Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P09889 (PPA5_PIG) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 111. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tartrate-resistant acid phosphatase type 5

Short name=TR-AP
EC=3.1.3.2
Alternative name(s):
Tartrate-resistant acid ATPase
Short name=TrATPase
Type 5 acid phosphatase
Uteroferrin
Short name=UF
Gene names
Name:ACP5
OrganismSus scrofa (Pig) [Reference proteome]
Taxonomic identifier9823 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus

Protein attributes

Sequence length340 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Uteroferrin is a phosphoprotein phosphatase, synthesized in response to progesterone. It appears to function in transplacental transport of iron in pig.

Catalytic activity

A phosphate monoester + H2O = an alcohol + phosphate.

Cofactor

Binds 2 iron ions per subunit.

Subcellular location

Secreted.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020
Chain21 – 340320Tartrate-resistant acid phosphatase type 5
PRO_0000023984

Sites

Metal binding411Iron 1
Metal binding791Iron 1
Metal binding791Iron 2
Metal binding821Iron 1
Metal binding1181Iron 2
Metal binding2131Iron 2
Metal binding2481Iron 2
Metal binding2501Iron 1

Amino acid modifications

Glycosylation1241N-linked (GlcNAc...)
Glycosylation1551N-linked (GlcNAc...) Potential
Disulfide bond169 ↔ 227

Experimental info

Sequence conflict183 – 1842Missing Ref.2

Secondary structure

......................................................... 340
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P09889 [UniParc].

Last modified October 1, 1993. Version 4.
Checksum: CEE15351288179F7

FASTA34038,012
        10         20         30         40         50         60 
MDTWTVLLIL QASLVLPGAV GTRTNTRTAP TPILRFVAVG DWGGVPNAPF HTAREMANAK 

        70         80         90        100        110        120 
AIATTVKTLG ADFILSLGDN FYFTGVHDAK DKRFQETFED VFSDPSLRNV PWHVLAGNHD 

       130        140        150        160        170        180 
HLGNVSAQIA YSKISKRWNF PSPYYRLRFK IPRSNVSVAI FMLDTVTLCG NSDDFVSQQP 

       190        200        210        220        230        240 
ERPRNLALAR TQLAWIKKQL AAAKEDYVLV AGHYPVWSIA EHGPTHCLVK QLLPLLTTHK 

       250        260        270        280        290        300 
VTAYLCGHDH NLQYLQDENG LGFVLSGAGN FMDPSKKHLR KVPNGYLRFH FGAENSLGGF 

       310        320        330        340 
AYVEITPKEM SVTYIEASGK SLFKTKLPRR ARSEHQHRRA 

« Hide

References

[1]"Uteroferrin and intracellular tartrate-resistant acid phosphatases are the products of the same gene."
Ling P., Roberts R.M.
J. Biol. Chem. 268:6896-6902(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
Tissue: Spleen.
[2]"cDNA sequence, gene organization, and progesterone induction of mRNA for uteroferrin, a porcine uterine iron transport protein."
Simmen R.C.M., Srinivas V., Roberts R.M.
DNA 8:543-554(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
[3]"Structure of the gene for uteroferrin."
Vallet J.L., Fahrenkrug S.C.
DNA Cell Biol. 19:689-696(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]"Molecular cloning and temporal expression during pregnancy of the messenger ribonucleic acid encoding uteroferrin, a progesterone-induced uterine secretory protein."
Simmen R.C.M., Baumbach G.A., Roberts R.M.
Mol. Endocrinol. 2:253-262(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE OF 186-215 AND 247-301.
[5]"Assignment of the uteroferrin gene (ACP5) to swine chromosome 2q12-q21 by fluorescence in situ hybridization."
Yasue H., Kusumoto H., Mikami H.
Cytogenet. Cell Genet. 71:249-252(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE OF 108-195.
[6]"Sequence homology in the metalloproteins; purple acid phosphatase from beef spleen and uteroferrin from porcine uterus."
Hunt D.F., Yates J.R. III, Shabanowitz J., Zhu N.-Z., Zirino T., Averill B.A., Daurat-Larroque S.T., Shewale J.G., Roberts R.M., Brew K.
Biochem. Biophys. Res. Commun. 144:1154-1160(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: PARTIAL PROTEIN SEQUENCE.
[7]"Crystal structure of mammalian purple acid phosphatase."
Guddat L.W., McAlpine A.S., Hume D., Hamilton S., de Jersey J., Martin J.L.
Structure 7:757-767(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.55 ANGSTROMS) OF 28-340.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M98553 mRNA. Translation: AAA31129.1.
M30284 mRNA. Translation: AAA31139.1.
M30283 Genomic DNA. Translation: AAA31138.1.
AF292105 Genomic DNA. Translation: AAG10065.1.
M31214 mRNA. Translation: AAA31134.1.
M31215 mRNA. Translation: AAA31135.1.
S80099 mRNA. Translation: AAD14321.1.
PIRA46096.
RefSeqNP_999374.1. NM_214209.1.
UniGeneSsc.575.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1UTEX-ray1.55A28-340[»]
ProteinModelPortalP09889.
SMRP09889. Positions 30-331.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9823.ENSSSCP00000014466.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID397414.
KEGGssc:397414.

Organism-specific databases

CTD54.

Phylogenomic databases

eggNOGCOG1409.
HOVERGENHBG000433.
KOK14379.

Family and domain databases

InterProIPR024927. Acid_Pase_5.
IPR004843. Calcineurin-like_PHP_apaH.
[Graphical view]
PfamPF00149. Metallophos. 1 hit.
[Graphical view]
PIRSFPIRSF000898. Acid_Ptase_5. 1 hit.
ProtoNetSearch...

Other

EvolutionaryTraceP09889.
PMAP-CutDBP09889.

Entry information

Entry namePPA5_PIG
AccessionPrimary (citable) accession number: P09889
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: October 1, 1993
Last modified: April 16, 2014
This is version 111 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references