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P09875

- UD2B1_RAT

UniProt

P09875 - UD2B1_RAT

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Protein
UDP-glucuronosyltransferase 2B1
Gene
Ugt2b1, Udpgtr2
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.

Catalytic activityi

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

GO - Molecular functioni

  1. glucuronosyltransferase activity Source: RGD
Complete GO annotation...

GO - Biological processi

  1. biphenyl catabolic process Source: RGD
  2. cellular response to ethanol Source: RGD
  3. cellular response to glucocorticoid stimulus Source: RGD
  4. cellular response to growth hormone stimulus Source: RGD
  5. cellular response to testosterone stimulus Source: RGD
  6. drug metabolic process Source: RGD
  7. response to lipopolysaccharide Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

BRENDAi2.4.1.17. 5301.
SABIO-RKiP09875.

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucuronosyltransferase 2B1 (EC:2.4.1.17)
Short name:
UDPGT 2B1
Alternative name(s):
UDPGTr-2
Gene namesi
Name:Ugt2b1
Synonyms:Udpgtr2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi708541. Ugt2b1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei494 – 51017Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
  3. intracellular membrane-bounded organelle Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323 By similarity
Add
BLAST
Chaini24 – 529506UDP-glucuronosyltransferase 2B1
PRO_0000036025Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi134 – 1341N-linked (GlcNAc...) Reviewed prediction
Glycosylationi316 – 3161N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP09875.
PRIDEiP09875.

Expressioni

Inductioni

By phenobarbital.

Gene expression databases

GenevestigatoriP09875.

Interactioni

Protein-protein interaction databases

MINTiMINT-4570571.
STRINGi10116.ENSRNOP00000002724.

Structurei

3D structure databases

ProteinModelPortaliP09875.
SMRiP09875. Positions 286-447.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1819.
HOGENOMiHOG000220831.
HOVERGENiHBG004033.
InParanoidiP09875.
KOiK00699.
PhylomeDBiP09875.
TreeFamiTF315472.

Family and domain databases

InterProiIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEiPS00375. UDPGT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P09875-1 [UniParc]FASTAAdd to Basket

« Hide

MSMKQTSVFL LIQLICYFRP GACGKVLVWP TEYSHWINIK IILNELAQRG    50
HEVTVLVSSA SILIEPTKES SINFEIYSVP LSKSDLEYSF AKWIDEWTRD 100
FETLSIWTYY SKMQKVFNEY SDVVENLCKA LIWNKSLMKK LQGSQFDVIL 150
ADAVGPCGEL LAELLKTPLV YSLRFCPGYR CEKFSGGLPL PPSYVPVVLS 200
ELSDRMTFVE RVKNMLQMLY FDFWFQPFKE KSWSQFYSDV LGRPTTLTEM 250
MGKADIWLIR TFWDLEFPHP FLPNFDFVGG LHCKPAKPLP REMEEFVQSS 300
GEHGVVVFSL GSMVKNLTEE KANVVASALA QIPQKVVWRF DGKKPDTLGS 350
NTRLYKWIPQ NDLLGHPKTK AFVAHGGTNG IYEAIYHGIP IVGIPLFADQ 400
PDNINHMVAK GAAVRVDFSI LSTTGLLTAL KIVMNDPSYK ENAMRLSRIH 450
HDQPVKPLDR AVFWIEYVMR HKGAKHLRST LHDLSWFQYH SLDVIGFLLL 500
CVVGVVFIIT KFCLFCCRKT ANMGKKKKE 529
Length:529
Mass (Da):60,485
Last modified:July 1, 1989 - v1
Checksum:i14DF0224BF1C3044
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M13506 mRNA. Translation: AAA42313.1.
M35086
, M35202, M35080, M35082, M35083 Genomic DNA. Translation: AAA42310.1.
PIRiA42233.
RefSeqiNP_775417.1. NM_173295.1.
UniGeneiRn.9969.

Genome annotation databases

GeneIDi286954.
KEGGirno:286954.
UCSCiRGD:708541. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M13506 mRNA. Translation: AAA42313.1 .
M35086
, M35202 , M35080 , M35082 , M35083 Genomic DNA. Translation: AAA42310.1 .
PIRi A42233.
RefSeqi NP_775417.1. NM_173295.1.
UniGenei Rn.9969.

3D structure databases

ProteinModelPortali P09875.
SMRi P09875. Positions 286-447.
ModBasei Search...

Protein-protein interaction databases

MINTi MINT-4570571.
STRINGi 10116.ENSRNOP00000002724.

Protein family/group databases

CAZyi GT1. Glycosyltransferase Family 1.

Proteomic databases

PaxDbi P09875.
PRIDEi P09875.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 286954.
KEGGi rno:286954.
UCSCi RGD:708541. rat.

Organism-specific databases

CTDi 71773.
RGDi 708541. Ugt2b1.

Phylogenomic databases

eggNOGi COG1819.
HOGENOMi HOG000220831.
HOVERGENi HBG004033.
InParanoidi P09875.
KOi K00699.
PhylomeDBi P09875.
TreeFami TF315472.

Enzyme and pathway databases

BRENDAi 2.4.1.17. 5301.
SABIO-RKi P09875.

Miscellaneous databases

NextBioi 625139.

Gene expression databases

Genevestigatori P09875.

Family and domain databases

InterProi IPR002213. UDP_glucos_trans.
[Graphical view ]
PANTHERi PTHR11926. PTHR11926. 1 hit.
Pfami PF00201. UDPGT. 1 hit.
[Graphical view ]
PROSITEi PS00375. UDPGT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Rat liver UDP-glucuronosyltransferase. Sequence and expression of a cDNA encoding a phenobarbital-inducible form."
    McKenzie P.I.
    J. Biol. Chem. 261:6119-6125(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  2. "Organization of the rat UDP-glucuronosyltransferase, UDPGTr-2, gene and characterization of its promoter."
    McKenzie P.I., Rodbourn L.
    J. Biol. Chem. 265:11328-11332(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiUD2B1_RAT
AccessioniPrimary (citable) accession number: P09875
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: April 16, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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