Reviewed,
UniProtKB/Swiss-Prot P09873 (CHYM_FELCA)
Last modified
July 28, 2009.
Version 66.
History...
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Chymosin EC=3.4.23.4 | ||
| Gene names |
| ||
| Organism | Felis catus (Cat) (Felis silvestris catus) | ||
| Taxonomic identifier | 9685 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Carnivora › Feliformia › Felidae › Felinae › Felis |
Protein attributes
| Sequence length | 54 AA. |
| Sequence status | Fragment. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Chymosin is synthesized in the mucosa of the stomach. The enzyme hydrolyzes casein to paracasein. |
| Catalytic activity | Broad specificity similar to that of pepsin A. Clots milk by cleavage of a single 105-Ser-Phe-|-Met-Ala-108 bond in kappa-chain of casein. |
| Subunit structure | Monomer. |
| Sequence similarities | Belongs to the peptidase A1 family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Digestion |
| Molecular function | Aspartyl protease Hydrolase Protease |
| PTM | Zymogen |
| Technical term | Direct protein sequencing |
| Gene Ontology (GO) | |
| Biological process | digestion Inferred from electronic annotation. Source: UniProtKB-KW proteolysisInferred from electronic annotation. Source: InterPro |
| Molecular function | aspartic-type endopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
References
| [1] | "Isolation and partial characterization of prochymosin and chymosin from cat." Jensen T., Axelsen N.H., Foltmann B. Biochim. Biophys. Acta 705:249-256(1982) [PubMed: 6810938] [Abstract] Cited for: PROTEIN SEQUENCE. |
Cross-references
Sequence databases | |
|---|---|
| PIR | A20146. |
3D structure databases | |
| HSSP | HSSP built from PDB template 4CMS based on UniProtKB P00794. |
| ModBase | Search... |
Protein family/group databases | |
| MEROPS | A01.006. |
Phylogenomic databases | |
| HOVERGEN | P09873. |
Enzyme and pathway databases | |
| BRENDA | 3.4.23.4. 273949. |
Family and domain databases | |
| InterPro | IPR001461. Peptidase_A1. IPR001969. Peptidase_aspartic_AS. IPR012848. Propep_A1. [Graphical view] |
| PANTHER | PTHR13683. Peptidase_A1. 1 hit. |
| Pfam | PF07966. A1_Propeptide. 1 hit. [Graphical view] |
| PROSITE | PS00141. ASP_PROTEASE. Partial match. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | CHYM_FELCA | ||||||||
| Accession | Primary (citable) accession number: P09873 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Peptidase families Classification of peptidase families and list of entries |
| SIMILARITY comments Index of protein domains and families |
