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Protein

Tartrate-resistant acid phosphatase type 5

Gene

ACP5

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Uteroferrin is a phosphoprotein phosphatase, synthesized in response to progesterone. It appears to function in transplacental transport of iron in pig.

Catalytic activityi

A phosphate monoester + H2O = an alcohol + phosphate.

Cofactori

Fe cationNote: Binds 2 iron ions per subunit.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi41Iron 11
Metal bindingi79Iron 11
Metal bindingi79Iron 21
Metal bindingi82Iron 11
Metal bindingi118Iron 21
Metal bindingi213Iron 21
Metal bindingi248Iron 21
Metal bindingi250Iron 11

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Ion transport, Iron transport, Transport

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BRENDAi3.1.3.2. 6170.

Names & Taxonomyi

Protein namesi
Recommended name:
Tartrate-resistant acid phosphatase type 5 (EC:3.1.3.2)
Short name:
TR-AP
Alternative name(s):
Tartrate-resistant acid ATPase
Short name:
TrATPase
Type 5 acid phosphatase
Uteroferrin
Short name:
UF
Gene namesi
Name:ACP5
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Add BLAST20
ChainiPRO_000002398421 – 340Tartrate-resistant acid phosphatase type 5Add BLAST320

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi124N-linked (GlcNAc...)1
Glycosylationi155N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi169 ↔ 227

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP09889.
PeptideAtlasiP09889.
PRIDEiP09889.

Miscellaneous databases

PMAP-CutDBP09889.

Interactioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000014466.

Structurei

Secondary structure

1340
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi34 – 39Combined sources6
Helixi53 – 69Combined sources17
Beta strandi72 – 76Combined sources5
Turni82 – 84Combined sources3
Helixi93 – 97Combined sources5
Turni98 – 101Combined sources4
Helixi105 – 107Combined sources3
Beta strandi112 – 114Combined sources3
Helixi118 – 122Combined sources5
Helixi125 – 130Combined sources6
Helixi131 – 133Combined sources3
Beta strandi142 – 150Combined sources9
Beta strandi157 – 162Combined sources6
Helixi165 – 169Combined sources5
Helixi172 – 174Combined sources3
Helixi186 – 202Combined sources17
Beta strandi206 – 211Combined sources6
Beta strandi220 – 222Combined sources3
Helixi226 – 231Combined sources6
Helixi233 – 238Combined sources6
Beta strandi242 – 246Combined sources5
Beta strandi248 – 256Combined sources9
Beta strandi262 – 266Combined sources5
Beta strandi268 – 270Combined sources3
Helixi279 – 281Combined sources3
Beta strandi287 – 291Combined sources5
Beta strandi299 – 305Combined sources7
Beta strandi310 – 316Combined sources7
Beta strandi321 – 327Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1UTEX-ray1.55A28-340[»]
ProteinModelPortaliP09889.
SMRiP09889.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP09889.

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2679. Eukaryota.
COG1409. LUCA.
HOVERGENiHBG000433.
InParanoidiP09889.
KOiK14379.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR024927. Acid_Pase_5.
IPR004843. Calcineurin-like_PHP_ApaH.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PIRSFiPIRSF000898. Acid_Ptase_5. 1 hit.
SUPFAMiSSF56300. SSF56300. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P09889-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTWTVLLIL QASLVLPGAV GTRTNTRTAP TPILRFVAVG DWGGVPNAPF
60 70 80 90 100
HTAREMANAK AIATTVKTLG ADFILSLGDN FYFTGVHDAK DKRFQETFED
110 120 130 140 150
VFSDPSLRNV PWHVLAGNHD HLGNVSAQIA YSKISKRWNF PSPYYRLRFK
160 170 180 190 200
IPRSNVSVAI FMLDTVTLCG NSDDFVSQQP ERPRNLALAR TQLAWIKKQL
210 220 230 240 250
AAAKEDYVLV AGHYPVWSIA EHGPTHCLVK QLLPLLTTHK VTAYLCGHDH
260 270 280 290 300
NLQYLQDENG LGFVLSGAGN FMDPSKKHLR KVPNGYLRFH FGAENSLGGF
310 320 330 340
AYVEITPKEM SVTYIEASGK SLFKTKLPRR ARSEHQHRRA
Length:340
Mass (Da):38,012
Last modified:October 1, 1993 - v4
Checksum:iCEE15351288179F7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti183 – 184Missing (PubMed:2598770).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M98553 mRNA. Translation: AAA31129.1.
M30284 mRNA. Translation: AAA31139.1.
M30283 Genomic DNA. Translation: AAA31138.1.
AF292105 Genomic DNA. Translation: AAG10065.1.
M31214 mRNA. Translation: AAA31134.1.
M31215 mRNA. Translation: AAA31135.1.
S80099 mRNA. Translation: AAD14321.1.
PIRiA46096.
RefSeqiNP_999374.1. NM_214209.1.
UniGeneiSsc.575.

Genome annotation databases

GeneIDi397414.
KEGGissc:397414.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M98553 mRNA. Translation: AAA31129.1.
M30284 mRNA. Translation: AAA31139.1.
M30283 Genomic DNA. Translation: AAA31138.1.
AF292105 Genomic DNA. Translation: AAG10065.1.
M31214 mRNA. Translation: AAA31134.1.
M31215 mRNA. Translation: AAA31135.1.
S80099 mRNA. Translation: AAD14321.1.
PIRiA46096.
RefSeqiNP_999374.1. NM_214209.1.
UniGeneiSsc.575.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1UTEX-ray1.55A28-340[»]
ProteinModelPortaliP09889.
SMRiP09889.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000014466.

Proteomic databases

PaxDbiP09889.
PeptideAtlasiP09889.
PRIDEiP09889.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi397414.
KEGGissc:397414.

Organism-specific databases

CTDi54.

Phylogenomic databases

eggNOGiKOG2679. Eukaryota.
COG1409. LUCA.
HOVERGENiHBG000433.
InParanoidiP09889.
KOiK14379.

Enzyme and pathway databases

BRENDAi3.1.3.2. 6170.

Miscellaneous databases

EvolutionaryTraceiP09889.
PMAP-CutDBP09889.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR024927. Acid_Pase_5.
IPR004843. Calcineurin-like_PHP_ApaH.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PIRSFiPIRSF000898. Acid_Ptase_5. 1 hit.
SUPFAMiSSF56300. SSF56300. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPPA5_PIG
AccessioniPrimary (citable) accession number: P09889
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: October 1, 1993
Last modified: November 30, 2016
This is version 126 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.