P09859 (ANTR_CHICK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Gastrin/cholecystokinin-like peptide Alternative name(s): Antral peptide
Organism	Gallus gallus (Chicken)
Taxonomic identifier	9031 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	105 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Potent stimulus of gastric acid, but not of pancreatic secretion.
Subcellular location	Secreted.
Sequence similarities	Belongs to the gastrin/cholecystokinin family.

Ontologies

Keywords
Biological process	Digestion
Cellular component	Secreted
Domain	Signal
Molecular function	Hormone
PTM	Amidation Cleavage on pair of basic residues Sulfation
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological process	digestion Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	hormone activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 20	20	Potential
	Propeptide	21 – 38	18			PRO_0000010656
	Peptide	41 – 93	53	Gastrin/cholecystokinin-like peptide Ref.2		PRO_0000010657
	Propeptide	97 – 105	9			PRO_0000010658
Amino acid modifications
	Modified residue	87	1	Sulfotyrosine
	Modified residue	93	1	Phenylalanine amide Ref.3

Sequences

	Sequence		Length	Mass (Da)
	P09859 [UniParc]. Last modified October 1, 1996. Version 3. Checksum: 9DB4B005EBD931DC	FASTA	105	11,625
	10 20 30 40 50 60 MKTKVFLGLI LSAAVTACLC RPAAKAPGGS HRPTSSLARR DWPEPPSQEQ QQRFISRFLP 70 80 90 100 HVFAELSDRK GFVQGNGAVE ALHDHFYPDW MDFGRRSTED AADAA

References

[1]	"Molecular characterization and physiological regulation of a TATA-less gene encoding chicken gastrin." Wu S.V., Dimaline R., Walsh J.H., Campbell B.J. Eur. J. Biochem. 230:439-446(1995) [PubMed: 7607213] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
[2]	"Identification of four chicken gastrins, obtained by processing at post-Phe bonds." Bjoernskov I., Rehfeld J.F., Johnsen A.H. Peptides 13:595-601(1992) [PubMed: 1523171] [Abstract] Cited for: PROTEIN SEQUENCE OF 41-93. Tissue: Gastric antrum.
[3]	"Isolation from chicken antrum, and primary amino acid sequence of a novel 36-residue peptide of the gastrin/CCK family." Dimaline R., Young J., Gregory H. FEBS Lett. 205:318-322(1986) [PubMed: 3743781] [Abstract] Cited for: PROTEIN SEQUENCE OF 58-93. Tissue: Gastric antrum.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U25125 Genomic DNA. Translation: AAA65926.1. U25124 mRNA. Translation: AAA65925.1.
IPI	IPI00603959.
PIR	S65677.
RefSeq	NP_990731.1. NM_205400.1.
UniGene	Gga.782.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	396365.
KEGG	gga:396365.
Phylogenomic databases
HOVERGEN	HBG098151.
Family and domain databases
InterPro	IPR001651. Gastrin. IPR013152. Gastrin/cholecystokinin_CS. [Graphical view]
Pfam	PF00918. Gastrin. 1 hit. [Graphical view]
SMART	SM00029. GASTRIN. 1 hit. [Graphical view]
PROSITE	PS00259. GASTRIN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ANTR_CHICK

Accession

Primary (citable) accession number: P09859

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
Last sequence update:	October 1, 1996
Last modified:	September 21, 2011
This is version 63 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program