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Protein

Membrane sensor protein UhpC

Gene

uhpC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC senses external glucose-6-phosphate and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB.4 Publications

GO - Molecular functioni

GO - Biological processi

  • anion transport Source: GO_Central
  • phosphorelay signal transduction system Source: EcoCyc
  • transmembrane transport Source: GO_Central
Complete GO annotation...

Enzyme and pathway databases

BioCyciEcoCyc:UHPC-MONOMER.
ECOL316407:JW3642-MONOMER.

Protein family/group databases

TCDBi2.A.1.4.4. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Membrane sensor protein UhpCCurated
Gene namesi
Name:uhpC1 Publication
Ordered Locus Names:b3667, JW3642
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11053. uhpC.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25CytoplasmicCuratedAdd BLAST25
Transmembranei26 – 45HelicalSequence analysisAdd BLAST20
Topological domaini46 – 66PeriplasmicCuratedAdd BLAST21
Transmembranei67 – 87HelicalSequence analysisAdd BLAST21
Topological domaini88 – 95CytoplasmicCurated8
Transmembranei96 – 118HelicalSequence analysisAdd BLAST23
Topological domaini119 – 121PeriplasmicCurated3
Transmembranei122 – 144HelicalSequence analysisAdd BLAST23
Topological domaini145 – 162CytoplasmicCuratedAdd BLAST18
Transmembranei163 – 183HelicalSequence analysisAdd BLAST21
Topological domaini184PeriplasmicCurated1
Transmembranei185 – 205HelicalSequence analysisAdd BLAST21
Topological domaini206 – 244CytoplasmicCuratedAdd BLAST39
Transmembranei245 – 265HelicalSequence analysisAdd BLAST21
Topological domaini266 – 289PeriplasmicCuratedAdd BLAST24
Transmembranei290 – 310HelicalSequence analysisAdd BLAST21
Topological domaini311 – 322CytoplasmicCuratedAdd BLAST12
Transmembranei323 – 343HelicalSequence analysisAdd BLAST21
Topological domaini344 – 349PeriplasmicCurated6
Transmembranei350 – 370HelicalSequence analysisAdd BLAST21
Topological domaini371 – 379CytoplasmicCurated9
Transmembranei380 – 400HelicalSequence analysisAdd BLAST21
Topological domaini401 – 410PeriplasmicCurated10
Transmembranei411 – 431HelicalSequence analysisAdd BLAST21
Topological domaini432 – 439Cytoplasmic1 Publication8

GO - Cellular componenti

  • integral component of plasma membrane Source: EcoCyc
  • intracellular Source: GOC
  • intrinsic component of plasma membrane Source: EcoliWiki
  • membrane Source: EcoliWiki
  • plasma membrane Source: EcoliWiki
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001998811 – 439Membrane sensor protein UhpCAdd BLAST439

Proteomic databases

PaxDbiP09836.
PRIDEiP09836.

Interactioni

Protein-protein interaction databases

BioGridi4262582. 25 interactors.
STRINGi511145.b3667.

Structurei

3D structure databases

ProteinModelPortaliP09836.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CXY. Bacteria.
COG2271. LUCA.
HOGENOMiHOG000274727.
InParanoidiP09836.
KOiK07783.
OMAiYIWLLAC.
PhylomeDBiP09836.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR021159. Sugar-P_transporter_CS.
IPR000849. Sugar_P_transporter.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
PIRSFiPIRSF002808. Hexose_phosphate_transp. 1 hit.
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS00942. GLPT. 1 hit.
PS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P09836-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPFLKAPAD APLMTDKYEI DARYRYWRRH ILLTIWLGYA LFYFTRKSFN
60 70 80 90 100
AAVPEILANG VLSRSDIGLL ATLFYITYGV SKFVSGIVSD RSNARYFMGI
110 120 130 140 150
GLIATGIINI LFGFSTSLWA FAVLWVLNAF FQGWGSPVCA RLLTAWYSRT
160 170 180 190 200
ERGGWWALWN TAHNVGGALI PIVMAAAALH YGWRAGMMIA GCMAIVVGIF
210 220 230 240 250
LCWRLRDRPQ ALGLPAVGEW RHDALEIAQQ QEGAGLTRKE ILTKYVLLNP
260 270 280 290 300
YIWLLSFCYV LVYVVRAAIN DWGNLYMSET LGVDLVTANT AVTMFELGGF
310 320 330 340 350
IGALVAGWGS DKLFNGNRGP MNLIFAAGIL LSVGSLWLMP FASYVMQATC
360 370 380 390 400
FFTIGFFVFG PQMLIGMAAA ECSHKEAAGA ATGFVGLFAY LGASLAGWPL
410 420 430
AKVLDTWHWS GFFVVISIAA GISALLLLPF LNAQTPREA
Length:439
Mass (Da):48,257
Last modified:August 1, 1992 - v3
Checksum:iD8097864B7877700
GO

Sequence cautioni

The sequence AAA24722 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAA62019 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M17102 Genomic DNA. Translation: AAA24722.1. Different initiation.
M89479 Genomic DNA. Translation: AAA24726.1.
L10328 Genomic DNA. Translation: AAA62019.1. Different initiation.
U00096 Genomic DNA. Translation: AAC76690.2.
AP009048 Genomic DNA. Translation: BAE77626.1.
PIRiD65168. RGECUC.
RefSeqiNP_418123.2. NC_000913.3.
WP_000936566.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76690; AAC76690; b3667.
BAE77626; BAE77626; BAE77626.
GeneIDi948184.
KEGGiecj:JW3642.
eco:b3667.
PATRICi32122827. VBIEscCol129921_3789.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M17102 Genomic DNA. Translation: AAA24722.1. Different initiation.
M89479 Genomic DNA. Translation: AAA24726.1.
L10328 Genomic DNA. Translation: AAA62019.1. Different initiation.
U00096 Genomic DNA. Translation: AAC76690.2.
AP009048 Genomic DNA. Translation: BAE77626.1.
PIRiD65168. RGECUC.
RefSeqiNP_418123.2. NC_000913.3.
WP_000936566.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP09836.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262582. 25 interactors.
STRINGi511145.b3667.

Protein family/group databases

TCDBi2.A.1.4.4. the major facilitator superfamily (mfs).

Proteomic databases

PaxDbiP09836.
PRIDEiP09836.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76690; AAC76690; b3667.
BAE77626; BAE77626; BAE77626.
GeneIDi948184.
KEGGiecj:JW3642.
eco:b3667.
PATRICi32122827. VBIEscCol129921_3789.

Organism-specific databases

EchoBASEiEB1046.
EcoGeneiEG11053. uhpC.

Phylogenomic databases

eggNOGiENOG4105CXY. Bacteria.
COG2271. LUCA.
HOGENOMiHOG000274727.
InParanoidiP09836.
KOiK07783.
OMAiYIWLLAC.
PhylomeDBiP09836.

Enzyme and pathway databases

BioCyciEcoCyc:UHPC-MONOMER.
ECOL316407:JW3642-MONOMER.

Miscellaneous databases

PROiP09836.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR021159. Sugar-P_transporter_CS.
IPR000849. Sugar_P_transporter.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
PIRSFiPIRSF002808. Hexose_phosphate_transp. 1 hit.
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS00942. GLPT. 1 hit.
PS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUHPC_ECOLI
AccessioniPrimary (citable) accession number: P09836
Secondary accession number(s): P76728, Q2M7Y0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: August 1, 1992
Last modified: November 2, 2016
This is version 135 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.