889. Positions 30-331.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9823.ENSSSCP00000014466.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 397414.
    KEGGi ssc:397414.

    Organism-specific databases

    CTDi 54.

    Phylogenomic databases

    eggNOGi COG1409.
    HOVERGENi HBG000433.
    KOi K14379.

    Miscellaneous databases

    EvolutionaryTracei P09889.
    PMAP-CutDB P09889.

    Family and domain databases

    Gene3Di 3.60.21.10. 1 hit.
    InterProi IPR024927. Acid_Pase_5.
    IPR004843. Calcineurin-like_PHP_apaH.
    IPR029052. Metallo-depent_PP-like.
    [Graphical view ]
    Pfami PF00149. Metallophos. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000898. Acid_Ptase_5. 1 hit.
    SUPFAMi SSF56300. SSF56300. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Uteroferrin and intracellular tartrate-resistant acid phosphatases are the products of the same gene."
      Ling P., Roberts R.M.
      J. Biol. Chem. 268:6896-6902(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
      Tissue: Spleen.
    2. "cDNA sequence, gene organization, and progesterone induction of mRNA for uteroferrin, a porcine uterine iron transport protein."
      Simmen R.C.M., Srinivas V., Roberts R.M.
      DNA 8:543-554(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "Molecular cloning and temporal expression during pregnancy of the messenger ribonucleic acid encoding uteroferrin, a progesterone-induced uterine secretory protein."
      Simmen R.C.M., Baumbach G.A., Roberts R.M.
      Mol. Endocrinol. 2:253-262(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE OF 186-215 AND 247-301.
    5. "Assignment of the uteroferrin gene (ACP5) to swine chromosome 2q12-q21 by fluorescence in situ hybridization."
      Yasue H., Kusumoto H., Mikami H.
      Cytogenet. Cell Genet. 71:249-252(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE OF 108-195.
    6. "Sequence homology in the metalloproteins; purple acid phosphatase from beef spleen and uteroferrin from porcine uterus."
      Hunt D.F., Yates J.R. III, Shabanowitz J., Zhu N.-Z., Zirino T., Averill B.A., Daurat-Larroque S.T., Shewale J.G., Roberts R.M., Brew K.
      Biochem. Biophys. Res. Commun. 144:1154-1160(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: PARTIAL PROTEIN SEQUENCE.
    7. "Crystal structure of mammalian purple acid phosphatase."
      Guddat L.W., McAlpine A.S., Hume D., Hamilton S., de Jersey J., Martin J.L.
      Structure 7:757-767(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.55 ANGSTROMS) OF 28-340.

    Entry informationi

    Entry nameiPPA5_PIG
    AccessioniPrimary (citable) accession number: P09889
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: October 1, 1993
    Last modified: October 1, 2014
    This is version 114 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references

    External Data

    Dasty 3