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Protein

Troponin C, slow skeletal and cardiac muscles

Gene

TNNC1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi65 – 761Add BLAST12
Calcium bindingi105 – 1162Add BLAST12
Calcium bindingi141 – 1523Add BLAST12

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Muscle protein

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-GGA-390522. Striated Muscle Contraction.

Names & Taxonomyi

Protein namesi
Recommended name:
Troponin C, slow skeletal and cardiac muscles
Short name:
TN-C
Gene namesi
Name:TNNC1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 12

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000737011 – 161Troponin C, slow skeletal and cardiac musclesAdd BLAST161

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP09860.
PRIDEiP09860.

Expressioni

Gene expression databases

BgeeiENSGALG00000001459.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000002212.

Structurei

Secondary structure

1161
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi8 – 11Combined sources4
Helixi14 – 27Combined sources14
Turni28 – 30Combined sources3
Helixi32 – 34Combined sources3
Helixi38 – 47Combined sources10
Helixi54 – 64Combined sources11
Beta strandi68 – 72Combined sources5
Helixi74 – 85Combined sources12
Beta strandi86 – 90Combined sources5
Helixi93 – 104Combined sources12
Beta strandi109 – 113Combined sources5
Helixi114 – 117Combined sources4
Helixi118 – 121Combined sources4
Beta strandi124 – 126Combined sources3
Helixi130 – 140Combined sources11
Beta strandi141 – 143Combined sources3
Beta strandi144 – 149Combined sources6
Helixi150 – 158Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AJ4NMR-A3-161[»]
1DTLX-ray2.15A1-161[»]
1FI5NMR-A81-161[»]
1LA0NMR-A1-161[»]
1SBJNMR-A81-161[»]
1SCVNMR-A81-161[»]
2CTNNMR-A3-89[»]
3CTNNMR-A86-161[»]
ProteinModelPortaliP09860.
SMRiP09860.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP09860.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 51EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini52 – 87EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini92 – 127EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini128 – 161EF-hand 4PROSITE-ProRule annotationAdd BLAST34

Sequence similaritiesi

Belongs to the troponin C family.Curated
Contains 4 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0027. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00760000118901.
HOGENOMiHOG000233018.
HOVERGENiHBG012180.
InParanoidiP09860.
KOiK05865.
OMAiMNDIYKA.
OrthoDBiEOG091G0QHM.
PhylomeDBiP09860.
TreeFamiTF318191.

Family and domain databases

CDDicd00051. EFh. 2 hits.
Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13499. EF-hand_7. 1 hit.
PF13833. EF-hand_8. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 4 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 3 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P09860-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDDIYKAAVE QLTEEQKNEF KAAFDIFVLG AEDGCISTKE LGKVMRMLGQ
60 70 80 90 100
NPTPEELQEM IDEVDEDGSG TVDFDEFLVM MVRCMKDDSK GKTEEELSDL
110 120 130 140 150
FRMFDKNADG YIDLEELKIM LQATGETITE DDIEELMKDG DKNNDGRIDY
160
DEFLEFMKGV E
Length:161
Mass (Da):18,431
Last modified:July 1, 1989 - v1
Checksum:i426BBC46D117B247
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16024 mRNA. Translation: AAA48654.1.
D13037 mRNA. Translation: BAA02369.1.
PIRiA27204.
RefSeqiNP_990464.1. NM_205133.1.
UniGeneiGga.3041.

Genome annotation databases

EnsembliENSGALT00000002214; ENSGALP00000002212; ENSGALG00000001459.
GeneIDi396032.
KEGGigga:396032.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16024 mRNA. Translation: AAA48654.1.
D13037 mRNA. Translation: BAA02369.1.
PIRiA27204.
RefSeqiNP_990464.1. NM_205133.1.
UniGeneiGga.3041.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AJ4NMR-A3-161[»]
1DTLX-ray2.15A1-161[»]
1FI5NMR-A81-161[»]
1LA0NMR-A1-161[»]
1SBJNMR-A81-161[»]
1SCVNMR-A81-161[»]
2CTNNMR-A3-89[»]
3CTNNMR-A86-161[»]
ProteinModelPortaliP09860.
SMRiP09860.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000002212.

Proteomic databases

PaxDbiP09860.
PRIDEiP09860.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000002214; ENSGALP00000002212; ENSGALG00000001459.
GeneIDi396032.
KEGGigga:396032.

Organism-specific databases

CTDi7134.

Phylogenomic databases

eggNOGiKOG0027. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00760000118901.
HOGENOMiHOG000233018.
HOVERGENiHBG012180.
InParanoidiP09860.
KOiK05865.
OMAiMNDIYKA.
OrthoDBiEOG091G0QHM.
PhylomeDBiP09860.
TreeFamiTF318191.

Enzyme and pathway databases

ReactomeiR-GGA-390522. Striated Muscle Contraction.

Miscellaneous databases

EvolutionaryTraceiP09860.
PROiP09860.

Gene expression databases

BgeeiENSGALG00000001459.

Family and domain databases

CDDicd00051. EFh. 2 hits.
Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13499. EF-hand_7. 1 hit.
PF13833. EF-hand_8. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 4 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 3 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTNNC1_CHICK
AccessioniPrimary (citable) accession number: P09860
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: November 30, 2016
This is version 139 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Slow skeletal muscle Tn-C can bind 3 calcium ions per molecule. Domain I does not bind calcium.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.