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Protein

Membrane sensor protein UhpC

Gene

uhpC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC senses external glucose-6-phosphate and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB.4 Publications

GO - Molecular functioni

GO - Biological processi

  • phosphorelay signal transduction system Source: EcoCyc

Enzyme and pathway databases

BioCyciEcoCyc:UHPC-MONOMER

Protein family/group databases

TCDBi2.A.1.4.4 the major facilitator superfamily (mfs)

Names & Taxonomyi

Protein namesi
Recommended name:
Membrane sensor protein UhpCCurated
Gene namesi
Name:uhpC1 Publication
Ordered Locus Names:b3667, JW3642
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11053 uhpC

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25CytoplasmicCuratedAdd BLAST25
Transmembranei26 – 45HelicalSequence analysisAdd BLAST20
Topological domaini46 – 66PeriplasmicCuratedAdd BLAST21
Transmembranei67 – 87HelicalSequence analysisAdd BLAST21
Topological domaini88 – 95CytoplasmicCurated8
Transmembranei96 – 118HelicalSequence analysisAdd BLAST23
Topological domaini119 – 121PeriplasmicCurated3
Transmembranei122 – 144HelicalSequence analysisAdd BLAST23
Topological domaini145 – 162CytoplasmicCuratedAdd BLAST18
Transmembranei163 – 183HelicalSequence analysisAdd BLAST21
Topological domaini184PeriplasmicCurated1
Transmembranei185 – 205HelicalSequence analysisAdd BLAST21
Topological domaini206 – 244CytoplasmicCuratedAdd BLAST39
Transmembranei245 – 265HelicalSequence analysisAdd BLAST21
Topological domaini266 – 289PeriplasmicCuratedAdd BLAST24
Transmembranei290 – 310HelicalSequence analysisAdd BLAST21
Topological domaini311 – 322CytoplasmicCuratedAdd BLAST12
Transmembranei323 – 343HelicalSequence analysisAdd BLAST21
Topological domaini344 – 349PeriplasmicCurated6
Transmembranei350 – 370HelicalSequence analysisAdd BLAST21
Topological domaini371 – 379CytoplasmicCurated9
Transmembranei380 – 400HelicalSequence analysisAdd BLAST21
Topological domaini401 – 410PeriplasmicCurated10
Transmembranei411 – 431HelicalSequence analysisAdd BLAST21
Topological domaini432 – 439Cytoplasmic1 Publication8

GO - Cellular componenti

  • integral component of plasma membrane Source: EcoCyc
  • intracellular Source: GOC
  • intrinsic component of plasma membrane Source: EcoliWiki
  • membrane Source: EcoliWiki
  • plasma membrane Source: EcoliWiki

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001998811 – 439Membrane sensor protein UhpCAdd BLAST439

Proteomic databases

PaxDbiP09836
PRIDEiP09836

Interactioni

Protein-protein interaction databases

BioGridi4262582, 27 interactors
STRINGi316385.ECDH10B_3850

Structurei

3D structure databases

ProteinModelPortaliP09836
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CXY Bacteria
COG2271 LUCA
HOGENOMiHOG000274727
InParanoidiP09836
KOiK07783
OMAiCTDWGQF
PhylomeDBiP09836

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR011701 MFS
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
IPR021159 Sugar-P_transporter_CS
IPR000849 Sugar_P_transporter
PfamiView protein in Pfam
PF07690 MFS_1, 1 hit
PIRSFiPIRSF002808 Hexose_phosphate_transp, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit
PROSITEiView protein in PROSITE
PS00942 GLPT, 1 hit
PS50850 MFS, 1 hit

Sequencei

Sequence statusi: Complete.

P09836-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPFLKAPAD APLMTDKYEI DARYRYWRRH ILLTIWLGYA LFYFTRKSFN
60 70 80 90 100
AAVPEILANG VLSRSDIGLL ATLFYITYGV SKFVSGIVSD RSNARYFMGI
110 120 130 140 150
GLIATGIINI LFGFSTSLWA FAVLWVLNAF FQGWGSPVCA RLLTAWYSRT
160 170 180 190 200
ERGGWWALWN TAHNVGGALI PIVMAAAALH YGWRAGMMIA GCMAIVVGIF
210 220 230 240 250
LCWRLRDRPQ ALGLPAVGEW RHDALEIAQQ QEGAGLTRKE ILTKYVLLNP
260 270 280 290 300
YIWLLSFCYV LVYVVRAAIN DWGNLYMSET LGVDLVTANT AVTMFELGGF
310 320 330 340 350
IGALVAGWGS DKLFNGNRGP MNLIFAAGIL LSVGSLWLMP FASYVMQATC
360 370 380 390 400
FFTIGFFVFG PQMLIGMAAA ECSHKEAAGA ATGFVGLFAY LGASLAGWPL
410 420 430
AKVLDTWHWS GFFVVISIAA GISALLLLPF LNAQTPREA
Length:439
Mass (Da):48,257
Last modified:August 1, 1992 - v3
Checksum:iD8097864B7877700
GO

Sequence cautioni

The sequence AAA24722 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAA62019 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M17102 Genomic DNA Translation: AAA24722.1 Different initiation.
M89479 Genomic DNA Translation: AAA24726.1
L10328 Genomic DNA Translation: AAA62019.1 Different initiation.
U00096 Genomic DNA Translation: AAC76690.2
AP009048 Genomic DNA Translation: BAE77626.1
PIRiD65168 RGECUC
RefSeqiNP_418123.2, NC_000913.3
WP_000936566.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC76690; AAC76690; b3667
BAE77626; BAE77626; BAE77626
GeneIDi948184
KEGGiecj:JW3642
eco:b3667
PATRICifig|511145.12.peg.3789

Entry informationi

Entry nameiUHPC_ECOLI
AccessioniPrimary (citable) accession number: P09836
Secondary accession number(s): P76728, Q2M7Y0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: August 1, 1992
Last modified: March 28, 2018
This is version 142 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health