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Protein

Molybdenum import ATP-binding protein ModC

Gene

modC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system.UniRule annotation

Catalytic activityi

ATP + H2O + molybdate(Out) = ADP + phosphate + molybdate(In).UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi31 – 38ATPUniRule annotation8

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Molybdenum, Nucleotide-binding

Enzyme and pathway databases

BioCyciEcoCyc:MODC-MONOMER.
ECOL316407:JW0748-MONOMER.
MetaCyc:MODC-MONOMER.

Protein family/group databases

TCDBi3.A.1.8.1. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Molybdenum import ATP-binding protein ModCUniRule annotation (EC:3.6.3.29UniRule annotation)
Gene namesi
Name:modCUniRule annotation
Synonyms:chlD, narD
Ordered Locus Names:b0765, JW0748
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10152. modC.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000925371 – 352Molybdenum import ATP-binding protein ModCAdd BLAST352

Proteomic databases

PaxDbiP09833.
PRIDEiP09833.

Interactioni

Subunit structurei

The complex is composed of two ATP-binding proteins (ModC), two transmembrane proteins (ModB) and a solute-binding protein (ModA).UniRule annotation

Protein-protein interaction databases

BioGridi4261147. 8 interactors.
IntActiP09833. 2 interactors.
STRINGi511145.b0765.

Structurei

3D structure databases

ProteinModelPortaliP09833.
SMRiP09833.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 229ABC transporterUniRule annotationAdd BLAST229

Sequence similaritiesi

Belongs to the ABC transporter superfamily. Molybdate importer (TC 3.A.1.8) family. [View classification]UniRule annotation
Contains 1 ABC transporter domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CGB. Bacteria.
COG4148. LUCA.
InParanoidiP09833.
KOiK02017.
OMAiMLELDFS.
PhylomeDBiP09833.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR015852. ABC_transpr_ModC.
IPR004606. Mo-pterin-bd.
IPR008995. Mo/tungstate-bd_C_term_dom.
IPR011868. ModC_ABC_ATP-bd.
IPR027417. P-loop_NTPase.
IPR005116. Transp-assoc_OB_typ1.
[Graphical view]
PfamiPF00005. ABC_tran. 1 hit.
PF03459. TOBE. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF50331. SSF50331. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR02142. modC_ABC. 1 hit.
TIGR00638. Mop. 1 hit.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
PS51241. MODC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P09833-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLELNFSQTL GNHCLTINET LPANGITAIF GVSGAGKTSL INAISGLTRP
60 70 80 90 100
QKGRIVLNGR VLNDAEKGIC LTPEKRRVGY VFQDARLFPH YKVRGNLRYG
110 120 130 140 150
MSKSMVDQFD KLVALLGIEP LLDRLPGSLS GGEKQRVAIG RALLTAPELL
160 170 180 190 200
LLDEPLASLD IPRKRELLPY LQRLTREINI PMLYVSHSLD EILHLADRVM
210 220 230 240 250
VLENGQVKAF GALEEVWGSS VMNPWLPKEQ QSSILKVTVL EHHPHYAMTA
260 270 280 290 300
LALGDQHLWV NKLDEPLQAA LRIRIQASDV SLVLQPPQQT SIRNVLRAKV
310 320 330 340 350
VNSYDDNGQV EVELEVGGKT LWARISPWAR DELAIKPGLW LYAQIKSVSI

TA
Length:352
Mass (Da):39,102
Last modified:June 20, 2003 - v4
Checksum:i15D9CAAE511AF7D8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti244 – 250PHYAMTA → SALRDDR in AAB06895 (PubMed:8564363).Curated7
Sequence conflicti244 – 250PHYAMTA → SALRDDR in AAA83840 (PubMed:3553151).Curated7
Sequence conflicti269 – 352AALRI…VSITA → LRYYPHSGFRCFSWFYNRRS KPAFVTIAGKSC in AAA83840 (PubMed:3553151).CuratedAdd BLAST84
Sequence conflicti269 – 352AALRI…VSITA → LRYYPHSGFRCFSWFYNRRS KPAFVTIAGKSC in AAB00837 (PubMed:3553151).CuratedAdd BLAST84

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U27192 Genomic DNA. Translation: AAB60173.1.
M16182 Genomic DNA. Translation: AAA83840.1.
U07867 Genomic DNA. Translation: AAB06895.1.
L34009 Genomic DNA. Translation: AAB00837.1.
U00096 Genomic DNA. Translation: AAC73852.1.
AP009048 Genomic DNA. Translation: BAA35429.1.
PIRiE64812. BVECHD.
RefSeqiNP_415286.1. NC_000913.3.
WP_000891692.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73852; AAC73852; b0765.
BAA35429; BAA35429; BAA35429.
GeneIDi945362.
KEGGiecj:JW0748.
eco:b0765.
PATRICi32116731. VBIEscCol129921_0791.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U27192 Genomic DNA. Translation: AAB60173.1.
M16182 Genomic DNA. Translation: AAA83840.1.
U07867 Genomic DNA. Translation: AAB06895.1.
L34009 Genomic DNA. Translation: AAB00837.1.
U00096 Genomic DNA. Translation: AAC73852.1.
AP009048 Genomic DNA. Translation: BAA35429.1.
PIRiE64812. BVECHD.
RefSeqiNP_415286.1. NC_000913.3.
WP_000891692.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP09833.
SMRiP09833.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261147. 8 interactors.
IntActiP09833. 2 interactors.
STRINGi511145.b0765.

Protein family/group databases

TCDBi3.A.1.8.1. the atp-binding cassette (abc) superfamily.

Proteomic databases

PaxDbiP09833.
PRIDEiP09833.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73852; AAC73852; b0765.
BAA35429; BAA35429; BAA35429.
GeneIDi945362.
KEGGiecj:JW0748.
eco:b0765.
PATRICi32116731. VBIEscCol129921_0791.

Organism-specific databases

EchoBASEiEB0150.
EcoGeneiEG10152. modC.

Phylogenomic databases

eggNOGiENOG4105CGB. Bacteria.
COG4148. LUCA.
InParanoidiP09833.
KOiK02017.
OMAiMLELDFS.
PhylomeDBiP09833.

Enzyme and pathway databases

BioCyciEcoCyc:MODC-MONOMER.
ECOL316407:JW0748-MONOMER.
MetaCyc:MODC-MONOMER.

Miscellaneous databases

PROiP09833.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR015852. ABC_transpr_ModC.
IPR004606. Mo-pterin-bd.
IPR008995. Mo/tungstate-bd_C_term_dom.
IPR011868. ModC_ABC_ATP-bd.
IPR027417. P-loop_NTPase.
IPR005116. Transp-assoc_OB_typ1.
[Graphical view]
PfamiPF00005. ABC_tran. 1 hit.
PF03459. TOBE. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF50331. SSF50331. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR02142. modC_ABC. 1 hit.
TIGR00638. Mop. 1 hit.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
PS51241. MODC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMODC_ECOLI
AccessioniPrimary (citable) accession number: P09833
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: June 20, 2003
Last modified: November 30, 2016
This is version 152 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.