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Protein

Membrane sensor protein UhpC

Gene

uhpC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC senses external glucose-6-phosphate and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB.4 Publications

GO - Molecular functioni

GO - Biological processi

  • anion transport Source: GO_Central
  • phosphorelay signal transduction system Source: EcoCyc
  • transmembrane transport Source: GO_Central
Complete GO annotation...

Enzyme and pathway databases

BioCyciEcoCyc:UHPC-MONOMER.
ECOL316407:JW3642-MONOMER.

Protein family/group databases

TCDBi2.A.1.4.4. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Membrane sensor protein UhpCCurated
Gene namesi
Name:uhpC1 Publication
Ordered Locus Names:b3667, JW3642
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11053. uhpC.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525CytoplasmicCuratedAdd
BLAST
Transmembranei26 – 4520HelicalSequence analysisAdd
BLAST
Topological domaini46 – 6621PeriplasmicCuratedAdd
BLAST
Transmembranei67 – 8721HelicalSequence analysisAdd
BLAST
Topological domaini88 – 958CytoplasmicCurated
Transmembranei96 – 11823HelicalSequence analysisAdd
BLAST
Topological domaini119 – 1213PeriplasmicCurated
Transmembranei122 – 14423HelicalSequence analysisAdd
BLAST
Topological domaini145 – 16218CytoplasmicCuratedAdd
BLAST
Transmembranei163 – 18321HelicalSequence analysisAdd
BLAST
Topological domaini184 – 1841PeriplasmicCurated
Transmembranei185 – 20521HelicalSequence analysisAdd
BLAST
Topological domaini206 – 24439CytoplasmicCuratedAdd
BLAST
Transmembranei245 – 26521HelicalSequence analysisAdd
BLAST
Topological domaini266 – 28924PeriplasmicCuratedAdd
BLAST
Transmembranei290 – 31021HelicalSequence analysisAdd
BLAST
Topological domaini311 – 32212CytoplasmicCuratedAdd
BLAST
Transmembranei323 – 34321HelicalSequence analysisAdd
BLAST
Topological domaini344 – 3496PeriplasmicCurated
Transmembranei350 – 37021HelicalSequence analysisAdd
BLAST
Topological domaini371 – 3799CytoplasmicCurated
Transmembranei380 – 40021HelicalSequence analysisAdd
BLAST
Topological domaini401 – 41010PeriplasmicCurated
Transmembranei411 – 43121HelicalSequence analysisAdd
BLAST
Topological domaini432 – 4398Cytoplasmic1 Publication

GO - Cellular componenti

  • integral component of plasma membrane Source: EcoCyc
  • intracellular Source: GOC
  • intrinsic component of plasma membrane Source: EcoliWiki
  • membrane Source: EcoliWiki
  • plasma membrane Source: EcoliWiki
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 439439Membrane sensor protein UhpCPRO_0000199881Add
BLAST

Proteomic databases

PaxDbiP09836.

Interactioni

Protein-protein interaction databases

BioGridi4262582. 25 interactions.
STRINGi511145.b3667.

Structurei

3D structure databases

ProteinModelPortaliP09836.
SMRiP09836. Positions 19-428.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CXY. Bacteria.
COG2271. LUCA.
HOGENOMiHOG000274727.
InParanoidiP09836.
KOiK07783.
OMAiYIWLLAC.
OrthoDBiEOG6M9DW7.
PhylomeDBiP09836.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR021159. Sugar-P_transporter_CS.
IPR000849. Sugar_P_transporter.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
PIRSFiPIRSF002808. Hexose_phosphate_transp. 1 hit.
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS00942. GLPT. 1 hit.
PS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P09836-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPFLKAPAD APLMTDKYEI DARYRYWRRH ILLTIWLGYA LFYFTRKSFN
60 70 80 90 100
AAVPEILANG VLSRSDIGLL ATLFYITYGV SKFVSGIVSD RSNARYFMGI
110 120 130 140 150
GLIATGIINI LFGFSTSLWA FAVLWVLNAF FQGWGSPVCA RLLTAWYSRT
160 170 180 190 200
ERGGWWALWN TAHNVGGALI PIVMAAAALH YGWRAGMMIA GCMAIVVGIF
210 220 230 240 250
LCWRLRDRPQ ALGLPAVGEW RHDALEIAQQ QEGAGLTRKE ILTKYVLLNP
260 270 280 290 300
YIWLLSFCYV LVYVVRAAIN DWGNLYMSET LGVDLVTANT AVTMFELGGF
310 320 330 340 350
IGALVAGWGS DKLFNGNRGP MNLIFAAGIL LSVGSLWLMP FASYVMQATC
360 370 380 390 400
FFTIGFFVFG PQMLIGMAAA ECSHKEAAGA ATGFVGLFAY LGASLAGWPL
410 420 430
AKVLDTWHWS GFFVVISIAA GISALLLLPF LNAQTPREA
Length:439
Mass (Da):48,257
Last modified:August 1, 1992 - v3
Checksum:iD8097864B7877700
GO

Sequence cautioni

The sequence AAA24722.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAA62019.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M17102 Genomic DNA. Translation: AAA24722.1. Different initiation.
M89479 Genomic DNA. Translation: AAA24726.1.
L10328 Genomic DNA. Translation: AAA62019.1. Different initiation.
U00096 Genomic DNA. Translation: AAC76690.2.
AP009048 Genomic DNA. Translation: BAE77626.1.
PIRiD65168. RGECUC.
RefSeqiNP_418123.2. NC_000913.3.
WP_000936566.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76690; AAC76690; b3667.
BAE77626; BAE77626; BAE77626.
GeneIDi948184.
KEGGiecj:JW3642.
eco:b3667.
PATRICi32122827. VBIEscCol129921_3789.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M17102 Genomic DNA. Translation: AAA24722.1. Different initiation.
M89479 Genomic DNA. Translation: AAA24726.1.
L10328 Genomic DNA. Translation: AAA62019.1. Different initiation.
U00096 Genomic DNA. Translation: AAC76690.2.
AP009048 Genomic DNA. Translation: BAE77626.1.
PIRiD65168. RGECUC.
RefSeqiNP_418123.2. NC_000913.3.
WP_000936566.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP09836.
SMRiP09836. Positions 19-428.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262582. 25 interactions.
STRINGi511145.b3667.

Protein family/group databases

TCDBi2.A.1.4.4. the major facilitator superfamily (mfs).

Proteomic databases

PaxDbiP09836.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76690; AAC76690; b3667.
BAE77626; BAE77626; BAE77626.
GeneIDi948184.
KEGGiecj:JW3642.
eco:b3667.
PATRICi32122827. VBIEscCol129921_3789.

Organism-specific databases

EchoBASEiEB1046.
EcoGeneiEG11053. uhpC.

Phylogenomic databases

eggNOGiENOG4105CXY. Bacteria.
COG2271. LUCA.
HOGENOMiHOG000274727.
InParanoidiP09836.
KOiK07783.
OMAiYIWLLAC.
OrthoDBiEOG6M9DW7.
PhylomeDBiP09836.

Enzyme and pathway databases

BioCyciEcoCyc:UHPC-MONOMER.
ECOL316407:JW3642-MONOMER.

Miscellaneous databases

PROiP09836.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR021159. Sugar-P_transporter_CS.
IPR000849. Sugar_P_transporter.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
PIRSFiPIRSF002808. Hexose_phosphate_transp. 1 hit.
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS00942. GLPT. 1 hit.
PS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence of the uhp region of Escherichia coli."
    Friedrich M.J., Kadner R.J.
    J. Bacteriol. 169:3556-3563(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Kadner R.J.
    Submitted (AUG-1990) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  3. "Structure and function of the uhp genes for the sugar phosphate transport system in Escherichia coli and Salmonella typhimurium."
    Island M.D., Wei B.-Y., Kadner R.J.
    J. Bacteriol. 174:2754-2762(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "DNA sequence and analysis of 136 kilobases of the Escherichia coli genome: organizational symmetry around the origin of replication."
    Burland V.D., Plunkett G. III, Daniels D.L., Blattner F.R.
    Genomics 16:551-561(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  6. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  7. "Identification of uhp polypeptides and evidence for their role in exogenous induction of the sugar phosphate transport system of Escherichia coli K-12."
    Weston L.A., Kadner R.J.
    J. Bacteriol. 169:3546-3555(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION, FUNCTION.
  8. "Interplay between the membrane-associated UhpB and UhpC regulatory proteins."
    Island M.D., Kadner R.J.
    J. Bacteriol. 175:5028-5034(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  9. "The histidine kinase domain of UhpB inhibits UhpA action at the Escherichia coli uhpT promoter."
    Wright J.S., Olekhnovich I.N., Touchie G., Kadner R.J.
    J. Bacteriol. 182:6279-6286(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  10. "Glucose-6-phosphate-dependent phosphoryl flow through the Uhp two-component regulatory system."
    Verhamme D.T., Arents J.C., Postma P.W., Crielaard W., Hellingwerf K.J.
    Microbiology 147:3345-3352(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  11. "Global topology analysis of the Escherichia coli inner membrane proteome."
    Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.
    Science 308:1321-1323(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS], SUBCELLULAR LOCATION.
    Strain: K12 / MG1655 / ATCC 47076.

Entry informationi

Entry nameiUHPC_ECOLI
AccessioniPrimary (citable) accession number: P09836
Secondary accession number(s): P76728, Q2M7Y0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: August 1, 1992
Last modified: July 6, 2016
This is version 132 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.