##gff-version 3 P09838 UniProtKB Chain 1 510 . . . ID=PRO_0000218792;Note=DNA nucleotidylexotransferase P09838 UniProtKB Domain 27 124 . . . Note=BRCT;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00033 P09838 UniProtKB Region 1 22 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P09838 UniProtKB Region 151 510 . . . Note=Mediates interaction with DNTTIP2;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P04053 P09838 UniProtKB Region 258 262 . . . Note=Involved in DNA binding;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11823435,ECO:0000269|PubMed:23856622;Dbxref=PMID:11823435,PMID:23856622 P09838 UniProtKB Motif 11 17 . . . Note=Nuclear localization signal;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P06526 P09838 UniProtKB Binding site 333 338 . . . Ontology_term=ECO:0000305,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0000305,ECO:0007744|PDB:4I2B,ECO:0007744|PDB:4I2C,ECO:0007744|PDB:4I2D,ECO:0007744|PDB:4I2E P09838 UniProtKB Binding site 342 345 . . . Ontology_term=ECO:0000305,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0000305,ECO:0007744|PDB:4I2B,ECO:0007744|PDB:4I2C,ECO:0007744|PDB:4I2D,ECO:0007744|PDB:4I2E P09838 UniProtKB Binding site 343 343 . . . Ontology_term=ECO:0000305,ECO:0007744,ECO:0007744;evidence=ECO:0000305,ECO:0007744|PDB:1JMS,ECO:0007744|PDB:4I2B P09838 UniProtKB Binding site 345 345 . . . Ontology_term=ECO:0000305,ECO:0007744,ECO:0007744;evidence=ECO:0000305,ECO:0007744|PDB:1JMS,ECO:0007744|PDB:4I2B P09838 UniProtKB Binding site 434 434 . . . Ontology_term=ECO:0000305,ECO:0007744,ECO:0007744;evidence=ECO:0000305,ECO:0007744|PDB:1JMS,ECO:0007744|PDB:4I2B P09838 UniProtKB Binding site 449 450 . . . Ontology_term=ECO:0000305,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0000305,ECO:0007744|PDB:4I2B,ECO:0007744|PDB:4I2C,ECO:0007744|PDB:4I2D,ECO:0007744|PDB:4I2E P09838 UniProtKB Modified residue 134 134 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:21183079;Dbxref=PMID:21183079 P09838 UniProtKB Alternative sequence 482 482 . . . ID=VSP_059967;Note=In isoform TDT-L. K->KGKTVTISPLDGKVSKLQKAL;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11136823,ECO:0000303|PubMed:16141072,ECO:0000303|PubMed:3755527;Dbxref=PMID:11136823,PMID:16141072,PMID:3755527 P09838 UniProtKB Mutagenesis 29 29 . . . Note=Almost complete loss of exonuclease activity in TDT-L%3B when associated with A-170 and A-473. Decreased transferase activity in TDT-S%3B when associated with A-170 and A-473. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11938351;Dbxref=PMID:11938351 P09838 UniProtKB Mutagenesis 170 170 . . . Note=Almost complete loss of exonuclease activity in TDT-L%3B when associated with A-29 and A-473. Decreased transferase activity in TDT-S%3B when associated with A-29 and A-473. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11938351;Dbxref=PMID:11938351 P09838 UniProtKB Mutagenesis 342 342 . . . Note=Nearly abolishes enzyme activity. H->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23856622;Dbxref=PMID:23856622 P09838 UniProtKB Mutagenesis 398 398 . . . Note=Nearly abolishes enzyme activity. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23856622;Dbxref=PMID:23856622 P09838 UniProtKB Mutagenesis 399 399 . . . Note=Nearly abolishes enzyme activity. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23856622;Dbxref=PMID:23856622 P09838 UniProtKB Mutagenesis 400 400 . . . Note=Reduces enzyme activity. H->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23856622;Dbxref=PMID:23856622 P09838 UniProtKB Mutagenesis 403 403 . . . Note=Nearly abolishes enzyme activity. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23856622;Dbxref=PMID:23856622 P09838 UniProtKB Mutagenesis 473 473 . . . Note=Almost complete loss of exonuclease activity in TDT-L%3B when associated with A-29 and A-170. Decreased transferase activity in TDT-S%3B when associated with A-29 and A-170. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11938351;Dbxref=PMID:11938351 P09838 UniProtKB Mutagenesis 473 473 . . . Note=Nearly abolishes enzyme activity. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23856622;Dbxref=PMID:23856622 P09838 UniProtKB Mutagenesis 475 475 . . . Note=Nearly abolishes enzyme activity. H->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23856622;Dbxref=PMID:23856622 P09838 UniProtKB Sequence conflict 26 26 . . . Note=T->M;Ontology_term=ECO:0000305;evidence=ECO:0000305 P09838 UniProtKB Sequence conflict 99 99 . . . Note=L->F;Ontology_term=ECO:0000305;evidence=ECO:0000305 P09838 UniProtKB Sequence conflict 193 193 . . . Note=R->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 P09838 UniProtKB Sequence conflict 287 287 . . . Note=Q->K;Ontology_term=ECO:0000305;evidence=ECO:0000305 P09838 UniProtKB Sequence conflict 309 309 . . . Note=E->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305 P09838 UniProtKB Sequence conflict 367 367 . . . Note=D->H;Ontology_term=ECO:0000305;evidence=ECO:0000305 P09838 UniProtKB Sequence conflict 441 445 . . . Note=DRRAF->ECAC;Ontology_term=ECO:0000305;evidence=ECO:0000305 P09838 UniProtKB Helix 154 156 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4I2A P09838 UniProtKB Helix 166 181 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4I2A P09838 UniProtKB Helix 185 199 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4I2A P09838 UniProtKB Helix 208 211 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4I2A P09838 UniProtKB Helix 219 231 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4I2A P09838 UniProtKB Helix 235 242 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4I2A P09838 UniProtKB Helix 244 253 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4I2A P09838 UniProtKB Helix 260 268 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4I2A P09838 UniProtKB Helix 274 279 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4I2A P09838 UniProtKB Helix 287 294 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4I2A P09838 UniProtKB Helix 296 300 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4I2A P09838 UniProtKB Helix 305 322 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4I2A P09838 UniProtKB Beta strand 327 330 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4I2A P09838 UniProtKB Helix 332 335 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4I2A P09838 UniProtKB Beta strand 339 342 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4I2A P09838 UniProtKB Beta strand 344 349 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4I2A P09838 UniProtKB Helix 355 372 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4I2A P09838 UniProtKB Beta strand 375 381 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4I2A P09838 UniProtKB Helix 387 389 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5D49 P09838 UniProtKB Beta strand 394 396 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4I2A P09838 UniProtKB Beta strand 401 411 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4I2A P09838 UniProtKB Helix 412 414 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4I2A P09838 UniProtKB Beta strand 425 437 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4I2A P09838 UniProtKB Helix 440 442 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4I2A P09838 UniProtKB Helix 443 451 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4I2A P09838 UniProtKB Helix 454 468 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4I2A P09838 UniProtKB Beta strand 470 472 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4I2A P09838 UniProtKB Beta strand 477 479 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4I2A P09838 UniProtKB Turn 480 483 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4I2A P09838 UniProtKB Beta strand 484 486 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4I2E P09838 UniProtKB Helix 491 498 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4I2A P09838 UniProtKB Helix 505 507 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4I2A