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Protein

UDP-glucuronosyltransferase 2B1

Gene

Ugt2b1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.

Catalytic activityi

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

GO - Molecular functioni

  • glucuronosyltransferase activity Source: RGD

GO - Biological processi

  • biphenyl catabolic process Source: RGD
  • cellular glucuronidation Source: RGD
  • cellular response to ethanol Source: RGD
  • cellular response to glucocorticoid stimulus Source: RGD
  • cellular response to growth hormone stimulus Source: RGD
  • cellular response to testosterone stimulus Source: RGD
  • drug metabolic process Source: RGD
  • response to lipopolysaccharide Source: RGD

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

BRENDAi2.4.1.17 5301
ReactomeiR-RNO-156588 Glucuronidation
SABIO-RKiP09875

Protein family/group databases

CAZyiGT1 Glycosyltransferase Family 1

Chemistry databases

SwissLipidsiSLP:000001699

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucuronosyltransferase 2B1 (EC:2.4.1.17)
Short name:
UDPGT 2B1
Alternative name(s):
UDPGTr-2
Gene namesi
Name:Ugt2b1
Synonyms:Udpgtr2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 14

Organism-specific databases

RGDi708541 Ugt2b1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei494 – 510HelicalSequence analysisAdd BLAST17

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23By similarityAdd BLAST23
ChainiPRO_000003602524 – 529UDP-glucuronosyltransferase 2B1Add BLAST506

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi134N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi316N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP09875
PRIDEiP09875

PTM databases

iPTMnetiP09875
PhosphoSitePlusiP09875

Expressioni

Inductioni

By phenobarbital.

Gene expression databases

BgeeiENSRNOG00000001990
ExpressionAtlasiP09875 baseline and differential
GenevisibleiP09875 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000002724

Structurei

3D structure databases

ProteinModelPortaliP09875
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UDP-glycosyltransferase family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1192 Eukaryota
COG1819 LUCA
GeneTreeiENSGT00760000118949
HOGENOMiHOG000220831
HOVERGENiHBG004033
InParanoidiP09875
KOiK00699
OMAiRSQYIFV
PhylomeDBiP09875
TreeFamiTF315472

Family and domain databases

InterProiView protein in InterPro
IPR002213 UDP_glucos_trans
IPR035595 UDP_glycos_trans_CS
PfamiView protein in Pfam
PF00201 UDPGT, 1 hit
PROSITEiView protein in PROSITE
PS00375 UDPGT, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P09875-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSMKQTSVFL LIQLICYFRP GACGKVLVWP TEYSHWINIK IILNELAQRG
60 70 80 90 100
HEVTVLVSSA SILIEPTKES SINFEIYSVP LSKSDLEYSF AKWIDEWTRD
110 120 130 140 150
FETLSIWTYY SKMQKVFNEY SDVVENLCKA LIWNKSLMKK LQGSQFDVIL
160 170 180 190 200
ADAVGPCGEL LAELLKTPLV YSLRFCPGYR CEKFSGGLPL PPSYVPVVLS
210 220 230 240 250
ELSDRMTFVE RVKNMLQMLY FDFWFQPFKE KSWSQFYSDV LGRPTTLTEM
260 270 280 290 300
MGKADIWLIR TFWDLEFPHP FLPNFDFVGG LHCKPAKPLP REMEEFVQSS
310 320 330 340 350
GEHGVVVFSL GSMVKNLTEE KANVVASALA QIPQKVVWRF DGKKPDTLGS
360 370 380 390 400
NTRLYKWIPQ NDLLGHPKTK AFVAHGGTNG IYEAIYHGIP IVGIPLFADQ
410 420 430 440 450
PDNINHMVAK GAAVRVDFSI LSTTGLLTAL KIVMNDPSYK ENAMRLSRIH
460 470 480 490 500
HDQPVKPLDR AVFWIEYVMR HKGAKHLRST LHDLSWFQYH SLDVIGFLLL
510 520
CVVGVVFIIT KFCLFCCRKT ANMGKKKKE
Length:529
Mass (Da):60,485
Last modified:July 1, 1989 - v1
Checksum:i14DF0224BF1C3044
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13506 mRNA Translation: AAA42313.1
M35086
, M35202, M35080, M35082, M35083 Genomic DNA Translation: AAA42310.1
PIRiA42233
RefSeqiNP_775417.1, NM_173295.1
UniGeneiRn.9969

Genome annotation databases

EnsembliENSRNOT00000002724; ENSRNOP00000002724; ENSRNOG00000001990
GeneIDi286954
KEGGirno:286954
UCSCiRGD:708541 rat

Similar proteinsi

Entry informationi

Entry nameiUD2B1_RAT
AccessioniPrimary (citable) accession number: P09875
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: February 28, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome