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Protein

UDP-glucuronosyltransferase 2B1

Gene

Ugt2b1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.

Catalytic activityi

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

GO - Molecular functioni

  • glucuronosyltransferase activity Source: RGD

GO - Biological processi

  • biphenyl catabolic process Source: RGD
  • cellular response to ethanol Source: RGD
  • cellular response to glucocorticoid stimulus Source: RGD
  • cellular response to growth hormone stimulus Source: RGD
  • cellular response to testosterone stimulus Source: RGD
  • drug metabolic process Source: RGD
  • response to lipopolysaccharide Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

BRENDAi2.4.1.17. 5301.
SABIO-RKP09875.

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucuronosyltransferase 2B1 (EC:2.4.1.17)
Short name:
UDPGT 2B1
Alternative name(s):
UDPGTr-2
Gene namesi
Name:Ugt2b1
Synonyms:Udpgtr2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 14

Organism-specific databases

RGDi708541. Ugt2b1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei494 – 510HelicalSequence analysisAdd BLAST17

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23By similarityAdd BLAST23
ChainiPRO_000003602524 – 529UDP-glucuronosyltransferase 2B1Add BLAST506

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi134N-linked (GlcNAc...)Sequence analysis1
Glycosylationi316N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP09875.
PRIDEiP09875.

PTM databases

iPTMnetiP09875.
PhosphoSitePlusiP09875.

Expressioni

Inductioni

By phenobarbital.

Gene expression databases

ExpressionAtlasiP09875. baseline and differential.
GenevisibleiP09875. RN.

Interactioni

Protein-protein interaction databases

MINTiMINT-4570571.
STRINGi10116.ENSRNOP00000002724.

Structurei

3D structure databases

ProteinModelPortaliP09875.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UDP-glycosyltransferase family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1192. Eukaryota.
COG1819. LUCA.
GeneTreeiENSGT00760000118949.
HOGENOMiHOG000220831.
HOVERGENiHBG004033.
InParanoidiP09875.
KOiK00699.
OMAiNTISGMM.
PhylomeDBiP09875.
TreeFamiTF315472.

Family and domain databases

InterProiIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEiPS00375. UDPGT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P09875-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSMKQTSVFL LIQLICYFRP GACGKVLVWP TEYSHWINIK IILNELAQRG
60 70 80 90 100
HEVTVLVSSA SILIEPTKES SINFEIYSVP LSKSDLEYSF AKWIDEWTRD
110 120 130 140 150
FETLSIWTYY SKMQKVFNEY SDVVENLCKA LIWNKSLMKK LQGSQFDVIL
160 170 180 190 200
ADAVGPCGEL LAELLKTPLV YSLRFCPGYR CEKFSGGLPL PPSYVPVVLS
210 220 230 240 250
ELSDRMTFVE RVKNMLQMLY FDFWFQPFKE KSWSQFYSDV LGRPTTLTEM
260 270 280 290 300
MGKADIWLIR TFWDLEFPHP FLPNFDFVGG LHCKPAKPLP REMEEFVQSS
310 320 330 340 350
GEHGVVVFSL GSMVKNLTEE KANVVASALA QIPQKVVWRF DGKKPDTLGS
360 370 380 390 400
NTRLYKWIPQ NDLLGHPKTK AFVAHGGTNG IYEAIYHGIP IVGIPLFADQ
410 420 430 440 450
PDNINHMVAK GAAVRVDFSI LSTTGLLTAL KIVMNDPSYK ENAMRLSRIH
460 470 480 490 500
HDQPVKPLDR AVFWIEYVMR HKGAKHLRST LHDLSWFQYH SLDVIGFLLL
510 520
CVVGVVFIIT KFCLFCCRKT ANMGKKKKE
Length:529
Mass (Da):60,485
Last modified:July 1, 1989 - v1
Checksum:i14DF0224BF1C3044
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13506 mRNA. Translation: AAA42313.1.
M35086
, M35202, M35080, M35082, M35083 Genomic DNA. Translation: AAA42310.1.
PIRiA42233.
RefSeqiNP_775417.1. NM_173295.1.
UniGeneiRn.9969.

Genome annotation databases

EnsembliENSRNOT00000002724; ENSRNOP00000002724; ENSRNOG00000001990.
GeneIDi286954.
KEGGirno:286954.
UCSCiRGD:708541. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13506 mRNA. Translation: AAA42313.1.
M35086
, M35202, M35080, M35082, M35083 Genomic DNA. Translation: AAA42310.1.
PIRiA42233.
RefSeqiNP_775417.1. NM_173295.1.
UniGeneiRn.9969.

3D structure databases

ProteinModelPortaliP09875.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4570571.
STRINGi10116.ENSRNOP00000002724.

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

PTM databases

iPTMnetiP09875.
PhosphoSitePlusiP09875.

Proteomic databases

PaxDbiP09875.
PRIDEiP09875.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000002724; ENSRNOP00000002724; ENSRNOG00000001990.
GeneIDi286954.
KEGGirno:286954.
UCSCiRGD:708541. rat.

Organism-specific databases

CTDi71773.
RGDi708541. Ugt2b1.

Phylogenomic databases

eggNOGiKOG1192. Eukaryota.
COG1819. LUCA.
GeneTreeiENSGT00760000118949.
HOGENOMiHOG000220831.
HOVERGENiHBG004033.
InParanoidiP09875.
KOiK00699.
OMAiNTISGMM.
PhylomeDBiP09875.
TreeFamiTF315472.

Enzyme and pathway databases

BRENDAi2.4.1.17. 5301.
SABIO-RKP09875.

Miscellaneous databases

PROiP09875.

Gene expression databases

ExpressionAtlasiP09875. baseline and differential.
GenevisibleiP09875. RN.

Family and domain databases

InterProiIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEiPS00375. UDPGT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUD2B1_RAT
AccessioniPrimary (citable) accession number: P09875
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: November 2, 2016
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.