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Protein

Apolipoprotein A-II

Gene

Apoa2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Lipid transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-174800. Chylomicron-mediated lipid transport.
R-MMU-975634. Retinoid metabolism and transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Apolipoprotein A-II
Short name:
Apo-AII
Short name:
ApoA-II
Alternative name(s):
Apolipoprotein A2
Cleaved into the following chain:
Proapolipoprotein A-II
Short name:
ProapoA-II
Gene namesi
Name:Apoa2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:88050. Apoa2.

Subcellular locationi

  • Secreted By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Amyloid, HDL, Secreted

Pathology & Biotechi

Involvement in diseasei

Defects in Apoa2 are the cause of senescence accelerated mouse (SAM), the senile amyloid is a mutated apolipoprotein A-II.

Keywords - Diseasei

Disease mutation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Add BLAST18
ChainiPRO_000042535419 – 102Proapolipoprotein A-IIAdd BLAST84
ChainiPRO_000000200824 – 102Apolipoprotein A-II2 PublicationsAdd BLAST79

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei24Pyrrolidone carboxylic acid; in Apolipoprotein A-IIBy similarity1
Modified residuei49Methionine sulfoxideBy similarity1

Keywords - PTMi

Cleavage on pair of basic residues, Oxidation, Pyrrolidone carboxylic acid

Proteomic databases

PaxDbiP09813.
PeptideAtlasiP09813.
PRIDEiP09813.

PTM databases

iPTMnetiP09813.
PhosphoSitePlusiP09813.

Expressioni

Tissue specificityi

Plasma.

Gene expression databases

BgeeiENSMUSG00000005681.
CleanExiMM_APOA2.
GenevisibleiP09813. MM.

Interactioni

Subunit structurei

Monomer. Interacts with APOA1BP and NDRG1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi198156. 1 interactor.
IntActiP09813. 5 interactors.
MINTiMINT-1855567.
STRINGi10090.ENSMUSP00000005824.

Structurei

3D structure databases

ProteinModelPortaliP09813.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the apolipoprotein A2 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J3V8. Eukaryota.
ENOG4111552. LUCA.
GeneTreeiENSGT00390000003306.
HOGENOMiHOG000033999.
HOVERGENiHBG050544.
InParanoidiP09813.
KOiK08758.
OMAiAYFEKTQ.
OrthoDBiEOG091G0Z27.
TreeFamiTF338165.

Family and domain databases

InterProiIPR006801. ApoA-II.
[Graphical view]
PANTHERiPTHR11027. PTHR11027. 1 hit.
ProDomiPD010397. ApoA-II. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF82936. SSF82936. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P09813-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLLAMVALL VTICSLEGAL VKRQADGPDM QSLFTQYFQS MTDYGKDLME
60 70 80 90 100
KAKTSEIQSQ AKAYFEKTHE QLTPLVRSAG TSLVNFFSSL MNLEEKPAPA

AK
Length:102
Mass (Da):11,309
Last modified:October 3, 2012 - v2
Checksum:iF50142E0D118665B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti43D → E in CAA27731 (PubMed:2426658).Curated1
Sequence conflicti43D → E in AAA37248 (PubMed:2514123).Curated1
Sequence conflicti43D → E in AAA37250 (PubMed:2118905).Curated1
Sequence conflicti43D → E in AAH31786 (PubMed:15489334).Curated1
Sequence conflicti48L → F in CAA44616 (PubMed:1683229).Curated1
Sequence conflicti49M → V in CAA27731 (PubMed:2426658).Curated1
Sequence conflicti49M → V in AAA37248 (PubMed:2514123).Curated1
Sequence conflicti49M → V in AAA37250 (PubMed:2118905).Curated1
Sequence conflicti49M → V in AAH31786 (PubMed:15489334).Curated1
Sequence conflicti61A → V in CAA27731 (PubMed:2426658).Curated1
Sequence conflicti61A → V in AAA37250 (PubMed:2118905).Curated1
Sequence conflicti61A → V in AAH31786 (PubMed:15489334).Curated1

Mass spectrometryi

Molecular mass is 8709.2±0.071 Da from positions 24 - 102. Determined by ESI. Strain C57BL/6. Without methionine sulfoxide.1 Publication
Molecular mass is 8719.5 Da from positions 24 - 102. Determined by ESI. Strain BALB/c. Without methionine sulfoxide.1 Publication
Molecular mass is 8725.3±0.283 Da from positions 24 - 102. Determined by ESI. Strain C57BL/6. With 1 methionine sulfoxide.1 Publication
Molecular mass is 8742 Da from positions 24 - 102. Determined by ESI. Strain C57BL/6. With 2 methionine sulfoxides.1 Publication
Molecular mass is 8735.2 Da from positions 24 - 102. Determined by ESI. Strain BALB/c. With 1 methionine sulfoxide.1 Publication
Molecular mass is 9294±0.707 Da from positions 19 - 102. Determined by ESI. Strain C57BL/6. Without methionine sulfoxide.1 Publication
Molecular mass is 9304 Da from positions 19 - 102. Determined by ESI. Strain BALB/c. Without methionine sulfoxide.1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti28P → Q in SAM. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04119 mRNA. Translation: CAA27731.1.
M32360 Genomic DNA. Translation: AAA37248.1.
M79361 mRNA. Translation: AAA37249.1.
M79362 mRNA. Translation: AAA37250.1.
X62772 mRNA. Translation: CAA44616.1.
AK145823 mRNA. Translation: BAE26675.1.
AC084821 Genomic DNA. No translation available.
CH466520 Genomic DNA. Translation: EDL39118.1.
CH466520 Genomic DNA. Translation: EDL39119.1.
CH466520 Genomic DNA. Translation: EDL39120.1.
CH466520 Genomic DNA. Translation: EDL39121.1.
BC031786 mRNA. Translation: AAH31786.1.
CCDSiCCDS35773.1.
PIRiA37887.
B37887. B23594.
I48250.
JS0392. A23594.
RefSeqiNP_001292478.1. NM_001305549.1.
NP_001292479.1. NM_001305550.1.
NP_001292514.1. NM_001305585.1.
NP_038502.2. NM_013474.2.
UniGeneiMm.389209.

Genome annotation databases

EnsembliENSMUST00000005824; ENSMUSP00000005824; ENSMUSG00000005681.
ENSMUST00000111319; ENSMUSP00000106951; ENSMUSG00000005681.
ENSMUST00000111320; ENSMUSP00000106952; ENSMUSG00000005681.
ENSMUST00000111321; ENSMUSP00000106953; ENSMUSG00000005681.
GeneIDi11807.
KEGGimmu:11807.
UCSCiuc007dnk.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04119 mRNA. Translation: CAA27731.1.
M32360 Genomic DNA. Translation: AAA37248.1.
M79361 mRNA. Translation: AAA37249.1.
M79362 mRNA. Translation: AAA37250.1.
X62772 mRNA. Translation: CAA44616.1.
AK145823 mRNA. Translation: BAE26675.1.
AC084821 Genomic DNA. No translation available.
CH466520 Genomic DNA. Translation: EDL39118.1.
CH466520 Genomic DNA. Translation: EDL39119.1.
CH466520 Genomic DNA. Translation: EDL39120.1.
CH466520 Genomic DNA. Translation: EDL39121.1.
BC031786 mRNA. Translation: AAH31786.1.
CCDSiCCDS35773.1.
PIRiA37887.
B37887. B23594.
I48250.
JS0392. A23594.
RefSeqiNP_001292478.1. NM_001305549.1.
NP_001292479.1. NM_001305550.1.
NP_001292514.1. NM_001305585.1.
NP_038502.2. NM_013474.2.
UniGeneiMm.389209.

3D structure databases

ProteinModelPortaliP09813.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198156. 1 interactor.
IntActiP09813. 5 interactors.
MINTiMINT-1855567.
STRINGi10090.ENSMUSP00000005824.

PTM databases

iPTMnetiP09813.
PhosphoSitePlusiP09813.

Proteomic databases

PaxDbiP09813.
PeptideAtlasiP09813.
PRIDEiP09813.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000005824; ENSMUSP00000005824; ENSMUSG00000005681.
ENSMUST00000111319; ENSMUSP00000106951; ENSMUSG00000005681.
ENSMUST00000111320; ENSMUSP00000106952; ENSMUSG00000005681.
ENSMUST00000111321; ENSMUSP00000106953; ENSMUSG00000005681.
GeneIDi11807.
KEGGimmu:11807.
UCSCiuc007dnk.2. mouse.

Organism-specific databases

CTDi336.
MGIiMGI:88050. Apoa2.

Phylogenomic databases

eggNOGiENOG410J3V8. Eukaryota.
ENOG4111552. LUCA.
GeneTreeiENSGT00390000003306.
HOGENOMiHOG000033999.
HOVERGENiHBG050544.
InParanoidiP09813.
KOiK08758.
OMAiAYFEKTQ.
OrthoDBiEOG091G0Z27.
TreeFamiTF338165.

Enzyme and pathway databases

ReactomeiR-MMU-174800. Chylomicron-mediated lipid transport.
R-MMU-975634. Retinoid metabolism and transport.

Miscellaneous databases

ChiTaRSiApoa2. mouse.
PROiP09813.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000005681.
CleanExiMM_APOA2.
GenevisibleiP09813. MM.

Family and domain databases

InterProiIPR006801. ApoA-II.
[Graphical view]
PANTHERiPTHR11027. PTHR11027. 1 hit.
ProDomiPD010397. ApoA-II. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF82936. SSF82936. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiAPOA2_MOUSE
AccessioniPrimary (citable) accession number: P09813
Secondary accession number(s): Q3UKX6, Q61317
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: October 3, 2012
Last modified: November 2, 2016
This is version 158 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

The apo A-II stoichiometry in HDL molecules varies among inbred mice strains, because of structural polymorphisms affecting the apo A-II gene, which influence its translational efficiency.
The sequence presented here is that of strain BALB/c and C3H/HeJ.

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.