Reviewed, UniProtKB/Swiss-Prot P09875 (UD2B1_RAT)

Names and origin

Protein names

Recommended name:
    UDP-glucuronosyltransferase 2B1
      Short name=UDPGT 2B1
      Short name=UDPGTr-2
    EC=2.4.1.17

Gene names

Name:	Ugt2b1
Synonyms:	Udpgtr2

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	529 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.
Catalytic activity	UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.
Subcellular location	Microsome membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein Potential.
Induction	By phenobarbital.
Sequence similarities	Belongs to the UDP-glycosyltransferase family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane Microsome
Domain	Signal Transmembrane
Molecular function	Glycosyltransferase Transferase
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	drug metabolic process Ref.1 Traceable author statement. Source: RGD
Cellular component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW microsome Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glucuronosyltransferase activity Ref.1 Inferred from mutant phenotype. Source: RGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 23	23	By similarity
	Chain	24 – 529	506	UDP-glucuronosyltransferase 2B1		PRO_0000036025
Regions
	Transmembrane	494 – 510	17	Potential
Amino acid modifications
	Glycosylation	134	1	N-linked (GlcNAc...) Potential
	Glycosylation	316	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	P09875-1 [UniParc]. Last modified July 1, 1989. Version 1. Checksum: 14DF0224BF1C3044	FASTA	529	60,485
	10 20 30 40 50 60 MSMKQTSVFL LIQLICYFRP GACGKVLVWP TEYSHWINIK IILNELAQRG HEVTVLVSSA 70 80 90 100 110 120 SILIEPTKES SINFEIYSVP LSKSDLEYSF AKWIDEWTRD FETLSIWTYY SKMQKVFNEY 130 140 150 160 170 180 SDVVENLCKA LIWNKSLMKK LQGSQFDVIL ADAVGPCGEL LAELLKTPLV YSLRFCPGYR 190 200 210 220 230 240 CEKFSGGLPL PPSYVPVVLS ELSDRMTFVE RVKNMLQMLY FDFWFQPFKE KSWSQFYSDV 250 260 270 280 290 300 LGRPTTLTEM MGKADIWLIR TFWDLEFPHP FLPNFDFVGG LHCKPAKPLP REMEEFVQSS 310 320 330 340 350 360 GEHGVVVFSL GSMVKNLTEE KANVVASALA QIPQKVVWRF DGKKPDTLGS NTRLYKWIPQ 370 380 390 400 410 420 NDLLGHPKTK AFVAHGGTNG IYEAIYHGIP IVGIPLFADQ PDNINHMVAK GAAVRVDFSI 430 440 450 460 470 480 LSTTGLLTAL KIVMNDPSYK ENAMRLSRIH HDQPVKPLDR AVFWIEYVMR HKGAKHLRST 490 500 510 520 LHDLSWFQYH SLDVIGFLLL CVVGVVFIIT KFCLFCCRKT ANMGKKKKE

References

[1]	"Rat liver UDP-glucuronosyltransferase. Sequence and expression of a cDNA encoding a phenobarbital-inducible form." McKenzie P.I. J. Biol. Chem. 261:6119-6125(1986) [PubMed: 3084479] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Liver.
[2]	"Organization of the rat UDP-glucuronosyltransferase, UDPGTr-2, gene and characterization of its promoter." McKenzie P.I., Rodbourn L. J. Biol. Chem. 265:11328-11332(1990) [PubMed: 2113533] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	M13506 mRNA. Translation: AAA42313.1. M35086 , M35202, M35080, M35082, M35083 Genomic DNA. Translation: AAA42310.1.
IPI	IPI00190402.
PIR	A42233.
RefSeq	NP_775417.1.
UniGene	Rn.9969
3D structure databases
SMR	P09875. Positions 286-447.
ModBase	Search...
Protein family/group databases
CAZy	GT1. Glycosyltransferase Family 1.
Proteomic databases
PRIDE	P09875.
Genome annotation databases
Ensembl	ENSRNOG00000001990. Rattus norvegicus. [Contig view]
GeneID	286954.
KEGG	rno:286954.
Organism-specific databases
RGD	708541. Ugt2b1.
Phylogenomic databases
HOVERGEN	P09875.
OMA	P09875. AIEKHSG.
Enzyme and pathway databases
BRENDA	2.4.1.17. 248.
Gene expression databases
ArrayExpress	P09875.
GermOnline	ENSRNOG00000001990. Rattus norvegicus.
Family and domain databases
InterPro	IPR002213. UDP_glucos_trans. [Graphical view]
PANTHER	PTHR11926. UDP_glucos_trans. 1 hit.
Pfam	PF00201. UDPGT. 1 hit. [Graphical view]
PROSITE	PS00375. UDPGT. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	625139.

Entry information

Entry name

UD2B1_RAT

Accession

Primary (citable) accession number: P09875

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
Last sequence update:	July 1, 1989
Last modified:	June 16, 2009
This is version 74 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)