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P09875 (UD2B1_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
UDP-glucuronosyltransferase 2B1
Short name=UDPGT 2B1
EC=2.4.1.17
Alternative name(s):
UDPGTr-2
Gene names
Name:Ugt2b1
Synonyms:Udpgtr2
OrganismRattus norvegicus (Rat)
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length529 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.

Catalytic activity

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

Subcellular location

Microsome membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein Potential.

Induction

By phenobarbital.

Sequence similarities

Belongs to the UDP-glycosyltransferase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 By similarity
Chain24 – 529506UDP-glucuronosyltransferase 2B1
PRO_0000036025

Regions

Transmembrane494 – 51017Helical; Potential

Amino acid modifications

Glycosylation1341N-linked (GlcNAc...) Potential
Glycosylation3161N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
P09875 [UniParc].

Last modified July 1, 1989. Version 1.
Checksum: 14DF0224BF1C3044

FASTA52960,485
        10         20         30         40         50         60 
MSMKQTSVFL LIQLICYFRP GACGKVLVWP TEYSHWINIK IILNELAQRG HEVTVLVSSA 

        70         80         90        100        110        120 
SILIEPTKES SINFEIYSVP LSKSDLEYSF AKWIDEWTRD FETLSIWTYY SKMQKVFNEY 

       130        140        150        160        170        180 
SDVVENLCKA LIWNKSLMKK LQGSQFDVIL ADAVGPCGEL LAELLKTPLV YSLRFCPGYR 

       190        200        210        220        230        240 
CEKFSGGLPL PPSYVPVVLS ELSDRMTFVE RVKNMLQMLY FDFWFQPFKE KSWSQFYSDV 

       250        260        270        280        290        300 
LGRPTTLTEM MGKADIWLIR TFWDLEFPHP FLPNFDFVGG LHCKPAKPLP REMEEFVQSS 

       310        320        330        340        350        360 
GEHGVVVFSL GSMVKNLTEE KANVVASALA QIPQKVVWRF DGKKPDTLGS NTRLYKWIPQ 

       370        380        390        400        410        420 
NDLLGHPKTK AFVAHGGTNG IYEAIYHGIP IVGIPLFADQ PDNINHMVAK GAAVRVDFSI 

       430        440        450        460        470        480 
LSTTGLLTAL KIVMNDPSYK ENAMRLSRIH HDQPVKPLDR AVFWIEYVMR HKGAKHLRST 

       490        500        510        520 
LHDLSWFQYH SLDVIGFLLL CVVGVVFIIT KFCLFCCRKT ANMGKKKKE

« Hide

References

[1]"Rat liver UDP-glucuronosyltransferase. Sequence and expression of a cDNA encoding a phenobarbital-inducible form."
McKenzie P.I.
J. Biol. Chem. 261:6119-6125(1986) [PubMed: 3084479] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.
[2]"Organization of the rat UDP-glucuronosyltransferase, UDPGTr-2, gene and characterization of its promoter."
McKenzie P.I., Rodbourn L.
J. Biol. Chem. 265:11328-11332(1990) [PubMed: 2113533] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		M13506 mRNA. Translation: AAA42313.1.
M35086 expand/collapse EMBL AC list , M35202, M35080, M35082, M35083 Genomic DNA. Translation: AAA42310.1.
IPIIPI00190402.
PIRA42233.
RefSeqNP_775417.1. NM_173295.1.
UniGeneRn.9969.

3D structure databases

ProteinModelPortalP09875.
SMRP09875. Positions 286-447.
ModBaseSearch...

Protein-protein interaction databases

STRINGP09875.

Protein family/group databases

CAZyGT1. Glycosyltransferase Family 1.

Proteomic databases

PRIDEP09875.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000002724; ENSRNOP00000002724; ENSRNOG00000001990.
GeneID286954.
KEGGrno:286954.
UCSCNM_173295. rat.

Organism-specific databases

CTD71773.
RGD708541. Ugt2b1.

Phylogenomic databases

eggNOGroNOG13826.
GeneTreeENSGT00560000076681.
HOVERGENHBG004033.
InParanoidP09875.
OMAAIEKHSG.
OrthoDBEOG4SJ5DW.
PhylomeDBP09875.

Enzyme and pathway databases

BRENDA2.4.1.17. 5301.

Gene expression databases

ArrayExpressP09875.
GenevestigatorP09875.
GermOnlineENSRNOG00000001990. Rattus norvegicus.

Family and domain databases

InterProIPR002213. UDP_glucos_trans.
[Graphical view]
KOK00699.
PANTHERPTHR11926. UDP_glucos_trans. 1 hit.
PfamPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEPS00375. UDPGT. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio625139.

Entry information

Entry nameUD2B1_RAT
AccessionPrimary (citable) accession number: P09875
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: November 16, 2011
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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