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P09850

- XYNA_BACCI

UniProt

P09850 - XYNA_BACCI

Protein

Endo-1,4-beta-xylanase

Gene

xlnA

Organism
Bacillus circulans
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 1 (01 Jul 1989)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Endohydrolysis of (1->4)-beta-D-xylosidic linkages in xylans.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei106 – 1061Nucleophile1 PublicationPROSITE-ProRule annotation
    Active sitei200 – 2001Proton donor1 PublicationPROSITE-ProRule annotation

    GO - Molecular functioni

    1. endo-1,4-beta-xylanase activity Source: UniProtKB-EC

    GO - Biological processi

    1. xylan catabolic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Keywords - Biological processi

    Carbohydrate metabolism, Polysaccharide degradation, Xylan degradation

    Enzyme and pathway databases

    SABIO-RKP09850.
    UniPathwayiUPA00114.

    Protein family/group databases

    CAZyiGH11. Glycoside Hydrolase Family 11.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Endo-1,4-beta-xylanase (EC:3.2.1.8)
    Short name:
    Xylanase
    Alternative name(s):
    1,4-beta-D-xylan xylanohydrolase
    Gene namesi
    Name:xlnA
    OrganismiBacillus circulans
    Taxonomic identifieri1397 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2828Add
    BLAST
    Chaini29 – 213185Endo-1,4-beta-xylanase1 PublicationPRO_0000007996Add
    BLAST

    Structurei

    Secondary structure

    1
    213
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi33 – 386
    Beta strandi42 – 487
    Beta strandi53 – 608
    Beta strandi62 – 7211
    Beta strandi78 – 10124
    Turni102 – 1043
    Beta strandi105 – 11511
    Beta strandi121 – 1288
    Beta strandi131 – 14414
    Beta strandi148 – 16215
    Beta strandi166 – 1683
    Beta strandi170 – 1734
    Helixi174 – 18310
    Beta strandi190 – 20314
    Beta strandi205 – 2139

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1BCXX-ray1.81A29-213[»]
    1BVVX-ray1.80A29-213[»]
    1C5HX-ray1.55A29-213[»]
    1C5IX-ray1.80A29-213[»]
    1HV0X-ray1.60A29-213[»]
    1HV1X-ray1.80A29-213[»]
    1XNBX-ray1.49A29-213[»]
    1XNCX-ray1.60A29-213[»]
    2BVVX-ray1.50A29-213[»]
    3LB9X-ray3.00A/B/C29-213[»]
    3VZJX-ray2.41A/B/C/D29-213[»]
    3VZKX-ray1.55A/B29-213[»]
    3VZLX-ray2.00A/B/C/D29-213[»]
    3VZMX-ray1.86A29-213[»]
    3VZNX-ray1.67A/B29-213[»]
    3VZOX-ray1.73A29-213[»]
    ProteinModelPortaliP09850.
    SMRiP09850. Positions 29-213.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP09850.

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Family and domain databases

    Gene3Di2.60.120.180. 1 hit.
    InterProiIPR008985. ConA-like_lec_gl_sf.
    IPR001137. Glyco_hydro_11.
    IPR013319. Glyco_hydro_11/12.
    IPR018208. Glyco_hydro_11_AS.
    [Graphical view]
    PfamiPF00457. Glyco_hydro_11. 1 hit.
    [Graphical view]
    PRINTSiPR00911. GLHYDRLASE11.
    SUPFAMiSSF49899. SSF49899. 1 hit.
    PROSITEiPS00776. GLYCOSYL_HYDROL_F11_1. 1 hit.
    PS00777. GLYCOSYL_HYDROL_F11_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P09850-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFKFKKNFLV GLSAALMSIS LFSATASAAS TDYWQNWTDG GGIVNAVNGS    50
    GGNYSVNWSN TGNFVVGKGW TTGSPFRTIN YNAGVWAPNG NGYLTLYGWT 100
    RSPLIEYYVV DSWGTYRPTG TYKGTVKSDG GTYDIYTTTR YNAPSIDGDR 150
    TTFTQYWSVR QSKRPTGSNA TITFTNHVNA WKSHGMNLGS NWAYQVMATE 200
    GYQSSGSSNV TVW 213
    Length:213
    Mass (Da):23,359
    Last modified:July 1, 1989 - v1
    Checksum:i4BA0A35238CC0135
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X07723 Genomic DNA. Translation: CAA30553.1.
    PIRiS01734.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X07723 Genomic DNA. Translation: CAA30553.1 .
    PIRi S01734.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1BCX X-ray 1.81 A 29-213 [» ]
    1BVV X-ray 1.80 A 29-213 [» ]
    1C5H X-ray 1.55 A 29-213 [» ]
    1C5I X-ray 1.80 A 29-213 [» ]
    1HV0 X-ray 1.60 A 29-213 [» ]
    1HV1 X-ray 1.80 A 29-213 [» ]
    1XNB X-ray 1.49 A 29-213 [» ]
    1XNC X-ray 1.60 A 29-213 [» ]
    2BVV X-ray 1.50 A 29-213 [» ]
    3LB9 X-ray 3.00 A/B/C 29-213 [» ]
    3VZJ X-ray 2.41 A/B/C/D 29-213 [» ]
    3VZK X-ray 1.55 A/B 29-213 [» ]
    3VZL X-ray 2.00 A/B/C/D 29-213 [» ]
    3VZM X-ray 1.86 A 29-213 [» ]
    3VZN X-ray 1.67 A/B 29-213 [» ]
    3VZO X-ray 1.73 A 29-213 [» ]
    ProteinModelPortali P09850.
    SMRi P09850. Positions 29-213.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    CAZyi GH11. Glycoside Hydrolase Family 11.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00114 .
    SABIO-RK P09850.

    Miscellaneous databases

    EvolutionaryTracei P09850.

    Family and domain databases

    Gene3Di 2.60.120.180. 1 hit.
    InterProi IPR008985. ConA-like_lec_gl_sf.
    IPR001137. Glyco_hydro_11.
    IPR013319. Glyco_hydro_11/12.
    IPR018208. Glyco_hydro_11_AS.
    [Graphical view ]
    Pfami PF00457. Glyco_hydro_11. 1 hit.
    [Graphical view ]
    PRINTSi PR00911. GLHYDRLASE11.
    SUPFAMi SSF49899. SSF49899. 1 hit.
    PROSITEi PS00776. GLYCOSYL_HYDROL_F11_1. 1 hit.
    PS00777. GLYCOSYL_HYDROL_F11_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence of a Bacillus circulans xylanase gene."
      Yang R.C.A., MacKenzie C.R., Narang S.A.
      Nucleic Acids Res. 16:7187-7187(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Mutational and crystallographic analyses of the active site residues of the Bacillus circulans xylanase."
      Wakarchuk W.W., Campbell R.L., Sung W.L., Davoodi J., Yaguchi M.
      Protein Sci. 3:467-475(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS), MUTAGENESIS.
    3. "The pKa of the general acid/base carboxyl group of a glycosidase cycles during catalysis: a 13C-NMR study of Bacillus circulans xylanase."
      McIntosh L.P., Hand G., Johnson P.E., Joshi M.D., Koerner M., Plesniak L.A., Ziser L., Wakarchuk W.W., Withers S.G.
      Biochemistry 35:9958-9966(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR.

    Entry informationi

    Entry nameiXYNA_BACCI
    AccessioniPrimary (citable) accession number: P09850
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: July 1, 1989
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3