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P09875

- UD2B1_RAT

UniProt

P09875 - UD2B1_RAT

Protein

UDP-glucuronosyltransferase 2B1

Gene

Ugt2b1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 1 (01 Jul 1989)
      Previous versions | rss
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    Functioni

    UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.

    Catalytic activityi

    UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

    GO - Molecular functioni

    1. glucuronosyltransferase activity Source: RGD

    GO - Biological processi

    1. biphenyl catabolic process Source: RGD
    2. cellular response to ethanol Source: RGD
    3. cellular response to glucocorticoid stimulus Source: RGD
    4. cellular response to growth hormone stimulus Source: RGD
    5. cellular response to testosterone stimulus Source: RGD
    6. drug metabolic process Source: RGD
    7. response to lipopolysaccharide Source: RGD

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Enzyme and pathway databases

    BRENDAi2.4.1.17. 5301.
    SABIO-RKP09875.

    Protein family/group databases

    CAZyiGT1. Glycosyltransferase Family 1.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UDP-glucuronosyltransferase 2B1 (EC:2.4.1.17)
    Short name:
    UDPGT 2B1
    Alternative name(s):
    UDPGTr-2
    Gene namesi
    Name:Ugt2b1
    Synonyms:Udpgtr2
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi708541. Ugt2b1.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW
    3. intracellular membrane-bounded organelle Source: RGD

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323By similarityAdd
    BLAST
    Chaini24 – 529506UDP-glucuronosyltransferase 2B1PRO_0000036025Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi134 – 1341N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi316 – 3161N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiP09875.
    PRIDEiP09875.

    Expressioni

    Inductioni

    By phenobarbital.

    Gene expression databases

    GenevestigatoriP09875.

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-4570571.
    STRINGi10116.ENSRNOP00000002724.

    Structurei

    3D structure databases

    ProteinModelPortaliP09875.
    SMRiP09875. Positions 286-447.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei494 – 51017HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UDP-glycosyltransferase family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1819.
    HOGENOMiHOG000220831.
    HOVERGENiHBG004033.
    InParanoidiP09875.
    KOiK00699.
    PhylomeDBiP09875.
    TreeFamiTF315472.

    Family and domain databases

    InterProiIPR002213. UDP_glucos_trans.
    [Graphical view]
    PANTHERiPTHR11926. PTHR11926. 1 hit.
    PfamiPF00201. UDPGT. 1 hit.
    [Graphical view]
    PROSITEiPS00375. UDPGT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P09875-1 [UniParc]FASTAAdd to Basket

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    MSMKQTSVFL LIQLICYFRP GACGKVLVWP TEYSHWINIK IILNELAQRG    50
    HEVTVLVSSA SILIEPTKES SINFEIYSVP LSKSDLEYSF AKWIDEWTRD 100
    FETLSIWTYY SKMQKVFNEY SDVVENLCKA LIWNKSLMKK LQGSQFDVIL 150
    ADAVGPCGEL LAELLKTPLV YSLRFCPGYR CEKFSGGLPL PPSYVPVVLS 200
    ELSDRMTFVE RVKNMLQMLY FDFWFQPFKE KSWSQFYSDV LGRPTTLTEM 250
    MGKADIWLIR TFWDLEFPHP FLPNFDFVGG LHCKPAKPLP REMEEFVQSS 300
    GEHGVVVFSL GSMVKNLTEE KANVVASALA QIPQKVVWRF DGKKPDTLGS 350
    NTRLYKWIPQ NDLLGHPKTK AFVAHGGTNG IYEAIYHGIP IVGIPLFADQ 400
    PDNINHMVAK GAAVRVDFSI LSTTGLLTAL KIVMNDPSYK ENAMRLSRIH 450
    HDQPVKPLDR AVFWIEYVMR HKGAKHLRST LHDLSWFQYH SLDVIGFLLL 500
    CVVGVVFIIT KFCLFCCRKT ANMGKKKKE 529
    Length:529
    Mass (Da):60,485
    Last modified:July 1, 1989 - v1
    Checksum:i14DF0224BF1C3044
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M13506 mRNA. Translation: AAA42313.1.
    M35086
    , M35202, M35080, M35082, M35083 Genomic DNA. Translation: AAA42310.1.
    PIRiA42233.
    RefSeqiNP_775417.1. NM_173295.1.
    UniGeneiRn.9969.

    Genome annotation databases

    GeneIDi286954.
    KEGGirno:286954.
    UCSCiRGD:708541. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M13506 mRNA. Translation: AAA42313.1 .
    M35086
    , M35202 , M35080 , M35082 , M35083 Genomic DNA. Translation: AAA42310.1 .
    PIRi A42233.
    RefSeqi NP_775417.1. NM_173295.1.
    UniGenei Rn.9969.

    3D structure databases

    ProteinModelPortali P09875.
    SMRi P09875. Positions 286-447.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-4570571.
    STRINGi 10116.ENSRNOP00000002724.

    Protein family/group databases

    CAZyi GT1. Glycosyltransferase Family 1.

    Proteomic databases

    PaxDbi P09875.
    PRIDEi P09875.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 286954.
    KEGGi rno:286954.
    UCSCi RGD:708541. rat.

    Organism-specific databases

    CTDi 71773.
    RGDi 708541. Ugt2b1.

    Phylogenomic databases

    eggNOGi COG1819.
    HOGENOMi HOG000220831.
    HOVERGENi HBG004033.
    InParanoidi P09875.
    KOi K00699.
    PhylomeDBi P09875.
    TreeFami TF315472.

    Enzyme and pathway databases

    BRENDAi 2.4.1.17. 5301.
    SABIO-RK P09875.

    Miscellaneous databases

    NextBioi 625139.

    Gene expression databases

    Genevestigatori P09875.

    Family and domain databases

    InterProi IPR002213. UDP_glucos_trans.
    [Graphical view ]
    PANTHERi PTHR11926. PTHR11926. 1 hit.
    Pfami PF00201. UDPGT. 1 hit.
    [Graphical view ]
    PROSITEi PS00375. UDPGT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Rat liver UDP-glucuronosyltransferase. Sequence and expression of a cDNA encoding a phenobarbital-inducible form."
      McKenzie P.I.
      J. Biol. Chem. 261:6119-6125(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.
    2. "Organization of the rat UDP-glucuronosyltransferase, UDPGTr-2, gene and characterization of its promoter."
      McKenzie P.I., Rodbourn L.
      J. Biol. Chem. 265:11328-11332(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiUD2B1_RAT
    AccessioniPrimary (citable) accession number: P09875
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: July 1, 1989
    Last modified: October 1, 2014
    This is version 112 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3