Reviewed, UniProtKB/Swiss-Prot P09873 (CHYM_FELCA)

Names and origin

Protein names

Recommended name:
    Chymosin
    EC=3.4.23.4

Gene names

Name:

CYM

Organism

Felis catus (Cat) (Felis silvestris catus)

Taxonomic identifier

9685 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Carnivora › Feliformia › Felidae › Felinae › Felis

Protein attributes

Sequence length	54 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Chymosin is synthesized in the mucosa of the stomach. The enzyme hydrolyzes casein to paracasein.
Catalytic activity	Broad specificity similar to that of pepsin A. Clots milk by cleavage of a single 105-Ser-Phe-|-Met-Ala-108 bond in kappa-chain of casein.
Subunit structure	Monomer.
Sequence similarities	Belongs to the peptidase A1 family.

Ontologies

Keywords
Biological process	Digestion
Molecular function	Aspartyl protease Hydrolase Protease
PTM	Zymogen
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	digestion Inferred from electronic annotation. Source: UniProtKB-KW proteolysis Inferred from electronic annotation. Source: InterPro
Molecular function	aspartic-type endopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Propeptide	1 – 27	27	Activation peptide		PRO_0000025992
	Chain	28 – ›54	›27	Chymosin Ref.1		PRO_0000025993
Experimental info
	Non-terminal residue	54	1

Sequences

	Sequence		Length	Mass (Da)
	P09873-1 [UniParc]. Last modified July 1, 1989. Version 1. Checksum: 0E7D7DA3AC2AC474	FASTA	54	6,129
	10 20 30 40 50 SEITRVPLHK GKSLRKALKE HGLLEBFDKV SNEPLADFLD SEYFGKIYIG TPPZ

References

[1]	"Isolation and partial characterization of prochymosin and chymosin from cat." Jensen T., Axelsen N.H., Foltmann B. Biochim. Biophys. Acta 705:249-256(1982) [PubMed: 6810938] [Abstract] Cited for: PROTEIN SEQUENCE.

Cross-references

Sequence databases
PIR	A20146.
3D structure databases
ModBase	Search...
Protein family/group databases
MEROPS	A01.006.
Phylogenomic databases
eggNOG	maNOG16699.
HOVERGEN	P09873.
Enzyme and pathway databases
BRENDA	3.4.23.4. 273949.
Family and domain databases
InterPro	IPR001461. Peptidase_A1. IPR012848. Propep_A1. [Graphical view]
PANTHER	PTHR13683. Peptidase_A1. 1 hit.
Pfam	PF07966. A1_Propeptide. 1 hit. [Graphical view]
PROSITE	PS00141. ASP_PROTEASE. Partial match. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CHYM_FELCA

Accession

Primary (citable) accession number: P09873

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
Last sequence update:	July 1, 1989
Last modified:	January 19, 2010
This is version 68 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)