##gff-version 3
P09848	UniProtKB	Signal peptide	1	19	.	.	.	Ontology_term=ECO:0000255;evidence=ECO:0000255	
P09848	UniProtKB	Propeptide	20	868	.	.	.	ID=PRO_0000011767;Note=XBetaGly;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P09849	
P09848	UniProtKB	Chain	869	1927	.	.	.	ID=PRO_0000011768;Note=Lactase/phlorizin hydrolase;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P09849	
P09848	UniProtKB	Topological domain	20	1882	.	.	.	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255	
P09848	UniProtKB	Transmembrane	1883	1901	.	.	.	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255	
P09848	UniProtKB	Topological domain	1902	1927	.	.	.	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255	
P09848	UniProtKB	Region	44	286	.	.	.	Note=Glycosyl hydrolase-1 1%3B Region I;Ontology_term=ECO:0000255;evidence=ECO:0000255	
P09848	UniProtKB	Region	362	855	.	.	.	Note=Glycosyl hydrolase-1 2%3B Region II;Ontology_term=ECO:0000255;evidence=ECO:0000255	
P09848	UniProtKB	Region	902	1366	.	.	.	Note=Glycosyl hydrolase-1 3%3B Region III. Phlorizin hydrolase/glycosylceramidase activity;Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255,ECO:0000269|PubMed:9762914;Dbxref=PMID:9762914	
P09848	UniProtKB	Region	1220	1244	.	.	.	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
P09848	UniProtKB	Region	1373	1846	.	.	.	Note=Glycosyl hydrolase-1 4%3B Region IV. Lactase activity;Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255,ECO:0000269|PubMed:9762914;Dbxref=PMID:9762914	
P09848	UniProtKB	Region	1647	1927	.	.	.	Note=Required for homodimerization and transport to the plasma membrane;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9593732;Dbxref=PMID:9593732	
P09848	UniProtKB	Active site	1065	1065	.	.	.	Note=Proton donor%3B for phlorizin hydrolase/Glycosylceramidase activity;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:9762914;Dbxref=PMID:9762914	
P09848	UniProtKB	Active site	1273	1273	.	.	.	Note=Nucleophile%3B for phlorizin hydrolase/Glycosylceramidase activity;Ontology_term=ECO:0000255,ECO:0000305;evidence=ECO:0000255|PROSITE-ProRule:PRU10055,ECO:0000305|PubMed:9762914;Dbxref=PMID:9762914	
P09848	UniProtKB	Active site	1538	1538	.	.	.	Note=Proton donor%3B for lactase activity;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:9762914;Dbxref=PMID:9762914	
P09848	UniProtKB	Active site	1749	1749	.	.	.	Note=Nucleophile%3B for lactase activity;Ontology_term=ECO:0000255,ECO:0000305;evidence=ECO:0000255|PROSITE-ProRule:PRU10055,ECO:0000305|PubMed:9762914;Dbxref=PMID:9762914	
P09848	UniProtKB	Glycosylation	42	42	.	.	.	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255	
P09848	UniProtKB	Glycosylation	368	368	.	.	.	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255	
P09848	UniProtKB	Glycosylation	418	418	.	.	.	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255	
P09848	UniProtKB	Glycosylation	512	512	.	.	.	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255	
P09848	UniProtKB	Glycosylation	821	821	.	.	.	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255	
P09848	UniProtKB	Glycosylation	934	934	.	.	.	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255	
P09848	UniProtKB	Glycosylation	946	946	.	.	.	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255	
P09848	UniProtKB	Glycosylation	989	989	.	.	.	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255	
P09848	UniProtKB	Glycosylation	1174	1174	.	.	.	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255	
P09848	UniProtKB	Glycosylation	1340	1340	.	.	.	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255	
P09848	UniProtKB	Glycosylation	1508	1508	.	.	.	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255	
P09848	UniProtKB	Glycosylation	1656	1656	.	.	.	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255	
P09848	UniProtKB	Glycosylation	1672	1672	.	.	.	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255	
P09848	UniProtKB	Glycosylation	1761	1761	.	.	.	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255	
P09848	UniProtKB	Glycosylation	1814	1814	.	.	.	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255	
P09848	UniProtKB	Natural variant	190	190	.	.	.	ID=VAR_055882;Note=S->L;Dbxref=dbSNP:rs35156533	
P09848	UniProtKB	Natural variant	219	219	.	.	.	ID=VAR_026705;Note=V->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1902057;Dbxref=dbSNP:rs3754689,PMID:1902057	
P09848	UniProtKB	Natural variant	268	268	.	.	.	ID=VAR_026706;Note=In COLACD. Q->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16400612;Dbxref=dbSNP:rs121908937,PMID:16400612	
P09848	UniProtKB	Natural variant	362	362	.	.	.	ID=VAR_026707;Note=I->V;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:1902057,ECO:0000269|PubMed:2460343;Dbxref=dbSNP:rs4954449,PMID:1902057,PMID:2460343	
P09848	UniProtKB	Natural variant	1363	1363	.	.	.	ID=VAR_026708;Note=In COLACD. G->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16400612;Dbxref=dbSNP:rs386833833,PMID:16400612	
P09848	UniProtKB	Natural variant	1593	1593	.	.	.	ID=VAR_055883;Note=V->M;Dbxref=dbSNP:rs35891837	
P09848	UniProtKB	Natural variant	1639	1639	.	.	.	ID=VAR_026709;Note=N->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1902057;Dbxref=dbSNP:rs2322659,PMID:1902057	
P09848	UniProtKB	Mutagenesis	1273	1273	.	.	.	Note=No effect on lactase activity. Decreased phlorizin hydrolase activity. No effect on localization to the plasma membrane. E->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9762914;Dbxref=PMID:9762914	
P09848	UniProtKB	Mutagenesis	1749	1749	.	.	.	Note=Loss of lactase activity. No effect on phlorizin hydrolase activity. No effect on localization to the plasma membrane. E->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9762914;Dbxref=PMID:9762914	
P09848	UniProtKB	Sequence conflict	1096	1096	.	.	.	Note=A->T;Ontology_term=ECO:0000305;evidence=ECO:0000305